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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun zhang meng-xia zhang xiao-xiang meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

TICKET attracts pollen tubes and mediates reproductive isolation between relative species in Brassicaceae

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Science China(Life Sciences) 2019年第11期62卷 1413-1419页

作者： Jiang-Guo meng meng-xia zhang Wei-Cai Yang Hong-Ju Li State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Collage of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China

In flowering plants,pollen tubes are attracted to the ovule by secreted peptides to release the sperm cells for double *** process is species-specific and acts as an important stage of reproductive isolation between *** we identified a cysteine-rich peptide TICKET2 in Arabidopsis thaliana and its orthologs in Arabidopsis lyrata and Capsella rebella that can attract the conspecific pollen tubes,but not the pollen tubes of relative species in *** knockout of the AtTICKET subclade compromised the pollen tube attraction *** study identified a new pollen tube attracting signal and shed light on the molecular basis of reproductive isolation.

关键词： pollen tube attraction peptide attractant reproductive isolation

A regularization algorithm of dynamic light scattering for estimating the particle size distribution of dual-substance mixture in water

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Particuology 2024年第6期89卷 246-257页

作者： Yanghong Wang Ziqiang meng Zipei zhang Min xia Li xia Wei Li School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China

Dynamic light scattering(DLS)is a nondestructive,well-established technique for the size characterization of proteins,nanoparticles,polymers,and colloidal ***,current DLS techniques are only applied to particle groups of single composition due to the limitation of their inversion *** this study,we propose a particle size distribution inversion algorithm based on the Tikhnonov regularization method that can be applied to the dual-substance particle *** algorithm retrieves the particle size distributions of two substances,respectively,by taking advantage of their refractive index *** simulation results reveal that the algorithm has excellent accuracy and stability when the scattering angle is 30°.Instead of the original identity matrix,the first-order difference matrix and second-order difference matrix are used as the regular matrix when utilizing the Tikhnonov algorithm,which obviously improves the anti-interference,accuracy,and stability of the ***,the inversion of particle size distribution is carried out at a 0.01%–1%noise level,which shows that the algorithm has an available antinoise ***,experimental particle size measurements for a mixture of polystyrene beads and toner particles demonstrate that the proposed algorithm is superior to the traditional Tikhnonov algorithm in applicability and accuracy.

关键词： Dynamic light scattering Dual-substance mixture Particle sized istribution Tikhnonov regularization

Unified method for typical gear failure modeling and stiffness calculation based on the matrix equation

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Frontiers of Mechanical Engineering 2024年第3期19卷 93-114页

作者： Fanshan meng Xin zhang Heng xia Jiaxu WANG School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Mechanical Transmissions for Advanced Equipment Chongqing UniversityChongqing 400044China

The failure types in gear systems vary,with typical ones mainly including pitting,cracking,wear,and broken *** modeling and stiffness calculation methods have been developed for various gear failure types.A unified method for typical gear failure modeling and stiffness calculation is introduced in this study by considering the deviations in the time-varying meshing stiffness(TVMS)of faulty gears resulting from the use of different ***,a gear tooth is discretized into a large number of microelements expressed with a matrix,and unified models of typical gear failures are built by adjusting the values of the matrix *** values and positions of the microelements in the tooth failure model matrix have the same physical meaning as the parameter variables in the potential energy method(PEM),so the matrix-based failure model can be perfectly matched with ***,a unified method for TVMS is *** of healthy and faulty gears with pitting,wear,crack,and broken tooth is performed with the matrix equation,and the corresponding TVMS values are calculated by incorporating the matrix models with *** the basis of the results,the mechanism of typical fault types that affect TVMS is analyzed,and the conclusions are verified through the finite element *** developed unified method is a promising technique for studying the dynamic response characteristics of gear systems with different failure types because of its superiority in eliminating stiffness deviations.

