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黄连及其配伍在消渴病中的应用

中华中医药学刊 2024年第8期42卷 163-166页

作者：吴梦梦周迪夷浙江中医药大学第二临床医学院浙江杭州310053 杭州市红十字会医院浙江杭州310003

黄连味苦性寒,善泄善燥,是消渴病治疗中应用颇广的传统中药之一。现代研究表明黄连的主要成分小檗碱可通过多条细胞信号通路发挥作用,提高糖尿病患者胰岛β细胞抗氧化应激能力,改善胰岛功能,提高胰岛素敏感性,降低患者血糖及糖化血红蛋... 详细信息

黄连味苦性寒,善泄善燥,是消渴病治疗中应用颇广的传统中药之一。现代研究表明黄连的主要成分小檗碱可通过多条细胞信号通路发挥作用,提高糖尿病患者胰岛β细胞抗氧化应激能力,改善胰岛功能,提高胰岛素敏感性,降低患者血糖及糖化血红蛋白水平,并且可减少血管内皮损伤,降低糖尿病血管并发症的风险。黄连单药使用即可对消渴病起到良好的治疗效果,与木香、葛根、人参、天花粉、黄芩、知母等相伍成药对,既可增强临床效果,又可防其苦寒败胃。黄连复方葛根芩连汤、大黄黄连泻心汤、黄连解毒汤、半夏泻心汤、黄连温胆汤、小陷胸汤则可通过多靶点、多途径、多环节发挥作用,达到降糖减脂、改善患者临床症状的效果。总之黄连及其配伍可通过抑制糖异生、调节肠道菌群结构、改善胰岛功能、降低胰岛素抵抗等多重途径,标本兼治,实现降糖降脂、延缓糖尿病进展之功效。对黄连单药及其药对、复方在消渴病治疗中的应用作以叙述,以期为消渴病的临床治疗提供思路。

关键词：黄连消渴病糖尿病配伍

Interaction between Surface Acoustic Wave and Quantum Hall Effects

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Chinese Physics Letters 2024年第4期41卷 105-109页

作者：刘萧吴蒙蒙王任飞王兴豪张文锋董昱江杜瑞瑞刘阳林熙 International Center for Quantum Materials Peking UniversityBeijing 100871China Center for Excellence University of Chinese Academy of SciencesBeijing 100190China Hefei National Laboratory Hefei 230088China Interdisciplinary Institute of Light-Element Quantum Materials and Research Center for Light-Element Advanced Materials Peking UniversityBeijing 100871China

Surface acoustic wave(SAW)is a powerful technique for investigating quantum phases appearing in twodimensional electron *** electrons respond to the piezoelectric field of SAW through screening,attenuating its amplitude,and shifting its velocity,which is described by the relaxation *** this work,we systematically study this interaction using orders of magnitude lower SAW amplitude than those in previous *** high magnetic fields,when electrons form highly correlated states such as the quantum Hall effect,we observe an anomalously large attenuation of SAW,while the acoustic speed remains considerably high,inconsistent with the conventional relaxation *** anomaly exists only when the SAW power is sufficiently low.

关键词： relaxation quantum inconsistent

基于MPS方法的固定半潜式平台波浪爬升数值模拟

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海洋工程 2024年第4期42卷 44-56页

作者：吴萌萌王尼娜万德成上海交通大学船舶海洋与建筑工程学院船海计算水动力学研究中心(CMHL) 上海200240 中国电建集团华东勘测设计研究院有限公司浙江杭州310014

在波浪与半潜式平台相互作用的情况下,波浪会沿着平台立柱爬升,并对平台立柱产生砰击作用。在极端情况下,波浪甚至可能砰击至平台下甲板,严重影响平台的安全。因此,对于半潜式平台设计来说,准确预测平台在波浪中的波浪爬升和砰击效应具... 详细信息

在波浪与半潜式平台相互作用的情况下,波浪会沿着平台立柱爬升,并对平台立柱产生砰击作用。在极端情况下,波浪甚至可能砰击至平台下甲板,严重影响平台的安全。因此,对于半潜式平台设计来说,准确预测平台在波浪中的波浪爬升和砰击效应具有重要意义。采用无网格粒子法求解器MPSGPU-SJTU对波浪作用下的固定半潜式平台问题进行了数值研究,将MPS(moving particle semi-implicit)方法与GPU(graphics processing unit)并行加速技术相结合,并将其应用于规则波作用下的固定半潜式平台波浪爬升与波浪砰击问题的数值模拟。3种不同波高的规则波波浪被应用于半潜式平台数值模拟中,随着波高的增加,平台下甲板更多区域受到了波浪的砰击,同时平台设置的测压点处压力峰值也随之增大。

