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Salt-assisted vapor-liquid-solid growth of high-quality ultrathin nickel oxide flakes for artificial synapses in image recognition applications

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Nano Research 2024年第5期17卷 4622-4630页

作者： Hui Zhang Zongjie Shen Alei Li Lin Wang Qinan Wang Yunfei Li Yunlei Zhong Juntong Zhu Yong Zhang mengjiao han Dan Tian Chun Zhao Lixing Kang Qingwen Li School of Physical Science and Technology Shanghai Tech UniversityShanghai 201210China Division of Advanced Materials Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China College of Energy Soochow Institute for Energy and Materials Innovationsand Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215123China Songshan Lake Materials Laboratory Dongguan 523808China School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China

Transition metal oxides have attracted intense interest owing to their abundant physical and chemical properties.The controlled preparation of large-area,high-quality two-dimensional crystals is essential for revealing their inherent properties and realizing high-performance devices.However,fabricating two-dimensional(2D)transition metal oxides using a general approach still presents substantial challenges.Herein,we successfully achieve highly crystalline nickel oxide(NiO)flakes with a thickness as thin as 3.3 nm through the salt-assisted vapor-liquid-solid(VLS)growth method,which demonstrated exceptional stability under ambient conditions.To explore the great potential of the NiO crystal in this work,an artificial synapse based on the NiO-flake resistive switching(RS)layer is investigated.Short-term and long-term synaptic behaviors are obtained with external stimuli.The artificial synaptic performance provides the foundation of the neuromorphic application,including handwriting number recognition based on artificial neuron network(ANN)and the virtually unsupervised learning capability based on generative adversarial network(GAN).This pioneering work not only paves new paths for the synthesis of 2D oxides in the future but also demonstrates the substantial potential of oxides in the field of neuromorphic computing.

关键词： nickel oxide(NiO)flakes vapor-liquid-solid(VLS)growth memristor synapse generative adversarial network(GAN)

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Computational tools for plant genomics and breeding

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Science China Life Sciences 2024年第8期 1579-1590页

作者： Hai Wang mengjiao Chen Xin Wei Rui Xia Dong Pei Xuehui Huang Bin han State Key Laboratory of Maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed Laboratory State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of Forestry Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal University College of Horticulture South China Agricultural University National Center for Gene Research CAS Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences

Plant genomics and crop breeding are at the intersection of biotechnology and information technology.Driven by a combination of highthroughput sequencing,molecular biology and data science,great advances have been made in omics technologies at every step along the central dogma,especially in genome assembling,genome annotation,epigenomic profiling,and transcriptome profiling.These advances further revolutionized three directions of development.One is genetic dissection of complex traits in crops,along with genomic prediction and selection.The second is comparative genomics and evolution,which open up new opportunities to depict the evolutionary constraints of biological sequences for deleterious variant discovery.The third direction is the development of deep learning approaches for the rational design of biological sequences,especially proteins,for synthetic biology.All three directions of development serve as the foundation for a new era of crop breeding where agronomic traits are enhanced by genome design.

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填石路基快速施工工艺与压实质量控制

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山东交通学院学报 2024年第1期32卷 29-36,42页

作者：韩沛李小勇李梦娇山东高速工程检测有限公司山东济南250002 山东高速工程项目管理有限公司山东济南250002

为分析采用快速施工工艺碾压的填石路基的压实质量,采用有限元软件ABAQUS建立长方体三维土基模型,模拟分析由36、22 t压路机在500、700 kN 2种激振力下压实填石路基的力学响应;在现场试验路段,采用36 t压路机碾压松铺厚度为75、85 cm的... 详细信息

