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Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells

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World Journal of Gastroenterology 2022年第11期28卷 1139-1158页

作者： Hsi-Lung Hsieh Ming-Chin Yu Li-Ching Cheng Mei-Yi Chu Tzu-Hao Huang Ta-Sen yeh Ming-Ming Tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333TaiwanChina Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333TaiwanChina Department of Neurology Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina Department of General Surgery Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

BACKGROUND Gastric injury is the most common digestive system disease worldwide and involves inflammation,which can lead to gastric ulcer or gastric cancer(GC).Matrix metallopeptidase-9[MMP-9(gelatinase-B)]plays an important role in inflammation and GC *** and quercetin-rich diets represent potential food supplements and a source of medications for treating gastric injury given their anti-inflammatory ***,the effects and mechanisms of action of quercetin on human chronic gastritis and whether quercetin can relieve symptoms remain *** To assess whether tumor necrosis factor-α(TNF-α)-induced MMP-9 expression mediates the anti-inflammatory effects of quercetin in normal human gastric mucosal epithelial *** The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-α-induced MMP-9 protein overexpression to evaluate the antiinflammatory effects of *** cell counting Kit-8 assay was used to evaluate the effects of varying quercetin doses on cell viability in the normal GES-1 cell *** migration was measured using Transwell *** expression of proto-oncogene tyrosine-protein kinase Src(cSrc),phospho(p)-c-Src,extracellular-signal-regulated kinase 2(ERK2),p-ERK1/2,c-Fos,p-c-Fos,nuclear factor kappa B(NF-κB/p65),and p-p65 and the effects of their inhibitors were examined using Western blot analysis and measurement of luciferase activity.p65 expression was detected by ***-9 m RNA and protein levels were measured by quantitative reverse transcription polymerase chain reaction(q RT–PCR)and gelatin zymography,*** q RT-PCR and gelatin zymography showed that TNF-αinduced MMP-9 m RNA and protein expression in a dose-and time-dependent *** effects were reduced by the pretreatment of GES-1 cells with quercetin or a TNF-αantagonist(TNFR inhibitor)in a dose-and timedependent *** and TNF-αa

关键词： Anti-inflammatory Quercetin Matrix metallopeptidase-9 Tumor necrosis factor-α Normal human gastric epithelial cells

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Stress-controlled fatigue of HfNbTaTiZr high-entropy alloy and associated deformation and fracture mechanisms

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Journal of Materials Science & Technology 2022年第19期114卷 191-205页

作者： Shuying Chen Weidong Li Ling Wang Tao Yuan Yang Tong Ko-Kai Tseng Jien-Wei yeh Qingang Xiong Zhenggang Wu Fan Zhang Tingkun Liu Kun Li Peter KLiaw Institute for Advanced Studies in Precision Materials Yantai UniversityYantai 264005China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Department of Industrial and Systems Engineering Ohio UniversityAthensOH 45701USA Department of Materials Science and Engineering High Entropy Materials CenterNational Tsing Hua UniversityHsinchu30013TaiwanChina State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China School of Light Industry and Engineering South China University of TechnologyGuangzhou 510640China College of Materials Science and Engineering Hunan UniversityChangsha 410082China WPI Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China

The stress-controlled fatigue tests are carried out at a stress ratio of 0.1 and a frequency of 10 Hz,and span both low-cycle and high-cycle regimes by varying the applied stress *** high-cycle fa-tigue regime gives a fatigue strength of 497 MPa and a fatigue ratio of *** equivalent conditions,the alloy’s fatigue strength is greater than all other high-entropy alloys(HEAs)with reported high-cycle fatigue data,dilute body-centered cubic alloys,and many structural alloys such as steels,titanium al-loys,and aluminum *** in-depth analyses of crack-propagation trajectories,fracture-surface morphologies and deformation plasticity by means of various microstructural analysis techniques and theoretical frameworks,the alloy’s remarkable fatigue resistance is attributed to delayed crack initiation in the high-cycle regime,which is achieved by retarding the formation of localized persistent slip bands,and its good resistance to crack propagation in the low-cycle regime,which is accomplished by intrin-sic toughening backed up by extrinsic ***,the stochastic nature of the fatigue data is neatly captured with a 2-parameter Weibull model.