关键词： MPS方法固定半潜式平台 GPU并行加速技术波浪爬升波浪砰击

强师计划背景下地方师范院校内生性发展路径探析

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湖州师范学院学报 2024年第6期46卷 62-67页

作者：吴蒙蒙乔磊浙江万里学院商学院浙江宁波315000 普洱学院教师教育学院云南普洱665000

地方师范院校的内生性发展是学校改变以往依附式、输血式、脱域式的思路和做法,增强自身发展能力的重要举措,也是深化地方师范院校内涵式和特色化发展、合理调整教育资源再配置的有效途径。地方师范院校的内生性发展还存在主体缺位、资... 详细信息

地方师范院校的内生性发展是学校改变以往依附式、输血式、脱域式的思路和做法,增强自身发展能力的重要举措,也是深化地方师范院校内涵式和特色化发展、合理调整教育资源再配置的有效途径。地方师范院校的内生性发展还存在主体缺位、资源失位、定位偏位、发展错位等问题。针对这些问题,地方师范院校应该以主体参与作为基础保障,以资源整合作为基本前提,以明晰师范性和在地性定位作为关键因素,以内涵发展作为根本路径,探索地方师范院校从“输血”式的外源式发展向“造血”式的内生性发展的转化路径。

关键词：强师计划地方师范院校内生性发展

价值、势能和技术:预算绩效指标共识的形成机制

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华南理工大学学报（社会科学版） 2024年第2期26卷 132-142页

作者：李文彬吴梦梦华南理工大学公共管理学院广东广州510640

交互式对话理论认为,政府绩效评价是评价方、被评对象和利益相关者通过对话谋求共识的过程,而绩效指标则是共识的基础。基于该理论,以C镇构建部门整体支出核心绩效指标体系为案例,对多元主体通过对话形成预算绩效指标共识的研究发现:势... 详细信息

交互式对话理论认为,政府绩效评价是评价方、被评对象和利益相关者通过对话谋求共识的过程,而绩效指标则是共识的基础。基于该理论,以C镇构建部门整体支出核心绩效指标体系为案例,对多元主体通过对话形成预算绩效指标共识的研究发现:势能驱动、价值牵引和技术弥合机制促成了共识的形成。其中,政治势能对价值牵引产生深刻影响,而技术弥合则通过协调政治势能与价值牵引之间的关系,凝聚三种机制合力进而助力共识形成。与交互式对话理论的比较发现,我国背景下交互式对话的实践呈现出一定的独特性,包括对话主体的多元化和对话基础的约束性。这一发现不仅能够为我国基层预算绩效管理的发展提供理论指引,也有助于提升交互式对话理论的精细化和本土化,并为基层政府机构创建对话惯例和开展组织学习提供参考。

关键词：交互式对话指标共识政治势能价值牵引技术弥合

Constitutive modelling of idealised granular materials using machine learning method

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 1038-1051页

作者： mengmeng wu Zhangqi Xia Jianfeng Wang Department of Architecture and Civil Engineering City University of Hong KongHong KongChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

Predicting the constitutive response of granular soils is a fundamental goal in *** paper presents a machine learning(ML)framework for the prediction of the stress-strain behaviour and shearinduced contact fabric evolution of an idealised granular material subject to triaxial *** MLbased framework is comprised of a set of mini-triaxial tests which provide a benchmark for the setup and validation of the discrete element method(DEM)model of the granular materials,a parametric DEM simulation programme of virtual triaxial tests which provides datasets of micro-and macro-mechanical information,as well as a multi-layer perceptron(MLP)neural network which is trained and tested using the DEM-based *** ML model only requires the initial void ratio of the granular sample as the input for predicting its constitutive *** excellent agreement between the ML model prediction and experimental test and DEM simulation results indicates that the MLebased modelling approach is capable of capturing accurately the effects of initial void ratio on the constitutive behaviour of idealised granular materials,bypassing the need to incorporate the complex micromechanics underlying the macroscopic mechanical behaviour of granular ***,a detailed comparison between the used MLP model and long short-term memory(LSTM)model was made from the perspective of technical algorithm,prediction accuracy,and computational efficiency.

关键词： Machine learning(ML) Multi-layer perceptron(MLP) Contact fabric Granular material Discrete element method(DEM)

DEM study on effect of particle roundness on biaxial shearing of sand

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Underground Space 2021年第6期6卷 678-694页

作者： mengmeng wu Linghong Xiong Jianfeng Wang Department of Architecture and Civil Engineering City University of Hong KongHong KongChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

In this study,discrete element method(DEM)simulations of a biaxial test were used to examine the effect of particle roundness on the mechanical behavior of sands at both the macro and micro ***,a stack of microcomputed tomography images were binarized,segmented,and labeled using advanced image processing and analysis ***,a spherical harmonic(SH)analysis,which involves a complete set of orthogonal functions,was implemented to rebuild the natural particle ***,five templates of virtual particles were built in a DEM simulation,four of which were obtained from SH degrees of 3,8,12,and 15,and one template was an elementary sphere.A flexible membrane was numerically generated to allow the material to deform freely under a prescribed confining ***,the effect of particle roundness on the mechanical properties of granular materials was investigated and *** shear bands were found to intersect,forming an X shape in both the rotation and displacement ***,a lower particle roundness results in higher deviatoric stress and stronger dilation in the volumetric change.A decrease in particle roundness leads to less rotation of particles despite a higher displacement *** addition,a larger SH degree leads to smaller normalized contact forces of the *** implies that decreasing the roundness results in higher anisotropy of the contact forces.

