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Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression

Journal of Genetics and Genomics 2024年第8期51卷 811-823页

作者： Qiao meng Jing ning Jingjing Lu Jing Zhang Ming Zu Jing Zhang Xiurui Han Huiling Zheng Yueqing Gong Xinyu Hao Ying Xiong Fang Gu Wenling Han Weiwei Fu Jun Wang Shigang ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases(BZ0371) Beijing 100191China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterNHC Key Laboratory of Medical Immunology(Peking University)Beijing 100191China Peking University Center for Human Disease Genomics Beijing 100191China

The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis(UC),and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC ***,we find that the IL-17 receptor subunit,CMTM4,is reduced in UC patients and dextran sulfate sodium(DSS)-induced *** deletion of CMTM4(Cmtm4^(-/-))in mice leads to a higher susceptibility to DSS-induced colitis than in wild-type,and the gut microbiome significantly changes in *** causal role of the gut microbiome is confirmed with a cohousing *** further identify that S100a8/9 is significantly up-regulated in Cmtm4^(-/-)colitis,with the block of its receptor RAGE that reverses the phenotype associated with the CMTM4 ***4 deficiency rather suppresses S100a8/9 expression in vitro via the IL17 pathway,further supporting that the elevation of S100a8/9 in vivo is most likely a result of microbial *** together,the results suggest that CMTM4 is involved in the maintenance of intestinal homeostasis,suppression of S100a8/9,and prevention of colitis *** study further shows CMTM4 as a crucial innate immunity component,confirming its important role in UC development and providing insights into potential targets for the development of future therapies.

关键词： Ulcerative colitis CMTM4 Gut microbiota IL-17 receptor C(IL-17RC) S100a8/9

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Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control

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贫困所致传染病(英文) 2024年第2期13卷 1-3页

作者： Ma Xuejiao Lu Shenning ding Wei Deng Shanying Wang Duoquan Xiao ning Mlacha Yeromin Husain Lewis Zhou Xiaonong National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Center for Tropical Diseases National Center for International Research On Tropical Diseases Shanghai China University of Hong Kong Hong Kong China School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China Ifakara Health Institute Dar-es-Salaam Tanzania Institute of Development Studies Brighton UK

Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China's partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK's partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China's engagement in global health by distilling the experience from the innovative tripartite partnership of the project.

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Electronic structures and Mott state of epitaxial TaS_(2) monolayers

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 91-97页

作者： Qichao Tian Chi ding Xiaodong Qiu Qinghao meng Kaili Wang Fan Yu Yuyang Mu Can Wang Jian Sun Yi Zhang National Laboratory of Solid State Microstructure School of PhysicsNanjing UniversityNanjing 20093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China School of Physics and Electronic Sciences Changsha University of Science and TechnologyChangsha 410114China Hefei National Laboratory Hefei 230088China

Layered material TaS2hosts multiple structural phases and exotic correlated quantum states,including charge density wave(CDW),superconductivity,quantum spin liquid,and Mott insulating ***,we synthesized TaS_(2)monolayers in H and T phases using the molecular beam epitaxial(MBE)method and studied their electronic structures via angle-resolved photoemission spectroscopy(ARPES).We found that the H phase TaS_(2)(H-TaS_(2))monolayer is metallic,with an energy band crossing the Fermi *** contrast,the T phase TaS_(2)(T-TaS_(2))monolayer shows an insulated energy gap at the Fermi level,while the normal calculated band structure implies it should be metallic without any band ***,by considering Hubbard interaction potential U,further density functional theory(DFT)calculation suggests that monolayer T-TaS_(2)could be a CDW Mott insulator,and the DFT+U calculation matches well with the ARPES *** significantly,the temperature-dependent ARPES result indicates that the CDW Mott state in the T-TaS_(2)monolayer is more robust than its bulk counterpart and can persist at room *** results reveal that the dimensional effect can enhance the CDW Mott state and provide valuable insights for further exploring the exotic properties of monolayer TaS2.

