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Brightening heavily doped upconversion nanoparticles by tuning characteristics of core-shell structures

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Journal of Rare Earths 2024年第5期42卷 947-954,I0005页

作者： Yangyang Niu Zhihao Bao Yuqin Gao mengchao Guo Jingyao liu Jinjun Shao Min Lu Ze Yuan Xiaoji Xie School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing211816China

Heavily doped upconversion nanoparticles(UCNPs)potentially have exceptional photon upconversion abilities that are promising for diverse applications,such as lasing and super-resolution microscopy.However,heavily doped UCNPs typically can only offer mediocre upconversion luminescence intensity,and there still lacks general guidelines for the design and synthesis of heavily doped UCNPs.Herein,in order to boost the upconversion luminescence of heavily doped UCNPs,we studied the influence of characteristics of the core-shell structure on heavily doped UCNPs'upconversion luminescence.We find that some empirical guidelines derived from conventional UCNPs are not suitable for heavily doped UCNPs.Using NaYbF_(4):Tm@NaYF_(4) core-shell UCNPs with a high concentration of Yb_(3+)as a representative,our studies reveal that a rather thick inert NaYF4 shell is needed to protect the UCNPs from surface quenching,and the upconversion luminescence may undergo the cooperative sensitization process,which should be due to the highly concentrated Yb~(3+)dopant.In addition,the upconversion luminescence of heavily doped NaYbF4:Tm UCNPs exhibits no obvious dependence on the type of inert shell.Furthermore,our results show that confining both Yb~(3+)and Tm~(3+)dopants in a thin layer(known as theδ-doping strategy)does not work well in the heavily doped UCNPs.Accordingly,we propose a NaYbF_(4):Tm@NaYbF_(4)@NaYF_(4) core-shell-shell structure to enhance the luminescence of heavily doped UCNPs,by weakening the dissipation of excitation energy and strengthening the absorption.These findings should be helpful to establish general design principles for developing the brightest possible UCNPs that can meet the requirements of various applications.

关键词： Luminescence Upconversion Nanomaterials Rare earths Lanthanide doping

Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li Kang Yang Chenpeng Xi mengchao Li Borong Li Gui Xu Yuanbin Xiao Xiancai Cui Zhiliang liu Lingyun Li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal batteries.In this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal anode.The polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional theory.The organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

In Situ Growth of 3D Hierarchical ZnO@Ni_xCo_(1-x)(OH)_y Core/Shell Nanowire/Nanosheet Arrays on Ni Foam for High-Performance Aqueous Hybrid Supercapacitors

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Transactions of Tianjin University 2018年第3期24卷 201-211页

作者： Fumin Wang mengchao liu Xubin Zhang Guojun Lv Mingshuai Sun School of Chemical Engineering and Technology Tianjin University

In this study, we designed and synthesized a novel battery-type electrode featuring three-dimensional(3D) hierarchical ZnO@Ni_xCo_(1-x)(OH)_y core/shell nanowire/nanosheet arrays arranged on Nifoam substrate via a two-step protocol including a wet chemical process followed by electro-deposition. We then characterized its composition, structure and surface morphology by X-ray diff raction, energy-dispersive X-ray spectrometry(EDS), X-ray photoelectron spectroscopy, scanning electron microscopy(SEM), transmission electron microscopy, EDS elemental mapping. Our electrochemical measurements show that the ZnO@Ni_(0.67)Co_(0.33)(OH)_y electrode material exhibited a noticeably high specific capacity of as much as 255(mA ·h)/g at 1 A/g. Additionally, it demonstrated a superior rate capability, as well as an excellent cycling stability with 81.6% capacity retention over 2000 cycles at 5 A/g. This sample delivered a high energy density of 64 W·h/kg and a power density of 250 W/kg at a current density of 1 A/g. With such remarkable electrochemical properties, we expect the 3D hierarchical hybrid electrode material presented in this work to have promising applications for the next generation of energy storage systems.

关键词： 3D 混合数组扫描电子显微镜生长层电极材料 Ni 泡沫

无托槽隐形矫治器在儿童前牙美学治疗中的应用效果及对舒适满意度和咀嚼功能的影响

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中国美容医学 2024年第1期33卷 133-137页

作者：马艺萌刘梦超中国人民武装警察部队特色医学中心口腔科天津300300 天津医院口腔科天津300202

目的:研究无托槽隐形矫治器在儿童前牙美学治疗中的效果,并观察是否影响患儿的舒适满意度及咀嚼功能。方法:本文采用前瞻性研究,选择笔者医院2018年1月-2022年1月行前牙正畸治疗的86例患者为研究对象,随机将患者分为观察组和对照组,每... 详细信息

