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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao you Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Operation Efficiency and Influencing Factors of Listed Companies of Swine Industry:Empirical Analysis Based on Data of 16 Listed Companies in 2010-2014

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Asian Agricultural Research 2017年第3期9卷 14-19,23页

作者： mengqi you Zhenhong QI Ai’e WANG Xinrui LI Weihong HUANG Wenbin WAN College of Economics and Management Huazhong Agricultural UniversityWuhan 430070China Hubei Rural Development Research Center Wuhan 430070China

Listed companies of the swine industry,as an important form of agricultural industrialized operation,are typical representatives of large-scale production and the level of their operation efficiency exerts a direct influence on the healthy development of the swine *** the DEA-based Malmquist method,this paper made a static and dynamic evaluation of the operation efficiency of 16 listed companies in China's swine industry in 2010-2014. It obtained following results:( i) The overall efficiency of listed companies of China's swine industry remained at high level and the development trend was excellent.( ii) Different types of enterprises had difference in the overall efficiency,pure technical efficiency and scale efficiency. In general,pig feed processing companies had the best performance,followed by slaughtering and deep processing companies,and swine breeding companies were the worst.( iii) The total factor productivity characterized by the Malmquist index declined year by year in 2010-2013 and was improved in 2014,mainly due to technological progress.( iv) The total asset turnover ratio,equity concentration,and R & D management level had a significantly positive impact on the operation efficiency of listed companies in the swine industry,while the human capital had a significantly negative impact.

关键词： Operation efficiency Influencing factor Listed companies of swine industry DEA-based Malmquist DEA-Tobit

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Research on the Recognition Algorithm of Chinese Traditional Scales Based on Decision Tree

Research on the Recognition Algorithm of Chinese Traditional...

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第37届中国控制会议

作者： Yang Deng Li Zhou Shan Ni Si Zhang mengqi you Music Department Arts and Communication School China University of Geosciences （Wuhan）

The affective computing of music is an essential component of the music artificial intelligence field, especially those regards human-computer interaction technology, as for music mode is a crucial component of musical emotion perceptions. To be more specific, the recognition skill of scales, the music mode material remains manually used today, which endow this research a great practical significance for using the algorithm to recognizing them in high speed. This paper describes how to classify the Chinese traditional scales（CTS） and annotate the emotional colors of the Chinese traditional music（CTM） through algorithm recognition methods, based on setting up a decision tree. This algorithm-testing database consists of MIDI samples either in CTS or not, while taking three steps to determine it: sample pre-processing, decision tree classification, result verification. The experiment results show the accuracy of this cognition method on samples were non restrict to CTS. Which prove the feasibility of indirectly obtaining emotion colors through the process to identify and classify CTM based on the decision tree.

关键词： music affective computing decision tree Chinese traditional scales recognition algorithm

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基于模板匹配的中国民族音乐调式识别研究

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复旦学报（自然科学版） 2020年第3期59卷 262-269页

作者：游梦琪陈柳姣周莉贺晶娴中国地质大学(武汉)艺术与传媒学院湖北武汉430074

本文以中国民族音乐理论为研究基础,构建民族音乐调式模板对中国民族音乐调式进行匹配.实验测试数据包含多个五声调式、七声调式以及西洋大小调式的MIDI文件样本.通过实验样本预处理、模板匹配、结果核验等多个步骤最终计算出调式的识... 详细信息

本文以中国民族音乐理论为研究基础,构建民族音乐调式模板对中国民族音乐调式进行匹配.实验测试数据包含多个五声调式、七声调式以及西洋大小调式的MIDI文件样本.通过实验样本预处理、模板匹配、结果核验等多个步骤最终计算出调式的识别结果.实验结果表明:本算法对中国民族音乐调式的识别具有较高的准确率,能够识别出五声调式和七声调式.

关键词：模板匹配中国民族音乐调式音乐调式识别算法作曲

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“互联网+”背景下女大学生就业的机遇和挑战

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教育研究前沿（中英文版） 2023年第1期13卷 11-16页

作者：尤梦琪王贵芳浙江越秀外国语学院浙江绍兴312000

互联网技术的全面普及,势必带来更多的机遇和挑战。传统观念束缚下,女性就业问题迫在眉睫。在“互联网+”这个大背景下,推动女大学生就业的机遇和制衡其仍存在的挑战。本文从多样性多角度分析其内外在影响因素,剖析现状,进而提出相应建... 详细信息

互联网技术的全面普及,势必带来更多的机遇和挑战。传统观念束缚下,女性就业问题迫在眉睫。在“互联网+”这个大背景下,推动女大学生就业的机遇和制衡其仍存在的挑战。本文从多样性多角度分析其内外在影响因素,剖析现状,进而提出相应建议和措施。旨在充分发挥就业和互联网相融合的作用,以改善女大学生就业瓶颈,帮助女大学生树立正确择业观和就业观,带动其更好的就业。

