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Polydopamine(PDA)-activated cobalt sulfide nanospheres responsive to tumor microenvironment(TME)for chemotherapeutic-enhanced photothermal therapy

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Chinese Chemical Letters 2021年第3期32卷 1055-1060页

作者： mengmeng hou Yuanxin Zhong Lei Zhang Zhigang Xu Yuejun Kang Peng Xue School of Materials and Energy Southwest UniversityChongqing 400715China State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400716China

Most recently,cobalt sulfide(CoS)nanospheres(NSs)have been demonstrated as an ideal high-efficient photothermal agent for tumor *** r,the surface of CoS NSs is lack of functio nal chemical groups or active radicals to incorporate therapeutic agents,which tremendously hinders their versatile utilization in medical ***,surface activation of CoS NSs was realized through the growth of polydopamine(PDA)in situ via alkaline-triggered *** the formation of CoS@PDA NSs,thiol-polyethylene glycol(SH-PEG)and chemotherapeutic agent of doxorubicin(DOX)were loaded onto the particle surface by means ofπ-πelectrostatic interaction and Michael addition *** CoS@PDA/PEG/DOX(CoPPD)NSs exhibited an admirable photothermal property and high loading capacity of DOX(44.6%).Furthermore,drug release can be accelerated under a more acidic pH condition mimicking tumor microenvironment(TME),ascribed to the protonation of amino group in DOX ***,a strong chemotherapeutic-enhanced photothermal therapeutic effect was demonstrated toward solid tumor under near-infrared(NIR)light irradiation without causing significant systemic *** this regard,this paradigm may offer valuable guidance for the design of multifunctional CoS-based nanoagents for medical treatment.

关键词： Cobalt sulfide nanospheres Polydopamine Tumor microenvironment Drug delivery Combination therapy

Qingnaoyizhi decoction suppresses the formation of glial fibrillary acidic protein-positive cells in cultured neural stem cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway

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Journal of Traditional Chinese Medicine 2015年第1期35卷 69-76页

作者： Wu Yanqing Jing Zhiwei Qin Xiude Zhou Zhen Wang Kai Song Wanshan Wang Xueyan hou mengmeng Zhang Yulian Kang Liyuan Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Department of Neurology the Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Institute of Clinical Foundational Chinese Medicine China Academy of Chinese Medical Sciences

OBJECTIVE: Inactivation of the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling axis plays a crucial role in determining the fate of neural stem cells(NSCs).Qingnaoyizhi decoction(QNYZD) has been used for the treatment of vascular dementia and has shown to improve synaptic remodeling. The aim of this study was to evaluate the effect of cerebrospinal fluid(CSF) containing QNYZD(CSF-QNYZD) on the differentiation of cultured NSCs and the involvement of the JAK2/STAT3 ***: The protein expression levels of glial fibrillary acidic protein(GFAP), tubulin, drosophila mothers against decapentaplegic protein(SMAD-1), STAT3, and phosphorylated-STAT3 were detected by western immunoblot analysis in the groups: control, CSF, JAK/STAT inhibitor(AG490),CSF-QNYZD, and CSF-XDZ(CSF-Xidezhen). The differentiation of NSCs was determined by immunofluorescence staining. The proliferation of NSCs was measured using the Cell Counting Kit-8 proliferation ***: Compared with the control group,CSF-QNYZD and AG490 significantly increased the number and expression of tubulin-positive cells, reduced the number and expression of GFAP-positive cells, and down-regulated the expression of p-STAT3. However, CSF-QNYZD also decreased the expression of SMAD-1 and ***: Enhanced neuronal differentiation may be associated with the down-regulation of glial differentiation instead of promoting proliferationin treated NSCs. Furthermore, QNYZD may play a direct role in suppressing the formation of GFAP-positive cells and enhancing neuronal differentiation by inhibiting JAK2/STAT3 activation. Overall, these results provide insights into the possible mechanism underlying QNYZD-mediated neurogenesis.