目的:研究无托槽隐形矫治器在儿童前牙美学治疗中的效果,并观察是否影响患儿的舒适满意度及咀嚼功能。方法:本文采用前瞻性研究,选择笔者医院2018年1月-2022年1月行前牙正畸治疗的86例患者为研究对象,随机将患者分为观察组和对照组,每组43例。观察组患儿采取无托槽隐形矫治器矫治,对照组患儿采取传统固定矫治器矫治。比较两组患儿的治疗美学效果、咀嚼指标、上气道形态、颞下颌关节、矫治测量指标以及并发症之间的差异。结果:观察组患儿的前牙美学分类为Ⅰ类的比例显著高于对照组(P0.05)。结论:无托槽隐形矫治器应用于儿童前牙美学治疗中,能显著提升患儿舒适满意度和咀嚼功能,治疗效果显著。

关键词：无托槽隐形矫治器前牙儿童美学效果颞下颌关节上气道形态舒适满意度咀嚼功能

Recent development in selective Tau tracers for PET imaging in the brain

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Chinese Chemical Letters 2022年第7期33卷 3339-3348页

作者： Yuying Li Tianqing liu mengchao Cui Key Laboratory of Radiopharmaceuticals Ministry of EducationBeijing Normal UniversityBeijing 100875China

Abnormal Tau deposition is a crucial pathological hallmark of various neurodegenerative disorders defined as tauopathies,of which Alzheimer’s disease is the most prominent one.To date,a large number of chemical entities with different structures have been developed as Tau imaging tracers for the early diagnosis of tauopathies.Several of them with excellent bio-properties are currently being assessed in clinical trials,and more recently,the Tauvid^(TM)([^(18)F]Flortaucipir,also known as[^(18)F]AV1451 or[^(18)F]T807)as the first Tau tracer was approved by the U.S.Food and Drug Administration in 2020.This review summarized the latest development of Tau tracers and analyzed their chemical structures,with particular attention to the effects of chemical structures on biological properties.In addition,we also discuss the limitations of current Tau imaging tracers,issues that need attention in the development of new tracers,and possible future directions.

关键词： Tau PET imaging Tauopathies Alzheimer’s disease Selectivity

Proteomic analysis of a chronic obstructive pulmonary disease mouse model to determine the efficacy of treatment using Guben Zhike decoction

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Journal of Traditional Chinese Medical Sciences 2021年第1期8卷 34-42页

作者： Mingzhe Wang Guoxing liu Yao Xiao Zhe Cai Chang liu Lin Pan Ying liu mengchao liu Hongchun Zhang Graduate School Beijing University of Chinese MedicineBeijing 100029China National Clinical Research Center for Respiratory Diseases and Traditional Chinese Medicine Department of Pulmonary Diseases China-Japan Friendship HospitalBeijing 100029China Respiratory Department Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Nephropathy Department Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Clinical Research Institute China-Japan Friendship HospitalBeijing 100029China No.4 Department of Healthcare China-Japan Friendship HospitalBeijing 100029China Nephropathy Department Beijing Traditional Chinese Medical HospitalBeijing 100010China

Background:Guben Zhike decoction(GBZKD)is derived from the experience of Professor Enxiang Chao,an esteemed master of Chinese medicine,while treating chronic obstructive pulmonary disease(COPD).GBZKD reinforces the healthy qi and consolidates defensive qi.This study explored the efficacy and potential mechanism of action of GBZKD in a COPD mouse model using proteomics.Methods:A COPD mouse model was established through cigarette smoke exposure and intranasal lipopolysaccharide administration.The model was verified through lung function test and lung histopathological observation.Label-free quantitative proteomics was used to detect the lung tissue proteins of mice from the GBZKD,COPD,and control groups.Results:GBZKD markedly improved the lung function and associated pathological conditions in the COPD mouse model.Proteomic analysis identified 4316 proteins,of which 3696 were quantitative proteins.We highlighted 287 and 184 proteins with significant regulatory roles in the lung tissues of COPD mice and GBZKD-treated mice,respectively.These proteins participated in multiple functions,including complement/coagulation cascade,immune response,and metabolic pathways.Conclusion:GBZKD exhibits multitarget and multipathway therapeutic effects in a COPD mouse model.