关键词： Grain shape Roundness Flexible membrane Spherical harmonic analysis Discrete element method

介孔氧化硅分子筛负载金属氧化物高温煤气脱硫剂结构调控与脱硫过程放硫的研究进展

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低碳化学与化工 2024年第6期49卷 105-114页

作者：刘佳雯段新伟武蒙蒙米杰王建成太原理工大学省部共建煤基能源清洁高效利用国家重点实验室煤科学与技术教育部重点实验室山西太原030024 太原理工大学环境科学与工程学院山西太原030060

煤气化是煤炭清洁高效利用的核心技术,但气化粗煤气中所含硫化氢(H_(2)S)会腐蚀设备并污染环境,因此需要对煤气进行净化脱硫。介孔氧化硅分子筛具有大比表面积、大孔容和有序的介孔结构等特性,将其作为金属氧化物的载体可促进金属氧化... 详细信息

煤气化是煤炭清洁高效利用的核心技术,但气化粗煤气中所含硫化氢(H_(2)S)会腐蚀设备并污染环境,因此需要对煤气进行净化脱硫。介孔氧化硅分子筛具有大比表面积、大孔容和有序的介孔结构等特性,将其作为金属氧化物的载体可促进金属氧化物的分散,并为脱硫反应提供大量的反应活性位点,减少传质阻力。脱硫剂构效关系是煤气脱硫技术的关键科学难题之一,然而对于负载型高温煤气脱硫剂而言,上述关系受介孔氧化硅分子筛、脱硫活性组分种类、脱硫剂改性手段和脱硫条件等多因素叠加影响,因而要明晰其本质极具挑战。为此,首先探讨了不同介孔氧化硅分子筛的孔道结构特性,剖析了介孔氧化硅分子筛负载活性组分后的脱硫行为差异,发现拥有丰富孔结构及较厚孔壁的载体的脱硫剂在高温脱硫过程中表现更优。同时,分析了近年来针对锌基、锰基和铁基等金属氧化物负载型脱硫剂的结构调控策略及其对脱硫性能的影响规律,认为通过金属掺杂复合改性可提高活性组分脱硫活性;并对脱硫过程中的放硫机制、放硫规律及抑制手段进行了探讨,认为在脱硫剂中引入催化羰基硫(COS)氢解助剂可有效抑制放硫行为。本综述内容可为高性能高温脱硫剂结构设计与功能化构筑提供理论依据。

关键词：高温煤气脱硫介孔氧化硅分子筛金属氧化物放硫羰基硫

Strength criterion effect of the translator and destabilization model of gas-bearing coal seam

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International Journal of Mining Science and Technology 2019年第2期29卷 327-333页

作者： Gang Wang Rui Wang mengmeng wu Cheng Fan Xiang Song Mine Disaster Prevention and Control-Ministry of State Key Laboratory Breeding Base Shandong University of Science & Technology College of Mining and Safety Engineering Shandong University of Science & Technology Department of Civil and Architectural Engineering City University of Hong Kong

Coal seam destabilization inflicts damage to equipment, causes property loss and personnel casualties,and severely threatens mining safety and efficient production. To further understand this destabilization based on the basic theory of Lippmann seam destabilization, a mathematical model was introduced for gas pressure distribution by considering intermediate principal stress and support ***, we established a translation model suitable for the entire roadway coal seam with rocky roof and floor by applying the unified form of yield criterion in the state of plane strain. We also obtained the analytic expressions of coal seam stress distribution on both sides of the roadway and the widths of plastic and disturbance zones. Afterward, we analyzed several typical cases with different material yield criteria, obtained the plastic zone widths of the coal seam under different gas pressures, and assessed the effects of support resistance, roadway size, and coal strength on coal seam destabilization. Results showed that: the results obtained on the basis of Wilson and Mohr–Coulomb criteria are considerably conservative, and the use of Druker–Prager criteria to evaluate the rockburst-induced coal seam destabilization is safer than the use of the two other criteria; coal seam stability is correlated with gas pressure;and high-pressure gas accelerates the coal seam destabilization.

关键词： Coal seam destabilization Strength criterion effect Gas Stress distribution