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Microstructure control of organic semiconductors via UV-ozone for high-sensitivity NO2 detection

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Science China(Technological Sciences) 2021年第5期64卷 1057-1064页

作者： HOU SiHui FAN HuiDong wu mengge YU XinGe YU JunSheng State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China Department of Biomedical Engineering City University of Hong KongHong KongChina

Developing high sensitive organic semiconductors(OSCs)in organic thin-film transistors(OTFTs)is the key for OTFT based gas ***,we report a simple processing route of highly sensitive OSCs for high performance OTFT based nitrogen dioxide(NO2)sensors,where the active OSC layer is based on ultraviolet-ozone(UVO)treated poly(3-hexylthiophene-2,5-diyl)(P3HT).Compared to conventional P3HT based OTFT sensors,the reported device exhibits a remarkable improvement of the gas response from 350%to 30000%.The studies in morphologies,chemical compositions and microstructures of the UVOtreated films reveal that a large number of carrier traps generated in the P3HT films is the decisive reason for the enhancement of sensing ***,the optimized device shows great potential of practical applications on the stand points of sensitivity,selectivity,reusability and the ability of recovery,as well as limit of detection of~7.3 *** simple method provides an innovative understanding for the role of the carrier traps in sensing performance and demonstrates a bright future for developing high performance OTFT gas sensors.

关键词： ultraviolet-ozone organic thin-film transistors gas sensors carrier traps nitrogen dioxide

Muscle-inspired soft robots based on bilateral dielectric elastomer actuators

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Microsystems & Nanoengineering 2023年第5期9卷 245-254页

作者： Yale Yang Dengfeng Li Yanhua Sun mengge wu Jingyou Su Ying Li Xinge Yu Lu Li Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)ChengduPR China Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqingPR China Hong Kong Centre for Cerebro-Cardiovascular Health Engineering(COCHE) Hong KongSARChina Department of Biomedical Engineering City University of Hong KongHong KongSARChina

Muscle groups perform their functions in the human body via bilateral muscle actuation,which brings bionic inspiration to artificial robot *** soft robotic systems with artificial muscles and multiple control dimensions could be an effective means to develop highly controllable soft ***,we report a bilateral actuator with a bilateral deformation function similar to that of a muscle group that can be used for soft *** construct this bilateral actuator,a low-cost VHB 4910 dielectric elastomer was selected as the artificial muscle,and polymer films manufactured with specific shapes served as the actuator *** end-to-end connecting these bilateral actuators,a gear-shaped 3D soft robot with diverse motion capabilities could be developed,benefiting from adjustable actuation *** on the ground with all feet on the ground,a crawling soft robot with dexterous movement along multiple directions was ***,the directional steering was instantaneous and *** two feet standing on the ground,it also acted as a rolling soft robot that can achieve bidirectional rolling motion and climbing motion on a 2°***,inspired by the orbicularis oris muscle in the mouth,a mouthlike soft robot that could bite and grab objects 5.3 times of its body weight was *** bidirectional function of a single actuator and the various combination modes among multiple actuators together allow the soft robots to exhibit diverse functionalities and flexibility,which provides a very valuable reference for the design of highly controllable soft robots.

关键词： robot artificial dielectric

Origami-inspired folding assembly of dielectric elastomers for programmable soft robots

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Microsystems & Nanoengineering 2022年第2期8卷 73-83页

作者： Yanhua Sun Dengfeng Li mengge wu Yale Yang Jingyou Su Tszhung Wong Kangming Xu Ying Li Lu Li Xinge Yu Junsheng Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054People's Republic of China Chongqing Key Laboratory of Materials Surface&Interface Science Chongqing Co-Innovation Center for Micro/Nano Optoelectronic Materials and DevicesMicro/Nano Optoelectronic Materials and Devices International Science and Technology Cooperation Base of ChinaSchool of Materials Science and EngineeringChongqing University of Arts and SciencesChongqing 402160People's Republic of China Department of Biomedical Engineering City University of Hong KongHong Kong SAR 999077People's Republic of China