关键词： Neural stem cells Glial fibrillary acidicprotein Cell differentiation Janus kinase 2 STAT3transcription factor Qingnaoyizhi decoction

Adverse Effect of Nonalcoholic Fatty Liver Disease on the Therapeutic Response in Patients with Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 67-75页

作者： Siyu Zhang Xiaoxiao Zhang Huiming Jin Yao Dou Lu Li Xiwei Yuan Chen Dong mengmeng hou Yue-min Nan Jia Shang Department of Traditional and Western Medical Hepatology Third Hospital of Hebei Medical University&Hebei Key Laboratory of Mechanism of Liver Fibrosis in Chronic Liver DiseaseShijiazhuangHebeiChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhouHenanChina

Background and Aims:The impact of nonalcoholic fatty liver disease(NAFLD)on the treatment outcome of chronic hepatitis B(CHB)is undefined and deserves an in-depth ***:Histologically-proven CHB receiving first-line antiviral regimens as initial therapy was enrolled and grouped by the concurrence of NAFLD,and followed up at six monthly *** response related data were recorded and compared at multiple time ***-Meier and Cox regression analyses were utilized to estimate the impact of NAFLD on complete virological response(CVR).Results:We enrolled 267 patients(CHB:164;CHB with NAFLD:103)with comparable follow-up *** were also comparable in baseline HBV DNA levels and HBeAg *** with concomitant NAFLD showed less significant decline in HBV DNA,qHBsAg,pgRNA,and liver enzyme levels over time;moreover,their cumulative incidences of CVR were significantly lower and that of low-level viremia(LLV)were significantly higher at 6,12,18,24 *** CVR of CHB was delayed with the presence NAFLD(11.0 vs.7.0 months,p<0.001)and further prolonged with higher grade of liver steatosis(Grade 2–3 vs.1:13.0 vs.9.0 months).On multivariate analysis,HBeAg positivity(HR:0.650,p=0.036),grade of steatosis(G2[HR:0.447,p=0.004];G3[HR:0.085,p=0.002])and HBV DNA(log10 IU/mL)(HR:0.687,p<0.001)were significantly associated with delayed CVR,whereas grade of necroinflammation(HR:1.758,p<0.001)accelerated the ***:In CHB patients receiving initial antiviral therapy,NAFLD was associated with higher levels of HBV DNA,pgRNA,and liver enzymes,and higher incidence of LLV and delayed CVR.

关键词： Chronic hepatitis B Nonalcoholic fatty liver disease Therapeutic response HBV pregenomic RNA Low-level viremia

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1900—1928年天津戏曲音乐生活初探

中国音乐 2024年第2期 69-77页

作者：侯梦梦天津音乐学院音乐学系

1900年至1928年,天津因独特的地理位置和特殊的社会环境,成为国内最发达的城市之一。这一时期天津戏曲演出场所的增多和扩大、观众社会观念上对戏曲音乐的认可以及社会舆论给予戏曲音乐教化功能的高度肯定,使得河北梆子、京剧和评剧的... 详细信息

1900年至1928年,天津因独特的地理位置和特殊的社会环境,成为国内最发达的城市之一。这一时期天津戏曲演出场所的增多和扩大、观众社会观念上对戏曲音乐的认可以及社会舆论给予戏曲音乐教化功能的高度肯定,使得河北梆子、京剧和评剧的传播和发展达到了顶峰,昆曲、粤剧和文明戏也得到了空前的发展。总体来说,这一时期的天津戏曲音乐生活上呈现曲折发展的态势,其特征表现为:戏曲音乐商业化程度加深、戏曲音乐的社会功能得到重视、演员性别的女性化倾向以及“名角”逐渐占据演出重心等。

关键词：清末民初天津戏曲河北梆子京剧评剧

The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation

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aBIOTECH 2022年第3期3卷 178-196页

作者： Xuezhu Liao Yuanjun Ye Xiaoni Zhang Dan Peng mengmeng hou Gaofei Fu Jianjun Tan Jianli Zhao Rihong Jiang Yechun Xu Jinmei Liu Jinliang Yang Wusheng Liu Luke RTembrock Genfa Zhu Zhiqiang Wu Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518120China Guangdong Provincial Key Lab of Ornamental Plant Germplasm Innovation and Utilization Environmental Horticulture Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou510640China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology Yunnan UniversityKunming650504China Guangxi Engineering and Technology Research Center for Woody Spices Guangxi Key Laboratory for Cultivation and Utilization of Special Non-Timber Forest CropsGuangxi Forestry Research InstituteNanning530002China Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE68583USA Department of Horticultural Science North Carolina State UniversityRaleighNC27607USA Department of Agricultural Biology Colorado State UniversityFort CollinsCO80523USA Kunpeng Institute of Modern Agriculture at Foshan Foshan528200China