关键词：互联网+ 女大学生就业机遇挑战

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： you Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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基于动态规划的自适应和弦编配算法研究

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复旦学报（自然科学版） 2019年第3期58卷 393-400页

作者：邓阳周莉许多岳诚成游梦琪周蕊格中国地质大学(武汉)艺术与传媒学院武汉430074 同济大学道路与交通工程教育部重点实验室上海201804 伦敦大学学院全球繁荣研究所英国伦敦WC1E6BT 亚利桑那州立大学赫伯格艺术与设计学院美国坦佩85281

和弦的编配是作曲过程中耗时较长的一个重要步骤,传统作曲中的和弦编配主要采用人工完成,尚无成熟的自动和弦编配技术.本文针对以上问题,根据和弦构成规律与进行逻辑,提出了和弦体系构造函数(CFCS),设计出一种自动和弦编配的动态规划算... 详细信息

和弦的编配是作曲过程中耗时较长的一个重要步骤,传统作曲中的和弦编配主要采用人工完成,尚无成熟的自动和弦编配技术.本文针对以上问题,根据和弦构成规律与进行逻辑,提出了和弦体系构造函数(CFCS),设计出一种自动和弦编配的动态规划算法,以此来实现机器自动和弦编配.通过对多个算例进行实验,检测结果验证本算法是有效可行的.

关键词：智能作曲和弦编配动态规划和弦体系构造函数

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Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： Morteza Abyadeh Vivek Gupta Yuyi you Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

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When AI meets sustainable 6G

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Science China(Information Sciences) 2025年第1期68卷 4-22页

作者： Xiaohu you Yongming HUANG Cheng ZHANG Jiaheng WANG Hao YIN Hequan WU National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Chinese Academy of Military Science China Information Communication Technologies Group

Sixth-generation(6G) networks are anticipated to achieve transformative advancements, characterized by extreme connectivity, deep integration with artificial intelligence(AI) and sensing, and airground integration. The evolution of 6G exhibits two major trends: ubiquitous intelligence and sustainability. The former aims to embed state-of-the-art AI technology into the 6G network, from the physical layers to applications, while the latter emphasizes reducing energy consumption while enhancing network performance to address environmental concerns. Despite the amazing progress in recent years, AI advancements come with substantial increases in data and computational overhead, posing critical challenges for integrating AI into sustainable 6G networks. First, high energy consumption from large datasets and heavyweight AI models contradicts6G's green goals. Second, the precise collection of large datasets, message delivery latency, and inference delays in AI models pose challenges for real-time tasks in 6G. Third, the uninterpretability and unpredictability of AI models complicate meeting the stringent requirements for controllable transmission in dynamic wireless environments. Addressing these challenges and achieving sustainable 6G with ubiquitous intelligence calls for a revolutionary design of 6G architecture and AI frameworks. To this end, this paper introduces a novel and practical methodology for green, real-time, and controllable 6G native intelligence,starting with knowledge graph(KG) analysis to extract small but critical datasets, followed by the development of distributed lightweight AI models, and the use of digital twins(DTs) to create precise replicas of physical 6G networks. This leads to a pervasive multi-level(PML)-AI framework supported by a task-centric, three-layer 6G architecture. The AI framework operates through non-real-time and real-time cycles, leveraging three key technologies: wireless data KGs for efficient data management,lightweight AI mode

关键词： artificial intelligence sustainable 6G green real-time controllable

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中药穴位贴敷神阙穴治疗儿童功能性便秘临床研究

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河北中医 2022年第8期44卷 1267-1271页

作者：游梦祺张君韩少博北京中医药大学房山医院儿科北京102400

目的观察中药穴位贴敷神阙穴治疗儿童功能性便秘的临床疗效。方法选择120例儿童功能性便秘患者,均为实证便秘,按照随机数字表法分为对照组和观察组,各60例。对照组采用双歧杆菌三联活菌散常规治疗,观察组采用中药穴位贴敷神阙穴治疗。2... 详细信息

目的观察中药穴位贴敷神阙穴治疗儿童功能性便秘的临床疗效。方法选择120例儿童功能性便秘患者,均为实证便秘,按照随机数字表法分为对照组和观察组,各60例。对照组采用双歧杆菌三联活菌散常规治疗,观察组采用中药穴位贴敷神阙穴治疗。2组均7 d为1个疗程,连续治疗2个疗程。比较2组治疗前后Bristol粪便性状分级及Cleveland便秘评分系统(CCS)、便秘患者生活质量自评量表(PAC-QOL)中文版、中医证候、便秘症状评分变化,并比较2组临床疗效、不良反应。结果治疗后,2组CCS、PAC-QOL评分和中医证候各项评分及总分、便秘症状各项评分和总分均较本组治疗前显著降低(P0.05)。结论中药穴位贴敷神阙穴治疗能有效降低儿童功能性便秘实证患儿的便秘严重程度,改善生活质量。

关键词：便秘儿童穴位贴敷法穴,神阙穴儿童功能性实证

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