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A time-synchronized multimodal monitoring system for general anesthesia

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Medicine in Novel Technology and Devices 2024年第3期23卷 116-127页

作者： Zhenhu liang Guanwei Geng Qifeng Song mengmeng Tang Institute of Electrical Engineering Yanshan UniversityQinhuangdao066004China Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province Qinhuangdao066004China

In clinical settings,different kinds of patient monitoring systems and depth of anesthesia monitoring(DoA)systems have been widely used to assess the depth of sedation and patient's ***,all these monitoring systems are independent of each *** date,no monitoring system has focused on the synchronized neural activities,cerebral metabolism,autonomic nervous system,and drug effects on the brain,as well as their interactions between neural activities and cerebral metabolism(i.e.,neurovascular coupling),and between brain and heart(i.e.,brain-heart coupling).In this study,we developed a time-synchronized multimodal monitoring system(TSMMS)that integrates electroencephalogram(EEG),near-infrared spectroscopy(NIRS),and standard physiological monitors(electrocardiograph,blood pressure,oxygen saturation)to provide a comprehensive view of the patient's physiological state during *** coherence and Granger causality(GC)methods were used to quantify the neurovascular coupling and brain-heart *** response surface model was used to estimate the combined propofol-remifentanil drug effect on the *** integrates data from various devices for a comprehensive analysis of vital *** enhances anesthesia monitoring through detailed EEG features,neurovascular,and brain-heart coupling ***,a response surface model estimates the combined effects of propofol and remifentanil,aiding anesthesiologists in drug *** conclusion,TSMMS provides a new tool for studying the coupling mechanism among neural activities,cerebral metabolism,and autonomic nervous system during general anesthesia.

关键词： General anesthesia Multimodal monitoring system Time-synchronized Neurovascular coupling Brain-heart coupling

Synthesis and electromagnetic wave absorption performances of a novel(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)high-entropy MAX phase

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journal of Materials Science & Technology 2023年第6期137卷 112-122页

作者： Linjing Qiao jianqiang Bi Guandong liang Chen Liu Zhuangzhuang Yin Yao Yang Hongyi Wang Shaoyin Wang mengmeng Shang Weili Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China School of Materials Science and Engineering Shandong UniversityJinan 250061China

Herein,a novel kind of high-entropy MAX phases,(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders were success-fully synthesized by a newly proposed two-step solid state reaction *** oxidation experiments demonstrate that the oxidation products of Al_(2)Mo_(3)O_(12) and rutile TiO 2 are formed at about 600 and 800℃,***,the dielectric and electromagnetic(EM)wave absorption properties of(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders and those after oxidation at different temperatures were also *** results show that the as-synthesized(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders possess excellent EM wave absorption performances with the minimum reflection loss(RL)of-45.80 dB(at 1.7 mm thickness)and the maximum effective absorption bandwidth(E AB)of 3.6 GHz(at 1.5 mm thickness).After oxidation at 400-800℃,due to the coupling of conductivity loss and polarization loss,(Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2)powders can retain good EM wave absorption properties in a certain frequency *** this paper,the effects of oxidation on EM wave absorption properties of high-entropy MAX phases were systematically investigated for the first *** work manifests that high-entropy MAX phases are promising EM wave absorbing candidates and can maintain good EM wave absorption performances after oxidation.

关键词： (Mo_(0.25)Cr_(0.25)Ti_(0.25)V_(0.25))_(3)AlC_(2) High-entropy MAX phase Two-step synthesis Oxidation Electromagnetic wave absorption

Plant functional trait diversity and structural diversity co-underpin ecosystem multifunctionality in subtropical forests

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Forest Ecosystems 2023年第2期10卷 153-161页

作者： Shuai Ouyang mengmeng Gou Pifeng Lei Yue Liu liang Chen Xiangwen Deng Zhonghui Zhao Yelin Zeng Yanting Hu Changhui Peng Wenhua Xiang Faculty of Life Science and Technology Central South University of Forestry and TechnologyChangsha410004China Huitong National Station for Scientific Observation and Research of Chinese Fir Plantation Ecosystems in Hunan Province Huitong438107China Ecology and Nature Conservation Institute Chinese Academy of ForestryBeijing100101China Institute of Environment Sciences Department of Biological SciencesUniversity of Quebec at MontrealMontrealQCH3C 3P8Canada

Tree species diversity is assumed to be an important component in managing forest ecosystems because of effects on multiple functions or ecosystem ***,the importance of tree diversity in determining multifunctionality in structurally complex subtropical forests relative to other regulators(e.g.,soil microbial diversity,stand structure,and environmental conditions)remains *** this study,effects of aboveground(species richness and functional and structural diversity)and belowground(bacterial and fungal diversity)biodiversity,functional composition(community-weighted means of species traits),stand structure(diameter at breast height and stand density),and soil factors(pH and bulk density)on multifunctionality(including biomass production,carbon stock,and nutrient cycling)were examined along a tree diversity gradient in subtropical *** community-weighted mean of tree maximum height was the best predictor of ecosystem *** diversity explained a higher proportion of the variation in multifunctionality than that of species richness and fungal *** structure-played an important role in modulating the effects of tree diversity on *** work highlights that species composition and maximizing forest structural complexity are effective strategies to increase forest multifunctionality while also conserving biodiversity in the management of multifunctional forests under global environmental changes.

