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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

Virologica Sinica 2023年第4期38卷 606-619页

作者： Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy Mirko Trilling Kathrin Sutter mengji lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute for Virology University Hospital of EssenUniversity of Duisburg-EssenEssen45147Germany Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan430022China

A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the ***,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since *** magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those *** mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82%and 76%,respectively,over the time period of ten months after ***,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75%of CIs during the ***,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.

关键词： COVID-19 SARS-CoV-2 T cell response Convalescence

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Ischemic preconditioning protects against liver ischemia/reperfusion injury via heme oxygenase-1-mediated autophagy

Ischemic preconditioning protects against liver ischemia/rep...

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第九届全国免疫学学术大会

作者： Anding Liu Haoshu Fang Yan Yang Shenpei Liu Dongliang Yang mengji lu Olaf Dirsch Uta Dahmen Experimental Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Experimental Transplantation Surgery Department of GeneralVisceral and Vascular SurgeryFriedrich-Schiller-University Jena Department of Pathophysiology Anhui Medical University Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Institute of Virology University Hospital of EssenUniversity of Duisburg-Essen EssenEssen45122 Germany

Background:Ischemic preconditioning(IPC)exerts a protective effect in hepatic ischemia/reperfusion(I/R)*** exact mechanism of IPC action remains largely *** studies suggest that autophagy plays an important role in protecting against I/R ***,the role of autophagy in IPC-afforded protection and its regulatory mechanisms in liver I/R injury remain poorly *** study was designed to determine whether IPC could protect against liver I/R injury via heme oxygenase-1(HO-1)-mediated ***:IPC was produced by 10 min of ischemia followed by 10 min reperfusion prior to 60 min of *** a rat model of hepatic I/R injury,rats were pretreated with wortmannin or rapamycin to evaluate the contribution of autophagy to the protective effects of ***-1 was inhibited with tin protoporphyrinⅨ(SnPP).In a mouse model of hepatic I/R injury,autophagy or HO-1 was inhibited with vacuolar protein sorting 34(Vps34)small interfering RNA(siRNA)orHO-1 siRNA,***:IPC ameliorated liver I/R injury,as indicated by lower serum aminotransferase levels,lower hepatic inflammatory cytokines,and less severe I/R-associated histopathologic *** treatment induced autophagy activation,as indicated by an increase of LC3-Ⅱ,degradation of p62 and accumulation of autophagic vacuoles in response to I/R *** IPC-induced autophagy was inhibited with wortmannin in rats or Vps34-specific siRNA in mice,liver I/R injury was worsened,while rapamycin treatment increased autophagy and mimicked the protective effects of ***,IPC increased HO-1 *** inhibition of HO-1 with tin protoporphyrinⅨ(SnPP)in rats or HO-1-specific siRNA in mice decreased IPC-induced autophagy and diminished the protective effects of IPC against I/R ***:IPC protects against liver I/R injury,at least in part,via HO-1-mediated autophagy.

关键词： Autophagy Ischemic Preconditioning Hepatoprotection Liver I/R injury Heme oxygenase-1

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Control of Viral Infection by Activation of Innate Immune Responses

Control of Viral Infection by Activation of Innate Immune Re...

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第3届新生病毒性疾病控制学术研讨会

作者： mengji lu Institute of Virology,University Hospital of Essen,Germany Wuhan Institute of Virology,Chinese Academy of Science,China

Pathogen invasion may be sensed through various pattern recognition receptors (PRRs) including Toll like receptors(TLRs) and helicases,that are expressed in immune cells as well as in somatic *** the infection immunol...

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RNAi induces innate immunity through multiple cellular signaling pathways

RNAi induces innate immunity through multiple cellular signa...

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中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Zhongji Meng Xiaoyong Zhang Jun Wu Rongjuan Pei Yang Xu Dongliang Yang Michael Roggendorf mengji lu Department of Infectious Diseases Taihe HospitalHubei University of Medicine Institute of Virology University Hospital of EssenUniversity Duisburg-Essen Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Microbiology Tongji Medical CollegeHuazhong University of Science and Technology

Background & Aims Our previous Conclusions showed that the knockdown of woodchuck hepatitis virus(WHV) by RNA interference(RNAi) led to upregulation of interferon stimulated genes(ISGs) in primary *** the present study,we tested the hypothesis that the cellular signaling pathways recognizing RNA molecules may be involved the ISG stimulation by *** Primary murine hepatocytes(PM-

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The Impact of Amino Acid Substitutions in HBsAg on the Biological Characteristic of HBV in vivo

The Impact of Amino Acid Substitutions in HBsAg on the Biolo...

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2013年湖北省暨武汉微生物学会会员代表大会暨学术年会

作者： Songxia Li Chunchen Wu Liang Cao Hui Wang Kaitao Zhao Yongxuan Yao mengji lu Xinwen Chen State Key Lab of Virology Wuhan Institute of VirologyChinese Academy of Sciences Institute of Virology University Hospital of Essen Department of Microbiology Tongji Medical CollegeHuazhong University of Science and Technology

HBsAg(Hepatitis B Virus surface antigen)can induce protective immune response and play an important role in the interaction between HBV and *** of S gene result in the change of the antigenicity and immunogenicity of ... 详细信息

关键词： HBsAg S genetic variability glycosylation HBV replication HBV secretion

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CORRECTION:Correction to:Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference

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Virologica Sinica 2020年第6期35卷 885-886页

作者： Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu luping Zhou Guizhou Zou mengji lu Zhenhua Zhang Department of Infectious Diseases The Second Hospital of Anhui Medical UniversityHefei 230601China Institute of Clinical Virology The Second Hospital of Anhui Medical UniversityHefei 230601China Department of Intemal Medicine The Second Hospital of FuyangFuyang 236015China Institute for Virology University Hospital of EssenUniversity of Duisburg-Essen45147 EssenGermany

In the original version of Fig.41 and 4J,the cutoff lines were accidently shifted during figure *** 41 and 4J are re-drawn and provided below.

