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Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

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Journal of environmental Sciences 2024年第3期137卷 500-514页

作者： Shan Cao meng Wang Jiao Pan Dengjie Luo Samavia Mubeen Caijin Wang Jiao Yue Xia wu Qijing wu Hui Zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen Guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HcZIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HcZIP2

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Sandpaper-templated Stretchable Immunosensing Electrodes for Sub-picomolar Progesterone Detection

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 874-880页

作者： Li, Zhaoxian meng, Xingyu Fang, Chuyao Yi, Zhenkai wu, Yaoyao Liu, Xuanxuan Zhong, Wei Zhang, Limei Xie, Zhuang Sun Yat sen Univ Sch Mat Sci & Engn Key Lab Polymer Composite & Funct Mat Minist Educ Guangzhou 510275 Peoples R China Sun Yat sen Univ Affiliated Hosp 1 Reprod Med Ctr Dept Obstet & Gynecol Guangzhou 510080 Peoples R China

Female hormone detection, particularly non-invasive monitoring progesterone (P4) levels in body fluids, plays a critical role in female health management and disease diagnosis. However, the challenge still exists because of the ultralow abundance of P4 (ensitive methods for wearable detection. Herein, we present a simple sandpaper-templated stretchable immunosensing electrode designed for ultra-sensitive detection of P4 at sub-picomolar level. A molding technique is employed to replicate the sandpaper textures to provide a microstructured elastomeric substrate for electrode preparation. Such microstructured surface coated with poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS)/LiTFSI [LiTFSI=lithium bis(trifluoromethanesulfonyl) imide] provided a stretchable polymer electrode with high conductivity, and further decoration with gold nanoparticles (AuNPs) enabled the immunosensing for P4 by electrochemical impedance spectroscopy (EIS) measurements. Through adjusting the AuNPs deposition conditions, ultrasensitive detection of P4 is realized with a low limit of detection (LOD) of ca. 10 fmol/L and a tunable dynamic range up to mol/L. Notably, the stretchable electrode exhibits stable electrochemical performance, enabling the detection of P4 at sub-picomolar levels even under mechanical strain of 30%. This innovative electrochemical sensor holds significant promise for non-invasive, on-site monitoring of P4 levels in healthcare, as well as hormone detection in food safety and environment surveillance.

关键词： Progesterone Immunosensor Microstructured electrode Stretchable biosensor Electrochemical sensing ELECTROCHEMICAL SenSOR BIOSenSOR ESTRADIOL HORMONES

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3D printed grafts with gradient structures for organized vascular regeneration

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International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao Fu Zhuang Li Zhaojie Zhang meng Zhu Qing Gao Shaofei wu Guosheng Fu Yong He Jiayin Fu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China School of Mechanical engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis and stenosi... 详细信息

Synthetic vascular grafts suitable for small-diameter arteries(enosis after in vivo *** designing SDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(SML).To facilitate rapid SML regeneration,a high-resolution 3D printing method was used to create a novel bilayer SDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of SML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate SML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide SDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of SML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

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Clinical Value of the Quantitative Flow Ratio to Predict Long-term Target Vessel Failure in Patients with In-stent Restenosis after Drug-coated Balloon Angioplasty

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Current Medical Science 2024年第3期44卷 561-567页

作者： Xiang-qi wu Long-bo LI Wei YOU Zhi-ming wu Lei ZHAO Zhi-hui WANG Pei-na meng Bin LIU Fei YE Department of Cardiology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Cardiology The Second Hospital of Jilin UniversityJilin130000China

Objective The study sought to investigate the clinical predictive value of quantitative flow ratio(QFR)for the long-term target vessel failure(TVF)outcome in patients with in-stent restenosis(ISR)by using drug-coated balloon(DCB)treatment after a long-term *** This was a retrospective study.A total of 186 patients who underwent DCB angioplasty for ISR in two hospitals from March 2014 to September 2019 were *** QFR of the entire target vessel was measured *** primary endpoint was TVF,including target vessel-cardiac death(TV-CD),target vessel-myocardial infarction(TV-MI),and clinically driven-target vessel revascularization(CD-TVR).Results The follow-up time was 3.09±1.53 years,and 50 patients had *** QFR immediately after percutaneous coronary intervention(PCI)was significantly lower in the TVF group than in the no-TVF *** Cox regression analysis indicated that the QFR immediately after PCI was an excellent predictor for TVF after the long-term follow-up[hazard ratio(HR):5.15×10−5(6.13×10−8−0.043);Pence interval:0.834–0.938;sensitivity:83.40%,specificity:88.00;Pents who underwent DCB angioplasty.A lower QFR immediately after PCI was associated with a worse TVF outcome.

关键词： percutaneous coronary intervention in-stent restenosis target vessel failure quantitative flow ratio

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Redox-Active Dihydrophenazine-Based Macrocycle:Synthesis,Conformation-Adaptive Behavior and Host-Guest Complexation with Tetracyanoquinodimethane

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Chinese Journal of Chemistry 2024年第16期42卷 1895-1900页

作者： Qiong-Yan Hong Bin Huang meng-Xiang wu Lin Xu Xiao-Li Zhao Xueliang Shi Hai-Bo Yang Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular&Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal University3663 N.Zhongshan RoadShanghai 200062China

A novel macrocycle based on conformation-adaptive and electron-rich dihydrophenazine was designed and *** the one hand,the macrocycle showed host-guest interactions with tetracyanoquinodimethane(TCNQ)driving by charge transfer interaction between ***,host-guest complexation was accompanied by fluorescence quenching and conformational change of the *** the other hand,the oxidation of the macrocycle resulted in its diradical cation analogue and induced the release of the guest molecule TCNQ,thereby accomplishing reversible binding ***,this work wellillustrates the chemical and structural versatility of dihydrophenazine in the synthesis of macrocycles and their host-guest chemistry.

