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Esophageal cancer global burden profiles, trends, and contributors

Cancer Biology & Medicine 2024年第8期21卷 656-666页

作者： Yi Teng Changfa Xia Maomao Cao Fan Yang Xinxin Yan Siyi He mengdi Cao Shaoli Zhang Qianru Li Nuopei Tan Jiachen wang Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective: This study aimed to provide a comprehensive overview of the global burden of esophageal cancer(EC) and determine the temporal trends and factors influencing changes in the global ***: The latest incidence and mortality data for EC worldwide were obtained from GLOBALCAN 2022. The mortality and disability-adjusted life years(DALYs) rates for EC from 1990±2019 were sourced from the 2019 Global Burden of Diseases. Trends in EC mortality and DALYs attributable to 11 risk factors or clusters of risk were analyzed using the joinpoint regression model. The trends in age-related EC burden were assessed using a decomposition ***: An estimated 511,054 new cases of EC were diagnosed in 2022 with 445,391 deaths worldwide. Approximately 75% of cases and deaths occurred in Asia. Nearly 50% of global EC deaths and DALYs were attributed to tobacco use in men in 2019, while 20% were attributed to high body mass index(BMI) in women. From 1990±2019, EC deaths and DALYs attributable to almost all risk factors had declining trends, while EC deaths and DALYs attributed to high BMI in men had upward trends. The age-related EC burden exhibited an upward trend driven by population growth and aging, which contributed to 307.4 thousand deaths and 7.2 million DALYs due to ***: The EC burden remains substantial worldwide. Effective tobacco and obesity control measures are critical for addressing the risk-attributable burden of EC. Population growth and aging pose challenges for EC prevention and control efforts.

关键词： Esophageal cancer aging disability-adjusted life years incidence mortality risk factors trends

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Attributable liver cancer deaths and disability-adjusted life years in China and worldwide: profiles and changing trends

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Cancer Biology & Medicine 2024年第8期21卷 679-691页

作者： mengdi Cao Changfa Xia Maomao Cao Fan Yang Xinxin Yan Siyi He Shaoli Zhang Yi Teng Qianru Li Nuopei Tan Jiachen wang Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective: Liver cancer is a major health concern globally and in China. This analysis investigated deaths and disability-adjusted life years(DALYs) with respect to etiologies and risk factors for liver cancer in China and ***: Global and China-specific data were collected on liver cancer deaths, DALYs, and age-standardized rates(ASRs) from the Global Burden of Disease Study 2019 database. Liver cancer etiologies were classified into five groups and risk factors were categorized into three levels. Each proportion of liver cancer burden was calculated in different geographic regions. The joinpoint regression model were used to assess the trends from 1990±***: Liver cancer accounted for 484,577 deaths worldwide in 2019 with an ASR of 5.9 per 100,000 population. China had an elevated liver cancer death ASR in 2019 and males had an ASR 1.7 times the global rate. The global ASR for DALYs peaked at 75±79 years of age but peaked earlier in China. Hepatitis B virus was the prominent etiology globally(39.5%) and in China(62.5%), followed by hepatitis C virus and alcohol consumption. In high sociodemographic index countries, non-alcoholic steatohepatitis has gained an increasing contribution as an etiologic factor. The liver cancer burden due to various etiologies has decreased globally in both genders. However, metabolic risk factors, particularly obesity, have had a growing contribution to the liver cancer burden, especially among ***: Despite an overall decreasing trend in the liver cancer burden in China and worldwide, there has been a rising contribution from metabolic risk factors, highlighting the importance of implementing targeted prevention and control strategies that address regional and gender disparities.

关键词： China Liver cancer deaths global risk factors

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Seco-cyclic phorbol derivatives and their anti-HIV-1 activities

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Chinese Journal of Natural Medicines 2024年第4期22卷 365-374页

作者： HUANG Xiaolei HUANG Xusheng LI Qirun MA mengdi CUI Yadong YANG Liumeng wang Haibo LUO Ronghua CHEN Jinglei YANG Jingxuan LIN Jinrong LI Duxin ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of ***,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand *** influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further *** research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol *** anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration *** findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding ***,compound S11,with an EC_(50) of 0.27μmol·L^(−1) and a CC_(50) of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δ*** results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity.

关键词： seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring Esterification Anti-HIV-1 agent

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Global, regional, and national burden of early-onset gastric cancer

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Cancer Biology & Medicine 2024年第8期21卷 667-678页

作者： Nuopei Tan Hongliang Wu Maomao Cao Fan Yang Xinxin Yan Siyi He mengdi Cao Shaoli Zhang Yi Teng Qianru Li Jiachen wang Changfa Xia Wanqing Chen Department of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Objective: The burden of gastric cancer(GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to ***: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database. The 5-year interval age-standardised incidence rates(ASIRs) were evaluated using cancer registry data from volumes X±XII of the Cancer Incidence in Five Continents(CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate(ASMR) and the Human Development Index(HDI).Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022, with male predominance. GC ASIRs and ASMRs were 9.2 and 6.1 per 100,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2% of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2003 to 2017, the incidence of GC notably decreased in most countries but peaked at 2008±2012 in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially ***: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.

