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Potential herb-drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3598-3637页

作者： Ling Ye Shicheng Fan Pengfei Zhao Chenghua Wu menghua Liu Shuang Hu Peng Wang Hongyu Wang Huichang Bi NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has spread *** treatments against COVID-19 remain urgently in need although vaccination significantly reduces the incidence,hospitalization,and *** present,antiviral drugs including Nirmatrelvir/Ritonavir(Paxlovid^(TM)),Remdesivir,and Molnupiravir have been authorized to treat COVID-19 and become more globally *** the other hand,traditional Chinese medicine(TCM)has been used for the treatment of epidemic diseases for a long ***,various TCM formulae against COVID-19 such as Qingfei Paidu decoction,Xuanfei Baidu granule,Huashi Baidu granule,Jinhua Qinggan granule,Lianhua Qingwen capsule,and Xuebijing injection have been widely used in clinical practice in China,which may cause potential herb-drug interactions(HDIs)in patients under treatment with antiviral drugs and affect the efficacy and safety of ***,information on potential HDIs between the above anti-COVID-19 drugs and TCM formulae is lacking,and thus this work seeks to summarize and highlight potential HDIs between antiviral drugs and TCM formulae against COVID-19,and especially pharmacokinetic HDIs mediated by metabolizing enzymes and/or *** well-characterized HDIs could provide useful information on clinical concomitant medicine use to maximize clinical outcomes and minimize adverse and toxic effects.

关键词： COVID-19 Antiviral drugs Anti-COVID-19 drugs Nirmatrelvir/Ritonavir(Paxlovid^(TM)) Remdesivir Molnupiravir Traditional Chinese medicine Pharmacokinetics Herb-drug interaction

Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai,2018–2021

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Virologica Sinica 2023年第5期38卷 671-679页

作者： Lijuan Lu Yuanyun Ao Ran Jia Huaqing Zhong Pengcheng Liu menghua Xu Liyun Su Lingfeng Cao Jin Xu Department of Clinical Laboratory Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201100China Shanghai Institute of Infectious Disease and Biosecurity Fudan UniversityShanghai201100China

Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in *** this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to *** overall detection rate of NoV was 11.9%(181/1545),with annual detection rates of 9.4%(36/381),13.6%(29/213),5.8%(13/226)and 14.2%(103/725),*** note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9%,65/594)(P=0.023)and 2021(14.2%,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GI group(1.1%,2/181),GII group(98.3%,178/181)and GIX group(0.6%,1/181)according to the VP1 *** most common NoV VP1 genotype was GII.4 Sydney_2012(63.5%,115/181),followed by GII.3(19.9%,36/181)and GII.2(9.4%,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GII.P16(44.8%,78/174),followed by GII.P31(25.9%,45/174)and GII.P12(21.3%,37/174).Among the 174 cases,GII.4 Sydney_2012[P16](36.8%,64/174)was the dominant genotype,followed by GII.4 Sydney_2012[P31](25.3%,44/174),GII.3[P12](20.1%,35/174)and GII.2[P16](8.0%,14/174).In particular,the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31]in 2018-2019 to GII.4 Sydney_2012[P16]in *** is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in *** data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.

关键词： Norovirus(NoV) Acute gastroenteritis Children Genotype Recombination

Orientation and mobility control of 4HCB organic film for flexible X-ray detectors with high performance

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Journal of Materials Science & Technology 2023年第4期135卷 46-53页

作者： Meng Xu menghua Zhu Dou Zhao Sixin Chen Shilin Liu Quanchao Zhang Pei Yuan Binbin Zhang Paul Sellin Wanqi Jie Yadong Xu State Key Laboratory of Solidification Processing MIIT Key Laboratory of Radiation Detection Materials and Devicesand School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Physics University of SurreyGuildford GU27XHUK

In comparison to inorganic counterparts,organic semiconducting(OSC)crystalline films are promising for building large-area and flexible ionizing radiation detectors for X-ray imaging or dosimetry due to their tissue equivalence,simple processing and large-scale production *** processes,how-ever,hinder the ability to generate aligned and large-area films with high carrier *** this work,the space-confined melt process is used to produce highly orientated 4HCB(4-hydroxycyanobenzene)OSC films with a large area of 15×18 mm^(2).The out-of-plane direction of the 4HCB film is,and the benzene rings are found to be extensively overlapped inside the in-plane direction,according to the XRD *** film exhibits a high resistivity up to 1012cm,and high hole mobility of 10.62 cm^(2)V^(−1)s^(−1).Furthermore,the 4HCB(80μm-thick film)based X-ray detectors can achieve a sensitivity of 93μC Gy air^(−1) cm^(−2)and on/offratio of *** device also shows steady flexibility,with no degradation in detecting function after 100 cycles of ***,the proposed 4HCB film detectors demonstrated a high-resolution X-ray imaging *** imaging of several materials with sharp edges(copper and polytetrafluoroethylene)has been *** work has developed a fast but efficient approach for producing large-area,highly oriented OSC films for high-performance X-ray detectors.