Compared with most flowers where the showy part comprises specialized leaves(petals)directly subtending the reproductive structures,most Zingiberaceae species produce showy“flowers”through modifications of leaves(bracts)subtending the true flowers throughout an *** alismatifolia,belonging to the Zingiberaceae family,a plant species originating from Southeast Asia,has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different ***,we present the chromosome-scale genome assembly of ***“Chiang Mai Pink”and explore the underlying mechanisms of bract *** genomic analysis revealed *** contains a residual signal of whole-genome *** genes,including pigment-related genes,exhibit functional and structural differentiation resulting in diverse bract colors among *** *** addition,we identified the key genes that produce different colored bracts in ***,such as F3′5'H,DFR,ANS and several transcription factors for anthocyanin synthesis,as well as chlH and CAO in the chlorophyll synthesis pathway by conducting transcriptomic analysis,bulked segregant analysis using both DNA and RNA data,and population genomic *** work provides data for understanding the mechanism of bract pigmentation and will accelerate breeding in developing novel cultivars with richly colored bracts in *** and related *** is also important to understand the variation in the evolution of the Zingiberaceae family.

关键词： Anthocyanin synthesis Siam tulip Floriculture Zingiberaceae Genome evolution

Strigolactones are required for nitric oxide to induce root elongation in response to nitrogen and phosphate deficiencies in rice

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Strigolactones are required for nitric oxide to induce root ...

2016年全国植物生物学大会

作者： Huwei Sun Jinyuan Tao mengmeng hou Yali Zhang State Key Laboratory of Crop Genetics and Germplasm Enhancement and Key Laboratory of Plant Nutrition and Fertilization in Low-Middle Reaches of the Yangtze RiverMinistry of AgricultureNanjing Agricultural University College of Agronomy National Key Laboratory of Wheat and Maize Crop ScienceCollaborative Innovation Center of Henan Grain CropsHenan Agricultural University

The response of the root system architecture to nutrient deficiencies is critical for sustainable agriculture. Nitric oxide(NO) is considered a key regulator of root growth,although the mechanisms remain unknown. Phenotypic,cellular and genetic analyses were undertaken in rice to explore the role of NO in regulating root growth and strigolactone(SL) signaling under nitrogen-deficient and phosphate-deficient conditions(LN and LP). LN-induced and LP-induced seminal root elongation paralleled NO production in root tips. NO played an important role in a shared pathway of LN-induced and LP-induced root elongation via increased meristem activity. Interestingly,no responses of root elongation were observed in SL d mutants compared with wild-type plants,although similar NO accumulation was induced by sodium nitroprusside(SNP) application. Application of abamine(the SL inhibitor) reduced seminal root length and p CYCB1;1::GUS expression induced by SNP application in wild type;furthermore,comparison with wild type showed lower SL-signalling genes in nia2 mutants under control and LN treatments and similar under SNP application. Western blot analysis revealed that NO,similar to SL,triggered proteasome-mediated degradation of D53 protein levels. Therefore,we presented a novel signaling pathway in which NO-activated seminal root elongation under LN and LP conditions,with the involvement of SLs.

关键词： nitric oxide nitrogen phosphate rice root strigolactone

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基于DT-LMD机床轴承故障信号提取研究

机床与液压 2015年第7期43卷 185-188页

作者：侯蒙蒙许同乐山东理工大学机械工程学院山东淄博255049

为了准确得到机床故障轴承的运行状态,结合双树复小波变换(Daul-Tree Complex Wavelet Transform,DT-CWT)和局域均值方法 (LMD)分解的方法提出了一种新的方法 (DT-LMD),对轴承故障振动信号提取,首先利用双树复小波变换对信号进行降噪和... 详细信息

为了准确得到机床故障轴承的运行状态,结合双树复小波变换(Daul-Tree Complex Wavelet Transform,DT-CWT)和局域均值方法 (LMD)分解的方法提出了一种新的方法 (DT-LMD),对轴承故障振动信号提取,首先利用双树复小波变换对信号进行降噪和重构,其次通过局域均值方法分解,再次利用该方法对机床轴承实际振动信号进行分解,提取其能量特征值并将特征值进行归一化处理,得到各个分量的能量值;最后判断轴承的故障类型。

关键词：故障轴承局域均值分解特征提取归一化处理