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中医药调控线粒体氧化应激治疗肺部炎症性疾病研究进展

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中国实验方剂学杂志 2024年第14期30卷 249-258页

作者：史梦迪王超由亚非芦丽莎杨阳景伟超刘璐佳王有鹏黑龙江中医药大学研究生院哈尔滨150040 黑龙江中医药大学附属第二医院哈尔滨150001

肺纤维化、慢性阻塞性肺疾病、急性肺损伤、哮喘和感染性肺炎等疾病是全球常见的肺部炎症性疾病。有证据表明,线粒体在受到炎症刺激时会产生大量的活性氧,形成氧化应激,影响肺部炎症性疾病的发生和发展。随着研究的深入,中医药在治疗肺... 详细信息

肺纤维化、慢性阻塞性肺疾病、急性肺损伤、哮喘和感染性肺炎等疾病是全球常见的肺部炎症性疾病。有证据表明,线粒体在受到炎症刺激时会产生大量的活性氧,形成氧化应激,影响肺部炎症性疾病的发生和发展。随着研究的深入,中医药在治疗肺部炎症性疾病方面取得了显著进展。越来越多的证据表明,中药单体及其活性成分,以及中药复方能够通过多靶点、多通路机制改善线粒体氧化应激状态,从而有效治疗肺部炎症性疾病。目前,国内外尚未对中医药在该领域的研究进行系统性回顾和总结。因此,该文旨在归纳和总结中医药通过调控线粒体氧化应激干预肺部炎症性疾病的作用机制,为其临床应用提供科学依据,并为中医药防治肺部炎症性疾病的深入研究提供新的思路和参考。

关键词：线粒体活性氧(ROS) 氧化应激中医药肺部炎症性疾病

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Locked nucleic acids based DNA circuits with ultra-low leakage

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Nano Research 2023年第1期16卷 865-872页

作者： Hao Hu Liquan Liu Lei Zhang Wei Zhang Kejun Dong Bei Yan Yaoqin Mu mengdi shi Longjie Li Xianjin Xiao Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430023China

DNA circuits based on toehold-mediated DNA strand displacement reaction are powerful tools owing to their programmability and ***,performance and practical application of the circuits are greatly restricted by leakage,which refers to the fact that there is no input(invading strand)in the circuit,and the output signal is still ***,we constructed locked nucleic acids-based DNA circuits with ultra-low *** binding affinity of LNA(locked nucleic acid)-DNA/LNA suppressed the leakage by inhibiting the breathing *** on the strategy,we have built various low-leakage DNA circuits,including translator circuit,catalytic hairpin assembly(CHA)circuit,entropy-driven circuit(EDC),and seesaw *** importantly,our strategy would not affect the desired main reactions:The output signal remained above 85%for all tested circuits,and the signalto-noise ratios were elevated to 148.8-fold at the *** believe our strategy will greatly promote the development and application of DNA circuits-based DNA nanotechnology.

关键词： DNA circuits leakage locked nucleic acid DNA strand displacement DNA nanotechnology

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分消走泄法治疗儿童特应性皮炎机制研究进展

陕西中医 2024年第5期45卷 715-718页

作者：谷胜男史梦迪杨阳刘璐佳王有鹏黑龙江中医药大学黑龙江哈尔滨150036 黑龙江中医药大学附属第二医院黑龙江哈尔滨150036

特应性皮炎是儿童常见的一种慢性、炎症性皮肤病,皮损多见于面部及四肢伸侧或腘窝,为红斑、丘疹等多形性皮损。中医认为本病由于先天不足,禀性不耐,腠理不密,卫外功能不固,易感风、湿、热邪侵袭肌表所致。在现代医学发达的今天,中药在... 详细信息

特应性皮炎是儿童常见的一种慢性、炎症性皮肤病,皮损多见于面部及四肢伸侧或腘窝,为红斑、丘疹等多形性皮损。中医认为本病由于先天不足,禀性不耐,腠理不密,卫外功能不固,易感风、湿、热邪侵袭肌表所致。在现代医学发达的今天,中药在治疗皮肤疾病方面仍有其独有的特色优势地位,显示了不可替代的作用。笔者基于分消走泄法,从分消走泄法的古今应用、与儿童特应性皮炎发病机制的相关性、治法用药等方面进行综述,以期为儿童特应性皮炎疾病的治疗提供更为丰富的理论依据。

关键词：特应性皮炎分消走泄法儿童机制研究风邪湿邪

基于分消走泄法调节湿热体质治疗儿童变态反应性疾病

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西部中医药 2024年第4期37卷 37-41页

作者：史梦迪杨阳司秀影刘璐佳王有鹏黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

王有鹏教授通过多年临床经验,分析变态反应性疾病儿童的体质,发现此类儿童多为湿热体质,在治疗上多应用分消走泄法进行治疗。此外,阐述分消走泄法治疗湿热性变态反应性疾病的机理,列举出了分消走泄法代表方剂温胆汤系列合方在临床上的... 详细信息

王有鹏教授通过多年临床经验,分析变态反应性疾病儿童的体质,发现此类儿童多为湿热体质,在治疗上多应用分消走泄法进行治疗。此外,阐述分消走泄法治疗湿热性变态反应性疾病的机理,列举出了分消走泄法代表方剂温胆汤系列合方在临床上的具体应用,如泻白散合温胆汤治疗咳嗽变异性哮喘、从龙汤合温胆汤治疗支气管哮喘、苍耳子散合温胆汤治疗过敏性鼻炎等,进一步印证了分消走泄法通过调节体质治疗儿童变态反应性疾病的有效性与新颖性。

