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Revealing the role of CCoAOMT1: fine-tuning bHLH transcription factors for optimal anther development

Science China(Life Sciences) 2024年第3期67卷 565-578页

作者： Zesen Lai Jianzheng wang Ying Fu menghan wang Hong Ma Shiqing Peng Fang Chang State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and Institute of Biodiversity SciencesInstitute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China School of Tropical Agriculture and Forestry Agriculture-Rural Affairs and Rural RevitalizationHainan UniversityHaikou 570228China Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of AgricultureInstitute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Department of Biology Huck Institutes of the Life SciencesPennsylvania State UniversityUniversity ParkPA 16802USA

The tapetum,a crucial innermost layer encompassing male reproductive cells within the anther wall,plays a pivotal role in normal pollen development.The transcription factors (TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1,a gatekeeper TF in the tapetum.Nevertheless,the regulatory mechanisms governing the activity of bHLH010/089/091 remain unknown.In this study,we reveal that caffeoyl coenzyme A O-methyltransferase 1 (CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089,probably through their K259 site.Our findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and bHLH089.Intriguingly,elevated CCoAOMT1 expression resulted in defective pollen development,mirroring the phenotype observed in bhlh010 bhlh089 mutants.Moreover,our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by CCoAOMT1.Importantly,transgenic plants with the probHLH089::bHLH089^(K259A)construct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 mutants.Collectively,these findings emphasize the need to maintain balanced TF homeostasis for male fertility.They firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development.

关键词： anther development nuclear localization bHLH O-methyltransferase transcription factor homeostasis

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LncRNAs unraveling their sponge role in glioblastoma and potential therapeutic applications

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BIOCELL 2024年第3期48卷 387-401页

作者： CAIJUAN LIU XINGHAO LI YUXUAN WU JINHUI YANG menghan wang YUNQI MA School of Pharmacy Binzhou Medical UniversityYantai264003China

Glioblastoma multiforme(GBM),the most common and aggressive primary brain tumor in adults,is the most malignant and still has no cure.However,the novel role of long non-coding RNAs(lncRNAs)in the pathogenesis of glioblastoma is attracting extensive attention.LncRNAs are transcribed RNA molecules over 200 nucleotides long that do not encode proteins.Unlike small non-coding RNAs,such as microRNAs(miRNAs),lncRNAs have more complex secondary and tertiary structures that enable them to interact with DNA,RNA,and proteins and perform multiple regulatory functions.LncRNAs act as molecular sponges,absorbing and sequestering other biomolecules,particularly miRNAs,thereby preventing these molecules from performing their normal functions.LncRNAs inﬂuence glioblastoma through gene expression regulation,molecular sponge capacity,epigenetic modulation,and signaling pathway interactions.In glioblastoma,a large number of lncRNAs have been found to be abnormally expressed,affecting tumor growth,invasion and resistance to treatment.Due to its regulatory role and disease-speciﬁc expression patterns,lncRNA has become a potential biomarker for glioblastoma and a promising new therapeutic target.This paper discusses the spongy role of lncRNAs in glioblastoma and its potential therapeutic applications,which will lay a foundation for our understanding of glioblastoma biology and the development of new diagnostic and therapeutic strategies in the future.

关键词： LncRNA miRNA Biomarker Molecular sponges Tumor microenvironment

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Role of Stokes Drift in Ocean Dynamics Under Typhoon Conditions in the Bohai Sea

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Journal of Ocean University of China 2024年第1期23卷 33-45页

作者： LI Haoqian WAN Kai wang menghan DENG Zeng’an CAO Yu North China Sea Marine Forecasting Center Qingdao 266061China Shandong Provincial Key Laboratory of Marine Ecology and Environment&Disaster Prevention and Mitigation Qingdao 266061China North China Sea Offshore Engineering Survey Institute Qingdao 266061China School of Marine Science and Technology Tianjin UniversityTianjin 300072China South China Sea Marine Forecasting Center Guangzhou 510006China

The effect of Stokes drift production(SDP),which includes Coriolis-Stokes forcing,Langmuir circulation,and Craik-Lei-bovich vortexes,on the upper ocean during typhoon passage in the Bohai Sea(BS),China,is investigated by using a coupled wave-current model.The role of SDP in turbulent mixing and the further dynamics during the entire typhoon period are comprehensively stud-ied.Experimental results show that SDP greatly increases turbulent mixing at all depths under typhoon conditions by up to seven times that under normal weather conditions.SDP generally strengthens sea surface cooling by more than 0.4℃,with the maximum reduction in sea surface temperature(SST)at the during-typhoon stage exceeding 2℃,which is approximately seven times larger than that under normal weather conditions.The SDP-induced decrease in current speed can exceed 0.2ms^(-1),and the change in current direction is generally opposite the wind direction.These results suggest that Stokes drift depresses the effect of strong winds on currents by intensifying turbulent mixing.Mixed layer depth(MLD)is distinctly increased by O(1)during typhoons due to SDP and can deepen by more than 5m.In addition,the continuous effects of SDP on SST,current,and MLD at the after-typhoon stage indi-cate a hysteretic response between SDP and typhoon actions.

