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The non-stationary and spatially varying associations between hand,foot and mouth disease and multiple environmental factors:A Bayesian spatiotemporal mapping model study

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Infectious Disease Modelling 2024年第2期9卷 373-386页

作者： Li Shen Minghao sun mengna Wei Qingwu Hu Yao Bai Zhongjun Shao Kun Liu School of Remote Sensing and Information Engineering Wuhan UniversityWuhanHubei ProvinceChina Department of Infection Disease Control and Prevention Xi'an Center for Disease Control and PreventionXi'anShaanxiChina Department of Epidemiology Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational EnvironmentSchool of Public HealthAir Force Medical UniversityXi'anShaanxi ProvinceChina

The transmission and prevalence of Hand,Foot and Mouth Disease(HFMD)are affected by a variety of natural and socio-economic environmental *** study aims to quantitatively investigate the non-stationary and spatially varying associations between various environmental factors and HFMD *** collected HFMD surveillance cases and a series of relevant environmental data from 2013 to 2021 in Xi'an,Northwest *** controlling the spatial and temporal mixture effects of HFMD,we constructed a Bayesian spatiotemporal mapping model and characterized the impacts of different driving factors into global linear,non-stationary and spatially varying *** results showed that the impact of meteorological conditions on HFMD risk varies in both type and magnitude above certain thresholds(temperature:30°C,precipitation:70 mm,solar radiation:13000 kJ/m^(2),pressure:945 hPa,humidity:69%).Air pollutants(PM_(2.5),PM_(10),NO_(2))showed an inverted U-shaped relationship with the risk of HFMD,while other air pollutants(O_(3),SO_(2))showed nonlinear ***,the driving effect of increasing temperature on HFMD was significant in the 3-year period,while the inhibitory effect of increasing precipitation appeared evident in the 5-year *** addition,the proportion of urban/suburban/rural area had a strong influence on HFMD,indicating that the incidence of HFMD firstly increased and then decreased during the rapid urbanization *** influence of population density on HFMD was not only limited by spatial location,but also varied between high and low *** road density inhibited the risk of HFMD,but higher night light index promoted the occurrence of *** findings further demonstrated that both ecological and socioeconomic environmental factors can pose multiple driving effects on increasing the spatiotemporal risk of HFMD,which is of great significance for effectively responding to the changes in HFMD epidemic outbreaks.

关键词： Hand,foot,and mouth disease(HFMD) Environmental factors Bayesian spatiotemporal mapping model Non-stationary effects Spatially varying effects

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Identification and characterization of endosymbiosis-related immune genes in deep-sea mussels Gigantidas platifrons

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Journal of Oceanology and Limnology 2020年第4期38卷 1292-1303页

作者： LI mengna CHEN Hao WANG Minxiao ZHONG Zhaoshan ZHOU Li LI Chaolun Center of Deep Sea Research and Key Laboratory of Marine Ecology&Environmental Sciences(CODR and KLMEES) Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Deep-sea mussels of the subfamily Bathymodiolinae are common and numerically dominant species widely distributed in cold seeps and hydrothermal *** long-time evolution,deep-sea mussels have evolved to be well adapted to the local environment of cold seeps and hydrothermal vents by various ways,especially by establishing endosymbiosis with chemotrophic ***,biological processes underlying the establishment and maintenance of symbiosis between host mussels and symbionts are largely *** the present study,Gigantidas platifrons genes possibly involved in the symbiosis with methane oxidation symbionts were identified and characterized by Lipopolysaccharide(LPS)pull-down and in situ *** immune related proteins including Toll-like receptor 2(TLR2),integrin,vacuolar sorting protein(VSP),matrix metalloproteinase 1(MMP1),and leucine-rich repeat(LRR-1)were identified by LPS pull-down *** five proteins were all conserved in either molecular sequences or functional domains and known to be key molecules in host immune recognition,phagocytosis,and lysosome-mediated ***,in situ hybridization of LRR-1,TLR2 and VSP genes was conducted to investigate their expression patterns in gill tissues of ***,LRR-1,TLR2,and VSP genes were found expressed exclusively in the bacteriocytes of ***,it was suggested that TLR2,integrin,VSP,MMP1,and LRR-1 might be crucial molecules in the symbiosis between *** and methane oxidation bacteria by participating in symbiosis-related immune processes.