Origami has become an optimal methodological choice for creating complex three-dimensional(3D)structures and soft *** simple and low-cost origami-inspired folding assembly provides a new method for developing 3D soft robots,which is ideal for future intelligent robotic ***,we present a series of materials,structural designs,and fabrication methods for developing independent,electrically controlled origami 3D soft robots for walking and soft *** 3D soft robots are based on soft actuators,which are multilayer structures with a dielectric elastomer(DE)film as the deformation layer and a laser-cut PET film as the supporting flexible *** triangular and rectangular design of the soft actuators allows them to be easily assembled into crawling soft robots and pyramidal-and square-shaped 3D *** crawling robot exhibits very stable crawling behaviors and can carry loads while *** by origami folding,the pyramidal and square-shaped 3D soft robots exhibit programmable out-of-plane deformations and easy switching between two-dimensional(2D)and 3D *** electrically controllable origami deformation allows the 3D soft robots to be used as soft manipulators for grasping and precisely locking 3D *** work proves that origami-inspired fold-based assembly of DE actuators is a good reference for the development of soft actuators and future intelligent multifunctional soft robots.

关键词： robot folding dielectric

Contractility detection of isolated mouse papillary muscle using myotronic Myostation-Intact device

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Animal Models and Experimental Medicine 2022年第5期5卷 445-452页

作者： Hong Lian Zhuyun Qin mengge wu Peipei Zuo Lina Bai Minjie Lu Lulu Li Haitao Zhang State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CenterFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Adult Surgical Intensive Care Unit Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine Fuwai Central-China HospitalCentral-China Subcenter of National Center for Cardiovascular DiseasesZhengzhouChina

Background:To understand the relationship between myocardial contractility and ex-ternal stimuli,detecting ex vivo myocardial contractility is ***:We elaborated a method for contractility detection of isolated C57 mouse papillary muscle using Myostation-Intact system under different frequencies,volt-ages,and calcium ***:The results indicated that the basal contractility of the papillary muscle was 0.27±0.03 mN at 10 V,500-ms pulse duration,and 1 *** 0.1 to 1.0 Hz,con-tractility decreased with an increase in frequency(0.45±0.11-0.10±0.02 mN).The voltage-initiated muscle contractility varied from 3 to 6 V,and the contractility gradu-ally increased as the voltage increased from 6 to 10 V(0.14±0.02-0.28±0.03 mN).Moreover,the muscle contractility increased when the calcium concentration was increased from 1.5 to 3 mM(0.45±0.17-1.11±0.05 mN);however,the contractility stopped increasing even when the concentration was increased to 7.5 mM(1.02±0.23 mN).Conclusions:Our method guaranteed the survivability of papillary muscle ex vivo and provided instructions for Myostation-Intact users for isolated muscle contractility investigations.

关键词： calcium concentration frequency isolated papillary muscle muscle contractility Myostation-intact voltage

Epidermal self-powered sweat sensors for glucose and lactate monitoring

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Bio-Design and Manufacturing 2022年第1期5卷 201-209页

作者： Xingcan Huang Jiyu Li Yiming Liu Tszhung Wong Jingyou Su Kuanming Yao Jingkun Zhou Ya Huang Hu Li Dengfeng Li mengge wu Enming Song Shijiao Han Xinge Yu Department of Biomedical Engineering City University of Hong KongHong Kong 999077China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054China

Sweat could be a carrier of informative biomarkers for health status identification;therefore,wearable sweat sensors have attracted significant attention for *** external power source is an important component of wearable sensors,however,the current power supplies,i.e.,batteries,limit further shrinking down the size of these devices and thus limit their application areas and ***,we report a stretchable self-powered biosensor with epidermal electronic format that enables the in situ detec-tion of lactate and glucose concentration in *** biofuel cells serve as self-powered sensing modules allowing the sweat sensor to exhibit a determination coefficient(R2)of 0.98 with a sensitivity of 2.48 mV/mM for lactate detection,and R2 of 0.96 with a sensitivity of 0.11 mV/μM for glucose *** microfluidic channels developed in an ultra-thin soft flexible polydimethylsiloxane layer not only enable the effective collection of sweat,but also provide excellent mechanical properties with stable performance output even under 30%*** presented soft sweat sensors can be integrated at nearly any location of the body for the continuous monitoring of lactate and glucose changes during normal daily activities such as *** results provide a promising approach to develop next-generation sweat sensors for real-time and in situ sweat analysis.