关键词： Organic semiconducting films Highly oriented X-ray Detector X-ray imaging Wearable detector

The d-orbital coupling modulation of CuNi alloy for acetonitrile electrochemical reduction and in-situ hydrogenation behavior characterization

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Science China Chemistry 2023年第11期66卷 3242-3251页

作者： Boling Liu Dong He Zunjian Ke Hongbo Wang Chongyang Tang Qi Zhang Hang Xu menghua Yang Yafei Yang Qi Liu Xiangheng Xiao School of Physics and Technology Wuhan UniversityWuhan 430072China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430072China Department of Physics City University of Hong KongHong Kong 999077China

Electrochemical reduction of acetonitrile to ethylamine with a high selectivity is a novel approach to manufacture valuable primary amines which are important raw material in organic chemical industry. However, the poor ethylamine Faradic efficiency(FE_(ethylamine)) and catalyst stability at the high current density prohibit this method from being practically used. Herein, CuNi alloy ultrafine-nano-particles based on the d-orbital coupling modulation were synthesized through the electrodeposition and their catalytic performance towards acetonitrile reduction reaction(ACNRR) has been systematically studied. The highest FE_(ethylamine)(97%) is achieved with the current density of-114 mA cm^(-2). For practical application, the current density can reach-602.8 mA cm^(-2) with 82.8% FE_(ethylamine)maintained. With the appearance of other organics which co-exist with acetonitrile in the SOHIO process, CuNi can also hydrogenate acetonitrile in it with more than 80% FE_(ethylamine). Our in-situ spectroscopy analysis and DFT calculations towards the acetonitrile hydrogenation behavior reveal that the evenly dispersed Ni in Cu modulates the dband so as to endow CuNi with the better acetonitrile adsorption, milder binding energy with the reaction intermediates, smaller barrier for *CH_3CH_2NH_2 desorption and higher ability for H_2O dissociation to provide *H.

关键词： CuNi alloy acetonitrile reduction reaction d-orbital coupling modulation in-situ spectroscopy analysis acetonitrile adsorption

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Novel high-voltage cathode for aqueous zinc ion batteries:Porous K_(0.5)VOPO_(4)·1.5H_(2)O with reversible solid-solution intercalation and conversion storage mechanism

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Journal of Energy Chemistry 2024年第6期93卷 71-78,I0003页

作者： Liyu Wang Mingliang Zhao Xiaoyu Zhang menghua Wu Yu Zong Yu Chen Xinliang Huang Mingjie Xing Xin Ning Wen Wen Daming Zhu Xiaochuan Ren Industrial Research Institute of Nonwovens&Technical Textiles College of Textiles&ClothingShandong Engineering Research Center for Specialty Nonwoven MaterialsQingdao UniversityQingdao 266071ShandongChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Cathode materials that possess high output voltage,as well as those that can be mass-produced using facile techniques,are crucial for the advancement of aqueous zinc-ion battery(ZIBs)applications,Herein,we present for the first time a new porous K_(0.5)VOPO_(4)·1.5H_(2)O polyanionic cathode(P-KIVP)with high output voltage(above 1.2 V)that can be manufactured at room temperature using straightforward coprecipitation and etching *** P-KVP cathode experiences anisotropic crystal plane expansion via a sequential solid-solution intercalation and phase co nversion pathway throughout the Zn^(2+)storage process,as confirmed by in-situ synchrotron X-ray diffraction and ex-situ X-ray photoelectron *** to other layered vanadium-based polyanionic materials,the P-KVP cathode experiences a progressive decline in voltage during the cycle,which is demonstrated to be caused by the irreversible conversion into amorphous VO_(x).By introducing a new electrolyte containing Zn(OTF)_(2) to a mixed triethyl phosphate and water solution,it is possible to impede this irreversible conversion and obtain a high output voltage and longer cycle life by forming a P-rich cathode electrolyte interface *** a proof-of-concept,the flexible fiber-shaped ZIBs based on modified electrolyte woven into a fabric watch band can power an electronic watch,highlighting the application potential of P-KVP cathode.

关键词： Aqueous zinc ion battery Cathode Porous material High voltage platform In-situ synchrotron X-ray diffraction

Intrinsic defects of nonprecious metal electrocatalysts for energy conversion: Synthesis, advanced characterization, and fundamentals

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ChemPhysMater 2022年第3期1卷 155-182页

作者： menghua Yang Jiangchao Liu Hang Xu Yongfeng Pei Changzhong Jiang Dong He Xiangheng Xiao Department of Physics Hubei Nuclear Solid Physics Key LaboratoryWuhan UniversityWuhan 430072China Hubei Yangtze Memory Laboratories Wuhan 430205China