关键词： Gigantidas platifrons endosymbiosis innate immunity pull-down assay immune recognition methane oxidation bacteria

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Unveiling the Effects of Interchain Hydrogen Bonds on Solution Gelation and Mechanical Properties of Diarylfluorene-Based Semiconductor Polymers

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Research 2020年第1期2020卷 547-561页

作者： Lubing Bai Yamin Han Chen sun Xiang An Chuanxin Wei Wei Liu Man Xu Lili sun Ning sun mengna Yu He Zhang Qi Wei Chunxiang Xu Yingguo Yang Tianshi Qin Linghai Xie Jinyi Lin Wei Huang Center for Supramolecular Optoelectronics(CSO) Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)30 South Puzhu RoadNanjing 211816China State Key Laboratory of Bioelectronics School of Electronic Science and Medical EngineeringSoutheast UniversityNanjing 210096China Center for Molecular Systems and Organic Devices(CMSOD) Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM)Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of Sciences239 Zhangheng RoadShanghai 201204China

The intrinsically rigid and limited strain of most conjugated polymers has encouraged us to optimize the extensible properties of conjugated ***,learning from the hydrogen bonds in glucose,which were facilitated to the toughness enhancement of cellulose,we introduced interchain hydrogen bonds to polydiarylfluorene by amide-containing side *** tuning the copolymerization ratio,we systematically investigated their influence on the hierarchical condensed structures,rheology behavior,tensile performances,and optoelectronic properties of conjugated *** to the reference copolymers with a low ratio of amide units,copolymers with 30%and 40%amide units present a feature of the shearthinning process that resembled the non-Newtonian fluid,which was enabled by the interchain dynamic hydrogen ***,we developed a practical and universal method for measuring the intrinsic mechanical properties of conjugated *** demonstrated the significant impact of hydrogen bonds in solution gelation,material crystallization,and thin film ***,the breaking elongation for P4 was even up to~30%,which confirmed the partially enhanced film ductility and toughness due to the increased amide ***,polymer light-emitting devices(PLEDs)based on these copolymers presented comparable performances and stable electroluminescence(EL).Thin films of these copolymers also exhibited random laser emission with the threshold as low as 0.52μJ/cm^(2),suggesting the wide prospective application in the field of flexible optoelectronic devices.

关键词： bonds conjugated film

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内质网应激在同型半胱氨酸调控巨噬细胞向泡沫细胞转化中的作用

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山西医科大学学报 2021年第4期52卷 437-442页

作者：李炜刘静郭丽廉诚高钊樊贝贝张晓东靳强张艳涛孙梦娜曾广伟西安国际医学中心医院心脏病医院心脏内科西安710100 空军军医大学第二附属医院心脏内科空军军医大学第一附属医院老年科

目的探讨内质网应激(endoplasmic reticulum stress,ERS)在同型半胱氨酸(homocysteine,Hcy)调控巨噬细胞向泡沫细胞转化中的作用。方法用佛波酯(PMA)将人源单核细胞(Thp-1)诱导分化成巨噬细胞,并随机分为对照组(control)、氧化低密度脂... 详细信息