关键词： Fatigue mechanisms Intrinsic toughening Extrinsic toughening Probabilistic modeling

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Waiting Time Distribution of Coronal Mass Ejections

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Chinese Journal of Astronomy and Astrophysics 2005年第2期5卷 193-197页

作者： Chin-Teh yeh Department of Astronomy Nanjing University Nanjing 210093

Inspired by the finding that the large waiting time of solar flares presents a power-law distribution, we investigate the waiting time distribution (WTD) of coronal mass ejections (CMEs). SOHO/LASCO CME observations from 1996 to 2003 are used in this study. It is shown that the observed CMEs have a similar power-law behavior to the flares, with an almost identical power-law index. This strongly supports the viewpoint that solar flares and CMEs are different manifestations of the same physical process. We have also investigated separately the WTDs of fast-type and slow-type CMEs and found that their indices are identical, which imply that both types of CME may originate from the same physical mechanism.

关键词： solar flares coronal mass ejections

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Respiratory training interventions improve health status of heart failure patients: A systematic review and network meta-analysis of randomized controlled trials

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World Journal of Clinical Cases 2019年第18期7卷 2760-2775页

作者： Mei-Hua Wang Mei-Ling yeh School of Nursing National Taipei University of Nursing and Health Sciences

BACKGROUND Prior studies indicate that doing breathing exercises improves physical performance and quality of life (QoL) in heart failure patients. However, these effects remain unclear and contradictory. AIM To determine the effects of machine-assisted and non-machine-assisted respiratory training on physical performance and QoL in heart failure patients. METHODS This was a systematic review and network meta-analysis study. A literature search of electronic databases was conducted for randomized controlled trials (RCTs) on heart failure. Respiratory training interventions were grouped as seven categories: IMT_Pn (inspiratory muscle training without pressure or < 10% maximal inspiratory pressure, MIP), IMT_Pl (inspiratory muscle training with low pressure, 10%-15% MIP), IMT_Pm (inspiratory muscle training with medium pressure, 30%-40% MIP), IMT_Ph (inspiratory muscle training with high pressure, 60% MIP or MIP plus aerobics), Aerobics (aerobic exercise or weight training), Qi_Ex (tai chi, yoga, and breathing exercise), and none. The four outcomes were heart rate, peak oxygen uptake (VO2 peak), 6-min walking distance test (6MWT), and Minnesota Living with Heart Failure QoL. The random-effects model, side-splitting model, and the surface under the cumulative ranking curve (SUCRA) were used to test and analyze the data. RESULTS A total of 1499 subjects from 31 RCT studies were included. IMT_Ph had the highest effect sizes for VO2 peak and 6MWT, IMT_Pm highest for QoL, and Qi_Ex highest for heart rate. Aerobics had the second highest for VO2 peak, Qi_Ex second highest for 6MWT, and IMT_Ph second highest for heart rate and *** This study supports that high- and medium-intensity machine-assisted training improves exercise capacity and QoL in hospital-based heart failure patients. After hospital discharge, non-machine-assisted training continuously improves cardiac function.

关键词： Heart failure Network meta-analysis Respiratory training Cardiac function Exercise capacity Quality of life

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Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms

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World Journal of Pediatrics 2022年第11期18卷 761-770页

作者： Lin Wan Chu-Ting Zhang Gang Zhu Jian Chen Xiu-Yu Shi Jing Wang Li-Ping Zou Bo Zhang Wen-Bin Shi Chien-Hung yeh Guang Yang Senior Department of Pediatrics Chinese PLA General HospitalBeijing100000China Department of Pediatrics the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese People’s Liberation Army BeijingChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Neurology and ICCTR Biostatistics and Research Design Center Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a *** sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain *** We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of *** recurrence of epileptic spasms following treatment was tracked for 12 *** were categorized as either non-relapse or relapse *** clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group *** Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a *** BASED score was significantly higher in the relapse *** in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse *** BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural *** with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.

