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Current Medical Science 2024年第2期44卷 261-272页

作者： meng-jie wang Yu XIA Qing-lei GAO Department of Obstetrics and Gynecology National Clinical Research Center for Obstetrics and GynecologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Cancer Invasion and Metastasis(Ministry of Education) Hubei Key Laboratory of Tumor Invasion and MetastasisTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

DNA damage occurs across tumorigenesis and tumor *** intrinsic DNA damage can not only increase the risk of mutations responsible for tumor generation but also initiate a cellular stress response to orchestrate the tumor immune microenvironment(TIME)and dominate tumor *** evidence documents that multiple signaling pathways,including cyclic GMP-AMP synthase-stimulator of interferon genes(cGAS-STING)and ataxia telangiectasia-mutated protein/ataxia telangiectasia and Rad3-related protein(ATM/ATR),are activated downstream of DNA damage and they are associated with the secretion of diverse *** cytokines possess multifaced functions in the anti-tumor immune ***,it is necessary to deeply interpret the complex TIME reshaped by damaged DNA and tumor-derived cytokines,critical for the development of effective tumor *** manuscript comprehensively reviews the relationship between the DNA damage response and related cytokines in tumors and depicts the dual immunoregulatory roles of these *** also summarize clinical trials targeting signaling pathways and cytokines associated with DNA damage and provide future perspectives on emerging technologies.

关键词： DNA damage tumor immune microenvironment inflammatory cytokines cancer therapy

Inhibition of Cyclin F Promotes Cellular Senescence through Cyclin-dependent Kinase 1-mediated Cell Cycle Regulation

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Current Medical Science 2023年第2期43卷 246-254页

作者： Xun LI You-jian LI meng-jie wang Ke-peng OU Ya-qi CHEN GI Cancer Research Institute Tongji HospitalHuazhong University of Science and TechnologyWuhan430030China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing402160China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China College of Pharmaceutical Sciences and Chinese Medicine Southwest UniversityChongqing400715China

Objective Kidney renal clear cell carcinoma(KIRC)is a common renal malignancy that has a poor *** a member of the F box family,cyclin F(CCNF)plays an important regulatory role in normal tissues and ***,the underlying mechanism by which CCNF promotes KIRC proliferation still remains *** Bioinformatics methods were used to analyze The Cancer Genome Atlas(TCGA)database to obtain gene expression and clinical prognosis *** CCK8 assay,EdU assay,and xenograft assay were used to detect cell *** cell senescence and potential mechanism were assessed by SA-β-gal staining,Western blotting,as well as *** Our data showed that CCNF was highly expressed in KIRC ***,downregulation of CCNF inhibited cell proliferation in vivo and in *** studies showed that the reduction of CCNF promoted cell senescence by decreasing cyclin-dependent kinase 1(CDK1),increasing the proinflammatory factors interleukin(IL)-6 and IL-8,and then enhancing the expression of p21 and *** We propose that the high expression of CCNF in KIRC may play a key role in tumorigenesis by regulating cell ***,CCNF shows promise as a new biomarker to predict the clinical prognosis of KIRC patients and as an effective therapeutic target.

关键词： cyclin F kidney renal clear cell carcinoma clinical outcome cyclin-dependent kinase 1 senescence

Analysis of uterine artery and sex hormones in treating diminished ovarian reserve with tiaojing decoction

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TMR Theory and Hypothesis 2019年第4期2卷 252-259页

作者： meng-jie wang Hui-Jun Xu Master of Science in Integrated Traditional Chinese and Western Medicine Center College of Basic Medical SciencesQingdao UniversityQingdaoChina Women's Division Qingdao Haici Medical GroupQingdaoChina

Objective: To observe the effect of tiaojing decoction and climen on diminished ovarian reserve patients with de ficiency of Kidney-Yin by sex hormone and uterine artery blood flow parameters. To verify the e ffectiveness of tiaojing decoction on diminished ovarian reserve and uterine artery blood flow parameters, explore the correlation between uterine artery blood flow parameters and sex hormones. Methods: Total 60 diminished ovarian reserve patients with deficiency of Kidney-Yin were randomly divided into the experimental group (n=30, taking tiaojing decoction and climen) and the control group (n=30, taking climen) and they were treated in 3 months. Observe bFSH, bE2, uterine artery PSV, EDV, S/D, RI before and after the treatment in the 2-4 day of menstruation. Results: After treatment, serum sex hormone levels and uterine artery blood flow parameters of the two groups were significantly different (P < 0.05), and the experimental group was significantly better than the control group. There was a linear correlation between PSV and FSH, PSV and E2, FSH and E2. Conclusion: Tiaojing decoction combined with climen has significant effect on diminished ovarian reserve patients with deficiency of Kidney-Yin. Uterine artery blood flow parameters can reflect the sex hormone levels.

关键词： Diminished Ovarian Reserve Tiaojing decoction Uterine artery blood flow

Over-expression of PPARγcan Down-regulate Skp2 Expression in Human Breast Tumor Cells

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Over-expression of PPARγcan Down-regulate Skp2 Expression i...

