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Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury

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Neural Regeneration Research 2018年第9期13卷 1650-1656页

作者： meng-qiang huang Xiao-Yu Cao Xu-Yi Chen Ying-Fu Liu Shuang-Long Zhu Zhong-Lei Sun Xian-Bin Kong Jing-Rui Huo Sai Zhang Yun-qiang Xu Graduate School Tianjin Medical University Department of Orthopedics Tianjin Medical University General Hospital Department of Rehabilitation Medicine First Affiliated Hospital of Anhui Medical University Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCenter for Neurology and Neurosurgery of Affiliated HospitalLogistics University of Chinese People's Armed Police Force Science and Technology Experiment Center Cangzhou Medical College Graduate School Jinzhou Medical University Graduate School Tianjin University of Traditional Chinese Medicine

Nerve scarring after peripheral nerve injury can severely hamper nerve regeneration and functional ***,the anti-inflammatory cytokine,interleukin-10,can inhibit nerve scar *** a（SSa） is a monomer molecule extracted from the Chinese medicine,*** can exert anti-inflammatory effects in spinal cord injury and traumatic brain ***,it has not been shown whether SSa can play a role in peripheral nerve *** this study,rats were randomly assigned to three *** the sham group,the left sciatic nerve was directly sutured after *** the sciatic nerve injury（SNI）＋ SSa and SNI groups,the left sciatic nerve was sutured and continuously injected daily with SSa（10 mg/kg） or an equivalent volume of saline for 7 *** linked immunosorbent assay results demonstrated that at 7 days after injury,interleukin-10 level was considerably higher in the SNI ＋ SSa group than in the SNI *** staining and western blot assay demonstrated that at 8 weeks after injury,type I and III collagen content was lower and nerve scar formation was visibly less in the SNI ＋ SSa group compared with the SNI ***,sciatic functional index and nerve conduction velocity were improved in the SNI ＋ SSa group compared with the SNI *** results confirm that SSa can increase the expression of the anti-inflammatory factor,interleukin-10,and reduce nerve scar formation to promote functional recovery of injured sciatic nerve.

关键词： nerve regeneration saikosaponin a anti-inflammatory factor inflammation interleukin-l O nerve scar peripheral nerve injury sciatic nerve injury sciatic functional index nerve conduction velocity neuroelectrophysiological function neural regeneration

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一种新的康复与代步外骨骼机器人研究

自动化学报 2016年第12期42卷 1933-1942页

作者：黄高张伟民 Marco Ceccarelli 余张国陈学超孟非黄强仿生机器人与系统教育部重点实验室北京理工大学机电学院智能机器人研究所仿生机器人与系统教育部国际合作联合实验室智能机器人与系统高精尖创新中心意大利卡西诺大学机器人与机电系统实验室复杂系统智能控制与决策国家重点实验室

针对老年人及下肢障碍者康复训练与代步问题,本文提出一种新的康复与代步外骨骼机器人.本文首先详细介绍了机器人各部分组成及机构设计方案,通过下肢外骨骼与轮椅的有机结合,有效保持或恢复老年人、脑卒中患者下肢运动能力的同时,为患... 详细信息

针对老年人及下肢障碍者康复训练与代步问题,本文提出一种新的康复与代步外骨骼机器人.本文首先详细介绍了机器人各部分组成及机构设计方案,通过下肢外骨骼与轮椅的有机结合,有效保持或恢复老年人、脑卒中患者下肢运动能力的同时,为患者提供一种方便的代步工具;运用脚蹬车运动制订康复训练策略,可保持下肢康复训练轨迹固定,保证患者安全;提出主从式操作方法及多模态康复训练控制流程提高使用者参与感.最后通过仿真与实验验证了所提康复系统的可行性与设计的正确性.

关键词：康复机器人外骨骼机构设计仿真实验

响应面法优化斑点叉尾鮰鱼皮明胶-壳聚糖可食膜的制备工艺

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海洋渔业 2017年第4期39卷 463-470页

作者：徐萌包建强黄雯王金梅上海海洋大学食品学院上海海洋大学水产动物遗传育种中心上海201306

以斑点叉尾鮰(Ietalurus punetaus)鱼皮明胶、壳聚糖、甘油为原料制备可食膜,采用响应面法对可食膜的制备工艺进行优化。在单因素试验的基础上,使用Design-Expert软件对鱼皮明胶添加量、热处理温度与甘油添加量进行三因素响应面试验设计... 详细信息

以斑点叉尾鮰(Ietalurus punetaus)鱼皮明胶、壳聚糖、甘油为原料制备可食膜,采用响应面法对可食膜的制备工艺进行优化。在单因素试验的基础上,使用Design-Expert软件对鱼皮明胶添加量、热处理温度与甘油添加量进行三因素响应面试验设计,以抗拉伸强度为响应值优化可食膜性能,并验证响应面预测值与实测值的一致性。结果表明,复合可食膜最佳制备工艺为:鮰鱼皮明胶添加量60%、热处理温度70℃、甘油添加量为10%时,制备得到的明胶-壳聚糖可食膜抗拉伸强度达最大值24.20 MPa,验证结果为23.44 MPa,二者相对误差为3.2%,实测值与响应面预测值拟合良好,说明通过响应面试验设计优化是有效的。