为分析采用快速施工工艺碾压的填石路基的压实质量,采用有限元软件ABAQUS建立长方体三维土基模型,模拟分析由36、22 t压路机在500、700 kN 2种激振力下压实填石路基的力学响应;在现场试验路段,采用36 t压路机碾压松铺厚度为75、85 cm的填石路基,26 t压路机碾压松铺厚度为40 cm的填石路基,采用土压力传感器测试土压力,选用孔隙率和沉降差控制路基的压实质量。结果表明:2种激振力下36 t压路机碾压路基后的应力分别为22 t压路机的1.9倍、1.5倍;土压力主要由压路机振动产生,土压力随距路表深度的增大而减小,土压力降幅随距地表深度的增大而减小,现场试验结果与数值模拟结果一致;压路机碾压6遍后,2种松铺厚度路基的孔隙率均小于22%,建议沉降差的控制指标为3.0 mm;采用36 t压路机碾压松铺厚度为85 cm路基的最优工作效率较26 t压路机提高60%,工程成本降低36%。

关键词：数值模拟填石路基快速施工土压力孔隙率沉降差

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血液病住院患者衰弱状况调查分析

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中国社区医师 2024年第4期40卷 136-138页

作者：王梦娇孙锋涂涵程慧向阳锦州医科大学中国人民解放军联勤保障部队第967医院研究生培养基地辽宁大连116011 中国人民解放军联勤保障部队第967医院中医血液科辽宁大连116011

目的:调查血液病住院患者衰弱状况,为制定血液病患者临床治疗方案提供依据。方法:选取2021年6月—2022年2月中国人民解放军联勤保障部队第967医院血液科收治的血液病患者101例作为研究对象,采用Tilburg衰弱量表(TFI)评估患者衰弱状况,依... 详细信息

目的:调查血液病住院患者衰弱状况,为制定血液病患者临床治疗方案提供依据。方法:选取2021年6月—2022年2月中国人民解放军联勤保障部队第967医院血液科收治的血液病患者101例作为研究对象,采用Tilburg衰弱量表(TFI)评估患者衰弱状况,依据TFI评分将患者分为衰弱组与非衰弱组,比较两组血常规结果,统计衰弱组TFI各分数人数以及TFI各条目人数。结果:101例患者TFI≥5分49例,衰弱发生率为48.5%。衰弱组红细胞、血红蛋白水平低于非衰弱组,差异有统计学意义(P0.05)。衰弱组TFI评分7(5,12)分,7分占比最多(26.5%),≥10分占比较少(10%);衰弱组在躯体维度占比>50.0%的分别为疲劳感(87.8%)、行走困难(71.4%)、握力下降(65.3%)、自评身体健康(63.3%)、视力下降(55.1%);心理维度占比>50.0%分别为记忆力减退(67.3%)、抑郁(51.0%);社会维度占比>50.0%为社会关系(91.8%)。结论:血液病住院患者衰弱发生率较高,衰弱程度处于中等水平,发生可能与贫血有关,临床应重视对血液病患者衰弱的评估,根据患者衰弱时所表现出的特征,采取针对性干预措施。

关键词：血液病衰弱特征身体维度心理维度社会维度

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Systemic antibiotics increase microbiota pathogenicity and oral bone loss

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International Journal of Oral Science 2023年第1期15卷 99-112页

作者： Xulei Yuan Fuyuan Zhou He Wang Xinxin Xu Shihan Xu Chuangwei Zhang Yanan Zhang Miao Lu Yang Zhang mengjiao Zhou han Li Ximu Zhang Tingwei Zhang Jinlin Song Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical UniversityChongqingChina

Periodontitis is the most widespread oral disease and is closely related to the oral microbiota.The oral microbiota is adversely affected by some pharmacologic treatments.Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis,causing negative effects on the human body.Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed.In this research,mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss.The results demonstrated,for the first time,that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis.Moreover,the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue.Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier,decreased the pathogenicity of the oral microbiota,reversed the Th17/Treg imbalance in periodontal tissue,and alleviated alveolar bone loss.This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis.A Th17/Treg imbalance might be related to this relationship.Importantly,these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice.