关键词： gears matrix equation failure modeling TVMS calculation unified method

Three dimensional discrete element modelling of the conventional compression behavior of gas hydrate bearing coal

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International Journal of Coal Science & Technology 2024年第1期11卷 61-77页

作者： xia Gao Nannan Wang Baoyong zhang Qiqi Lin Qiang Wu Wei meng xia Liu Department of Architecture and Civil Engineering Heilongjiang University of Science and TechnologyHarbin150022China School of Qilu Transportation Shandong UniversityJinan250061China Department of Safety Engineering Heilongjiang University of Science and TechnologyHarbin150022China Jining Hongxiang Highway Survey Design and Research Institute Co.Ltd Jining272000China

To analyze the relationship between macro and meso parameters of the gas hydrate bearing coal(GHBC)and to calibrate the meso-parameters,the numerical tests were conducted to simulate the laboratory triaxial compression tests by PFC3D,with the parallel bond model employed as the particle contact constitutive ***,twenty simulation tests were conducted to quantify the relationship between the macro–meso ***,nine orthogonal simulation tests were performed using four meso-mechanical parameters in a three-level to evaluate the sensitivity of the meso-mechanical ***,the calibration method of the meso-parameters were then ***,the contact force chain,the contact force and the contact number were examined to investigate the saturation effect on the meso-mechanical behavior of *** results show that:(1)The elastic modulus linearly increases with the bonding stiffness ratio and the friction coefficient while exponentially increasing with the normal bonding strength and the bonding radius *** failure strength increases exponentially with the increase of the friction coefficient,the normal bonding strength and the bonding radius coefficient,and remains constant with the increase of bond stiffness ratio;(2)The friction coefficient and the bond radius coefficient are most sensitive to the elastic modulus and the failure strength;(3)The number of the force chains,the contact force,and the bond strength between particles will increase with the increase of the hydrate saturation,which leads to the larger failure strength.

关键词： Gas hydrate bearing coal Discrete element method Triaxial compression test Macro-meso mechanical propertie

Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management

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Chinese Journal of Polymer Science 2024年第7期42卷 1002-1014,I0010页

作者： Bo-Wen Wang Heng zhang Qing-xia He Hui-Tao Yu meng-meng Qin Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China International Engineering Institute Tianjin UniversityTianjin300350China

With the rapid development of high-power-density electronic devices,interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic ***,there is an urgent demand for advanced thermal interface materials(TIMs)with high cross-plane thermal conductivity and excellent compressibility to withstand increasingly complex operating *** achieve this aim,a promising strategy involves vertically arranging highly thermoconductive graphene on ***,with the currently available methods,achieving a balance between low interfacial thermal resistance,bidirectional high thermal conductivity,and large-scale production is ***,we prepared a graphene framework with continuous filler structures in in-plane and cross-plane directions by bonding corrugated graphene to planar graphene *** interface interaction between the graphene paper framework and polymer matrix was enhanced via surface functionalization to reduce the interface thermal *** resulting three-dimensional thermal framework endows the polymer composite material with a cross-plane thermal conductivity of 14.4 W·m^(-1)·K^(-1)and in-plane thermal conductivity of 130W·m^(-1)·K^(-1)when the thermal filler loading is 10.1 wt%,with a thermal conductivity enhancement per 1 wt%filler loading of 831%,outperforming various graphene structures as *** its high thermal conductivity,low contact thermal resistance,and low compressive modulus,the developed highly thermoconductive composite material demonstrates superior performance in TIM testing compared with TFLEX-700,an advanced commercial TIM,effectively solving the interfacial heat transfer issues in electronic *** novel filler structure framework also provides a solution for achieving a balance between efficient thermal management and ease of processing.

