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大豆细菌性斑点病防治药剂筛选

农药 2021年第9期60卷 687-690页

作者：张京孟维实孙瑛健徐伟张佳环吉林农业大学植物保护学院长春130118

[目的]针对大豆细菌性斑点病筛选有效药剂,为防治此病害提供依据。[方法]利用抑菌圈法,建立回归线,进行EC值分析。结合病情指数及防效进行差异显著性分析。[结果]45%代森铵AS(585 m L/hm^(2),均为制剂用量)和80%乙蒜素ES (165 mL/hm^(2)... 详细信息

[目的]针对大豆细菌性斑点病筛选有效药剂,为防治此病害提供依据。[方法]利用抑菌圈法,建立回归线,进行EC值分析。结合病情指数及防效进行差异显著性分析。[结果]45%代森铵AS(585 m L/hm^(2),均为制剂用量)和80%乙蒜素ES (165 mL/hm^(2))防治效果明显,达到80%以上;30%王铜SC (450 mL/hm^(2))、30%噻唑锌SC(570 mL/hm^(2))、20%噻菌铜SC (1125 mL/hm^(2))防治效果达70%以上。[结论]防治大豆细菌性斑点病首选45%代森铵AS和80%乙蒜素ES。30%王铜SC、30%噻唑锌SC、20%噻菌铜SC可以作为备选药剂。

关键词：大豆细菌性斑点病药剂筛选室内生物活性田间防效

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-wei Dong Liping Huang Xiaoping Wang wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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冲击振动压路机实验样机机架的谐响应动特性分析

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机械工程与自动化 2009年第1期 54-56,60页

作者：孟士伟张洪肇世华太原科技大学山西太原030024

根据冲击振动压路机实验样机结构设计图纸的几何参数,在AN SY S中建立样机机架的有限元模型;结合样机机架所承受的外部简谐激励载荷的频率范围,对其进行有限元谐响应分析以及谐载动态性能估计。

关键词：冲击振动压路机 ANSYS有限元谐响应分析

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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装载机用Ⅲ阶段柴油机电控特性的扩展与应用

装备制造技术 2015年第7期 140-143页

作者：孟士伟黄家胜汪勇广西柳工机械股份有限公司广西柳州545007

电控高压共轨+进气中冷技术将是Ⅲ阶段装载机用柴油机制造商采用的主流技术路线,此技术路线也是目前国际上最流行和成熟的技术方案。针对电控高压共轨技术及其扩展的丰富的电控特性,装载机整机产品开发过程需要从实用性、高效节能、可... 详细信息

电控高压共轨+进气中冷技术将是Ⅲ阶段装载机用柴油机制造商采用的主流技术路线,此技术路线也是目前国际上最流行和成熟的技术方案。针对电控高压共轨技术及其扩展的丰富的电控特性,装载机整机产品开发过程需要从实用性、高效节能、可靠性、安全性等角度综合考虑。保证扩展出的电控特性能够满足实用性要求,兼顾高效与节能环保,同时满足整机的可靠性和人机的安全性要求。

关键词：装载机柴油机电控特性高效节能可靠性安全性

Dynamic event-triggered data-driven iterative learning bipartite tracking control for nonlinear MASs with prescribed performance

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Science China(Information Sciences) 2025年第1期 292-305页

作者： Tao shi wei-wei CHE School of Mechatronic Engineering and Automation Shanghai University State Key Laboratory of Synthetical Automation for Process Industries Northeastern University College of Information Science and Engineering Northeastern University

This article proposes a distributed dynamic event-triggered data-driven iterative learning control(DET-DDILC)scheme under a predefined performance to tackle the bipartite tracking control problem for multiagent systems(MASs). An improved dynamic linearization technique is utilized to convert the nonlinear MASs into an iterative linear data model. First,a peer-to-peer mapping function is introduced to map the constrained distributed system output homeomorphism to an unconstrained one. In addition, a DET mechanism based on a time-iteration-varying function is devised to conserve network communication resources. Based on the unconstrained transformation and the designed DET mechanism, the DET-DDILC algorithm is devised to ensure that the bipartite tracking performance of MASs can be within the preset range. Finally, the effectiveness and feasibility of the designed control scheme are demonstrated via a simulation case by a comparison.