关键词： Burden of amplitudes and epileptiform discharges score Infantile spasms Multiscale entropy Prediction Relapse

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Prognosis and feasibility of en-bloc vascular resection in stage Ⅱ pancreatic adenocarcinoma

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World Journal of Gastroenterology 2010年第8期16卷 997-1002页

作者： K Dilip Chakravarty Jun-Te Hsu Chun-Nan yeh Ta-Sen yeh Tsann-Long Hwang Miin-Fu Chen Department of General Surgery Chang Gung Memorial Hospital

AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage pancreatic adenocarcinoma of the head and uncinate ***:We retrospectively analyzed 87 patients with stage pancreatic adenocarcinoma,who were subjected to pancreaticoduodenectomy (PD) and pylo-rus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital,Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV),***:The overall 1-and 3-year survival rates of patients undergoing PD/PPPD with and without vas-cular resection were 50.0% and 16.7%,and 44.4% and 12.2%,respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%,and 40.0% and 2.7%,respectively. In multivariate analysis,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced ***:In stage adenocarcinoma of the pancreatic head and uncinate process,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors,and en-bloc vascular resection is a feasible option in carefully selected patients.

关键词： Pancreatic neoplasms Adenocarcinoma Portal vein Superior mesenteric vein Pancreaticoduo-denectomy Chemotherapy

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Oxidation mechanism of aluminum nitride revisited

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Journal of Advanced Ceramics 2017年第1期6卷 27-32页

作者： Chun-Ting yeh Wei-Hsing TUAN Department of Materials Science and Engineering 'National Taiwan University' Taipei Taiwan 106 China

Different from the oxidation kinetics of other nitrides, the oxide layer on AlN can easily reach tens of micrometers at a temperature above 1200 °C. In the present study, the oxidation mechanism of AlN is investigated through microstructure observation. The analysis indicates that the oxide layer is full of small pores. The formation of pores generates additional surface area to induce further reaction. The reaction thus controls the oxidation in the temperature range from 1050 to 1350 °C. The oxidation rate becomes slow as the oxide layer reaches a critical thickness.

关键词： oxidation mechanism aluminum nitride diffusion reaction

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Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

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Bioactive Materials 2023年第10期28卷 112-131页

作者： Yuanyuan Jin Jiabin Zhang Yanteng Xu Ke Yi Fenfang Li Huicong Zhou Haixia Wang Hon Fai Chan yeh-Hsing Lao Shixian Lv Yu Tao Mingqiang Li Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou510630China Guangdong Provincial Key Laboratory of Liver Disease Research Guangzhou510630China School of Materials Science and Engineering Peking UniversityBeijing100871China Institute for Tissue Engineering and Regenerative Medicine School of Biomedical ScienceThe Chinese University of Hong Kong999077Hong KongChina Department of Pharmaceutical Sciences University at BuffaloThe State University of New YorkBuffaloNY14214USA

Reactive oxygen species(ROS)-associated oxidative stress,inflammation storm,and massive hepatocyte necrosis are the typical manifestations of acute liver failure(ALF),therefore specific therapeutic interventions are essential for the devastating ***,we developed a platform consisting of versatile biomimetic copper oxide nanozymes(Cu NZs)-loaded PLGA nanofibers(Cu NZs@PLGA nanofibers)and decellularized extracellular matrix(dECM)hydrogels for delivery of human adipose-derived mesenchymal stem/stromal cells-derived hepatocyte-like cells(hADMSCs-derived HLCs)(HLCs/Cu NZs@fiber/dECM).Cu NZs@PLGA nanofibers could conspicuously scavenge excessive ROS at the early stage of ALF,and reduce the massive accumulation of pro-inflammatory cytokines,herein efficiently preventing the deterioration of hepatocytes ***,Cu NZs@PLGA nanofibers also exhibited a cytoprotection effect on the transplanted ***,HLCs with hepatic-specific biofunctions and anti-inflammatory activity acted as a promising alternative cell source for ALF *** dECM hydrogels further provided the desirable 3D environment and favorably improved the hepatic functions of *** addition,the pro-angiogenesis activity of Cu NZs@PLGA nanofibers also facilitated the integration of the whole implant with the host ***,HLCs/Cu NZs@fiber/dECM performed excellent synergistic therapeutic efficacy on ALF *** strategy using Cu NZs@PLGA nanofiber-reinforced dECM hydrogels for HLCs in situ delivery is a promising approach for ALF therapy and shows great potential for clinical translation.