关键词： temperature monolayer state

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ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

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Nano Research 2024年第6期17卷 5409-5423页

作者： ding Wang Qi Jiang Ruoyu Shen Lijun Peng Wentao Zhou Tingting meng Fuqiang Hu Jianwei Wang Hong Yuan College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009China

The destruction of the intestinal barrier is likely to cause an increase in intestinal permeability and cause pathological *** studies have demonstrated that intestinal barrier function plays an important role in the occurrence and development of inflammatory bowel disease(IBD).Oral administration is the most common route for intestinal *** this study,a synergistic strategy is proposed for IBD management through active barrier repair combined with anti-inflammatory treatment,which can interrupt the pathological process of IBD,resulting in the significantly improved efficacy of existing *** on the specific pH values and high reactive oxygen species(ROS)levels in inflammatory sites of IBD,an orally administrated ROS-responsive drug delivery system targeting inflamed colon has been designed,and confirmed in vitro and in *** anti-inflammatory drug dexamethasone acetate(Dex)and the barrier function regulator LY294002 are delivered by the synthesized nanocarrier to treat IBD synergistically by inhibiting inflammation and actively repairing the intestinal barrier through tight junctions(TJs).The accumulation of nanocarriers in the inflamed colon and synergistic efficacy has been validated in mice with *** brief,a drug delivery system and a therapeutic strategy for IBD are successfully developed.

关键词： nanotechnology reactive oxygen species(ROS)-responsive targeted delivery inflammatory bowel disease(IBD) intestinal barrier combination treatment

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Evaluation and Influencing Factors on Particle Agglomeration in RAP

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 60-68页

作者：唐伟李宁 ZHUANG Yuan ZHAN He YU Xin WU Wenxiu ding Gongying College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China Jiangsu Expressway Engineering Maintenance Technology Center Nanjing 211106China Jinhua Highway and Transportation Management Center Jinhua 321000China

Asphalt extraction test and scanning electron microscopy(SEM) were used for analysis of agglomerations of reclaimed asphalt pavement(RAP) particles. In order to quantify the agglomeration degree of RAP, the fineness modulus ratio(FMR) and the percentage loss index(PLI) were proposed. In addition, grey correlation analysis was conducted to discuss the relationship between particle agglomerations and RAP size,asphalt content(AC), and surface area. Two indexes indicate that the agglomeration degree increases in general as the RAP size reduces. This can be attributed to that particles are prone to agglomeration in the case of higher AC. Based on the SEM images and the material composition of RAP, the particle agglomeration in RAP can be classified into weak agglomeration and strong agglomeration. Grey correlation analysis shows that AC is the crucial factor affecting the agglomeration degree and RAP variability. In order to produce consistent and stable reclaimed mixtures, disposal measures of RAP are suggested to lower the AC of RAP.

关键词： RAP particle agglomeration grey correlation analysis asphalt content

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DLX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5B axis in TDO-iPSCs-derived MSCs

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Genes & Diseases 2024年第4期11卷 49-52页

作者： Liying Dong Na Zhao Dongmei Wang meng Wang Yixin Zhang Liangjie Sun Chong ding Yixiang Wang Zeyun Ma Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China Department of Oral and Maxillofacial Surgery Peking University School and Hospital of StomatologyBeijing 100081China National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of StomatologyBeijing 100081China Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of StomatologyBeijing 100081China The Second Clinical Division Peking University School and Hospital of StomatologyBeijing 100081China Department of VIP Service Peking University School and Hospital of StomatologyBeijing 100081China Department of Restorative Dentistry and Biomaterials Sciences Harvard School of Dental MedicineBostonMA 02115USA Department of Prosthodontics Fudan UniversityShanghai 200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological HospitalFudan UniversityShanghai 200001China

Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO ***... 详细信息

关键词： patients clinically alveolar

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Pachymic acid exerts antitumor activities by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 170-180页

作者： Hao Zhang Kun Zhu Xue-Feng Zhang Yi-Hui ding Bing Zhu Wen meng Qing-Song ding Fan Zhang Department of Emergency Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006ZhejiangChina Department of Cardiothoracic Surgery The Third Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161000HeilongjiangChina Department of Cardiothoracic Surgery The Affiliated Heilongjiang Provincial Hospital of Harbin Institute of TechnologyHarbin 150036HeilongjiangChina

Objective:To determine the inhibitory effects of pachymic acid on lung adenocarcinoma(LUAD)cells and elucidate its underlying ***:CCK-8,wound healing,Transwell,Western blot,tube formation,and immunofluorescence assays were carried out to measure the effects of various concentrations of pachymic acid on LUAD cell proliferation,metastasis,angiogenesis as well as ***,molecular docking technology was used to detect the potential targeted binding association between pachymic acid and protein tyrosine phosphatase 1B(PTP1B).Moreover,PTP1B was overexpressed in A549 cells to detect the specific mechanisms of pachymic ***:Pachymic acid suppressed LUAD cell viability,metastasis as well as angiogenesis while inducing cell *** also targeted PTP1B and lowered PTP1B ***,PTP1B overexpression reversed the effects of pachymic acid on metastasis,angiogenesis,and autophagy as well as the expression of Wnt3a andβ-catenin in LUAD ***:Pachymic acid inhibits metastasis and angiogenesis,and promotes autophagy in LUAD cells by modulating the Wnt/β-catenin signaling pathway via targeting PTP1B.