关键词： Guben zhike decoction Chronic obstructive pulmonary disease Proteomic analysis Mouse model

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi CHENG Niang-mei liu Wen-han YANG Ye CHEN Wei ZHANG Xiang-zhi ZHENG Xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO Bi-xing liu Cong-sheng liu Xiao-long LI Qin WANG Ying-chao The United Innovation of mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular mechanism.Methods:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 h.Transwell,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),respectively.In vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of PZH.SK-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail vein.Totally 8 mice were randomly divided into PZH and control groups,4 mice in each group.After 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day 17.Transcriptome analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of PZH.Quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq results.Luciferase reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of PZH.Mechanical study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylation of YAP was also enhanced by PZH treatment in v

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

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不同胞元结构多孔钛合金支架的力学性能

医用生物力学 2024年第1期39卷 69-75页

作者：孙梦超罗洋刘婕高丽兰李瑞欣谭沿松张春秋天津理工大学天津市先进机电系统设计与智能控制重点实验室机电工程国家级实验教学示范中心天津300384 天津市医疗器械质量监督检验中心天津300384 嘉思特医疗器材(天津)股份有限公司天津市骨植入物界面功能化与个性研究企业重点实验室天津300190 天津市口腔医院天津300041

目的研究不同胞元结构对多孔钛合金支架静态力学性能和动态力学性能的影响,为临床下颌骨缺损修复支架的应用提供力学理论基础。方法采用3D打印技术制造钻石胞元、立方体胞元和截面立方体胞元结构的多孔钛合金支架,开展支架单轴压缩试验... 详细信息

目的研究不同胞元结构对多孔钛合金支架静态力学性能和动态力学性能的影响,为临床下颌骨缺损修复支架的应用提供力学理论基础。方法采用3D打印技术制造钻石胞元、立方体胞元和截面立方体胞元结构的多孔钛合金支架,开展支架单轴压缩试验和压缩棘轮疲劳试验,分析不同胞元结构支架的静态和动态力学性能。结果钻石胞元、截面立方体胞元、立方体胞元支架的弹性模量分别为1.17、0.566、0.322 GPa,屈服强度分别为71.8、65.1、31.8 MPa。棘轮应变达到稳定阶段后,截面立方体胞元结构、钻石胞元结构、立方体胞元结构支架的棘轮应变分别为3.3%、4.0%、4.5%。棘轮应变随平均应力、应力幅值和峰值保持时间的增加而增加,随加载速率的增加而减小。结论静态力学性能的评估结果为钻石胞元支架最优,截面立方体胞元支架次之,立方体胞元支架最差;动态力学性能评估结果为截面立方体胞元支架最优,钻石胞元支架次之,立方体胞元支架最差。研究结果为临床下颌骨缺损修复支架的构建提供新思路,也为该支架技术的进一步临床应用提供实验依据。

关键词：多孔钛合金支架胞元结构静态力学性能动态力学性能 3D打印

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增材制造马氏体时效钢的析出行为与强化机制

钢铁 2024年第6期59卷 49-59页

作者：刘庆冬张孟超刘明洋刘晓晖李慧王泽民赵波顾剑锋上海交通大学材料科学与工程学院上海大学材料科学与工程学院上海应用技术大学材料科学与工程学院上海毅速激光科技有限公司

为了提升中国增材制造模具的品质和国际竞争力，加速世界向增材制造的转变，从汽车一体化压铸技术对可替换增材制造镶块材料的需求出发，在18Ni300马氏体时效钢的基础上，通过降低Ni含量、调整Co成分、保持Al含量并添加适量Cu的成分设... 详细信息

为了提升中国增材制造模具的品质和国际竞争力，加速世界向增材制造的转变，从汽车一体化压铸技术对可替换增材制造镶块材料的需求出发，在18Ni300马氏体时效钢的基础上，通过降低Ni含量、调整Co成分、保持Al含量并添加适量Cu的成分设计策略，开发了一种易于增材制造新型合金钢。利用扫描电镜(SEM)、透射电镜(TEM)和原子探针层析技术(APT)等微纳结构表征手段，研究了打印态马氏体时效钢在回火过程中第二相的析出过程和强化机制。结果表明，不同温度回火时，马氏体时效钢表现出明显的析出强化效应，在560℃时达到硬度峰值(约为54HRC),460℃和600℃时的硬度均约为50HRC，两者抗拉强度相近，但后者屈服强度较低，同时伸长率、断面收缩率和室温冲击韧性均大幅度提高，断口表现出明显的塑性断裂。低温(460℃)回火时，出现明显的Ni、Cu等元素的团簇，为富Cu的β-Ni Al相形核早期的存在形式，同时还因调幅分解而出现Cr的成分起伏，并出现纳米薄膜状的奥氏体(γ)相；高温(600℃)回火时，形成纳米β-Ni Al相和细小的富Mo、W、Cr的Laves相，且两者与α-Fe基体分别存在[001]_β//[001]_α和[■23]Laves//[011]_α的位向关系，同时形成有利于塑韧性改善的α+γ的双相组织。低温(460℃)回火时形成的富Ni团簇和富Cr团簇，可能是高温(600℃)回火时β-Ni Al相和Laves相的前驱体，2种形态均是析出强化的主要贡献者。

关键词：增材制造马氏体时效钢析出强化 β-NiAl相 Laves相压铸模