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Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： WANG lu-ming ZHANG Wen-lan LYU Nuan SUO Yan-rong YANG Lin YU Bin JIANG Xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human ***-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to ***-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque *** paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU meng-qing LI lan YU Ai-ling CHEN Ken HUANG Yun-ke ZHAO Qiu-long HUANG Wen-ya HUANG Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous ***:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass *** 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table *** coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were *** 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA *** oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were *** was developed as a GXⅡproxy of ex vivo herbal crude ***:PGSDS effectively eliminates false responses caused by crude GXⅡ*** doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular *** ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)*** increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong lu Zhen Zheng Xiaobing lan Yi Wang Yan Zheng Xuefeng lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

Editorial:special topic on advanced energy catalytic materials

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Science China Materials 2024年第6期67卷 1681-1683页

作者： Shaojun Guo Yaqian lan School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Chemistry South China Normal UniversityGuangzhou 510630China

Aiming to lowering the society’s dependence on fossil fuels,energy catalysis stands at the forefront of technological advancement,which promises to revolutionize the way we harness,convert,and utilize renewable *** current special topic of our journal,titled"Advanced Energy Catalytic Materials",aims to highlight the latest innovations,challenges,and opportunities in this exciting field.

关键词： field utilize catalysis

Heterosis effect for larval performance of fall armyworm interstrain hybrids

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Insect Science 2024年第4期31卷 1296-1312页

作者： Laijiao lan Nicolas Nègre DGIMI University of MontpellierINRAEMontpellierFrance

Spodoptera frugiperda,also known as fall armyworm(FAW),is an invasive crop pest that can feed on a variety of host plants,posing a serious threat to food *** are two sympatric strains of FAW that are morphologically identical but described with different food preferences:the“rice strain”(SfR)and the“corn strain”(SfC).A few genetic loci exist to identify these two *** and Z-chromosome-linked haplotypes are the most used,but the biggest part of the genome displays little polymorphism between strains that could explain their adaptation to different *** have previously observed consistent transcription differences between the strains in both laboratory and natural ***,we wonder if there are effects from host-strain-associated loci,maternally or paternally inherited,on FAW performance that could explain the divergence between the two FAW *** test this hypothesis,we first produced two F1 hybrid generations(SfR♀×SfC♂,SfC♀×SfR♂).These reciprocal hybrids should be heterozygous for all chromosomes except for the maternally inherited mitochondrial and sexual W *** evaluate whether plant preference is determined by these genetic loci,we cultivated the two hybrids and the two parental strains in triplicate on an artificial diet and recorded several phenotypic traits such as weight over time,survival rate,emerging rate,developmental time,and sex ***,the same performance experiment was carried out on corn ***,on the artificial diet,the two hybrid genotypes were both more performant than the two parental strains in terms of survival rate,pupal emerging rate,and developmental time,whereas they were intermediate to the inbred parental strains in pupal *** the corn plant diet,both hybrid genotypes outperformed the two parental strains in larval *** these asymmetrical results revealed that mitochondrial or sex-linked haplotypes alone cannot explain the performance differences

关键词： fall armyworm Haldane's rule heterosis hybrid performance mitochondria

Preparation of(lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)phosphor ceramics with high thermal stability for near-infrared LED/LD

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Journal of Advanced Ceramics 2024年第3期13卷 354-363页

作者： Yuelong Ma Xingcan Li lan Wu Chenyang Shao Boqiang Zhang Tao Pang Lili lu Hui Qiu Ye Tian Guilu Wang Yanbo Hui Qianwen Guo Daqin Chen School of Mechanical and Electrical Engineering Henan University of TechnologyZhengzhou 450001China Huzhou Key Laboratory of Materials for Energy Conversion and Storage College of ScienceHuzhou UniversityHuzhou 313000China College of Physics and Energy Fujian Normal UniversityFuzhou 350117China SongShan Laboratory Zhengzhou 450046China College of Food Science and Engineering Henan University of TechnologyZhengzhou 450046China School of Mechanical Engineering Zhengzhou University of Science and TechnologyZhengzhou 450064China

Near-infrared(NIR)phosphor-converted light-emitting diodes/laser diodes(LEDs/LDs)are prospective lighting sources for NIR ***,developing NIR phosphor materials with desired thermal robustness and high photoelectric efficiency is a crucial challenge for their *** this work,based on the cationic radius matching effect,a series of(lu,Y)_(3)(Al,Sc,Cr)_(2)Al_(3)O_(12)NIR phosphor ceramics(luYScCr NIR-PCs)were fabricated by vacuum *** thermal stability(95%@150℃)was obtained in the prepared NIR-PCs,owing to their weak electron-phonon coupling effect(small Huang-Rhys factor).Being excited at 460 nm,NIR-PCs realized a broadband emission(650-850 nm)with internal quantum efficiency(IQE)of 60.68%.Combining NIR-PCs with LED/LD chips,the maximum output power of the encapsulated LED prototype was 447 mW@300 mA with photoelectric efficiency of as high as 18.6%@180 mA,and the maximum output power of the LD prototype was 814 mW@2.5 *** working temperatures of NIR-PCs were 70.8℃@300 mA(LED)and 102.8℃@3 A(LD).Finally,the prepared NIR-PCs applied in food detection were verified in this study,demonstrating their anticipated application prospects in the future.