关键词： Stokes drift production Langmuir turbulence rurbulent mixing typhoon coupled model

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On the role of wave breaking in ocean dynamics under typhoon Matsa in the Bohai Sea,China

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Acta Oceanologica Sinica 2022年第9期41卷 1-18页

作者： menghan wang Zengan Deng School of Marine Science and Technology Tianjin UniversityTianjin300072China Guangxi Key Laboratory of Marine Environment Change and Disaster in Beibu Gulf Qinzhou535011China

The role of wave breaking(WB) in the ocean dynamics in the Bohai Sea,China under typhoon condition is systematically investigated utilizing a coupled wave-current model.The influences of WB on ocean dynamics and processes(mixing coefficient,temperature,mixed layer depth,and current) during the entire typhoon period(including the pre-typhoon,during-typhoon and after-typhoon stages) are comprehensively detected and discussed.Experimental results show that WB greatly enhances the turbulent mixing at about top 10 m depth under typhoon condition,the increase can be up to 10 times that of the normal weather.At the same time,WB generally strengthens the sea surface cooling by ~1.2°C at the during-typhoon stage,about 3 times that in normal weather.The mixed layer depth,is rapidly increased by ~1.6–3.6 m during typhoon due to WB,particularly,the deepening is stronger in the region from 120.5°E to 121.0°E on account of close to the typhoon eye.In addition,WB renders the current speed more uniformly within the entire depth in the Bohai Sea,the change in speed is ~0.2 m/s,whereas the alternation in current vector is generally opposite to the wind direction except for the typhoon eye region,reflecting that WB has an inhibitory effect on the typhoon-forced current change.The effects of WB on vertical mixing coefficient response to the typhoon rapidly,while the impacts of WB on temperature,and mixed layer depth present hysteretic responses to typhoon.Finally,the mechanisms and distribution characteristics of WB-induced mixing and tidal mixing are compared under typhoon condition.

关键词： wave breaking tidal mixing turbulent mixing typhoon coupled model

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Evaluating the Applicability and Health Benefits of the Graded Heat Health Risk Early Warning Model-Jinan City,Shandong Province,China,2022

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China CDC weekly 2023年第29期5卷 642-646,I0001-I0003页

作者： Chen Chen Jing Liu menghan wang Liangliang Cui Tiantian Li China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Key Laboratory of Public Health Safety of Hebei Province College of Public HealthHebei UniversityBaoding CityHebei ProvinceChina Department of Environmental Health Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina

What is already known about this topic?The heat health early warning model serves as an effective strategy for reducing health risks related to heatwaves and improving population adaptability.Several high-income countries have taken the lead in conducting research and implementing measures aimed at safeguarding their populations.What is added by this report?The graded heat health risk early warning model(GHREWM)in Jinan City has demonstrated efficacy in safeguarding males,females,individuals aged above 75 years,and those with cardiopulmonary diseases.During the summer of 2022,the warning stage of GHREWM contributed to the prevention of 10.9 deaths per million individuals,concurrently averting health-related economic losses estimated at approximately 227 million Chinese Yuan(CNY).What are the implications for public health practice?The GHREWM has the potential to enhance cities’adaptability to climate change.It is crucial to incorporate additional adverse health endpoint data in the development of early warning models,as this will improve their applicability and protective efficacy.

关键词： income conducting measures

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Heritage tourism evolution in Guangfu Ancient City,Hebei Province,China:an analysis with the improved creative destruction model

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Built Heritage 2022年第3期6卷 28-42页

作者： menghan wang Xiaoran Bai Mingming Su School of Environment&Natural Resources Renmin University of ChinaBejing 100872China