关键词：响应面斑点叉尾鮰鱼皮明胶可食膜

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin meng Li Weibin Chen Pei Liu Tao huang Zhencheng huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Task-space Whole-body Control with Variable Contact Force Control for Position-controlled Humanoid Adaptation to Unknown Disturbance

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Journal of Bionic Engineering 2023年第5期20卷 2069-2087页

作者： Zelin huang Chencheng Dong Zhangguo Yu Xuechao Chen Fei meng qiang huang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing100081China

Whole-body control is beneficial for improving the disturbance adaptation of humanoid robots,since it can simultaneously optimize desired joint torque,joint acceleration,and contact force while considering whole-body dynamics and other physical ***,the lack of torque feedback information prevents the position-controlled humanoids from utilizing whole-body control directly,because it enhances the difficulty of guaranteeing desired contact force which is important for maintaining *** this paper,a whole-body control that integrates task-space inverse dynamics and variable contact force control is proposed for position-controlled humanoids to enhance the robot’s adaptability toward the unknown *** task-space inverse dynamics generates the desired joint acceleration and contact force with the consideration of whole-body dynamics and other limits to track the *** variable contact force control modifies references related to Center of Mass(CoM)and end effectors to ensure reasonable contact force tracking performance,thereby assuring good tracking performance of CoM and momentum to maintain robot *** and experiments of balancing and walking under unknown disturbance have been successfully conducted on a position-controlled humanoid robot,BHR-7P3,with the proposed method.

关键词： Whole-body control Contact force Admittance control Humanoid robot

High Dynamic Bounding and Jumping Motion of Quadruped Robot Based on Stable Optimization Control

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Journal of Bionic Engineering 2024年第1期21卷 101-111页

作者： Sai Gu Fei meng Botao Liu Junyao Gao qiang huang School of Mechatronical Engineering Beijing Institute of Technology100081 BeijingChina Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing 100081China

Aiming at the environment such as ravines and obstacles that may be encountered in the actual movement,this paper proposes a method for optimizing the bounding and jumping motion based on the ground touching force trajectory and the air motion trajectory of the quadruped *** method of optimizing the ground reaction force according to the speed of the demand and the height of the jump,and adjusting the stance and swing time according to the relationship of dynamics and momentum *** the same time,under the constraints of dynamics and energy consumption of the robot system,considering the jumping distance and height,a method for optimizing the air trajectory of bounding and jumping is *** switching and landing stability control are also ***,the experimental results show that the quadruped robot has strong bounding and jumping ability,and has achieved stable bounding movement and forward jump movement of 0.8 m.

关键词： Quadruped robot High dynamic motion control-Periodic limit cycle Trajectory optimization

Characterization of diffusion-bonded joint between Al and Mg using a Ni interlayer

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Rare Metals 2016年第7期35卷 537-542页

作者： Jian Zhang Guo-qiang Luo qiang Shen Lian-meng Zhang Zhi-Jun huang Research and Development Center of Wuhan Iron and Steel(Group)Corporation Wuhan 430080China State Key Laboratory of Advanced for Materials Synthesis andProcessing Wuhan University of TechnologyWuhan 430070China

Aluminum and magnesium were joined through diffusion bonding using Ni interlayer. The micro- structure and mechanical performance of the A1/Ni/Mg joints at different temperatures was investigated by means of scanning electron microscope （SEM）, electro-probe microanalyzer （EPMA）, X-ray diffraction （XRD）, Vickers hardness testing, and shear testing. The results show that the addition of Ni interlayer eliminates the formation of Mg-A1 intermetallic compounds and improves the bonding strength of the A1/Mg joints. The AI/Ni/Mg joints are formed by the diffusion of A1, Ni and Mg, Ni. The microstructure at the joint interface from A1 side to Mg side is A1 substrate/A1-Ni reaction layer/Ni interlayer/Mg-Ni reaction layer/Mg substrate multilayer structure. The mi- crohardness of the Mg-Ni reaction layer has the largest value of HV 255.0 owing to the existence of Mg2Ni phase. With the increase of bonding temperature, the shear strength of the joints increases firstly and then decreases. The A1/Ni/Mg joint bonds at 713 K for 90 min, exhibiting the maximum shear strength of 20.5 MPa, which is greater than that of bonding joint bonded directly or with Ag interlayer. The fracture of the joints takes place at the Mg- Ni interface rather than the A1-Ni interface, and the frac- ture way of the joints is brittle fracture.

关键词： A1-Mg Ni foil Diffusion bonding Microstructure Shear strength