关键词： Abiotic and biotic factors Biodiversity Functional composition Functional traits Soil microbial diversity Stand structure

Asymmetric macrocyclization enabled by Rh(Ⅲ)-catalyzed C-H activation:Enantioenriched macrocyclic inhibitor of Zika virus infection

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Chinese Chemical Letters 2024年第11期35卷 378-383页

作者： Chao Chen Wenwen Yu Guangen Huang Xuelian Ren Xiangli Chen Yixin Li Shenggui liang mengmeng Xu Mingyue Zheng Yaxi Yang He Huang Wei Tang Bing Zhou School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The development of enantioselective C-H macrocyclizations to efficiently access structurally diversified macrocycles is highly desirable,but remain a big ***,we reported the first rhodium(Ⅲ)-catalyzed asymmetric intramolecular C-H macrocyclization,enabling the efficient synthesis of structurally diverse enantioenriched *** robust enantioselective C-H macrocyclization has a broad functional group tolerance,excellent enantioselectivities(up to 98.5:1.5 e.r.)and a mild reaction condition,releasing CO_(2)as the single *** significantly,the resulting unique enantioenriched19-membered macrocycle 2f was found to demonstrate a potent in vitro anti-Zika virus(ZIKV)activity without obvious *** investigation revealed that the anti-ZIKV activity is presumably attributed to an autophagy inhibition in the early stage of viral infection by down-regulating the expression of autophagy related gene Atg12.

关键词： C-H activation Carboamidation Enantioselective macrocyclization Anti-Zika virus activity

Enhanced efficiency and stability in Sn-based perovskite solar cells by trimethylsilyl halide surface passivation

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journal of Energy Chemistry 2022年第8期31卷 604-611,I0016页

作者： Zheng Zhang liang Wang Ajay Kumar Baranwal Shahrir Razey Sahamir Gaurav Kapil Yoshitaka Sanehira Muhammad Akmal Kamarudin Kohei Nishimura Chao Ding Dong Liu Yusheng Li Hua Li mengmeng Chen Qing Shen Teresa SRipolles juan Bisquert Shuzi Hayase Graduate School of Informatics and Engineering University of Electro-Communication1-5-1 ChofugaokaChofuTokyo 182-8585Japan Escuela Técnica Superior de Ingeniería de Telecomunicación Universidad Rey Juan CarlosMadrid 28933Spain Institute of Advanced Materials(INAM) Universitat Jaume ICastelló12006Spain

Lead free tin perovskite solar cells(PKSCs)are the most suitable alternative candidate for conventional lead perovskite solar ***,the efficiency and the stability are insufficient,mainly because of the poor film quality and numerous *** we introduce an efficient strategy based on a simple trimethylsilyl halide surface passivation to increase the film quality and reduce the defect *** the same time,a hydrophobic protective layer on the perovskite surface is formed,which enhanced the PKSCs’*** efficiency of the solar cell after the passivation was enhanced from 10.05%to 12.22%with the improved open-circuit voltage from 0.57 V to 0.70 *** addition,after 92 days of storage in N_(2) filled glovebox,the modified T-PKSCs demonstrated high stability maintaining 80%of its initial *** work provides a simple and widely used strategy to optimize the surface/interface optoelectronic properties of perovskites for giving more efficient and stable solar cells and other optoelectronic devices.

关键词： Tin halide perovskite Trimethylsilyl halide Surface passivation Stability

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor

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Bioactive Materials 2021年第4期6卷 951-962页

作者： Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin jiang Ting Yin Ruijing liang Yifan Ma Lintao Cai Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Lab for Health InformaticsShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsShenzhen Institutes of Advanced Technology(SIAT)Chinese Academy of SciencesShenzhen518055PR China HRYZ Biotech Co. Shenzhen518057PR China

The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic ***,unsatisfactory curative results and side effects for tumor treatment are still unsolved *** we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in ***,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial *** groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T *** vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood ***,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid *** CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients.

关键词： CAR-T cell Bioorthogonal click chemistry Glycometabolic labeling Off-target effects Cell immunotherapy

印度-欧亚大陆侧向碰撞带的地壳组成:始-渐新世岩浆岩继承锆石U-Pb年龄及Hf同位素空间变化的启示

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岩石学报 2022年第11期38卷 3484-3502,I0017-I0019页

作者：董猛猛杨天南信迪梁明娟自然资源部深地动力学重点实验室中国地质科学院地质研究所北京100037 北京大学地球与空间科学学院北京100871 贵州省地质博物馆贵阳550081

在通过锆石U-Pb方法测定岩浆活动时代的过程中总会获取或多或少的继承锆石年龄数据,这些数据对于揭示岩浆岩所处构造单元的构造-岩浆事件序列具有独特优势。本文选择印度-欧亚大陆侧向碰撞带内NEE走向的始-渐新世岩浆岩带作为研究对象,... 详细信息