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基于Transformer模型的时序数据预测方法综述

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计算机科学与探索 2025年第1期19卷 45-64页

作者：孟祥福石皓源辽宁工程技术大学电子与信息工程学院辽宁葫芦岛125105

时序数据预测(TSF)是指通过分析历史数据的趋势性、季节性等潜在信息,预测未来时间点或时间段的数值和趋势。时序数据由传感器生成,在金融、医疗、能源、交通、气象等众多领域都发挥着重要作用。随着物联网传感器的发展,海量的时序数据... 详细信息

时序数据预测(TSF)是指通过分析历史数据的趋势性、季节性等潜在信息,预测未来时间点或时间段的数值和趋势。时序数据由传感器生成,在金融、医疗、能源、交通、气象等众多领域都发挥着重要作用。随着物联网传感器的发展,海量的时序数据难以使用传统的机器学习解决,而Transformer在自然语言处理和计算机视觉等领域的诸多任务表现优秀,学者们利用Transformer模型有效捕获长期依赖关系,使得时序数据预测任务取得了飞速发展。综述了基于Transformer模型的时序数据预测方法,按时间梳理了时序数据预测的发展进程,系统介绍了时序数据预处理过程和方法,介绍了常用的时序预测评价指标和数据集。以算法框架为研究内容系统阐述了基于Transformer的各类模型在TSF任务中的应用方法和工作原理。通过实验对比了各个模型的性能、优点和局限性,并对实验结果展开了分析与讨论。结合Transformer模型在时序数据预测任务中现有工作存在的挑战提出了该方向未来发展趋势。

关键词：深度学习时序数据预测数据预处理 Transformer模型

Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Science China Chemistry 2025年第1期 308-316页

作者： Sili Wang Jiancheng Huang Yanan Du wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan shi Bin Hong Xiaoying Bian Wen Liu State Key Laboratory of Chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health Commission (NHC) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(CXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective C3-methylation is believed to rely on a Cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of Cxm8, a Cbl-dependent radical SAM protein, with Cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. Cxm8 and Cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes C3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving CXM and a recently identified, C3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the Cxm8/Cxm9 complex and particularly the necessity of the DUF5825 protein for C3-methylase activity. This is the first example that a Cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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环孢素A纳米粒-凝胶制剂的制备及兔泪液药动学

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沈阳药科大学学报 2009年第7期26卷 507-511页

作者：钮萌萌于英伟石凯张立强林文辉崔福德沈阳药科大学药学院

目的制备环孢素A固体脂质纳米粒-原位凝胶复合制剂并考察其在家兔泪液中消除情况。方法采用乳化-超声法制备环孢素固体脂质纳米粒,用带正电的十八胺包衣以调节纳米粒表面的电性,用Cou lter LS 230测定纳米粒粒径,用电泳光散射法测定纳... 详细信息

目的制备环孢素A固体脂质纳米粒-原位凝胶复合制剂并考察其在家兔泪液中消除情况。方法采用乳化-超声法制备环孢素固体脂质纳米粒,用带正电的十八胺包衣以调节纳米粒表面的电性,用Cou lter LS 230测定纳米粒粒径,用电泳光散射法测定纳米粒的动电电位,将包衣纳米粒载于F127形成的原位凝胶中,考察制剂在家兔泪液中不同时间点药物浓度,以环孢素橄榄油滴眼液作对照,计算药物动力学参数。结果纳米粒粒径121 nm,动电电位+23 mv,纳米粒-凝胶制剂在家兔眼部经3 h的泪液代谢动力学参数AUC、MRT分别为蓖麻油制剂的3.4和4.0倍,包衣纳米粒的AUC和MRT也均比未包衣纳米粒有显著提高。结论环孢素A固体脂质纳米粒-原位凝胶制剂可显著提高环孢素在泪液中的浓度,延长作用时间,减少刺激性。

关键词：环孢素A 固体脂质纳米粒原位凝胶泪液药动学