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Earthworm regulation of nitrogen pools and dynamics and marker genes of nitrogen cycling: A meta-analysis

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Pedosphere 2022年第1期32卷 131-139页

作者： Rui XUE Chong WANG Xuelian liu mengli liu College of Resources Environmental SciencesChina Agricultural UniversityBeijing 100193China Beijing Key Laboratory of Biodiversity and Organic Farming Beijing 100193China State Key Laboratory of Direct-Fed Microbial Engineering Beijing Dabeinong Science and Technology Group Co.Ltd.(DBN)Beijing 100192China

Earthworms, as the ecosystem engineers, both directly and indirectly affect the nitrogen(N) cycle. We aimed to provide a quantitative assessment of the contribution of earthworms to the terrestrial ecosystem N cycle using meta-analysis of 130 publications selected. The natural logarithm of the response ratio(lnRR) was used to indicate the effect size of earthworms on N dynamic variables. The results showed that earthworms significantly affected soil N-cycling microorganisms, including the amoA gene abundance of soil ammonia-oxidizing bacteria(AOB), and significantly promoted soil N cycle processes,including denitrification, mineralization, and plant assimilation. The effects of earthworms on the N cycle were experimental design dependent and affected by factors such as the functional group of earthworm and residue input. The presence of the anecic earthworms decreased the rates of mineralization and nitrification, and increased nitrification and denitrification responses were more pronounced in the presence of the endogeic earthworms than that of the other two functional groups of earthworms. In addition, residue input enhanced the effects of earthworms on the N cycle. The effects of earthworms on nitrous oxide(N_(2) O) emission increased when residues were added. These findings indicate that residue input and introducing suitable functional groups of earthworms into the field can lead to N sustainability without increasing N2 O emission. This meta-analysis also provides systematic evidence for the positive effects of earthworms on the plant N pool, N availability(soil ammonium(NH_(4)^(+)) content), and soil microbial biomass N content, showing the potential to alter ecosystem functions and services in relation to N cycling.

关键词： ammonia-oxidizing bacteria denitrification earthworm functional group mineralization nitrification residue input

An implantable antibacterial drug-carrier:Mesoporous silica coatings with size-tunable vertical mesochannels

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Nano Research 2022年第5期15卷 4243-4250页

作者： mengli liu Fang Huang Chin-Te Hung Liwei Wang Wei Bi Yupu liu Wei Li Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Lab of Molecular Catalysis and Innovative Materialsand State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Zhongshan Hospital Fudan University(Xiamen Branch)Xiamen 361015China Department of Stomatology Zhongshan HospitalFudan UniversityShanghai 200032China

Implant-associated bacterial infection remains one of the most common and serious ***,a surface boasting long-term antibacterial ability for implants is highly ***,mesoporous silica coatings(MSCs)with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly *** facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of *** orientation assembly process endows the MSCs with vertical mesochannels,tunable mesopore size(ca.5.5-13.5 nm),and switchable substrates even with complex and diversified ***,the MSCs on titanium substrates(Ti@MSCs)exhibit excellent performances for drug adsorption and sustained *** saturation adsorption capacity can reach 0.544 μg·cm^(-2) towards minocycline hydrochloride(MC-HCl)antibiotic molecules,which is 6.5 times as the bare titanium(Ti)*** addition,the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore *** a proof of concept,the Ti@MSCs can realize a higher antibacterial rate(95.9%),compared with the bare Ti(70.3%).The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis.

关键词： mesoporous coatings silica vertical mesochannels metal substrates drug carriers

Highly stable hybrid single-micelle:A universal nanocarrier for hydrophobic bioimaging agents

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Nano Research 2022年第5期15卷 4582-4589页

作者： Qiaoyu Zhou Tiancong Zhao mengli liu Dongrui Yin Minchao liu Ahmed AElzatahry Fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Materials Science and Technology Program College of Arts and SciencesQatar UniversityPO Box 2713DohaQatar