关键词： GLOBOCAN Gastric cancer cancer burden incidence mortality

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Effect of Shrinkage Reducing Agent and Steel Fiber on the Fluidity and Cracking Performance of Ultra-High Performance Concrete

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Fluid Dynamics & Materials Processing 2024年第9期20卷 1941-1956页

作者： Yong Wan Li Li Jiaxin Zou Hucheng Xiao mengdi Zhu Ying Su Jin Yang Wuhan Metro Bridge and Tunnel Management Co. Ltd.Wuhan430068China School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China

Due to the low water-cement ratio of ultra-high-performance concrete(UHPC),fluidity and shrinkage cracking are key aspects determining the performance and durability of this type of *** this study,the effects of different types of cementitious materials,chemical shrinkage-reducing agents(SRA)and steel fiber(SF)were *** with M2-UHPC and M3-UHPC,M1-UHPC was found to have better fluidity and shrinkage cracking ***,different SRA incorporation methods,dosage and different SF types and aspect ratios were *** incorporation of SRA and SF led to a decrease in the fluidity of *** internal content of 1%(NSRA-1%),SRA external content of 1%(WSRA-1%),STS-0.22 and STE-0.7 decreased the fluidity of UHPC by 3.3%,8.3%,9.2%and 25%,***,SRA and SF improved the UHPC shrinkage cracking ***-1%and STE-0.7 reduced the shrinkage value of UHPC by 40%and 60%,respectively,and increased the crack resistance by 338%and 175%,*** addition,the addition of SF was observed to make the microstructure of UHPC more compact,and the compressive strength and flexural strength of 28 d were increased by 26.9%and 19.9%,respectively.

关键词： Ultra-high performance concrete chemical shrinkage reducing agent steel fiber shrinkage cracking repair and reinforcement

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财政分权对城市全要素生产率的非线性影响研究——基于调节效应与动态面板门槛模型的双重检验

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产业经济研究 2023年第2期 126-142页

作者：王盟迪彭小兵重庆大学公共管理学院重庆400044

自新时代中国变革性实践以来,地方政府价值主张和治理理念发生深刻转变。在此背景下,财政分权制度安排能否更好地改进城市生产效率,其演进轨迹与内在机理是否呈现新的特征,成为亟须回应的问题。基于2013—2019年中国281个城市的面板数据... 详细信息

自新时代中国变革性实践以来,地方政府价值主张和治理理念发生深刻转变。在此背景下,财政分权制度安排能否更好地改进城市生产效率,其演进轨迹与内在机理是否呈现新的特征,成为亟须回应的问题。基于2013—2019年中国281个城市的面板数据,采用两阶段系统GMM和动态面板门槛模型等估计方法,并考虑财政透明对地方政府权力的制约作用,系统检验了党的十八大以来财政分权与城市全要素生产率的非线性关系,以及财政透明对两者非线性关系的调节效应。为缓解内生性问题,运用文本挖掘技术构造地方政府贫困治理注意力指数,并将其作为财政分权的工具变量进行了稳健性检验,结论依然成立。研究发现:财政分权对城市全要素生产率具有“居中不良”效应,两者呈U形关系,这种关系由技术效率和规模效率主导;财政透明使财政分权与城市全要素生产率的U形关系曲线变得更加平缓,同时使U形曲线的拐点向左平移。进一步分析发现,上述结论在资源型和非资源型城市中存在显著异质性,特别是财政分权对技术进步的非线性影响以及财政透明对财政分权与技术进步非线性关系的调节效应截然相反。此外,动态面板门槛模型检验结果表明:财政分权处于高门槛区间时可以放大信息化水平、市场一体化和对外开放带来的经济效应;财政透明与对外开放具有良性互动的关系,并且能够在一定程度上化解对外开放与市场一体化“替代效应”的张力。研究有助于重新审视新时代下财政分权制度的经济效应,为地方政府深化财政体制改革释放制度红利提供了新的经验证据。

关键词：财政分权财政透明城市全要素生产率两阶段系统GMM 文本挖掘动态面板门槛模型

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Survey of hepatitis B virus infection for liver cancer screening in China:A population-based,cross-sectional study

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Chinese Medical Journal 2024年第12期137卷 1414-1420页

作者： Yongjie Xu Changfa Xia He Li Maomao Cao Fan Yang Qianru Li mengdi Cao Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of National Cancer Regional Medical Centre in Liaoning Province The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