Ancient cities and towns are popular tourism destinations worldwide.In this paper,Guangfu Ancient City in Yongnian County,Hebei Province,China,is taken as the case study and the modifed creative destruction model is applied as the analytical framework to evaluate the multiactor dynamics of heritage tourism development.A mixed method approach is adopted,including a local resident survey,in-depth interviews with staf of the Guangfu Ancient City tourism site and government ofcials responsible for the heritage conservation and tourism development of the site,and a review of online tourist reviews,relevant government documents and reports.Based on the modifed creative destruction model,local residents’attitudes towards tourism development,changes in tourist numbers,the level of business and government investments,and the motivations of diferent stakeholders in tourism development are assessed by synthesising on-site research,historical data and other materials.Then,the tourism development stages for Guangfu Ancient City are identifed as the precommodifcation stage before 2006,the early commodifcation stage from 2006 to 2011 and the advanced commodifcation stage from 2012 to 2017.The fndings indicate that with rapid increases in investments from both corporate and government sources and in the number of tourists,the attitude of local residents towards tourism development remained positive.The results show that instead of entering the initial destruction stage,Guangfu Ancient City is in the transition stage from advanced commodifcation to creative enhancement given the government’s dominant role in tourism development,the heritage conservation motives of tourism entrepreneurs,the benefts to residents from tourism development ensured by government policies,and the shift in tourist type to postmodern tourists with double demands.The applicability of the modifed creative destruction model is further discussed,and policy and management recommendations are generated to support the sustainable development of Guangfu Ancient C

关键词： Creative destruction Creative enhancement Heritage tourism Tourism commercialisation Stakeholder Guangfu Ancient City

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Electrical, mechanical and damage self-sensing properties of basalt fiber reinforced polymer composites modified by electrophoretic deposition

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Progress in Natural Science:Materials International 2023年第5期33卷 593-600页

作者： Haoming Sun Dong Xiang Jie Zhang Wei Tan Eileen Harkin-Jones Junjie wang menghan wang Bin wang Chunxia Zhao Hui Li Zhenyu Li Yuntao Li Yuanpeng Wu School of New Energy and Materials Southwest Petroleum University The Center of Functional Materials for Working Fluids of Oil and Gas Field Sichuan Engineering Technology Research Center of Basalt Fiber Composites Development and Application Southwest Petroleum University Collaborative Scientific Innovation Platform of Universities in Sichuan for Basalt Fiber Southwest Petroleum University School of Mechanical Engineering Southwest Petroleum University School of Engineering and Materials Science Queen Mary University of London School of Engineering Ulster University Department of Civil Engineering Tsinghua University College of Materials Science and Engineering Chongqing University

In this work, basalt fiber reinforced polymer(BFRP) with enhanced electrical, mechanical properties and in-situ damage self-sensing capability was prepared using carboxylic carbon nanotubes(COOH-CNTs) modified BF fabrics via electrophoretic deposition(EPD) at different voltages. The BFRP with BF fabrics modified at a deposition voltage of 20 V(EPD20-BFRP) showed the lowest electrical resistivity. Compared with unmodified BFRP, the tensile and flexual moduli of EPD20-BFRP increased by 37.5 % and 14.9 %, respectively. Single-layer EPD20-BFRP exhibited a high gauge factor(GF) of 44.3 during tensile damage self-sensing. The acoustic emission(AE) signals during tensile and flexual damage process agreed well with the relative resistance changes(RRC),which confirmed different damage stages within loading process, such as elastic deformation, damage evolution,crack coalescence, and complete fracture. In addition, the multi-layer BFRP containing a single-layer EPD20-BFRP on the upper or lower surface of laminate exhibited distinct electrical signal responses subjected to the flexural loading.

关键词： Carbon nanotubes and nanofibers Natural fibers Polymer-matrix composites (PMCs) Non-destructive testing

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High-performance fiber strain sensor of carbon nanotube/thermoplastic polyurethane@styrene butadiene styrene with a double percolated structure

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Frontiers of Materials Science 2022年第1期16卷 99-110页

作者： Dong XIANG Libing LIU Xiaoyu CHEN Yuanpeng WU menghan wang Jie ZHANG Chunxia ZHAO Hui LI Zhenyu LI Ping wang Yuntao LI School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400030China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China The Center of Functional Materials for Working Fluids of Oil and Gas Field Southwest Petroleum UniversityChengdu 610500China

In this work,a high-performance fiber strain sensor is fabricated by constructing a double percolated structure,consisting of carbon nanotube(CNT)/thermoplastic polyurethane(TPU)continuous phase and styrene butadiene styrene(SBS)phase,incompatible with TPU(CNT/TPU@SBS).Compared with other similar fiber strain sensor systems without double percolated structure,the CNT/TPU@SBS sensor achieves a lower percolation threshold(0.38 wt.%)and higher electrical conductivity.The conductivity of 1%-CNT/TPU@SBS(4.12×10^(-3) S·m^(-1))is two orders of magnitude higher than that of 1%-CNT/TPU(3.17×10^(-5) S·m^(-1))at the same CNT loading of 1 wt.%.Due to double percolated structure,the 1%-CNT/TPU@SBS sensor exhibits a wide strain detection range(0.2%-100%)and an ultra-high sensitivity(maximum gauge factor(GF)is 32411 at 100%strain).Besides,the 1%-CNT/TPU@SBS sensor shows a high linearity(R^(2)=0.97)at 0%-20%strain,relatively fast response time(214 ms),and stability(500 loading/unloading cycles).The designed sensor can efficiently monitor physiological signals and movements and identify load distribution after being woven into a sensor array,showing broad application prospects in wearable electronics.