目的探讨内质网应激(endoplasmic reticulum stress,ERS)在同型半胱氨酸(homocysteine,Hcy)调控巨噬细胞向泡沫细胞转化中的作用。方法用佛波酯(PMA)将人源单核细胞(Thp-1)诱导分化成巨噬细胞,并随机分为对照组(control)、氧化低密度脂蛋白处理组(oxidized low density lipoprotein,oxLDL)、Hcy与oxLDL共处理组(Hcy+oxLDL)以及4-苯基丁酸(4-PBA)联合Hcy和oxLDL共处理组(4-PBA+Hcy+oxLDL组)。采用油红O染色检测脂质沉积,ELISA试剂盒检测胆固醇含量,RT-PCR检测GRP78和GRP94的mRNA水平,Western blot检测GRP78和GRP94蛋白表达的变化。结果与control组相比,oxLDL组脂质沉积和胆固醇含量增加(P<0.05),ERS标志物GRP78和GRP94的mRNA和蛋白表达也明显增加(P<0.05)。与oxLDL组比,Hcy+oxLDL组脂质沉积、胆固醇含量以及ERS标志物GRP78和GRP94的mRNA和蛋白表达明显增加(P<0.05)。然而,ERS抑制剂4-PBA可显著降低Hcy与oxLDL共处理导致的脂质沉积和胆固醇含量增加(P<0.05)。结论Hcy能通过激活ERS调控巨噬细胞向泡沫细胞的转化,而ERS抑制剂4-PBA可以阻断这一作用。

关键词：同型半胱氨酸内质网应激巨噬细胞 4-PBA

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Alkyl-chain branched effect on the aggregation and photophysical behavior of polydiarylfluorenes toward stable deep-blue electroluminescence and efficient amplified spontaneous emission

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Chinese Chemical Letters 2019年第11期30卷 1959-1964页

作者： Lili sun Ning sun Lubing Bai Xiang An Bin Liu Chen sun Lixiang Fan Chuanxin Wei Yamin Han mengna Yu Jinyi Lin Dan Lu Ning Wang Linghai Xie Kang Shen Xinwen Zhang Yanan Xu Juan Cabanillas-Gonzalez Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211816China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)Xi'an 710072China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Madrid Institute for Advanced Studies(IMDEA Nanociencia) Ciudad Universitaria de CantoblancoCalle Faraday 9Madrid 28049Spain

The control of the condensed superstructure of light-emitting conjugated polymers(LCPs)is a crucial factor to obtain high performance and stable organic optoelectronic ***-chain engineering strategy is an effective platform to tune inter chain aggregation and photophysical behaviour of ***,we systematically investigated the alkyl-chain branched effecton the conformational transition and photophysical behaviour of polydiarylfluorenes toward efficient blue optoelectronic *** branched side chain will improve materials solubility to inhibit interchain aggregation in solution according to DLS and optical analysis,which is useful to obtain high quality ***,our branched PEODPF,POYDPF pristine film present high luminance efficiency of 36.1%and 39.6%,enhanced about 20%relative to that of *** to the liner-type sides'chain,these branched chains also suppress chain planarization and improve film morphological stability ***,the branched polymer also had excellent stable amplified spontaneous emission(ASE)behaviour with low threshold(4.72μJ/cm2)and a center peak of 465 nm,even thermal annealing at 220℃in the air ***,side-chain branched strategy for LCPs is an effective means to control interchain aggregation,film morphology and photophysical property of LCPs.

关键词： Light-emitting conjugated polymers Branched effect Aggregation behavior Robust deep-blue emission Efficient optoelectronic devices

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四氢姜黄素对脓毒血症小鼠心肌损伤的保护作用及其机制

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山西医科大学学报 2021年第4期52卷 443-450页

作者：王伟曾广伟廉诚刘慧张晓东安慧仙高钊方东张艳涛樊贝贝孙梦娜李炜西安国际医学中心医院心脏内科西安710100 空军军医大学第二附属医院心内科

目的研究四氢姜黄素(tetrahydrocurcumin,THC)对脓毒血症小鼠心肌损伤的保护作用及其分子机制。方法将40只C57BL/6J小鼠随机分为4组:对照组、LPS组、LPS+THC组和EX527+LPS+THC组,每组10只。采用腹腔注射脂多糖(LPS,10 mg/kg)的方法构建... 详细信息