关键词： thermal stability electron phonon coupling effect photoelectric efficiency near-infrared phosphor ceramics(NIR-PCs) NIR light-emitting diode/laser diode(LED/LD)prototype

Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第6期14卷 930-932页

作者： Xiao-lan Li Jian-qing Zhang Yun Li Xuan-jing Shen Huan-ya Yang Lin Yang meng Xu Qi-rui Bi Chang-liang Yao De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Academy of Sciences Beijing100049China

Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription

Taphonomy and Paleoecology of Lycoptera: A Case Study from the Lower Jehol Group in Western Liaoning, Northeastern China

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Journal of Earth Science 2024年第3期35卷 737-746页

作者： Zhongwu lan Rong Cao Shujing Zhang State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430078China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geology Trinity CollegeDublin 999015Ireland

Taphonomy and paleoecology(biological behavior)of the Early Cretaceous fish fossils are poorly *** study reports for the first time a detailed taphonomical and paleoecological study on Lycoptera in the Mesozoic strata of western Liaoning Province,NE *** XRD analysis shows that gismondine is the dominant clay minerals that could have contributed to the preservation of Lycoptera fossils and microbial mat fragments in the fossil-bearing *** may have formed under volcanism-related hydrothermal regime that was transformed from crystal and lithic ***μ-XRF imaging analysis shows a dominant chemical composition of Al,Si,P,S,Rh,K,Ca,Ti,C,Cr,Mn,Fe,Ni,among which P,Ca,C and S are enriched in the fish skeleton in comparison to the *** suggests a dominant apatite composition for the fish *** influence did not smear off these organic signals probably because of protection of *** coexistance of C and S with Ni is assumed to represent recovered primary productivity following volcanic explosions and toxic gas *** head of juvenile fish stays close to the body of adult *** further discoveries,such phenomenon is interpreted to suggest that adult fish actively protected juvenile fish in the presence of environmental pressures such as anoxia and deterioration of water quality induced by *** acidification and hypoxia in association with volcanism created a harmful environment causing mass extinction of *** adult Lycoptera protected their juveniles by its body at the moment before *** biological behavior will be increasingly reported given the wide occurrence of Lycoptera in Mesozoic strata.

关键词： Lycoptera taphonomy paleoecology fish Jehol Group NE China.

Surrogate modeling for unsaturated infiltration via the physics and equality-constrained artificial neural networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2282-2295页

作者： Peng lan Jingjing Su Sheng Zhang School of Civil Engineering Central South UniversityChangsha410075China Discipline of Civil Surveying and Environmental EngineeringPriority Research Centre for Geotechnical Science and EngineeringThe University of NewcastleCallaghanNSW2308Australia Qinghai University Qinghai810016China

Machine learning(ML)provides a new surrogate method for investigating groundwater flow dynamics in unsaturated *** pure data-driven methods(*** neural network,DNN)can provide rapid predictions,but they do require sufficient on-site data for accurate training,and lack interpretability to the physical processes within the *** this paper,we provide a physics and equalityconstrained artificial neural network(PECANN),to derive unsaturated infiltration solutions with a small amount of initial and boundary *** takes the physics-informed neural network(PINN)as a foundation,encodes the unsaturated infiltration physical laws(*** equation,RE)into the loss function,and uses the augmented Lagrangian method to constrain the learning process of the solutions of RE by adding stronger penalty for the initial and boundary *** unsaturated infiltration cases are designed to test the training performance of PECANN,***-dimensional(1D)steady-state unsaturated infiltration,1D transient-state infiltration,two-dimensional(2D)transient-state infiltration,and 1D coupled unsaturated infiltration and *** predicted results of PECANN are compared with the finite difference solutions or analytical *** results indicate that PECANN can accurately capture the variations of pressure head during the unsaturated infiltration,and present higher precision and robustness than DNN and *** is also revealed that PECANN can achieve the same accuracy as the finite difference method with fewer initial and boundary training ***,we investigate the effect of the hyperparameters of PECANN on solving RE *** provides an effective tool for simulating unsaturated infiltration.

关键词： Richards equation(RE) Unsaturated infiltration Data-driven solutions Numerical modeling Machine learning(ML)