关键词： Internal accident layout

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Regulation of antiviral CD8 T cell response by Sema4D/CD100 and its soluble form in HBV infection

Regulation of antiviral CD8 T cell response by Sema4D/CD100 ...

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第十一届全国免疫学学术大会

作者： Yang Sahngqing Wang lu Liu Yanan Wang Qin Yu Qing luo Jinzhuo Bayer Wibke Dittmer Ulf lu mengji Yang Dongliang Liu Jia Department of Infectious Disease Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Gastroenterology University Hospital of Essen University of Duisburg-Essen Institute for Virology University Hospital of Essen University of Duisburg-Essen

Backgroud:Sema4D/CD100 was the first semaphorin described to have immune functions and serves important roles in T cell priming,antibody *** cleavage of membrane CD100 gives rise to a soluble fragment of CD100(s CD100),which also have immunoregulatory *** we characterized the expression and the possible role of CD100/s CD100 in regulating antiviral response during HBV infection in patients and HBVreplicating mouse model.

关键词： hepatitis B virus Cytotoxic T lymphocytes CD100

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Rapamycin modulates the course of hepatitis B virus(HBV)infection in hydrodynamic injection mouse model:the role of Treg in HBV persistence

Rapamycin modulates the course of hepatitis B virus(HBV)infe...

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中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Shunmei Huang Zhitao Song Baoju Wang Junzhong Wang Zhenni Zhu Bin Zhu Xuemei Feng mengji lu Dongliang Yang Department of Infectious Diseases Union Hospital of Tongji Medical collegeHuazhong University of Science and Technology Institute of Virology Duisburg-Essen University

Background Hydrodynamic injection(HI) of pAAV/HBV1.2 inBALB/c mice leads to a transient HBV gene expression and replication in liver,representing a useful system for the study of HBV *** (RAPA ) can selected activated Treg in *** this study,the effect of RAPA on HBV replication was investigated in HBV HI mice model,and the possible role of Treg in HBV persistence was analyzed using RAPA treated mice *** HI was performed in BALB/c mice with pAAV/*** were treated with

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Synergic effect of NOD1 or NOD2 agonists with TLR3 agonists on murine LSEC to trigger HBV specific T cell response

Synergic effect of NOD1 or NOD2 agonists with TLR3 agonists ...

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第十一届全国免疫学学术大会

作者： Shunmei Huang Gao Xiaoyan Chen Liwen Yang Xilang Zou Shi Du Yanqin Sun Chan lu mengji Yang Dongliang Wu Jun Department of Infectious Disease Union Hospital of Tongji Medical CollegeHuazhong University of Science and Technology Department of Virology University Hospital of Essen

Aims:LSEC can switch from a tolerogenic to an immunogenic state and promote the development of T cell ***,we investigate the effect of LSEC in anti-HBV adaptive immune response,and explored the possibility of NOD1/NOD2-TLR3 agonists as immunomodulatory agents for the treatment of ***:CD8+ T cells were isolated from PSM2 HI mice and labeled with CFSE and then cocultured with NOD1(DAP)/NOD2(MDP)/TLR3(Poly(I:C)) stimulated-LSEC for 5 *** proliferation of CD8+ T cells,the phosphorylation status of NF-k B,MAPK and surface molecules expression in LSEC was detected by FACS.T cells primed by DAP/MDP/Poly(I:C) treated primary LSEC were transferred to the chronic HBV replication mice,serum markers of HBV were assayed by ELICA and q ***:Stimulation of LSEC with DAP or Poly(I:C) induced the activation of NFκB and MAPK,then significantly upregulated the expression of chemokines,*** DAP or Poly(I:C) treated LSEC could not induce the proliferation,but the production of IFN-γ and IL-2 of HBV stimulated CD8+ T cells primed by DAP-or Poly(I:C) treated ***,a signigcant reduction in HBVDNA,HBs Ag and HBe Ag level occurred in mice received T cells primed by DAP or poly(I:C)-treated *** treatment had no impact on LSEC or HBV-stimulated CD8+ T cells primed by MDP-treated *** with DAP or MDP plus Poly(I:C) increased the cytokine(TNF-α,IL-2,CXCL10,CCL5 and CCL8) and surface marker CD54,CD106,CD86 or CD86 expression in LSEC,*** or MDP plus Poly(I:C) treated LSEC synergisticallydecreased the levels of HBs Ag,HBe Ag and ***:The combinatory stimulation with DAP or MDP plus Poly(I:C) in vitro could synergistically render LSEC maturation and activate HBV specific T cells *** is a particular relevance for the regulation of the local innate immune response against HBV infections.

关键词： innate immunity LSEC T cell response HBV

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Replication and persistence of wild type and chimeric genomes of woodchuck hepatitis virus and hepatitis B virus in the mouse model based on hydrodynamic injection

Replication and persistence of wild type and chimeric genome...

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2012年鄂粤微生物学学术年会——湖北省暨武汉微生物学会成立六十年庆祝大会

作者： Pan Danzhen Wu Weimin Song Jingjiao Wang Junzhong Wang Baoju Wu Chunchen Lin Yong Chen Xinwen Yang Dongliang Xu Yang lu mengji

Background:The woodchuck model is an informative model for studies on hepatitis B virus(HBV) infection,including host immune responses and immunotherapies of chronic HBV ***,the specific reagents like vaccines for HBV research could not be directly used in the woodchuck ***,it is desirable to develop replication competent woodchuck hepatitis virus(WHV) carrying the relevant HBV genes.

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