关键词： double percolated structure strain sensor fiber carbon nanotube nanocomposite

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Highly stretchable, sensitive and wide linear responsive fabric-based strain sensors with a self-segregated carbon nanotube(CNT)/Polydimethylsiloxane(PDMS) coating

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Progress in Natural Science:Materials International 2022年第1期32卷 34-42页

作者： Libing Liu Xuezhong Zhang Dong Xiang Yuanpeng Wu Dan Sun Jiabin Shen menghan wang Chunxia Zhao Hui Li Zhenyu Li Ping wang Yuntao Li School of New Energy and Materials Southwest Petroleum University The Center of Functional Materials for Working Fluids of Oil and Gas Field Southwest Petroleum University School of Mechanical and Aerospace Engineering Queen's University Belfast State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University College of Materials Science and Engineering Chongqing University

Flexible strain sensors have received increasing attention with the development of wearable electronic devices.However, integrating wide strain detection range, high sensitivity while maintaining relatively wide linear response range for such sensor system still remain a challenge. A fabric based flexible sensor（S-CNT/PDMS-F） was designed and fabricated, and the sensor can simultaneously achieve high sensitivity, wide linear response and strain detection range by combining self-segregated carbon nanotube（CNT）/polydimethylsiloxane（PDMS）composites and elastic medical bandage. It has been observed that this new sensor system can achieve a high sensitivity with a gauge factor of 615, a large linear responsive range of 0–100% strain（R;= 0.993） and a wide strain detection range of ～ 200%, which is superior to almost all the reported CNT/PDMS flexible strain sensors.Compared to the similar fabric based strain sensor system deploying non self-segregated structure（C-CNT/PDMSF）, our S-CNT/PDMS-F demonstrates higher electrical conductivity and lower electrical percolation threshold and response time of 55 ms, as well as more stable and repeatable performance under cyclic loading conditions. The capability of the sensors in monitoring physiological activities and weight distribution has also been demonstrated.

关键词： Strain sensor Self-segregated structure Carbon nanotubes Polydimethylsiloxane Nanocomposites

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Revealing the role of CCoA OMT1: fine-tuning bH LH transcription factors for optimal anther development

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Science China Life Sciences 2023年

作者： Zesen Lai Jianzheng wang Ying Fu menghan wang Hong Ma Shiqing Peng Fang Chang School of Tropical Agriculture and Forestry Agriculture-Rural Affairs and Rural Revitalization Hainan University Key Laboratory of Biology and Genetic Resources of Tropical Crops Ministry of Agriculture Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences Department of Biology Huck Institutes of the Life Sciences Pennsylvania State University University Park State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and Institute of Biodiversity Sciences Institute of Plant Biology School of Life Sciences Fudan University

The tapetum, a crucial innermost layer encompassing male reproductive cells within the anther wall, plays a pivotal role in normal pollen development. The transcription factors(TFs) bHLH010/089/091 redundantly facilitate the rapid nuclear accumulation of DYSFUNCTIONAL TAPETUM 1, a gatekeeper TF in the tapetum. Nevertheless, the regulatory mechanisms governing the activity of bHLH010/089/091 remain unknown. In this study, we reveal that caffeoyl coenzyme A O-methyltransferase 1(CCoAOMT1) is a negative regulator affecting the nuclear localization and function of bHLH010 and bHLH089, probably through their K259 site. Our findings underscore that CCoAOMT1 promotes the nuclear export and degradation of bHLH010 and bHLH089. Intriguingly, elevated CCoAOMT1 expression resulted in defective pollen development, mirroring the phenotype observed in bhlh010 bhlh089 mutants. Moreover, our investigation revealed that the K259A mutation in the bHLH089 protein disrupted its translocation from the nucleus to the cytosol and impeded its degradation induced by CCoAOMT1. Importantly, transgenic plants with the probHLH089::bHLH089K259Aconstruct failed to rescue proper pollen development or gene expression in bhlh010 bhlh089 mutants. Collectively, these findings emphasize the need to maintain balanced TF homeostasis for male fertility. They firmly establish CCoAOMT1 as a pivotal regulator that is instrumental in achieving equilibrium between the induction of the tapetum transcriptional network and ensuring appropriate anther development.

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