As the first-line technology,micelles play a pivotal role in in vivo delivery of theranostic agents because of their high biocompatibility and ***,in complex physiological environments(extreme dilution,pH,and oxidation or reduction,etc.),they generally suffer from structural instability and insufficient protection for encapsulated *** is urgent to reinforce the structural stability of the micelles at the single-micelle *** using the FDA-approved Pluronic F127 surfactants and indocyanine green(ICG)bioimaging agents as model,herein,we propose the silane-crosslinking assisted strategy to reinforce the structural stability of the *** from the traditional silane hydrolysis under the harsh experimental conditions(acidic,alkaline,and high temperature hydrothermal,etc.),the ICG loaded F127@SiO_(2) hybrid single-micelles(ICG@H-micelles)with controllable sizes(15-35 nm)are synthesized at neutral pH and room temperature,which is crucial for the maintenance of the physicochemical properties of the encapsulated *** the ultra-thin SiO_(2)(<5 nm)at hydrophilic layer of the single-micelle,the structural and fluorescence stability of ICG@H-micelles are much higher than the conventional micelle(ICG@micelles)in the simulated physiological environments of dilution,oxidation or reduction,and low *** of the high structural and fluorescence stability,the ICG@H-micelles also exhibit longer duration time in the tumor and gastrointestinal tract bioimaging.

关键词： micelle SiO_(2) inorganic-organic hybrid mesoporous material bioimaging

Q-switched fiber laser operating at 1.5 μm based on WTe_2

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Chinese Optics Letters 2019年第2期17卷 25-28页

作者： mengli liu Yuyi Ouyang Huanran Hou Wenjun liu Zhiyi Wei State Key Laboratory of Information Photonics and Optical Communications School of Science Beijing University of Posts and Telecommunications Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

Compared with the extensively studied MoS2 and WS2, WTe_2 owns a smaller bandgap, which is applicable to a near-infrared system in photodetectors, communications, and ultrafast optics. In this work, the WTe_2 saturable absorber(SA) with the tapered fiber structure is prepared by the magnetron-sputtering technology, which enables the prepared SA to be low in cost and have strong nonlinearity. The modulation depth of the prepared WTe_2 SA is measured as 31.06%. The Q-switched fiber laser operating at 1.5 μm is successfully investigated by incorporating the proposed SA into the prepared ring cavity. To the best of our knowledge, this is the first attempt of WTe_2 in the Q-switched fiber laser at 1.5 μm.

关键词： Q-switched laser operating

High-power MoTe_2-based passively Q-switched erbium-doped fiber laser

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Chinese Optics Letters 2018年第2期16卷 59-63页

作者： mengli liu Wenjun liu Peiguang Yan Shaobo Fang Hao Teng Zhiyi Wei State Key Laboratory of Information Photonics and Optical Communications School of Science Beijing University of Posts and Telecommunications Beijing 100876 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China Shenzhen Key Laboratory of Laser Engineering College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China

Materials in the transition metal dichalcogenide family, including WS2, MoS2, WSe2, and MoSe2, etc., have captured a substantial amount of attention due to their remarkable nonlinearities and optoelectronic *** with WS2 and MoS2, the monolayered MoTe2 owns a smaller direct bandgap of 1.1 eV. It is beneficial for the applications in broadband absorption. In this letter, using the magnetron sputtering technique, MoTe2 is deposited on the surface of the tapered fiber to be assembled into the saturable absorber. We first implement the MoTe2-based Q-switched fiber laser operating at the wavelength of 1559 nm. The minimum pulse duration and signal-to-noise ratio are 677 ns and 63 dB, respectively. Moreover, the output power of 25 mW is impressive compared with previous work. We believe that MoTe2 is a promising 2D material for ultrafast photonic devices in the high-power Q-switched fiber lasers.

关键词： High-power MoTe2-based passively Q-switched erbium-doped fiber laser

Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy

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Nano Research 2023年第7期16卷 9642-9650页