关键词： Sweat sensor Self-powered Epidermal electronics Enzymatic biofuel cells Microfluidics

Identification of M2 macrophage-related genes for establishing a prognostic model in pancreatic cancer: FCGR3A as key gene

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Oncology Research 2024年第12期32卷 1851-1866页

作者： ZHEN WANG JUN FU SAISAI ZHU HAODONG TANG KUI SHI JIHUA YANG MENG WANG mengge wu DUNFENG QI Department of Hepatopancreatobiliary Surgery XuZhou Central Hospital Affiliated to Medical School of Southeast UniversityXuzhou221000China Department of Surgery School of MedicineSoutheast UniversityNanjing210000China Department of Oncology Albert Einstein College of MedicineBronxNY 10461USA

Background:Pancreatic ductal adenocarcinoma(PDAC)has a rich and complex tumor immune microenvironment(TIME).M2 macrophages are among the most extensively inﬁltrated immune cells in the TIME and are necessary for the growth and migration of ***,the mechanisms and targets mediating M2 macrophage inﬁltration in pancreatic cancer remain ***:The M2 macrophage inﬁltration score of patients was assessed using the xCell *** weighted gene co-expression network analysis(WGCNA),module genes associated with M2 macrophages were identiﬁed,and a predictive model was *** variations in immunological cell patterns,cancer mutations,and enrichment pathways between the cohorts with the high-and low-risk were ***,the expression of FCGR3A and RNASE2,as well as their association with M2 macrophages were evaluated using the HPA,TNMplot,and GEPIA2 databases and veriﬁed by tissue immunoﬂuorescence ***,in vitro cell experiments were conducted,where FCGR3A was knocked down in pancreatic cancer cells using siRNA to analyze its effects on M2 macrophage inﬁltration,tumor proliferation,and ***:The prognosis of patients in high-risk and low-risk groups was successfully distinguished using a prognostic risk score model of M2 macrophage-related genes(p=0.024).Between the high-and low-risk cohorts,there have been notable variations in immune cell inﬁltration patterns,tumor mutations,and biological *** risk score was linked to the manifestation of prevalent immunological checkpoints,immunological scores,and stroma values(all p<0.05).In vitro experiments and tissue immunoﬂuorescence staining revealed that FCGR3A can promote the inﬁltration or polarization of M2 macrophages and enhance tumor proliferation and ***:In this study,an M2 macrophage-related pancreatic cancer risk score model was established,and found that FCGR3A was correlated with tumor formation,metastasis,and M2 macrophage

关键词： Pancreatic ductal adenocarcinoma(PDAC) M2 macrophages Weighted gene co-expression network analysis(WGCNA) CIBERSORT Immunization Prognosis

Miniaturization of mechanical actuators in skin-integrated electronics for haptic interfaces

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Microsystems & Nanoengineering 2021年第5期7卷 31-39页

作者： Dengfeng Li Jiahui He Zhen Song Kuanming Yao mengge wu Haoran Fu Yiming Liu Zhan Gao Jingkun Zhou Lei Wei Zhengyou Zhang Yuan Dai Zhaoqian Xie Xinge Yu Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Hong Kong Centre for Cerebro-Cardiovascular Health Engineering(COCHE) Hong Kong SARChina State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalianChina lnstitute of Flexible Electronic Technology of Tsinghua JiaxingChina Tencent Robotics X ShenzhenChina Ningbo Institute of Dalian University of Technology NingboChina

Skin-integrated electronics,also known as electronic skin(e-skin);are rapidly developing and are gradually being adopted in biomedical fields as well as in our daily lives.E-skin capable of providing sensitive and high-resolution tactile sensations and haptic feedback to the human body would open a new e-skin paradigm for closed-loop human-machine ***,we report a class of materials and mechanical designs for the miniaturization of mechanical actuators and strategies for their integration into thin,soft e-skin for haptic *** mechanical actuators exhibit small dimensions of 5 mm diameter and 1.45 mm thickness and work in an electromagnetically driven vibrotactile mode with resonance frequency overlapping the most sensitive frequency of human *** mini actuators can be integrated simultaneously in a small area of 2 cm×2 cm to form a 3×3 haptic feedback array,which is small and compact enough to mount on a thumb ***,the thin,soft haptic interface exhibits good mechanical properties that work properly during stretching,bending,and twisting and therefore can conformally fit onto various parts of the human body to afford programmable tactile enhancement and Braille recognition with an accuracy rate over 85%.