关键词： Graphene paper Vertically aligned structure Cross-plane thermal conductivity Low compressive modulus Thermal interface material

Detailed reservoir inversion addressing geological problems in reservoir development

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Applied Geophysics 2007年第1期4卷 58-65页

作者： Shen Guoqiang meng xianjun xia Jizhuang zhang Xuefang Li xia Geophysical Research Institute Shengli Oilfield Ltd SINOPEC Dongying 257100 China

In the Ken 71 development block, fluvial facies of the Neogene Guantao Formation and delta facies of the Paleogene Dongying Formation are the main pay beds. It is a multiple oil and water system which is complicated by faults. Characteristics of the block include a dense well network, thin reservoirs, complicated horizontal relationships, and small velocity difference between reservoir and non-reservoir. Therefore, it is difficult to conduct detailed reservoir description for subsequent development project adjustment. We demonstrate a stochastic seismic inversion which aims at detailed reservoir description. It is a technology which utilizes multiple wells, seismic data, and geological calibration and integrates with 3D structural interpretation results to build a 3D multi-fault detailed and constrained geological model. On this basis, we adopted stochastic seismic inversion to conduct a multi-stratum parameters inversion such as impedance and lithology. As a result, thin interbedded strata in the block were well resolved and the results demonstrated the importance of detailed reservoir inversion for oilfield development.

关键词： Ken 71 block multi-well calibration detailed geological model impedance stochastic seismic inversion

Electrical control of excitonic oscillator strength and spatial distribution in a monolayer semiconductor

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Nano Research 2024年第9期17卷 8424-8430页

作者： Yanming Wang Junrong zhang Tianhua Ren meng xia Long Fang xiangyi Wang Xingwang zhang Kai zhang Junyong Wang School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Nanophotonic Materials and Devices&Key Laboratory of Nanodevices and Applications i-LabSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123China Institute of Applied Physics and Materials Engineering University of MacaoTaipaMacao 999078China College of New Energy Inner Mongolia University of TechnologyHohhot 010051China

Electrical modulation of luminescence is significant to modern light-emitting *** transition metal dichalcogenides are emerging direct-bandgap luminescent materials with unique excitonic properties,and the multiple exciton complexes provide new opportunities to modulate the property of luminescence in atomically thin ***,we report an electrical control of exciton emission in the oscillator strength and spatial distribution of excitons in a monolayer *** modulation of excitonic emission intensity with a degree of modulation of~92%has been demonstrated by an electric field at room *** spatial carrier redistribution tuned by a lateral electric field results in distinct excitonic emission patterns by *** modulation approach to exciton oscillator strength and distribution provides an efficient way to investigate the exciton diffusion dynamics and to construct electrically tunable optoelectronic devices.

关键词： monolayer semiconductor exciton electrical modulation spatial distribution

Seasonal thermal energy storage using natural structures:GIS-based potential assessment for northern China

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Building Simulation 2024年第4期17卷 561-574页

作者： Yichi zhang Jianjun xia Midea HVAC Heating&Ventilation Equipment Co. LtdFoshan528311China Building Energy Research Center Tsinghua UniversityBeijing100084China

Seasonal thermal energy storage(STES)allows storing heat for long-term and thus promotes the shifting of waste heat resources from summer to winter to decarbonize the district heating(DH)*** being a promising solution for sustainable energy system,large-scale STES for urban regions is lacking due to the relatively high initial investment and extensive land *** close the gap,this study assesses the potentials of using two naturally available structures for STES,namely valley and ground pit *** on geographical information system(GIS)methods,the available locations are searched from digital elevation model and selected considering several criteria from land uses and construction *** costs of dams to impound the reservoir and the yielded storage capacities are then quantified to guide the choice of suitable *** assessment is conducted for the northern China where DH systems and significant seasonal differences of energy demand *** total,2,273 valley sites and 75 ground pit sites are finally identified with the energy storage capacity of 15.2 billion GJ,which is much larger than the existing DH demand in northern *** results also prove that 682 valley sites can be achieved with a dam cost lower than 20 CNY/m^(3).By conducting sensitivity analysis on the design dam wall height and elevations,the choices of available natural structures are expanded but practical issues about water pressures and constructions are also ***,the identified sites are geographically mapped with nearest urban regions to reveal their roles in the DH *** general,560 urban regions are found with potential STES units and most of them have STES storage capacities larger than their own DH *** novel planning methodology of this study and publicly available datasets create possibilities for the implementations of large-scale STES in urban DH systems.

关键词： seasonal thermal energy storage geographical information system district heating water reservoir