目的研究四氢姜黄素(tetrahydrocurcumin,THC)对脓毒血症小鼠心肌损伤的保护作用及其分子机制。方法将40只C57BL/6J小鼠随机分为4组:对照组、LPS组、LPS+THC组和EX527+LPS+THC组,每组10只。采用腹腔注射脂多糖(LPS,10 mg/kg)的方法构建小鼠脓毒血症心肌损伤模型。对照组和LPS组小鼠每日给予等量生理盐水灌胃处理一次;在LPS腹腔注射前7 d,LPS+THC组和EX527+LPS+THC组小鼠每日给予THC[100 mg/(kg·d)]灌胃处理一次;且EX527+LPS+THC组小鼠在药物灌胃处理的同时给予5 mg/kg的EX527(SIRT1信号特异性阻断剂)腹腔注射处理一次。待LPS注射6 h后,用小动物超声仪检测各组小鼠左心室射血分数(LVEF)和左心室短轴缩短率(LVFS);用酶标仪测定血清中CK、CK-MB和TnI的活性;用ELISA法检测心肌组织IL-1β和TNF-α表达水平;用免疫组化染色法检测心肌组织中性粒细胞浸润程度;用试剂盒检测心肌组织MDA含量和SOD活性;用TUNEL试剂盒检测心肌细胞凋亡水平;用DHE荧光探针检测心肌组织内活性氧簇产量;用Western blot检测SIRT1、Ac-foxo1和gp91^(phox)蛋白表达情况。结果与对照组相比,LPS组小鼠血清CK、CK-MB和TnI活性均显著升高,LVEF和LVFS均显著降低,心肌组织氧化应激水平显著升高,炎症反应明显增强,心肌细胞凋亡率显著增加,SIRT1蛋白表达明显下调,foxo1的乙酰化水平明显上调(均P<0.05)。与LPS组相比,LPS+THC组小鼠经THC预处理后可明显改善LPS引起的上述改变(P<0.05)。然而,THC的保护效果均可被EX527显著逆转(P<0.05)。结论四氢姜黄素可通过激活SIRT1信号通路发挥抗氧化应激与抗炎作用,进而减轻了脓毒血症小鼠的心肌损伤。

关键词：四氢姜黄素脓毒血症心肌损伤氧化应激炎症 SIRT1

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基于仿射近似投影模型的无人机对地目标定位方法

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中国惯性技术学报 2022年第1期30卷 104-112,120页

作者：孙聪贾萌娜于起峰西安卫星测控中心宇航动力学国家重点实验室西安710043 中国空间技术研究院西安分院西安710000 国防科技大学空天科学学院长沙410073

鉴于透视投影模型在无人机对地目标远景成像环境下存在过参数化的问题,采用平行透视投影模型对无人机序列成像过程进行建模,并提出了基于仿射近似投影模型的无人机对地目标定位方法。基于平行透视投影模型的迭代因子分解法框架,依据无... 详细信息

鉴于透视投影模型在无人机对地目标远景成像环境下存在过参数化的问题,采用平行透视投影模型对无人机序列成像过程进行建模,并提出了基于仿射近似投影模型的无人机对地目标定位方法。基于平行透视投影模型的迭代因子分解法框架,依据无人机序列影像特征的多视图几何约束,结合优化最小化框架的低秩矩阵分解技术,进而可实现目标区域剔除位姿模糊歧义的高精度欧式三维重构,再充分利用机载导航系统提供的相机高精度位置信息,即可完成对地面目标的精确定位。仿真及半实物仿真试验结果表明,所提出的基于仿射近似投影模型的无人机对地目标定位方法正确有效,在实验室环境下对地目标定位精度优于2厘米。

关键词：仿射近似投影无人机因子分解对地定位

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立体Scheimpflug相机标定及极线校正方法

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光学学报 2022年第14期42卷 102-108页

作者：孙聪贾萌娜于起峰宇航动力学国家重点实验室陕西西安710043 西安卫星测控中心陕西西安710043 中国空间技术研究院西安分院陕西西安710000 国防科技大学空天科学学院湖南长沙410073