关键词： Acute liver failure Nanozyme Hepatocyte-like cells Human adipose-derived mesenchymal stem/stromal cells Electrospun nanofiber

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Low-power laser irradiation promotes the proliferation and osteogenic differentiation of human periodontal ligament cells via cyclic adenosine monophosphate

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International Journal of Oral Science 2013年第2期5卷 85-91页

作者： Jyun-Yi Wu Chia-Hsin Chen Li-Yin yeh Ming-Long yeh Chun-Chan Ting Yan-Hsiung Wang Institute of Biomedical Engineering National Cheng Kung University Department of Physical Medicine and Rehabilitation Kaohsiung Medical University Hospital Department of Physical Medicine and Rehabilitation Faculty of MedicineCollege of MedicineKaohsiung Medical University Department of Physical Medicine and Rehabilitation Kaohsiung Municipal Ta-Tung Hospital Department of Oral Hygiene College of MedicineKaohsiung Medical University School of Dentistry College of Dental MedicineKaohsiung Medical University Orthopaedic Research Center College of MedicineKaohsiung Medical University

Retaining or improving periodontal ligament （PDL） function is crucial for restoring periodontal defects. The aim of this study was to evaluate the physiological effects of low-power laser irradiation （LPLI） on the proliferation and osteogenic differentiation of human PDL （hPDL） cells. Cultured hPDL cel Is were irradiated （660 nm） daily with doses of O, 1, 2 or 4 J .cm-2. Cell proliferation was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide （MTT） assay, and the effect of LPLI on osteogenic differentiation was assessed by Alizarin Red S staining and alkaline phosphatase （ALP） activity. Additionally, osteogenic marker gene expression was confirmed by real-time reverse transcription-polymerase chain reaction （RT-PCR）. Our data showed that LPLI at a dose of 2 ***-2 significantly promoted hPDL cell proliferation at days 3 and 5. In addition, LPLI at energy doses of 2 and 4 ***-2 showed potential osteogenic capacity, as it stimulated ALP activity, calcium deposition, and osteogenic gene expression. We also showed that cyclic adenosine monophosphate （cAMP） is a critical regulator of the LPLI-mediated effects on hPDL cells. This study shows that LPLI can promote the proliferation and osteogenic differentiation of hPDL cells. These results suggest the potential use of LPLI in clinical applications for periodontal tissue regeneration.

关键词： cell proliferation cyclic adenosine monophosphate human periodontal ligament cells low-power laser irradiation osteogenic differentiation

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Novel supervised classification approach for multifrequency polarimetric SAR data

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Journal of Systems Engineering and Electronics 2015年第6期26卷 1216-1221页

作者： Biao You Bin Xu Jian Yang Chunmao yeh Jianshe Song Department of Electronic Engineering Tsinghua University Beijing Institute of Radio Measurement Xi'an Research Institute of Hi-Technology

A novel method is proposed for the supervised classification of multifrequency polarimetric synthetic aperture radar （PolSAR） images. The coherency matrices in P-, L-, and C-bands are mapped onto a 9×9 matrix Ω based on the eigenvalue decomposition of the coherency matrix of each band. A boxcar filter is then performed on the matrix Ω. The filtered data are put into a complex Wishart classifier. Finally, the effectiveness of the proposed method is demonstrated with JPL/AIRSAR multifrequency PolSAR data acquired over the Flevoland area.

关键词： synthetic aperture radar (SAR) polarimetry classifi-cation multifrequency.

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