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Nano Research 2024年第9期17卷 8017-8024页

作者： mengjie Ma Wenxiang Zhu Fan Liao Kui Yin Hui Huang Kun Feng Dongdong Gao Jinxin Chen Zenan Li Jun Zhong Lai Xu Yang Liu Mingwang Shao Zhenhui Kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) Macao University of Science and TechnologyTaipaMacao 999078China

Oxygen evolution reaction(OER)plays a crucial role in developing energy conversion and adjusting electronic structure of the electrocatalysts can effectively improve the catalytic activity and ***,it is a challenge to adjust the electronic structure on two-dimensional iridium dioxide nanosheets(IrO_(2)NS),which have the advantages of high atom ***,we regulate the surface properties of IrO_(2)NS through sulfonated carbon dots(SCDs)to promote the OER catalytic *** catalyst IrO_(2)NS/SCDs-2 exhibited excellent catalytic activity with a lower overpotential of 1.0 mV than IrO_(2)NS(230 mV)at the current density of 1. mA·cm^(-2)in a 0.5 M H_(2)SO_(4) *** after 1.0 h of stability testing,the overpotential of IrO_(2)NS/SCDs-2 only decreased by 4 ***,transient potential scanning test can visually demonstrate that the addition of SCDs improves the conductivity of the catalyst and increases the electron transfer rate.

关键词： sulfonated carbon dots oxygen evolution reaction electrocatalysis transient potential scanning

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1.Ascl1.Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1. Ascl1. and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S1.0β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1. Ascl1. and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

社会组织参与艾滋病防治工作绩效指标评价研究

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中国艾滋病性病 2017年第4期23卷 303-306页

作者：李菊梅吕柯王璐张广刘鹏沙莎金军怡杨伟华韩孟杰李慧中国疾病预防控制中心性病艾滋病预防控制中心北京102206 中国性病艾滋病防治协会北京100050 中华预防医学会北京100021

目的分析并完善社会组织参与艾滋病防治工作的绩效指标评价体系。方法通过查阅文献、现场访谈等方式收集社会组织参与艾滋病防治工作的绩效指标,结合目前社会组织参与艾滋病防治工作的实际情况,形成社会组织参与艾滋病防治工作绩效指标... 详细信息

目的分析并完善社会组织参与艾滋病防治工作的绩效指标评价体系。方法通过查阅文献、现场访谈等方式收集社会组织参与艾滋病防治工作的绩效指标,结合目前社会组织参与艾滋病防治工作的实际情况,形成社会组织参与艾滋病防治工作绩效指标体系初稿。随后,通过两次德尔菲法,对指标进行进一步筛选。结果初稿确定了32个工作绩效指标。参与德尔菲法调查专家共1.名,其从事艾滋病防治工作平均年限1..22年,参与社会组织领域工作平均年限1..41.。两轮调查的专家积极性系数均为1.0%(1./1.);专家权威程度(Cr)介于0.71.0.94。第一轮的重要性、可获得性及两者综合肯德尔和谐系数(W)分别为0.25、0.1.和0.20,删除4个指标;第二轮分别为0.36、0.26和0.34,删除5个指标。最终确定25个指标,其中通用指标1.个,高危人群干预领域5个,感染者和病人关怀领域共8个。结论通过德尔菲法最终确定的指标在理论上能够反映目前社会组织参与艾滋病防治工作的绩效情况,但指标在绩效应用中的可获得性、真实性、实用性等情况,仍需在实践中进一步验证与完善。

关键词：艾滋病防治工作社会组织德尔菲法绩效指标

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

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Neural Regeneration Research 2024年第10期19卷 2249-2258页

作者： Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng Department of Neurosurgery Institute of Brain DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1.and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1.axis.

关键词： arginine vasopressin growth hormone hypothalamo-neurohypophyseal system hypothalamus injury insulin-like growth factor 1 oxytocin regeneration

Covalent Organic Framework with Predesigned Single-Ion Traps for Highly Efficient Palladium Recovery from Wastes

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CCS Chemistry 2024年第8期6卷 1908-1919页

作者： Yinghui Xie Qiuyu Rong Caimei Wen Xiaolu Liu mengjie Hao Zhongshan Chen Hui Yang Geoffrey I.N.Waterhouse Shengqian Ma Xiangke Wang College of Environmental Science and Engineering North China Electric Power UniversityBeijing 102206 School of Chemical Sciences The University of AucklandAuckland 1142 Department of Chemistry University of North TexasDentonTexas 76201

The recovery of palladium from waste streams is of importance for metal recycling and environmental ***,we present a“single-ion trap”strategy for efficiently recovering Pd(II)from superacidic solutions and laboratory *** was realized by rational design and synthesis of an antiparallel stacked covalent organic framework(ACOF)with hydrazine-carbonyl sites and pyridine sites for cooperative Pd(II)*** single-ion traps provided Lewis base sites with a high Pd(II)binding affinity,enabling the trapping of Pd(II)ions under a wide range of *** developed ACOF-1.adsorbent demonstrated fast kinetics,excellent selectivity,and a high adsorption capacity of 41..9±1..2 mg/g for Pd(II)in a 3M HNO_(3) *** applied in a packed column,ACOF-1.dynamically captured Pd(II)from3M HNO_(3) solutions or laboratorywastes containing trace amounts of palladium and many other metals,realizing extraction efficiencies of 232.9 and 320.9 mg/g,*** experimental and theoretical studies revealed that the single-ion traps offered exceptionally strong binding of Pd(II)under both acidic and high ionic strength conditions,enabling selective adsorptive behavior not accessible using traditional ***,the general design strategy reported here could be used to create porous adsorbents for the capture of other precious metals.