关键词：变态反应性疾病分消走泄法儿童王有鹏

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白于山区典型人工林土壤质量综合评价

东北林业大学学报 2024年第10期52卷 79-86页

作者：刘喜东马雅莉高荣张立强张艳华张晨晨高东治石孟迪李江宁乔江波石长春陕西省林业科学院西安710082 榆林市榆阳区林业和种苗工作站陕西省林业科学院西北农林科技大学水土保持研究所陕西榆林毛乌素沙地生态系统国家定位观测研究站

以陕西省榆林市白于山区为例,选取40年生典型河北杨(Populus×hopeiensis Hu&Chow)、油松(Pinus tabuliformis)、樟子松(Pinus sylvestris ***)成熟人工林,以荒草地为对照,测定土壤深度(h)为0 详细信息

以陕西省榆林市白于山区为例,选取40年生典型河北杨(Populus×hopeiensis Hu&Chow)、油松(Pinus tabuliformis)、樟子松(Pinus sylvestris ***)成熟人工林,以荒草地为对照,测定土壤深度(h)为0

关键词：白于山区人工林土壤养分土壤质量评价

两种珍稀沙生植物草麻黄和沙芦草种子催芽技术研究

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草学 2024年第2期 13-18页

作者：孙玉洁张锡唐哈琦琦张逸康张艳乔一娜石孟迪马雅莉马存平石长春榆林学院陕西榆林719000 陕西省林业科学院陕西西安710043 陕西榆林毛乌素沙地生态系统国家定位观测研究站陕西榆林719053

草麻黄和沙芦草是我国重点保护野生植物,然而由于自身发芽率低和生境被破坏等原因,导致种群数量减少,为保护并提高两种珍稀植物的数量,本研究通过室内试验进行了两种珍稀植物的种子繁育技术研究。研究结果表明,不同生长激素对于草麻黄... 详细信息

草麻黄和沙芦草是我国重点保护野生植物,然而由于自身发芽率低和生境被破坏等原因,导致种群数量减少,为保护并提高两种珍稀植物的数量,本研究通过室内试验进行了两种珍稀植物的种子繁育技术研究。研究结果表明,不同生长激素对于草麻黄和沙芦草种子发芽影响不同。30mg/L的IAA处理可以明显促进草麻黄种子发芽;10mg/L浓度以上的6-BA和100mg/L的GA3均会明显抑制草麻黄种子发芽及活力。同样GA3浓度高于100mg/L均会抑制沙芦草种子发芽,20mg/L的细胞分裂素可以促进沙芦草种子发芽,40mg/L的IAA可以显著提高沙芦草发芽率。DMSO浸泡10min对种子发芽无影响;浸泡20min时,1%浓度DMSO促进效果最佳;当浸泡30min时,0.5%浓度的效果最佳。因此使用30mg/L和40mg/L的IAA分别有助于草麻黄和沙芦草种子发芽,提高种子活力,同时0.5%的DMSO浸泡30min更适合用于沙芦草种子发芽处理。

关键词：草麻黄沙芦草种子发芽植物激素二甲基亚砜

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Adaptive Space Expansion for Fast Motion Planning

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1499-1514页

作者： Shenglei shi Jiankui Chen State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning *** this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible *** ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary ***,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is ***,the ASE method successively does space exploring and space expan-sion until the final path has been ***,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in *** last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE *** demon-strate that the computation speed is much faster than that of the state-of-the-art *** source codes are available at https://***/shshlei/ompl.

关键词： Adaptive space expansion(ASE) hyper-ellipsoid ring informed sampling motion planning.

Quantization and Event-Triggered Policy Design for Encrypted Networked Control

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 946-955页

作者： Yongxia shi Ehsan Nekouei the Department of Electrical Engineering City University of Hong KongHong KongChina

This paper proposes a novel event-driven encrypted control framework for linear networked control systems(NCSs),which relies on two modified uniform quantization policies,the Paillier cryptosystem,and an event-triggered *** to the fact that only integers can work in the Pailler cryptosystem,both the real-valued control gain and system state need to be first quantized before *** is dramatically different from the existing quantized control methods,where only the quantization of a single value,e.g.,the control input or the system state,is *** handle this issue,static and dynamic quantization policies are presented,which achieve the desired integer conversions and guarantee asymptotic convergence of the quantized system state to the ***,the quantized system state is encrypted and sent to the controller when the triggering condition,specified by a state-based event-triggered strategy,is *** doing so,not only the security and confidentiality of data transmitted over the communication network are protected,but also the ciphertext expansion phenomenon can be ***,by tactfully designing the quantization sensitivities and triggering error,the proposed event-driven encrypted control framework ensures the asymptotic stability of the overall closedloop ***,a simulation example of the secure motion control for an inverted pendulum cart system is presented to evaluate the effectiveness of the theoretical results.

关键词： Cyber-security encrypted control event-triggered control(ETC) networked control systems(NCSs) semi-homomorphic encryption

No Reference Image Sharpness Assessment Based on Global Color Difference Variation

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Chinese Journal of Electronics 2024年第1期33卷 293-302页

作者： Chenyang shi Yandan LIN School of Artificial Intelligence Anhui Polytechnic University School of Mechanical Engineering Anhui Polytechnic University Department of Light Sources and Illuminating Engineering Fudan University Academy for Engineering & Technology Fudan University

Image quality assessment(IQA) model is designed to measure the image quality in consistent with subjective ratings by computational models. In this research, a valid no reference IQA(NR-IQA) model for color image sharpness assessment is proposed based on local color difference map in a color space. In the proposed model, the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system). The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation, and relative color difference variation expresses the variation in the image content. Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases, and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images. Besides, the model maintains the lowest computational complexity.

关键词： Image quality TV Image color analysis Databases Computational modeling Color Predictive models