作者： Minchao liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang mengli liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersiChemShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200433China Department of Musculoskeletal Cancer Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment ***,most of the reported cascade catalytic systems are designed based on symmetric-or co-assembly of multiple catalytic active sites,in which their functions are difficult to perform independently and may interfere with each *** in cascade catalytic system that involves fragile natural-enzymes,the strong oxidation of free-radicals toward natural-enzymes should be carefully considered,and the spatial distribution of the multiple catalytic active sites should be carefully organized to avoid the degradation of the enzyme catalytic ***,a spatially-asymmetric cascade nanocatalyst is developed for enhanced CDT,which is composed by a Fe_(3)O_(4)head and a closely connected mesoporous silica nanorod immobilized with glucose oxidase(mSiO_(2)-GOx).The mSiO_(2)-GOx subunit could effectively deplete glucose in tumor cells,and meanwhile produce a considerable amount of H_(2)O_(2)for subsequent Fenton reaction under the catalysis of Fe_(3)O_(4)subunit in the tumor *** the advantage of the spatial isolation of mSiO_(2)-GOx and Fe_(3)O_(4)subunits,the catalysis of GOx and freeradicals generation occur at different domains of the asymmetric nanocomposite,minimizing the strong oxidation of free-radicals toward the activity of GOx at the other *** addition,direct exposure of Fe_(3)O_(4)subunit without any shelter could further enhance the strong oxidation of free-radicals toward ***,compared with traditional core@shell structure,the long-term stability and efficiency of the asymmetric cascade catalytic for CDT is greatly increased by 138%,thus realizing improved cancer cell killing and tumor restrain efficiency.

关键词： mesoporous nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell

Soliton structures in the (1+1)-dimensional Ginzburg–Landau equation with a parity-time-symmetric potential in ultrafast optics

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Chinese Physics B 2018年第3期27卷 184-190页

作者： Wenyi Li Guoli Ma Weitian yu Yujia Zhang mengli liu Chunyu Yang1 and Wenjun liu State Key Laboratory of Information Photonics and Optical Communications School of Science Beijing University of Posts and Telecommunications Beijing 100876 China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

In this paper, the （l＋l）-dimensional variable-coefficient complex Ginzburg-Landau （CGL） equation with a parity- time （PT） symmetric potential U（x） is investigated. Although the CGL equations with a PT-symmetric potential are less reported analytically, the analytic solutions for the CGL equation are obtained with the bilinear method in this paper. Via the derived solutions, some soliton structures are presented with corresponding parameters, and the influences of them are analyzed and studied. The single-soliton structure is numerically verified, and its stability is analyzed against additive and multiplicative noises. In particular, we study the soliton dynamics under the impact of the PT-symmetric potential. Results show that the PT-symmetric potential plays an important role for obtaining soliton structures in ultrafast optics, and we can design fiber lasers and all-optical switches depending on the different amplitudes of soliton-like structures.

关键词： solitons parity-time symmetry Ginzburg-Landau equation bilinear method

Nanomaterials for refining tumor microenvironment and enhancing therapy in head and neck squamous cell carcinoma: a review

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Oncology and Translational Medicine 2024年第4期10卷 151-161页

作者： Kaifeng Zheng Ruibiao Song Ruifeng Li mengli liu Yunpeng Ba Wei Jiang Kelong Fan Department of Rhinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Application Center for Precision Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules(CAS)CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Zhongyuan Nanozyme Laboratory ZhengzhouHenanChina

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.

关键词： Nanomaterials Tumor microenvironment Antitumor therapy Tumor diagnosis Head and neck squamous cell carcinoma

Multi-distributed probabilistically shaped PAM-4 system for intra-data-center networks

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Chinese Optics Letters 2021年第11期19卷 32-37页

作者： mengli liu Mingyi Gao Junchi Ke Jiangsu Engineering Research Center of Novel Optical Fiber Technology and Communication Network Suzhou Key Laboratory of Advanced Optical Communication Network TechnologySchool of Electronic and Information EngineeringSoochow UniversitySuzhou 215006China

Probabilistically shaped(PS) pulse amplitude modulation(PAM) is a promising technique for intra-data-center networks due to its superior performance, for which a low-complexity and cost-effective distributed matching method is critical. In this work, we propose an energy-level-assigned method to yield PS-PAM-4 signals with various bit rates based on variable probabilistic distributions. We experimentally demonstrate the proposed method in a 25 Gbaud PS-PAM-4 transmission over a bandwidth of approximately 10 GHz. Compared to a uniform PAM-4 system, the proposed multi-distributed PS-PAM-4 system approaches the hard decision threshold at a wide range of received optical power for different applications.

关键词： probabilistic shaping pulse amplitude modulation feed-forward equalizer