针对立体Scheimpflug相机成像系统,研究了内外参数标定及极线校正方法。在立体Scheimpflug相机成像的对极几何基础上,提出了一种鲁棒的逐级标定方法,并根据内外参数标定结果构建了立体Scheimpflug相机极线校正模型。进一步建立了基于立... 详细信息

针对立体Scheimpflug相机成像系统,研究了内外参数标定及极线校正方法。在立体Scheimpflug相机成像的对极几何基础上,提出了一种鲁棒的逐级标定方法,并根据内外参数标定结果构建了立体Scheimpflug相机极线校正模型。进一步建立了基于立体Scheimpflug相机的三维数字图像相关(DIC)变形测量系统。实际测量实验结果显示,三维DIC变形测量系统的精度优于10μm,说明提出的立体Scheimpflug相机逐级标定及极线校正方法正确有效,精度可靠。

关键词：测量 Scheimpflug相机相机标定极线校正立体数字图像相关

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Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia

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Advances in Atmospheric Sciences 2020年第9期37卷 933-938页

作者： Yuepeng PAN mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang sun Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Center for Excellence in Urban Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Geographic Information Sciences Ministry of EducationSchool of Geographic SciencesEast China Normal UniversityShanghai 200241China CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Department of Earth Environmentaland Planetary SciencesBrown UniversityProvidenceRI 02912USA Institute at Brown for Environment and Society Brown UniversityProvidenceRI 02912USA College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China National Physical Laboratory Air Quality and Aerosol Metrology GroupEnvironment DepartmentHampton RoadTeddingtonMiddlesexTW110LWUK National Satellite Meteorological Center China Meteorological AdministrationBeijing100081China Key Laboratory of Stable Isotope Techniques and Applications Shenyang 110016China Centre for Environmental and Agricultural Informatics Cranfield UniversityCollege RoadMK430ALUK

While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East *** the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of *** satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are *** addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia *** the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well *** the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions.

关键词： ammonia nitrate Ammonia

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A Novel UDP-Glucosyltransferase Gene 3 Involved in Callose Synthesis and Influenced Fertility in Cotton

A Novel UDP-Glucosyltransferase Gene 3 Involved in Callose S...

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中国农学会棉花分会2018年年会

作者： Zhang mengna Luo Binglun Ke Liping Ren Huiming sun Yuqiang Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang Province College of Life SciencesZhejiang Sci-Tech University

Cotton(Gossypium hirsutum L.) has long been the world’s most important source of natural fiber and is one of the first genetically modified *** has obvious heterosis,which improves output and quality *** of stable male sterile materials to large-scale generation hybrid is currently the most effective ways to use heterosis and is crucially important in heterosis *** the initiation of pollen formation to fertilization,any abnormal developmental events may result in male *** the process of microsporogenesis and pollen development,callose(a linear β-1,3-glucan) plays an important role as temporary cell wall that protects *** we described a novel UDP-glucosyltransferase gene,named *** GhUGT3 gene was acquired from the differentially expressed genes of *** ***.C312 and its male sterile mutant *** gene was significantly differentially expressed with an unknown function in male *** GhUGT3 encoding product was similar with Arabidopsis AT1 G05560(UGT75 B1) in amino acid sequence,but with low similarity in nucleotide *** constructed vectors pCLCrVA-GhUGT to silence the target gene GhUGT3 in *** *** GhUGT3-silenced plants exhibited male sterility with anthers dehiscent slightly even to indehiscent absolutely,and few active pollens were *** observation of pollen mother cells with different development stages showed that callose deposition of GhUGT3-silenced plant was abnormal and microspores degenerated *** electron microscopy analysis of mature pollen grains showed pollens of GhUGT3-silenced plant shrank and lacked surface *** results indicated that GhUGT3 played an important role in development of active pollens and fertility by influencing callose deposition.

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