关键词： Th17/Treg diseases reversed

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Individual aortic baroreceptors are sensitive to different ranges of blood pressures

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Science China(Life Sciences) 2014年第7期57卷 502-509页

作者： CHEN mengjiao YANG MingHao han WenJuan AN ShuCheng LIU YiHui LIU ZhiQiang REN Wei MOE Key Laboratory for Modern Teaching Technology and College of Life Sciences Shaanxi Normal University

Many receptors,including thermal receptors and mechanical receptors,are only activated by stimuli within a clearly defined range of intensities.Differences in the receptive ranges enable individual receptors and their sensory centers to precisely detect the intensity of the stimulus and changes in intensity.Baroreceptors are the sensory terminals of the baroreflex.It is well understood that an increasing number of baroreceptors are recruited to produce afferent action potentials as the blood pressure increases,indicating that individual baroreceptors have different pressure thresholds.The present study revealed that individual baroreceptors could stop their afferent signals when the blood pressure exceeds a certain level,indicating that individual baroreceptors are sensitive to a specific range of blood pressure.The receptive ranges of individual baroreceptors differ in terms of the total range,the lower threshold,and the upper threshold.Of 85 baroreceptors examined in this study,the upper thresholds for about half were within the physiological blood pressure range.These results indicate that supraphysiological blood pressure is unlikely to be encoded by the recruitment of more baroreceptors.Instead,supraphysiological blood pressure levels might be signaled by an increase in the frequency of action potentials or by other mechanisms.In conclusion,our results indicate that rabbit baroreceptors are activated by blood pressure levels within specific receptive ranges.These findings should encourage further studies to examine the role of population coding of blood pressure by baroreceptors in the baroreflex.

关键词：压力感受器血压升高敏感主动脉动作电位机械感受器生理性阈值

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3D Tungsten Trioxide Nanosheets as Optoelectronic Materials for On-chip Quantification of Global Antioxidant Capacity

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Chemical Research in Chinese Universities 2021年第3期37卷 763-771页

作者： DAI mengjiao MA Weiguang han Fangjie han Dongfang han Lipeng WANG Wei ZHAO Bolin han Dongxue NIU Li WANG Zhenxin State Key Laboratory of Electroanalytical Chemistry c/o Engineering Laboratory for Modern Analytical TechniquesChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022P.R.China University of Science and Technology of China Hefei230026P.R.China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023P.R.China Center for Advanced Analytical Science c/o School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou510006P.R.China

The photoelectrochemical properties of semiconductors mainly depend on the size and shape of the corresponding nanoparticles.Herein,3D WO3 nanosheets were controllably synthesized with the aid of polyethyleneimine,which presents enhanced photocurrent responses.Based on this excellent photoelectrochemical property,a photoelectrochemical chip was prepared by lithography technology for the smart monitoring of the antioxidant capacity(AC)in red wine and exhibits a series of advantages including rapid response time,high sensitivity,and long-lasting stability.The mechanism of the present photoelectrochemical sensing was explored and shows a single electron transfer reaction.Furthermore,only 200µL of samples are required for one testing,which demonstrates that the present photoelectrochemical chip can be potentially integrated with a portable commercial device(such as a mobile phone)for further research and development of food and drug supervision.

关键词： 3D tungsten trioxide nanosheet Photoelectrochemical chip Antioxidant capacity assessment Red wine assessment Gallic acid

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Non-dormant Axillary Bud 1 regulates axillary bud outgrowth in sorghum

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Journal of Integrative Plant Biology 2018年第10期60卷 938-955页

作者： Jun Chen Limin Zhang mengjiao Zhu Lijie han Ya Lv Yishan Liu Pan Li Haichun Jing Hongwei Cai Department of Plant Genetics Breeding and Seed ScienceChina Agricultural UniversityBeijing Key Laboratory of Crop Genetic ImprovementLaboratory of Crop Heterosis and UtilizationMOEBeijing 100193China Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China Inner Mongolia Research Centre for Practaculture Chinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China Forage Crop Research Institute Japan Grassland Agricultural and Forage Seed Association388-5 HigashiakadaNasushiobaraTochigi 329-2742Japan