With the depletion of fossil fuels and environmental pollution, energy storage and conversion have become the focus of current research. Water splitting and fuel cell technologies have made outstanding contributions to energy conversion. However, the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) have slow kinetics, which limit the capacity of fuel cells. It is of great significance to develop catalysts for the OER and ORR and continuously improve their catalytic performance. Many studies have shown that intrinsic defects, especially vacancies (anion and cation vacancies), can effectively improve the efficiency of electrochemical energy storage and conversion. The introduction of intrinsic defects can generally expose more active sites, enhance conductivity, adjust the electronic state, and promote ion diffusion, thereby enhancing the catalytic performance. This review comprehensively summarizes the latest developments regarding the effects of intrinsic defects on the performance of non-noble metal electrocatalysts. According to the type of intrinsic defect, this article reviews in detail the regulation mechanism, preparation methods and advanced characterization techniques of intrinsic defects in different materials (oxides, non-oxides, etc.). Then, the current difficulties and future development of intrinsic defect regulation are analyzed and discussed thoroughly. Finally, the prospect of intrinsic defects in the field of electrochemical energy storage is further explored.

关键词： Intrinsic defects Anion vacancies Cation vacancies Transition metal-based materials Electrochemical energy conversion

Low operating voltage memtransistors based on ion bombarded p-type GeSe nanosheets for artificial synapse applications

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InfoMat 2023年第12期5卷 54-64页

作者： Jing Wang Dong He Rui Chen Hang Xu Hongbo Wang menghua Yang Qi Zhang Changzhong Jiang Wenqing Li Xiaoping Ouyang Xiangheng Xiao Department of Physics Wuhan UniversityWuhanHubeithe People's Republic of China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi'anShanxithe People's Republic of China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhanthe People's Republic of China

Two-dimensional(2D)layered materials have many potential applications in memristors owing to their unique atomic structures and electronic *** can overcome the in-memory bottleneck for use in brain-like neuromorphic ***,exploiting additional lateral memtransistors based on 2D layered materials remains *** are few studies on p-type semiconductors that have not been theoretically *** this study,a lateral memtransistor based on p-type GeSe nanosheets is investigated.A threeterminal GeSe memtransistor that modulated the interfacial barrier height was fabricated using low-energy ion irradiation;the memtransistor exhibited a low operating *** memtransistor successfully mimics biological synapse,including neuroplasticity functions,such as short-term plasticity,long-term plasticity,paired-pulse facilitation,and spike-timing-dependent *** mechanism of interfacial modulation was verified by experimental results and theoretical *** results show that it is feasible to modulate the interface of 2D GeSe nanosheets using low-energy ion irradiation to realize a lateral *** may provide promising opportunities for artificial neuromorphic system applications based on 2D layered materials.

关键词： artificial synapses GeSe nanosheet interfacial modulation low-energy ion irradiation memtransistor

Research on Subject Nature and Objective of Physical Education Training

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Journal of Contemporary Educational Research 2019年第6期3卷 31-34页

作者： Pengfei Wen menghua Wang School of Physical Education and Health Zhaoqing UniversityZhaoqing526061China

Physical education and training is considered as a new subject among the same type of *** has a short history background and is relatively ***,the influence of the discipline of physical education and training must not be ignored by simply blaming it as the youngest *** addition,especially in the case of rapid economic development and rapid improvement in living standards today,the influence of this discipline is relatively ***,this thesis mainly studies the subject nature and object of physical education *** research object of this subject can be studied from three key points,such as:the curriculum of the subject,the research method and the research of the subject of *** comprehensive development of physical education and physical education is a comprehensive discipline.

关键词： Physical Education Physical Training Subject Nature

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金刚石车削刀高误差下表面特征及力学表现

深圳大学学报（理工版） 2020年第5期37卷 543-550页

作者：戴玉琦张国庆周梦华深圳大学机电与控制工程学院广东深圳518060

为探究工件中心刀具干涉的形成机理,实现刀高误差的在线辨识,围绕刀高误差存在情况下,刀具干涉的产生及加工过程参数的影响等方面展开研究.通过分别建立车削行程中工件中心圆台及刀具后刀面的三维形貌方程,基于两者间的位置关系推导刀... 详细信息

为探究工件中心刀具干涉的形成机理,实现刀高误差的在线辨识,围绕刀高误差存在情况下,刀具干涉的产生及加工过程参数的影响等方面展开研究.通过分别建立车削行程中工件中心圆台及刀具后刀面的三维形貌方程,基于两者间的位置关系推导刀具干涉区域半径的数学模型,探讨加工过程参数对刀具干涉区域三维形貌的影响.根据所推导的数学模型,利用刀具与工件挤压面积的投影来表征切削力的变化,建立刀高误差的预测模型.理论与试验研究结果表明,刀高误差、切削深度、刀尖半径及刀具后角直接影响刀具干涉区域的范围与形貌,工件刀高误差可通过监测切削行程中的切削力进行在线辨识.

关键词：切削理论金刚石车削刀高误差中心圆锥刀具干涉切削力