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Characterization of a smog chamber for studying formation of gas-phase products and secondary organic aerosol

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Journal of Environmental Sciences 2024年第2期136卷 570-582页

作者： Qi Yuan Zhuozhi Zhang meng Wang Kin Fai Ho Tao Wang Shuncheng lee Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Public Health and Primary Care The Chinese University of Hong KongShatinHong KongChina

Smog chambers provide a potent approach to explore the secondary organic aerosol formation under varied *** study describes the construction and characterization of a new smog chamber facility for studying the formation mechanisms of gas-phase products and secondary organic aerosol from the photooxidation of volatile organic *** chamber is a 5.4 m^(3) Fluorinated Ethylene Propylene(FEP)Teflon reactor with the potential to perform photooxidation experiments at controlled temperature and relative *** characterizations were conducted for evaluation of stability of environmental parameters,mixing time,background contamination,light intensity,and wall losses of gases and *** photolysis rate of NO_(2)(J_(NO2))ranged from(1.02-3.32)×10^(-3)sec^(-1),comparable to the average J_(NO2)in ambient *** wall loss rates for NO,NO_(2),and O_(3)were 0.47×10^(-4),0.37×10^(-4),and 1.17×10^(-4)min^(-1),while wall loss of toluene was obsoletely found in a 6 hr *** particle number wall loss rates are(0.01-2.46)×10^(-3)min^(-1)for 40-350 nm with an average lifetime of more than one day.A series of toluene photooxidation experiments were carried out in absence of NO_xunder dry *** results of the simulation experiments demonstrated that the chamber is well designed to simulate photolysis progress in the atmosphere.

关键词： Smog chamber Gas-phase oxidation Chamber characterization Chemical mechanism

Integrated care and training in family practice in the 21st century:Taiwan as an example

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Family Medicine and Community Health 2016年第1期4卷 57-59页

作者： meng-chih lee Taichung Hospital Ministry of Health and Welfare199Section 1San Min RoadTaichung 403Taiwan Taiwan Association of Family Medicine Taiwan President-elect for the Asia Pacific Region World Organization of Family Doctors(WONCA)

As the President-elect for the Asia Pacific region of the World Organization of Family Doctors(WONCA),I would like to share my thoughts with Family Medicine and Community Health *** the 21st century,the new directions of family practice aim to provide patient-centered and prevention-oriented holistic care to members of the public in their communities,with an emphasis on the self-caring model and treatment of chronic *** previous studies have shown that countries with healthier populations have better primary health care *** a vigorous population,improving the medical health care system,providing comprehensive care for patients,and interinstitutional coordination are essential[1].

关键词： Taiwan prevention family

Alendronate inhibits cell invasion and MMP-2 secretion in human chondrosarcoma cell line

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Acta Pharmacologica Sinica 2007年第8期28卷 1231-1235页

作者： Te-jen Lai Sheng-feng HSU Te-mao li Horng-chaung HSU Juang-geng lIn Chin-jung HSU Ming-chih CHOU meng-chih lee Shun-fa yang Yi-chin FONG Institute of Medicine Chung Shah Medical University~3Department of PsychiatryChung Shan Medical University HospitalTaiwanChina Gruduate Institute of Acupuncture Science China Medical UniversityTaiwanChina Department of Orthopaedic Surgery China Medical University HospitalTaiwanChina Institute of Medicine Chung Shah Medical University School of Chinese Medicine China Medical UniversityTaiwanChina

Aim:Chondrosarcoma is a malignant primary bone tumor that responds poorly toboth chemotherapy and radiation *** aim of the present study was toinvestigate the effect of alendronate,a bisphosphonate,on the invasion andmigration of human chondrosarcoma cells(JJ012).Methods:JJ012 cells weretreated with alendronate of various concentrations up to 100μmol/L for a speci-fied period,and then gelatin zymography and matrigel invasion assay was per-formed to study the effects of alendronate on matrix metalloproteinase(MMP)-2activity and the invasion ability of JJ012 cells,***:Our datashowed that alendronate exerted a dose-and time-dependent inhibitory effect onthe invasion and migration of JJ012 ***,gelatin zymography andRT-PCR showed that alendronate treatment decreased the activity and mRNAlevels of MMP-2 in a concentration-dependent ***:Our find-ings suggest that alendronate may reduce MMP-2 secretion at the transcriptionaland translational levels,and inhibit the invasion of chondrosarcoma ***,alendronate may be a potential candidate for the systemic therapy of chondro-sarcomas,as well as other malignant diseases.