A clinical protocol: A double-blinded, randomized controlled trial on the effect of traditional Chinese medicine formula Shoutai Pill in the treatment of threatened abortion

中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议

作者： meng jie,wang huimin Laboratory Medicine Center,Affiliated hospital of Nantong University

Objective Skp2 is frequent amplified and overexpressed in breast cancer,making Skp2 a potential molecular target for cancer *** objective of this study was to examine the effect of PPARγoverexpression on Skp2 expression regulation in breast cancer cell *** this study, we investigated the role of PPARγand Skp2 in human breast cancer progression. Methods Immunohistochemical analysis was

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Clinical Research Communications 2021年第3期4卷 1-6页

作者： Li Li Jing-Yan Song Wen-Xiu Yang Cheng-Cheng Ji Yi-Ming Che meng-jie wang Ying-Xin wang Ning Zhang Shandong University of Traditional Chinese Medicine Jinan 250014ShandongChina Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014ShandongChina

for about 20%of all clinically confirmed *** is the main cause of early *** bleeding is the main clinical manifestation,which seriously affects the mental health and quality of life of pregnant ***,there is effective treatment for this condition.A recent meta-analysis showed that Shoutai Pill(ST Pill),a traditional Chinese medicine(TCM)formula,can effectively decrease the rate of threatened ***,high heterogeneity was found among the studies included in the meta-analysis,this conclusion on the efficacy of TCM is not *** several have been conducted,some of them do not describe randomization and blinding *** address these problems,this article proposes an improved clinical treatment scheme based on ST Pill,which is to be tested through a well-designed randomized controlled trial,for the treatment of threatened ***:This is a double-blinded,randomized,placebo-controlled trial to be conducted in a public Three-A hospital in China's Mainland.A total of 200 people will be *** computer-generated random numbers,the participants will be randomly divided into two groups at a ratio of 1:1(treatment group(treated with ST Pill group)and placebo group).Both groups will receive medication to the end of the 20th gestational week or 1 week after vaginal bleeding stops,depending on which is *** in the treatment group will be treated with ST Pill(20 pills/time,once a day),and those in the placebo group will receive a placebo drug which is similar in appearance and smell with ST *** main observation index is the live birth ***:Although the efficacy of ST Pill in threatened abortion is well-known,no study has tested its efficacy through a double-blinded,randomized ***,there is an urgent need for a standardized randomized double-blinded controlled trial to evaluate the clinical efficacy of ST *** Pill is likely to be a convenient and effective TCM

关键词： Shoutai Pill threatened abortion traditional Chinese medicine randomized controlled trial

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting wang Xia Wu Ling-jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Antiviral Activity and Mechanism Study of Oblongifolin M against Enterovirus 71

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Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

第十四届全国中药和天然药物学术研讨会

作者： meng-jie wang Ling Tao Hong Zhang Qi Dong Yi-fu Yang Ming-liang He Hongxi Xu Shanghai University of Traditional Chinese Medicine

＜正＞Enterovirus 71（EV71）is a non-enveloped,positive-sense,single-stranded RNA *** to the Picornaviridae family,it is the causative agent of hand,foot and mouth disease（HFMD）,and may lead to severe diseases such ...

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Science China Chemistry 2025年

作者： jie Zhang Yi Chen Guijun Li Zelin Sun Zhengong meng Wai-Yeung Wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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并购与企业研发:对中国制造业上市公司的研究

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中国工业经济 2017年第7期 137-155页

作者：任曙明许梦洁王倩董维刚大连理工大学管理与经济学部

本文扎根于中国制造业转型升级背景,探讨行业内的并购对企业研发的影响机制,从并购可能性和议价能力平均水平两个维度,揭示了并购通过改变企业对市场竞争条件变化的预期来影响其研发的机制。本文使用了行业内并购交易额与行业总资产之... 详细信息

本文扎根于中国制造业转型升级背景,探讨行业内的并购对企业研发的影响机制,从并购可能性和议价能力平均水平两个维度,揭示了并购通过改变企业对市场竞争条件变化的预期来影响其研发的机制。本文使用了行业内并购交易额与行业总资产之比的三年移动平均数、累积超额收益率滞后三年的均值,分别衡量并购可能性、议价能力的行业平均水平,并提出了含有交叉项的计量经济模型,检验影响方向和大小,以及这种影响在不同企业规模和所有制上的差异。研究表明,并购可能性越大,企业预期市场竞争压力越大,研发水平越高;但对不同规模的企业,并购可能性对研发努力的正向作用并未表现出显著的差异;而且,若议价能力的行业平均水平较高,企业研发也较强;从所有制来看,由于所面对的竞争压力较大,在非国有企业中,行业内可能发生的并购对研发的正向作用要大于国有企业。在政策上,政府应破除妨碍并购的制度因素,发挥并购在促进研发上的市场作用。

关键词：并购可能性议价能力的行业平均水平企业规模研发

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Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun Lin meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

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