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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： mou Gao Qin Dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Spatial pattern of location advantages of ports along the Maritime Silk Road

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Journal of Geographical Sciences 2021年第1期31卷 149-176页

作者： mou Naixia WANG Chunying CHEN Jinhai YANG Tengfei ZHANG Lingxian LIAO mengdi College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590ShandongChina Navigation College of Jimei University National-local Joint Engineering Research Center for Marine Navigation Aids ServicesXiamen 361021FujianChina Aerospace Information Research Institute CASBeijing 100094China

Location advantages of ports refer to the current developments of ports based on their conditions, such as geographic location, traffic accessibility and hinterland economy, etc., and the spatial pattern of ports’ location advantages reflects the spatial distributions, the regularities and the correlations among their conditions for development. A good understanding of the spatial patterns of ports’ location advantages can help to better identify the relative advantages of ports, position ports’ functions and make strategic plans for development. This paper selected 1259 ports from 63 countries along the Maritime Silk Road as research objects and builds an accessing model to analyze their location advantages on the bases of six factors: the influence of strategic shipping pivot, the competitiveness of port location potential, port network status, the influence of city, the influence of traffic trunk, and road network density in hinterland. The study has the following three findings. Firstly, the location advantages of ports show a 'high-low-high' distribution pattern from the west to the east, displaying an obvious 'core-periphery' regionalized distribution. Secondly, most ports have high location advantages, mainly located in Strait of Malacca, the United Arab Emirates, northern Mediterranean coastal region and China-Japan region, the top 10 ports are mainly located in Singapore, China, Malaysia and Japan, indicating that the shipping industry in Asia-Pacific region has stepped to the far front of the global competition;slow economic growths, wars, far away from the Belt and Road countries or bad climate have low location advantages, mainly located in African coastal areas, Oceania, Northeast Europe and Russia. Thirdly, compared with the landward location advantages, the seaward location advantages have a higher influence, and different indicators of location advantages have different influences on the evaluation results, the competitiveness of port location potent

关键词： Maritime Silk Road location advantages ports shipping network spatial patterns

Robust Tracking Control for Self-balancing Mobile Robots Using Disturbance Observer

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IEEE/CAA Journal of Automatica Sinica 2017年第3期4卷 458-465页

作者： mou Chen College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China IEEE

In this paper,a robust tracking control scheme based on nonlinear disturbance observer is developed for the self-balancing mobile robot with external unknown disturbances.A desired velocity control law is firstly designed using the Lyapunov analysis method and the arctan *** improve the tracking control performance,a nonlinear disturbance observer is developed to estimate the unknown disturbance of the self-balancing mobile *** the output of the designed disturbance observer,the robust tracking control scheme is presented employing the sliding mode method for the selfbalancing mobile *** simulation results further demonstrate the effectiveness of the proposed robust tracking control scheme for the self-balancing mobile robot subject to external unknown disturbances.

关键词： Disturbance observer robust tracking control self-balancing mobile robot sliding mode control(SMC)

Fractional-Order Control for a Novel Chaotic System Without Equilibrium

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IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 1000-1009页

作者： Shuyi Shao mou Chen the College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China IEEE

The control problem is discussed for a chaotic system without equilibrium in this *** the basis of the linear mathematical model of the two-wheeled self-balancing robot,a novel chaotic system which has no equilibrium is *** basic dynamical properties of this new system are studied via Lyapunov exponents and Poincar′e *** further demonstrate the physical realizability of the presented novel chaotic system,a chaotic circuit is *** using fractional-order operators,a controller is designed based on the state-feedback *** to the Gronwall inequality,Laplace transform and Mittag-Leffler function,a new control scheme is explored for the whole closed-loop *** the developed control scheme,the state variables of the closed-loop system are controlled to stabilize them to ***,the numerical simulation results of the chaotic system with equilibrium and without equilibrium illustrate the effectiveness of the proposed control scheme.

关键词： Chaotic system circuit implementation fractional-order stabilization

Adaptive dynamic surface control of NSVs with input saturation using a disturbance observer

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Chinese Journal of Aeronautics 2015年第3期28卷 853-864页

作者： Chen mou Yu Jing College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Abstract An adaptive dynamic surface control （DSC） scheme is proposed for the multiinput and multioutput （MIMO） attitude motion of nearspace vehicles （NSVs） in the presence of external dis turbance, system uncertainty and input saturation. The external disturbance and the system uncer tainty are efficiently tackled using a Nussbaum disturbance observer （NDO）, and the adaptive controller is constructed by combining the dynamic surface control technique to handle the problem of ＂explosion of complexity＂ inherent in the conventional backstepping methodl For handling the input saturation, an auxiliary system is designed with the same order as that of the studied MIMO attitude system. Using the error between the saturation input and the desired control input as the input of the designed auxiliary system, a series of signals are generated to compensate for the effect of the saturation in the dynamic surface control design. It is proved that the developed control scheme can guarantee that all signals of the closedloop control system are semiglobally uniformly bounded. Finally, simulation results illustrate that the proposed control scheme can achieve satis factory tracking performance under the composite effects of the input saturation and the external disturbance.