关键词： alendronate" bisphosphonate chondrosarcoma matrix metalloproteinase-2 invasion migration

Paclitaxel induces human KOSC3 oral cancer cell apoptosis through caspase pathways

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BIOCELL 2024年第7期48卷 1047-1054页

作者： YU-YAN LAN TSUN-chih CHENG YI-PING lee CHIA-YIH WANG BU-MIIN HUANG School of Medicine College of MedicineI-Shou UniversityKaohsiung82445Taiwan Department of Otolaryngology An Nan HospitalChina Medical UniversityTainan70965Taiwan Department of Cell Biology and Anatomy College of MedicineNational Cheng Kung UniversityTainan70101Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40402Taiwan

Background:Paclitaxel is a compound derived from Paciﬁc yew bark that induces various cancer cell ***,whether it also has anticancer activities in KOSC3 cells,an oral cancer cell line,is ***:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,ﬂow cytometry,and western blotting assays were carried out to assess cell viability,subG1 phase of the cell cycle,and apoptosis-related protein expression,***:Ourﬁndings indicate that paclitaxel could inhibit cell viability and increase the expression of apoptotic markers,including plasma membrane blebbing and the cleavage of poly ADP-ribose polymerase in KOSC3 ***,the treatment with paclitaxel remarkably elevated the percentage of the subG1 phase in KOSC3 *** addition,treatment with a pan-caspase inhibitor could recover paclitaxel-inhibited cell ***,caspase-8,caspase-9,caspase-7,and BH3 interacting domain death agonist(Bid)were activated in paclitaxel-treated KOSC3 ***:Paclitaxel induced apoptosis through caspase cascade in KOSC3 cells.

关键词： Paclitaxel Oral cancer KOSC3 cells Apoptosis Caspase pathways

Development and application of photocatalytic coating for roadside NO_(x) mitigation in Hong Kong

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Chinese Chemical Letters 2024年第3期35卷 153-157页

作者： Xinwei Li Pengge Wang Shuwen Han Yu Huang Wingkei Ho Steven Sai Hang Ho Shun-cheng lee meng Wang Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Loess and Quaternary Geology(SKLLQG)and Key Laboratory of Aerosol Chemistry and Physics Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Department of Science and Environmental Studies The Education University of Hong KongHong KongChina Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512United States

A facile chemical method for the development of photocatalytic coating products was proposed based on practical application perspective for the Hong Kong roadside nitrogen oxides(NO_(x))***_(2)-based photocatalytic coating PC-C film with crystallized size of around 5–6 nm was synthesized with the peptization of H_(2)O_(2).The PC-C coating possesses a super-hydrophilicity surface and is proven to have a NO_(x)degradation rate of 46.8%with an optimum pH level of *** addition,the PC-C coating presents a promising photocatalytic NO_(x)degradation compared with other commercially available coating products and P25 when applied on two building materials of poly-methyl methacrylate(PMMA)and concrete surface.A weather resistance simulation and a 180-day on-site field trial were carried out the attenuation effects of photocatalytic coating applied in outdoor *** on epidemiological estimation and field investigation,hospital admissions for respiratory diseases(HARD)and mortality cases(MC)could be reduced with the application of PC-C coating along the street *** work demonstrates the feasibility of air pollution control measures for the local roadside NO_(x)using photocatalytic technology,offering promising health benefits with environmental remediation.

关键词： Photocatalysis Coating NO_(x) mitigation Hong Kong Roadside

Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open- label, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 82-89页

作者： Yunyun Xiong Bruce C V Campbell Marc Fisher lee H Schwamm Mark Parsons Hao Li Yuesong Pan Xia meng Xingquan Zhao Yongjun Wang Neurology Beijing Tiantan HospitalBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Medicine and Neurology The University of MelbourneMelbourneVictoriaAustralia Neurology Beth Israel Deaconess Medical CenterBostonMassachusettsUSA Department of Neurology and Comprehensive Stroke Center Massachusetts General HospitalBostonMassachusettsUSA Department of Neurology University of New South Wales South Western Sydney Clinical SchoolLiverpoolNew South WalesAustralia