关键词： Pachymic acid Lung adenocarcinoma Protein tyrosine phosphatase 1B Wnt/β-catenin signaling pathway Metastasis Angiogenesis Autophagy

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Valence-tailored copper-based nanoparticles for enhanced chemodynamic therapy through prolonged ROS generation and potentiated GSH depletion

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Nano Research 2024年第7期17卷 6342-6352页

作者： Xinyang Li Binbin ding Jing Li Di Han Hao Chen Jia Tan Qi meng Pan Zheng Ping’an Ma Jun Lin State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Chemodynamic therapy(CDT),an inventive approach to cancer treatment,exploits innate chemical processes to trigger cell death through the generation of reactive oxygen species(ROS).While offering advantages over conventional treatments,the optimization of CDT efficacy presents challenges stemming from suboptimal catalytic efficiency and the counteractive ROS scavenging effect of intracellular glutathione(GSH).In this study,we aim to address this dual challenge by delving into the role of copper valence states in *** the unique attributes of copper-based nanoparticles,especially zero-valent copper nanoparticles(CuPd NPs),we aim to enhance the therapeutic potential of *** experiments reveal that zero-valent CuPd NPs outperform divalent copper nanoparticles(Ox-CuPd NPs)by displaying superior catalytic performance and sustaining ROS generation through a dual approach integrating peroxidase-like(POD-like)activity and Cu+***,zero-valent NPs exhibit enhanced GSH depletion compared to their divalent counterparts,thereby intensifying CDT and inducing ferroptosis,ultimately resulting in high-efficiency tumor growth *** findings reveal the impact of valences on CDT,providing novel insights for the optimization and design of CDT agents.

关键词： CuPd nanoparticle ferroptosis chemodynamic therapy valance tailoring tumor therapy

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第1期15卷 42-51页

作者： Qing-Quan LI Miao BI Song YANG Qing-Yuan WU Yi-Hui ding Xin-Yong SHEN Xiao-Ting SUN meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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Enhanced thermoelectric performance enabled by compositing ZrO_(2)in n-type SiGe alloy with low thermal conductivity

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Rare Metals 2024年第3期43卷 1167-1176页

作者： meng-Fei Wang Hua-Jun Lai Ji-Sheng Liang Jun-Liang Chen Wang-Yang ding Qi Zhou Ying Peng Cheng-Yan Liu Lei Miao Guangxi Key Laboratory for Relativity Astrophysics State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite StructuresSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China Guangxi Academy of Sciences Nanning530007China Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesGuilin University of Electronic TechnologyMinistry of EducationGuilin541004China Guangxi Key Laboratory of Precision Navigation Technology and Application School of Information and CommunicationGuilin University of Electronic TechnologyGuilin541004China

SiGe-based thermoelectric(TE)materials have gained increasing interests due to their low maintenance costs,environmental friendliness and long ***,the intrinsically high thermal conductivity of Si-based materials also results in poor TE *** this investigation,a zirconia(ZrO_(2))composite strategy was applied to an n-type SiGe alloy,tremendously elevating its TE *** mechanical alloying and spark plasma sintering(SPS)processes,the ZrO_(2)induced the formation of nanopores in the SiGe matrix via phosphorus ***,such increase in porosity enhanced the phonon scattering and dramatically suppressed lattice thermal conductivity,from 2.83 to 1.59 W·m^(-1)·K^(-1)at 873 ***,reduced phosphorus doping led to an increase in Seebeck coefficients and a relatively minor decrease in electrical conductivity,The power factor didn't deteriorate significantly,either,as its maximum of~3.43 mW·m^(-1-)K^(-2)was achieved at 873 K with(Si_(0.8)Ge_(0.2))_(0.097)P_(0.03)(ZrO_(2))_(0.003).In short,a peak figure of merit(ZT)of~1.27 at 873 K and an average ZT~0.7 from 323 to 873 K were *** study demonstrates that the electrical and thermal transportation of SiGe material can be synergistically tuned by compositing ZrO_(2),illustrating a novel strategy to optimize the TE properties of bulk materials.

关键词： Thermoelectric SiGe alloy ZrO2 composting P element adsorption nanopores

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