关键词： Auxiliary system Disturbance observer Dynamic surface controlInput saturation Near-space vehicle

Dynamic Flight Stability of a Model Hoverfly in Inclined-Stroke-Plane Hovering

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Journal of Bionic Engineering 2012年第3期9卷 294-303页

作者： Xiaolei mou Mao Sun Key Laboratory of Fluid Mechanics(Ministry of Education China)Beihang UniversityBeijing 100191P.R.China

Most hovering insects flap their wings in a horizontal plane, called ＇normal hovering＇. But some of the best hoverers, e.g. true hoverflies, hover with an inclined stroke plane. In the present paper, the longitudinal dynamic flight stability of a model hoverfly in inclined-stroke-plane hovering was studied. Computational fluid dynamics was used to compute the aerodynamic derivatives and the eigenvalue and eigenvector analysis was used to solve the equations of motion. The primary findings are as follows. （1） For inclined-stroke-plane hovering, the same three natural modes of motion as those for normal hovering were identified： one unstable oscillatory mode, one stable fast subsidence mode, and one stable slow subsidence mode. The unstable oscillatory mode and the fast subsidence mode mainly have horizontal translation and pitch rotation, and the slow subsidence mode mainly has vertical translation. （2） Because of the existence of the unstable oscillatory mode, inclined-stroke-plane hov- ering flight is not stable. （3） Although there are large differences in stroke plane and body orientations between the in- clined-stroke-plane hovering and normal hovering, the relative position between the mean center of pressure and center of mass for these two cases is not very different, resulting in similar stability derivatives, hence similar dynamic stability properties for these two types of hovering.

关键词： insect dynamic flight stability inclined-stroke-plane hovering natural modes of motion

Robust bounded control for uncertain flight dynamics using disturbance observer

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Journal of Systems Engineering and Electronics 2014年第4期25卷 640-647页

作者： mou Chen Bin Jiang College of Automation Engineering Nanjing University of Aeronautics and Astronautics

The robust bounded flight control scheme is developed for the uncertain longitudinal flight dynamics of the fighter with control input saturation invoking the backstepping technique. To enhance the disturbance rejection ability of the robust flight control for fighters, the sliding mode disturbance observer is designed to estimate the compounded disturbance including the unknown external disturbance and the effect of the control input saturation. Based on the backstepping technique and the compounded disturbance estimated output, the robust bounded flight control scheme is proposed for the fighter with the unknown external disturbance and the control input saturation. The closed-loop system stability under the developed robust bounded flight control scheme is rigorously proved using the Lyapunov method and the uniformly asymptotical convergences of all closed-loop signals are guaranteed. Finally, simulation results are presented to show the effectiveness of the proposed robust bounded flight control scheme for the uncertain longitudinal flight dynamics of the fighter.

关键词： flight dynamics bounded control robust control backstepping control disturbance observer.

Characteristic Decomposition: From Regular Sets to Normal Sets

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Journal of Systems Science & Complexity 2019年第1期32卷 37-46页

作者： mou Chenqi WANG Dongming LMIB–School of Mathematics and Systems Science/Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University LMIB–SKLSDE–School of Mathematics and Systems Science/Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University Centre National de la Recherche Scientifique

In this paper it is shown how to transform a regular triangular set into a normal triangular set by computing the W-characteristic set of their saturated ideal and an algorithm is proposed for decomposing any polynomial set into ?nitely many strong characteristic pairs, each of which is formed with the reduced lexicographic Gr?bner basis and the normal W-characteristic set of a characterizable ideal.

关键词： Characteristic decomposition characteristic pair normal set regular set W-characteristic set

Genomic Signal Enhancement by Clustering

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Communications in Theoretical Physics 2003年第5期39卷 631-634页

作者： ZHENGWei-mou InstituteofThcoreticalPhysics AcademiaSinicaBeijing100080China BeijingGenomicsInstituteBeijing101300 China

Weight matrix models for signal sequence motif are simple. A main limitation of the models is the assumption of independence between positions. Signal enhancement is achieved by taking the total likelihood as the objective function for maximization to cluster sequences into groups with different patterns. As an example, the initial and terminal signals for translation in rice genome are examined.

关键词： genomic signals cluster analysis