Background and purpose Recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)was not inferior to alteplase for ischaemic stroke within *** study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion(LVO)of anterior circulation beyond *** and design Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-III(TRACE III)is a multicentre,prospective,randomised,open-label,blind endpoint,controlled clinical *** who had an ischaemic stroke due to anterior circulation LVO(internal carotid artery,middle cerebral artery M1 and M2 segments)within 4.5–24hours from last known well(including wake-up stroke and no witness stroke)and with salvageable tissue(ischaemic core volume6s at 24 hours and NIHSS score change from baseline at *** outcomes are symptomatic intracerebral haemorrhage within 36 hours and mortality at 90 *** TRACE III will provide evidence for the efficacy and safety of rhTNK-tPA in patients who had an ischaemic strokes due to anterior circulation LVO beyond *** registration number NCT05141305.

关键词： Therapy random Rational

Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues

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Chinese Journal of Integrative Medicine 2024年第2期30卷 125-134页

作者： Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae lee Xianglong meng Yong-Ki Park Hyo Won Jung Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Korea College of Pharmacy&Graduate School of Pharmaceutical Sciences Ewha Womans UniversitySeoul 03760Korea Korean Medicine R&D Center Dongguk UniversityGyeongju 38066Korea Shanxi Key Laboratory of Traditional Herbal Medicines Processing Shanxi University of Chinese MedicineJinzhong(030619)ShanxiProvinceChina

Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes ***:The information about active components of C-DM1 extract and molecular mechanism was obtained from network pharmacology *** compounds of C-DM1 extract by high performance liquid chromatography-mass spectrometry(HPLC-MS)analysis were conducted for quality *** in vivo study,mice were induced diabetes by HFD for 12 *** mice in the normal group(Nor)were maintained with a regular diet and treated with saline by *** HFD model mice were randomly divided into 3 groups,including a HFD diabetic model group,a C-DM1 extract-administered group(C-DM1,500 mg/kg),and metformin-administered groups(Met,500 mg/kg),8 mice in each *** intake,body weight(BW),and fasting blood glucose(FBG)levels were recorded weekly for 4 *** 4 weeks of treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),blood glucose,low-density lipoprotein cholesterol(LDL-C)were determined using an automated clinical chemistry analyzer,and homeostatic model for assessing insulin resistance(HOMA-IR)levels and oral glucose tolerance test(OGTT)were *** histopathological changes of liver and pancreatic tissues were observed by hematoxylin-eosin *** receptor substrate(IRS)/phosphatidylinositol 3 kinase(PI3K)/protein kinase B(AKT)and adenosine 5'-monophosphate-activated protein kinase(AMPK)expressions in liver and pancreas tissues were detected by Western blot ***:HPLC-MS identified dihydroisotanshinone,dihydroisotanshinone I,cryptotanshinone,harpagoside,and atractyloside A in C-DM1 *** administration of C-DM1 extract significantly decreased body weight,calorie intake,and the levels of blood glucose and insulin in the diabetic mice(P<0.05 or P<0.01).The C-DM1 extract administration improved the im

关键词： high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron chih Hung Lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Water-Excluding Underwater Glue Induced by Marangoni Effect

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CCS Chemistry 2024年第5期6卷 1289-1299页

作者： Ke Zhang Xizi Wan Zi-Yu Liu Feilong Zhang Jingwei Lu Jingxin meng Ye Tian Haeshin lee Lei Jiang Shutao Wang CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001 University of Chinese Academy of Sciences Beijing 100049 Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190 Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083 The Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141

Marangoni effect at the two-phase interface with different surface tension as a unique mass transfer phenomenon has been widely used in daily life and ***,their marvelous liquid-driving capability between miscible liquids has long been ignored,especially in water ***,we first reveal a distinct underwater Marangoni effect between the solvent of glues and the water layer on solid *** by the Marangoni effect,organic solvents with water solubility,high dielectric constant,and low diffusivity could effectively exclude the interfacial water layer,enabling direct and effective contact between glues and solid *** experimental results and theoretical simulation proved that a relatively large ratio of the Marangoni number in the horizontal direction and to the vertical direction ensured an effective underwater adhesion of the water-excluding *** surface engineering approach provides an alternative to the traditional methods of molecular engineering for realizing underwater adhesion.

关键词： Marangoni effect underwater adhesion dynamic water-excluding water layer solvent diffusion