关键词： stretching properly mount

Stretchable,skin-conformable neuromorphic system for tactile sensory recognizing and encoding

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InfoMat 2023年第12期5卷 87-99页

作者： mengge wu Qiuna Zhuang Kuanming Yao Jian Li Guangyao Zhao Jingkun Zhou Dengfeng Li Rui Shi Guoqiang Xu Yingchun Li Zijian Zheng Zhihui Yang Junsheng Yu Xinge Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengduthe People's Republic of China Department of Biomedical Engineering City University of Hong KongHong Kongthe People's Republic of China Laboratory for Advanced Interfacial Materials and Devices School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHong Kongthe People's Republic of China Hong Kong Center for Cerebra-Cardiovascular Health Engineering Hong Kong Science ParkHong Kongthe People's Republic of China College of Science Harbin Institute of TechnologyShenzhenthe People's Republic of China Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhouthe People's Republic of China

Expanding wearable technologies to artificial tactile perception will be of significance for intelligent human-machine interface,as neuromorphic sensing devices are promising candidates due to their low energy consumption and highly effective operating ***-compatible and conformable features are required for the purpose of realizing wearable artificial tactile ***,we report an intrinsically stretchable,skin-integrated neuromorphic system with triboelectric nanogenerators as tactile sensing and organic electrochemical transistors as information *** integrated system provides desired sensing,synaptic,and mechanical characteristics,such as sensitive response(~0.04 kPa^(-1))to low-pressure,short-and long-term synaptic plasticity,great switching endurance(>10000 pulses),symmetric weight update,together with high stretchability of 100%*** neural encoding,demonstrations are capable of recognizing,extracting,and encoding features of tactile *** work provides a feasible approach to wearable,skin-conformable neuromorphic sensing system with great application prospects in intelligent robotics and replacement prosthetics.

关键词： neural encoding neuromorphic sensing system organic electrochemical transistors tactile sensation triboelectric nanogenerators

Thin,soft,skin-integrated electronics for real-time and wireless detectionof uricacid in sweat

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International Journal of Smart and Nano Materials 2023年第4期14卷 406-419页

作者： Yue Hu Lan Wang Jian Lia Yawen Yang Guangyao Zhao Yiming Liu Xingcan Huang Pengcheng wu Binbin Zhang Yanli Jia mengge wu Shengxin Jia Qiang Zhang Guoqiang Xu Rui Shi Dengfeng Li Yingchun Li Zhengchun Peng Xinge Yu Department of Biomedical Engineering City University of Hong KongHong KongP.R.China State Key Laboratory of Radio Frequency Heterogeneous Integration(Shenzhen University) College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenP.R.China Transfusion Department Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduP.R.China dHong Kong Center for Cerebra-Cardiovascular Health Engineering Hong Kong Science ParkNew TerritoriesHong KongP.R.China College of Science Harbin Institute of Technology(Shenzhen)ShenzhenGuangdongP.R.China CAS-CityU Joint Laboratory for Robotic Research Shenzhen Research Institute City University of Hong KongShenzhenP.R.China

Wearable sweat sensors are gaining significant attention due to their unparalleled potential for noninvasive health ***,as a kind of body fluid,contains informative physiological indicators that are related to personalized health *** in wearable sweat sampling and routing technologies,flexible,and stretchable materials,and wireless digital technologies have led to the development of integrated sweat sensors that are comfortable,flexible,light,and ***,we report a flexible and integrated wearable device via incorporating a microfluidic system and a sensing chip with skin-integrated electronic format toward in-situ monitoring of uric acid(UA)in sweat that associates with gout,cardiovascular,and renal *** microfluidic system validly realizes the real-time capture perspiration from human *** obtained detection range is 5-200μM and the detection limit is 1.79μM,which offers an importance diagnostic method for clinical relevant lab *** soft and flexible features of the constructed device allows it to be mounted onto nearly anywhere on the *** tested the sweat UA in diverse subjects and various body locations during exercise,and similar trends were also observed by using a commercial UA assay kit.

关键词： Sweat sensors skinintegrated electronics in-situ detection microchannels wearable device