Background:Hepatitis B virus(HBV)infection is the primary cause of hepatocellular carcinoma(HCC)in *** target population for HCC screening comprises individuals who test positive for hepatitis B surface antigen(HBsAg).However,current data on the prevalence of HBV infection among individuals who are eligible for HCC screening in China are *** aimed to assess the seroepidemiology of HBV infection among Chinese individuals eligible for HCC screening to provide the latest evidence for appropriate HCC screening strategies in ***:Questionnaires including information of sex,age,ethnicity,marital status,educational level,source of drinking water,as well as smoking and alcohol consumption history and serum samples were collected from females aged 45-64 years and males aged 35-64 years in 21 counties from 4 provinces in eastern and central China between 2015 and ***-linked immunosorbent assay methods were used to detect the serum HBV marker ***:A total of 603,082 individuals were enrolled,and serum samples were collected for analysis from January 1,2015 to December 31,*** prevalence of HBsAg positive in the study population was 5.23%(31,528/603,082).The prevalence of HBsAg positive was greater in males than in females(5.60%[17,660/315,183]vs 4.82%[13,868/287,899],χ^(2)=187.52,P<0.0001).The elderly participants exhibited a greater prevalence of HBV infection than younger participants(χ^(2)=41.73,P<0.0001).Birth cohort analysis revealed an overall downward trend in HBV prevalence for both males and *** born in more recent cohorts exhibited a lower prevalence of HBV infection as compared to those born ***:The current prevalence of HBV infection remains above 5%in populations eligible for HCC screening in *** efforts should be made to increase the accessibility of HCC screening among individuals with HBV infection.

关键词： Hepatitis B virus Liver cancer screening China Hepatitis B surface antigens Early detection of cancer

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Strong Interaction Between Redox Mediators and Defect-Rich Carbons Enabling Simultaneously Boosted Voltage Windows and Capacitance for Aqueous Supercapacitors

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Energy & Environmental Materials 2024年第4期7卷 269-276页

作者： Lu Guan Yifan Zhu Yi Wan mengdi Zhang Qiang Li Xiaoling Teng Yunlong Zhang Hao Yang Yan Zhang Han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemical Engineering China University of Petroleum (East China) College of Physics University-Industry Joint Center for Ocean Observation and Broadband Communication Qingdao University

Energy density,the Achilles'heel of aqueous supercapacitors,is simultaneously determined by the voltage window and specific capacitance of the carbon materials,but the strategy of synchronously boosting them has rarel... 详细信息

关键词： defect-rich carbons redox mediators strong interaction supercapacitors voltage windows

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美国《图书馆杂志》“年度图书馆”奖获得者服务特色分析

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图书情报工作 2020年第7期64卷 145-152页

作者：谈大军王梦迪华南师范大学经济与管理学院广州510006

[目的/意义]对美国《图书馆杂志》从1992年开始设立的"年度图书馆"奖的评选标准以及获奖图书馆的特色服务进行研究,旨在为我国图书馆开展特色化服务提供借鉴。[方法/过程]通过网络调查法和案例分析法,对2000-2018年获得"年度图书馆"奖... 详细信息

[目的/意义]对美国《图书馆杂志》从1992年开始设立的"年度图书馆"奖的评选标准以及获奖图书馆的特色服务进行研究,旨在为我国图书馆开展特色化服务提供借鉴。[方法/过程]通过网络调查法和案例分析法,对2000-2018年获得"年度图书馆"奖的19所图书馆开展的特色服务进行比较分析。[结果/结论]获奖图书馆的服务特色:重视公民教育,强化教育职能;强调均等服务理念,体现人文关怀;提供多元社区信息服务,参与社区建设;树立品牌意识,打造品牌项目。对我国图书馆界的启示:科学合理地进行角色定位;积极参与社区贫困计划;强化特色服务品牌意识;拓宽合作领域。

关键词：美国图书馆杂志年度图书馆奖特色服务

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Erratum to:Detecting gravitational wave with an interferometric seismometer array on lunar nearside[***.66,109513(2023)]

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 182-183页

作者： Junlang Li Fangfei Liu Yuan Pan Zijian wang mengdi Cao Mengyao wang Fan Zhang Jinhai Zhang Zong-Hong Zhu Department of Astronomy Beijing Normal UniversityBeijing 100875China Advanced Institute of Natural Sciences Beijing Normal University at ZhuhaiZhuhai 519087China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

This paper"Detecting gravitational wave with an interferometric seismometer array on lunar nearside"[1]was published in SCIENCE CHINA Physics,Mechanics&Astronomy(66,109513(2023),doi:10.1007/s11433-023-2179-9).Due to an oversight on our part,some errors were made in the originally published *** apologize for these errors and offer the corresponding explanations and corrections for the readers.

关键词： gravitational seism wave

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