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Identification of host proteins that interact with African swine fever virus pE301R

Engineering Microbiology 2024年第2期4卷 33-43页

作者： Menghan Shi Niu Zhou mengchen xiu Xiangzhi Li Fen Shan Wu Chen Wanping Li Cheng-Ming Chiang Xiaodong Wu Youming Zhang Aiying Li Jingjing Cao State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityQingdao 266237China Guangzhou Zoo Guangzhou 510075China Wildlife Microbiology Laboratory Guangzhou Wildlife Research CenterGuangzhou 510075China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesAdvanced Medical Research InstituteShandong UniversityQingdaoChina Simmons Comprehensive Cancer Center University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Biochemistry University of Texas Southwestern Medical CenterDallasTX 75390USA Department of Pharmacology University of Texas Southwestern Medical CenterDallasTX 75390USA China Animal Health and Epidemiology Center Qingdao 266032China

African swine fever virus(ASFV)infection poses enormous threats and challenges to the global pig industry;however,no effective vaccine is available against ASFV,attributing to the huge viral genome(approximately189 kb)and numerous encoding products(>150 genes)due to the limited understanding on the molecular mechanisms of viral *** the host-factor/viral-protein interaction network will reveal new targets for developing novel antiviral *** proteomic analysis,we identified 255 cellular proteins that interact with the ASFV-encoded pE301R protein when transiently expressed in HEK293T *** ontology(GO)annotation,Kyoto Encyclopedia of Genes and Genomes(KEGG)database enrichment,and protein-protein interaction(PPI)network analyses revealed that pE301R-interacting host proteins are potentially involved in various biological processes,including protein translation and folding,response to stimulation,and mitochondrial transmembrane *** interactions of two putative cellular proteins(apoptosis inducing factor mitochondria associated 1(AIFM1)and vimentin(VIM))with pE301R-apoptosis inducing factor have been verified by *** study revealed the inhibitory role of pE301R in interferon(IFN)induction that involves VIM sequestration by pE301R,identified interactions between ASFV pE301R and cellular proteins,and predicted the potential function of pE301R and its associated biological processes,providing valuable information to enhance our understanding of viral protein function,pathogenesis,and potential candidates for the prevention and control of ASFV infection.

关键词： African swine fever virus pE301R protein Protein-protein interaction network GO and KEGG analysis Interferon

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