关键词： antiparallel stacking covalent organic frameworks binding affinity selective adsorption Pd(II)recovery

Thyroid Hormone Biomonitoring:A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals

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Environment & Health 2024年第6期2卷 350-372页

作者： Shijie Chen mengjie Yu Yiming Yao Yongcheng Li Ana He Zijun Zhou Liyang Pan Nan Xiao Haining Luo Hongwen Sun MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300071China Tianjin Tianshi College Tianjin 301700China Dalian Center for Disease Control and Prevention DalianLiaoning Province 116000China Department of Center for Reproductive Medicine Tianjin Central Hospital Of Gynecology Obstetrics/Tianjin Key Laboratory Of Human Development And Reproductive RegulationTianjin 300052China

The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological ***,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human *** undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1.M),which exhibit activities akin to *** production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in *** to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and *** review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and ***,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic *** approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research *** integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects.

关键词： Thyroid stimulating hormone Emerging contaminants Data mining Thyroxine 3,3′,5-Triiodothyronine Homeostasis

精神困境、人性救赎与叙事革新:论迟子建《烟火漫卷》的救赎书写

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东北大学学报（社会科学版） 2024年第3期26卷 137-143页

作者：何梦洁上海交通大学人文学院上海200240

迟子建的《烟火漫卷》是一部深度挖掘人性与叩问灵魂的救赎作品。该作以个体的精神困境反映了道德滑坡、生态破坏与传统精神文明衰颓三个方面的问题,通过罪感人物的“自救”与“渡人”,提供了人性救赎与复归的可能。与迟子建以往的救赎... 详细信息

迟子建的《烟火漫卷》是一部深度挖掘人性与叩问灵魂的救赎作品。该作以个体的精神困境反映了道德滑坡、生态破坏与传统精神文明衰颓三个方面的问题,通过罪感人物的“自救”与“渡人”,提供了人性救赎与复归的可能。与迟子建以往的救赎作品相比,《烟火漫卷》在主题呈现、对话形式、叙事技巧和救赎方式等层面皆取得了叙事革新。这不但促使迟子建的救赎书写更臻于完善,而且该作也因此具有了里程碑式的意义,成为当代救赎文学不可或缺的范本。

关键词：迟子建《烟火漫卷》罪的发现人性救赎叙事革新

Establishment of a humanized ST6GAL1.mouse model for influenza research

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Animal Models and Experimental Medicine 2024年第3期7卷 337-346页

作者： Lyu Chao Han Feng Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina NHC Key Laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Zhejiang Provincial Key Laboratory of Medical Genetics Key Laboratory of Laboratory MedicineMinistry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhouChina

Background:This study aimed to construct and characterize a humanized influenza mouse model expressing ***:Humanized fragments,consisting of the endothelial cell-specific K1. promoter,human ST6GAL1.encoding gene,and luciferase gene,were microinjected into the fertilized eggs of *** manipulated embryos were transferred into the oviducts of pseudopregnant female *** offspring were identified using *** exhibiting elevated expression of the hST6GAL1.gene were selectively bred for propagation,and in vivo analysis was performed for *** of the humanized gene was tested by performing immunohistochemical(IHC)*** and biochemical analyses using the whole blood and serum of humanized hST6GAL1.mice were ***:Successful integration of the human ST6GAL1.gene into the mouse genome led to the overexpression of human SiaT *** mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1.ene expression in positive mice mirrored influenza virus infection *** IHC results revealed that hST6GAL1.was expressed in the lungs of humanized ***,the hematologic and biochemical parameters of the positive mice were within the normal ***:A humanized influenza mouse model expressing the hST6GAL1.gene was successfully established and characterized.

关键词： hST6GAL1 humanized mice influenza animal model

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1.mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1.mouse *** overexpression significantly ameliorated the performance of APP/PS1.mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1.mice of a younger age,CHIP overexpression promoted an increase in ADAM1. expression and inhibitedβ-site APP cleaving enzyme 1.insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1.***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1.mice carboxyl terminus of Hsp70 interacting protein gene therapy

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跨语言视角下汉语未完整体标记“着”的语义

当代语言学 2024年第1期26卷 54-69页

作者：张梦杰河南大学外语学院

本文在情境语义学的理论框架下,从跨语言的角度来分析汉语未完整体标记“着”是否具有法语和俄语未完整体标记所具有的惯常义、进行义和状态持续义等一系列语义。本文发现汉语“着”、法语未完整体标记和俄语未完整体标记共享惯常义、... 详细信息

本文在情境语义学的理论框架下,从跨语言的角度来分析汉语未完整体标记“着”是否具有法语和俄语未完整体标记所具有的惯常义、进行义和状态持续义等一系列语义。本文发现汉语“着”、法语未完整体标记和俄语未完整体标记共享惯常义、持续进行义和状态持续义。但是,汉语“着”不具有法语和俄语未完整体标记所共享的模态进行义、法语未完整体标记的准备义和描述未完整体用法,以及俄语未完整体标记的事实未完整体用法。本文采纳“未完整体共享语义核心假说”,认为“着”是对情境进行量化的全称量化算子,“着”和法语、俄语未完整体标记语义的异同主要源于三种语言未完整体标记在量化域中对情境限制的异同,而引起对量化情境限制异同的深层动因则是三种语言未完整体标记语法化路径的异同。

关键词：未完整体标记 “着” 跨语言视角情境语义学语法化