在通过锆石U-Pb方法测定岩浆活动时代的过程中总会获取或多或少的继承锆石年龄数据,这些数据对于揭示岩浆岩所处构造单元的构造-岩浆事件序列具有独特优势。本文选择印度-欧亚大陆侧向碰撞带内NEE走向的始-渐新世岩浆岩带作为研究对象,详细收集、梳理该岩浆岩带内现有测年结果中的继承锆石U-Pb年代学和Hf同位素数据,采用统计分析方法,尝试探讨被该岩浆岩带穿越的扬子、印支、保山、腾冲地块的构造-岩浆事件及其序列,对比分析其大地构造亲缘性和地块拼贴历史。继承锆石U-Pb年龄频率分布和Hf同位素数据统计结果显示,扬子与印支地块记录了相同的晋宁期、加里东期、印支期构造-岩浆事件,而腾冲与保山地块则记录了相同的加里东期、印支期构造-岩浆事件。结合现有地层学、古生物和古地磁等方面数据,我们提出扬子-印支与腾冲-保山地块作为两个具有不同结晶基底的独立地块,分别就位于古生代-早中生代古大洋(原、古特提斯洋)的两侧,该大洋板块双向俯冲于这两个地块之下,在两个地块内留下了可高度对比的构造-岩浆事件。由此提出,正向碰撞带班公湖-怒江缝合带内完备的地质记录与侧向碰撞带之间的关联、哀牢山洋的构造属性等是值得深入探究的重大问题。

关键词：统计分析继承锆石 U-Pb年龄 Hf同位素构造-岩浆事件青藏高原东南缘

考虑移动式储能的综合能源系统冰灾后抢修与调度协同优化

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电力自动化设备 2024年第1期44卷 10-16,56页

作者：孙亮孙萌萌赵海猛孙艳学东北电力大学电气工程学院吉林吉林132000 国网东北分部绿源水力发电公司云峰发电厂吉林通化134299

冰灾易造成大规模停电事故,此时综合能源系统中的热电耦合设备可协调电出力和热出力,降低损失。根据典型的气象数据模拟冰灾故障场景,建立除冰抢修、综合能源系统与移动式储能系统双层协同优化调度模型,以减少冰灾带来的不利影响。上层... 详细信息

冰灾易造成大规模停电事故,此时综合能源系统中的热电耦合设备可协调电出力和热出力,降低损失。根据典型的气象数据模拟冰灾故障场景,建立除冰抢修、综合能源系统与移动式储能系统双层协同优化调度模型,以减少冰灾带来的不利影响。上层优化模型为保障综合能源系统的电网快速恢复供电的除冰抢修调度模型,下层优化模型为综合能源系统与移动式储能系统调度模型,上层的各故障线路除冰抢修进度与下层的各节点实时切负荷情况相互传递、交互优化,保障在短时间内抢修更多的故障线路的同时恢复更多的用电负荷,并充分利用热电联产机组灵活的热电比以优化综合能源系统调度,有效减少系统整体经济损失。另外,下层优化模型依据故障后综合能源系统的切负荷情况调度移动式储能系统,进一步减少系统切负荷损失,同时可提高综合能源系统韧性。通过算例仿真验证所提方法的有效性。

关键词：冰灾除冰抢修综合能源系统移动式储能系统协同优化

一种海绵城市社会效益计算方法:以天津大学北洋园校区为例

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地学前缘 2020年第3期27卷 281-289页

作者：李萌萌郭祺忠练继建陈亮天津大学建筑工程学院天津300072 天津大学水利工程仿真与安全国家重点实验室天津300072 Department of Civil and Environmental Engineering State University of NewJerseyPiscatawayNJ 08854USA 河北工程大学水利水电学院河北邯郸056038

海绵城市的社会效益是指海绵设施建成后对社会的贡献,其远大于海绵城市所产生的直接经济效益。但是,海绵城市的社会效益难以客观计算,这阻碍了人们对海绵城市的深入了解。因此,客观合理计算海绵城市的社会效益不仅可以反映海绵城市建设... 详细信息

海绵城市的社会效益是指海绵设施建成后对社会的贡献,其远大于海绵城市所产生的直接经济效益。但是,海绵城市的社会效益难以客观计算,这阻碍了人们对海绵城市的深入了解。因此,客观合理计算海绵城市的社会效益不仅可以反映海绵城市建设是否合理有效,也可为政策的制定提供参考。为此,本文提出一种将主观评价与客观计算相结合的海绵城市社会效益计算方法,通过对可客观计算的社会效益进行主观评价,利用客观计算的效益值将主观评价分值货币化,以此客观计算其他仅可主观评价的社会效益。文中以天津大学北洋园校区为例计算校区内海绵设施的社会效益,结果显示:该校区雨水花园、下凹式绿地和雨水湿地等5种海绵设施的社会效益为1.0~15.5元/(m^2·a),植草沟为2.97元/(m·a)。其中,社会效益最高的是雨水湿地,下凹式绿地社会效益最低。根据天津大学北洋园校区各海绵设施建设面积,该校区海绵设施总社会效益约为232.8万元/a。

关键词：海绵城市社会效益主观评价客观计算货币价值