关键词： Dihydrophenazine Macrocycle Conformational adaptation Redox-active Host-guest interactions Charge transfer interaction Organic radical Supramolecular chemistry

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A CRISPR/RfxC as13d-mediated strategy for efficient RNA knockdown in mouse embryonic development

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Science China Life Sciences 2024年

作者： Lin Zhang Shi-meng Cao Hao wu meng Yan Jinsong Li Ling-Ling Chen State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular Andrology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of RNA Innovation Science and Engineering CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology University of Chinese Academy of Sciences Chinese Academy of Sciences Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University New Cornerstone Science Laboratory Shenzhen

The growing variety of RNA classes, such as mRNAs, lncRNAs, and circRNAs, plays pivotal roles in both developmental processes and various pathophysiological conditions. Nonetheless, our comprehension of RNA functions in live organisms remains limited due to the absence of durable and effective strategies for directly influencing RNA levels. In this study, we combined the CRISPR-RfxCas13d system with spermlike stem cell-mediated semi-cloning techniques, which enabled the suppressed expression of different RNA species. This approach was employed to interfere with the expression of three types of RNA molecules: Sfmbt2 mRNA, Fendrr lncRNA, and circMan1a2(2,3,4,5,6). The results confirmed the critical roles of these RNAs in embryonic development, as their loss led to observable phenotypes, including embryonic lethality, delayed embryonic development, and embryo resorption. In summary, our methodology offers a potent toolkit for silencing specific RNA targets in living organisms without introducing genetic alterations.

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Alternating spin splitting of electronic and magnon bands in two-dimensional altermagnetic materials

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Chinese Physics B 2024年第9期33卷 194-198页

作者： Qian Wang Da-Wei wu Guang-Hua Guo meng-Qiu Long Yun-Peng Wang School of Physics Central South UniversityChangsha 410083China

Unconventional antiferromagnetism dubbed as altermagnetism was first discovered in rutile structured magnets,which is featured by spin splitting even without the spin–orbital coupling *** interesting phenomenon has been discovered in more altermagnetic *** this work,we explore two-dimensional altermagnetic materials by studying two series of two-dimensional magnets,including MF4 with M covering all 3d and 4d transition metal elements,as well as TS2 with T=V,Cr,Mn,*** the magnetic symmetry operation of RuF4 and MnS2,it is verified that breaking the time inversion is a necessary condition for spin *** on symmetry analysis and first-principles calculations,we find that the electronic bands and magnon dispersion experience alternating spin splitting along the same *** work paves the way for exploring altermagnetism in two-dimensional materials.

关键词： two-dimensional altermagnetic materials altermagnetism spin splitting first-principles calculations

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南水北调中线工程受水区灰水足迹荷载系数时空变化及驱动因素研究

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长江流域资源与环境 2024年第5期33卷 971-981页

作者：吴梦南阳师范学院经济与管理学院河南南阳473061

控制水污染程度、提高水环境质量有利于南水北调中线工程高质量发展。在核算南水北调中线工程20个受水城市灰水足迹的基础上,计算各受水城市灰水足迹荷载系数,分析其时空分布特征,并利用对数平均迪氏指数(Logarithmic Mean Divisia Inde... 详细信息

控制水污染程度、提高水环境质量有利于南水北调中线工程高质量发展。在核算南水北调中线工程20个受水城市灰水足迹的基础上,计算各受水城市灰水足迹荷载系数,分析其时空分布特征,并利用对数平均迪氏指数(Logarithmic Mean Divisia Index,LMDI)模型对其驱动因素进行分解。结果表明:(1)2009~2020年南水北调中线工程受水区灰水足迹降幅达到24.54%,水环境质量得到一定改善;从灰水足迹的构成来看,农业占比最高,其次是生活,工业占比最低,且农业源、工业源污染的有效控制是受水区灰水足迹总量整体下降的主要原因。(2)在中线工程通水后,受水区灰水足迹荷载系数有所降低,但是水资源总量仍然远远不能满足水污染物的稀释需求,水环境压力巨大;各受水城市灰水足迹荷载系数存在显著不同,地区内部尤其是河南省内部的差异是受水区灰水足迹荷载系数不平衡的主要来源。(3)资本深化效应、资源禀赋效应及经济活度效应对灰水足迹荷载系数主要表现为正向驱动效应,而资本产出效应、经济环境效应则表现为负向驱动效应。各受水城市要继续走绿色发展道路,促进南水北调中线工程水资源可持续利用。

关键词：南水北调中线工程灰水足迹荷载系数 LMDI模型驱动因素

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Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling wu Xiangchuan meng Qingyang Zhang Xiaowan Han Feiya Yang Qinghua Wang Hai-Yu Hu Nianzeng Xing Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Photoacoustic agents combining photodynamic therapy(PDT) and photothermal therapy(PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2), X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2),X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-Se-NO_(2)-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect Phototherapy Photoacoustic imaging Hypoxia-responsive Prostate cancer

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Thickness dependence of superconductivity in layered GeP_(5)

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Rare Metals 2024年第3期43卷 1323-1328页

作者： Lin wu Ke-meng Yang Wei Gan Rui-Chun Xiao Ya-Jie Dai Xi Tang Hong Lin Hui Han Hui Li Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei230601China

Understanding the relationship between dimensionality and superconductivity has attracted substantial research *** this work,we report the effective modulation of superconductivity in GeP_(5)through *** superconducting phase transition temperature improves by~10%as the thickness of GeP_(5)decreases from bulk to~96 nm,behaving as a unique negative relationship between the superconducting phase transition temperatureand thickness.

关键词： superconductivity dimensionality

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