Tillering contributes to grain yield and plant architecture and therefore is an agronomically important trait in sorghum （Sorghum bicolor）. Here, we identified and functionally characterized a mutant of the Non- dormant Axillary Bud 1 （NAB1） gene from an ethyl methanesulfonate-mutagenized sorghum population. The nab1 mutants have increased tillering and reduced plant height. Map-based cloning revealed that NAB~ encodes a carotenoid-cleavage dioxygenase 7 （CCDT） orthologous to rice COryza sativa） HIGH-TILLERING DWARF1/ DWARF^7 and Arabidopsis thaliana MORE AXILLARY BRANCHING 3. NAB1 is primarily expressed in axillary nodes and tiller bases and NAB1 localizes to chloroplasts. The nab1 mutation causes outgrowth of basal axillary buds; removing these non-dormant basal axillary buds restoredthe wild-type phenotype. The tillering of nab1 plants was completely suppressed by exogenous application of the synthetic strigolactone analog GR24. Moreover, the nab1 plants had no detectable strigolactones and displayed stronger polar auxin transport than wild-type plants. Finally, RNA-seq showed that the expression of genes involved in multiple processes, including auxin-related genes, was significantly altered in nab1. These results suggest that NAB1 functions in strigolactone biosynthesis and the regulation of shoot branching via an interaction with auxin transport.

关键词： NAB Non-dormant Axillary Bud 1 regulates axillary bud outgrowth in sorghum Figure HTD

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传统导引养生功法习练与老年人生存质量关系的实证研究

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武术研究 2023年第9期8卷 98-102页

作者：韩梦姣四川文理学院体育学院四川达州635000

研究目的:探讨传统导引养生功法习练与老年人生存质量的关系。研究方法:2022年3-6月期间,在四川省达州市社区筛选符合实验条件的老年人120名,将其分为人数均等的对照组、实验1组和实验2组。对照组不进行实验干预,实验1组进行八段锦习练... 详细信息

研究目的:探讨传统导引养生功法习练与老年人生存质量的关系。研究方法:2022年3-6月期间,在四川省达州市社区筛选符合实验条件的老年人120名,将其分为人数均等的对照组、实验1组和实验2组。对照组不进行实验干预,实验1组进行八段锦习练,实验2组进行五禽戏习练,习练12周。实验干预前后借助《SF-36生存质量量表》和问卷对受试者进行调查,采用SPSS 21.0对数据资料进行统计分析。研究结果:(1)干预前对照组与实验组在生存质量各维度的得分均偏低,总均分小于60分。(2)对照组在干预后的生存质量呈现下降趋势,但与干预前相比不存在显著性差异;实验组在干预前后生存质量得分明显提高,且差异性显著。(3)实验1组在干预前后生存质量的差异非常显著,生存质量各项得分提高明显;而实验2组干预前后除在MH和总均分差异非常显著外,在其余各项上只存在显著差异。研究结论:(1)没有锻炼习惯的老年人生存质量偏低,且伴随年龄的增长,生存质量还将持续下降;(2)习练传统导引养生功法更能够明显改善老年人的生存质量;(3)不同传统导引养生功法的习练对老年人的生存质量产生不同的积极影响,与五禽戏相比,八段锦的习练对老年人生存质量的改善效果更为显著。

关键词：传统导引养生功法养生功法老年人生存质量

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高校线上线下混合式教学模式的探索——以《学校体育学》课程为例

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四川文理学院学报 2023年第3期33卷 127-131页

作者：韩梦姣四川文理学院体育学院四川达州635000

《学校体育学》是体育教育专业的一门专业主干课程,在国家体育事业建设和体育人才培养方面都具有非常重要的作用。随着“互联网+”带来的机遇与挑战,四川文理学院体育学院中的学校体育学教研团队借助现代信息技术,围绕“以学生发展为中... 详细信息

《学校体育学》是体育教育专业的一门专业主干课程,在国家体育事业建设和体育人才培养方面都具有非常重要的作用。随着“互联网+”带来的机遇与挑战,四川文理学院体育学院中的学校体育学教研团队借助现代信息技术,围绕“以学生发展为中心”的教育理念,对《学校体育学》课程进行线上线下混合式教学模式的研究与探索,以期为今后《学校体育学》课程以及其他体育理论课程的教学改革与实践提供一定的参考。

关键词：混合式教学模式学校体育学课程

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