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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li zhao Yajun Zhang zhe Yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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本科生全程导师制的价值意蕴及实践探索

北京科技大学学报（社会科学版） 2025年第1期41卷 32-38页

作者：赵萌北京科技大学北京100083

本科教育在人才培养工作中占据基础地位,如何推动本科教育理念和方式不断变革,谋求本科教育体制机制的创新发展是提升教育质量的关键所在。本科生全程导师制从学生多样化、个性化的需求出发,注重因材施教,逐渐成为提升人才培养质量的关... 详细信息

本科教育在人才培养工作中占据基础地位,如何推动本科教育理念和方式不断变革,谋求本科教育体制机制的创新发展是提升教育质量的关键所在。本科生全程导师制从学生多样化、个性化的需求出发,注重因材施教,逐渐成为提升人才培养质量的关键手段之一,并在教学实践中不断得到创新和优化。文章以北京科技大学近年来推行的本科生全程导师制为例,针对8921名本科生进行在校生满意度调查,分析得出该导师制在思想引导、学术指导以及创业就业等方面充分发挥了教师的积极作用,获得了广大学生的高度认可,由此探索构建符合新时代人才培养需求的本科人才培养新模式。

关键词：本科生全程导师制人才培养学生满意度

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong zhao meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

双轴应变对NbSe_(2)/MoSi_(2)N_(4)肖特基势垒的调控

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原子与分子物理学报 2025年第5期42卷 182-188页

作者：张宇哲安梦雅谢泉贵州大学大数据与信息工程学院新型光电子材料与技术研究所贵阳550025

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中... 详细信息

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中,构建了金属-半导体NbSe_(2)/MSN肖特基结并使用第一性原理密度泛函理论计算研究了该肖特基结的材料特性.发现NbSe_(2)/MSN接触具有超低肖特基势垒高度(Schottky barrier height,SBH),这有利于纳米电子学应用.SBH可以通过施加双轴应变的方式进行有效的调控.当施加拉伸应变时能实现NbSe_(2)/MSN肖特基结由p型肖特基接触转变为p型欧姆接触,而当施加较大的压缩应变时能实现p型肖特基接触和n型肖特基接触之间的转换.我们的研究结果为MSN的2D电触点的物理特性提供了见解,并将为设计基于MSN的2D纳米器件的高性能电触点提供关键的一步.

关键词： MoSi_(2)N_(4) NbSe_(2) 肖特基结欧姆接触

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Rapid and scalable preparation of highly quaternized polymer networks to achieve efficient simultaneous adsorption of iodide and pertechnetate

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Science China Chemistry 2025年第1期 337-349页

作者： Meiyun Xu Song Gu Fulong Chen zhe zhao Peng Liu Daoben Hua State Key Laboratory of Radiation Medicine and Protection School of Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Soochow University

The efficient separation of fission products,such as TcO4-and I-,holds strategic significance for the management of radioactive wastes and environmental *** this study,we propose an ultrafast strategy for scalable preparation of a highly quaternized organic network to facilitate efficient and synchronous separation of iodide and *** network can be prepared within a few minutes at room temperature,using polyethylenimine and 1,2,4,5-tetrakis（bromomethyl）benzene as building *** chlorine replacement,the network,abundantly decorated with quaternary ammonium groups （Cl@QPN）,exhibits an ultrahigh positive charge density of 7.6 mmol/*** enables the rapid and efficient enrichment of target anions through strong electrostatic Coulomb *** a result,Cl@QPN exhibits significantly higher adsorption rate constants of 0.830 g/（mg min） for ReO4-（a nonradioactive surrogate of TcO4-） and 0.677 g/（mg min） for I-compared to other ***,it possesses high adsorption capacities,reaching 1,681 mg/g for ReO4-and 917.4 mg/g for I-.Cl@QPN also demonstrates good selectivity towards target ions and shows efficient adsorption for99TcO4-.Additionally,Cl@QPN exhibits high dynamic processing capacities,handling up to 3,100 and 7,400 kg of simulated streams per kilogram of material for I-and ReO4-,respectively.

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Application of Muskingum routing method with variable parameters in ungauged basin

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Water Science and Engineering 2011年第1期4卷 1-12页

作者： Xiao-meng SONG Fan-zhe KONG zhao-xia ZHU School of Resource and Earth Science China University of Mining and Technology Xuzhou 221116 P. R. China Graduate School China University of Mining and Technology Xuzhou 221008 P. R. China Department of Resources and Survey Engineering Chongqing Vocational Institute of Engineering Chongqing 400037 B R. China

This paper describes a flood routing method applied in an ungauged basin, utilizing the Muskingum model with variable parameters of wave travel time K and weight coefficient of discharge x based on the physical characteristics of the river reach and flood, including the reach slope, length, width, and flood discharge. Three formulas for estimating parameters of wide rectangular, triangular, and parabolic cross sections are proposed. The influence of the flood on channel flow routing parameters is taken into account. The HEC-HMS hydrological model and the geospatial hydrologic analysis module HEC-GeoHMS were used to extract channel or watershed characteristics and to divide sub-basins. In addition, the initial and constant-rate method, user synthetic unit hydrograph method, and exponential recession method were used to estimate runoff volumes, the direct runoff hydrograph, and the baseflow hydrograph, respectively. The Muskingum model with variable parameters was then applied in the Louzigou Basin in Henan Province of China, and of the results, the percentages of flood events with a relative error of peak discharge less than 20% and runoff volume less than 10% are both 100%. They also show that the percentages of flood events with coefficients of determination greater than 0.8 are 83.33%, 91.67%, and 87.5%, respectively, for rectangular, triangular, and parabolic cross sections in 24 flood events. Therefore, this method is applicable to ungauged basins.

关键词： Muskingum model," flood routing." variable parameters ungauged basin HEC-HMS

Micromorphology and safety properties of meager and meager-lean coal for blast furnace injection

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 774-781页

作者： Long-zhe Jin Xiao-meng Niu School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Four types of meager and meager-lean coal and one type of high-quality anthracite were selected based on the safety requirements for blast furnace coal injection and domestic coal quality to conduct microstructure and component *** analyses of the organic and inorganic macerals and the chemical compositions of the selected coal samples indicate that the four types of meager and meager-lean coal have low volatilization,low ash content,and low sulfur content;these qualities are suitable for blast furnace *** test was conducted on the four types of meager and meager-lean coal and the anthracite mixed coal *** indicate that the mixture of meager and meager-lean coal and anthracite is beneficial to improve the grindability of pulverized *** explosive tests reveal that the selected coal samples are non-explosive or weakly *** the proportion of meager and meager-lean coal is less than 40wt%,the mixed coal powder would not explode during the blowing *** minimum ignition temperature test determines that the minimum ignition temperatures of the four types of meager and meager-lean coal and anthracite are 326,313,310,315,and 393°C,*** study provides a guiding research idea for the safety of meager and meager-lean coal used in blast furnace injection.

关键词： meager coal meager-lean coal microstructure safety property blast furnace injection

A novel Bayesian-based INS/GNSS integrated positioning method with both adaptability and robustness in urban environments

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Chinese Journal of Aeronautics 2024年第6期37卷 205-218页

作者： zhe YANG Hongbo zhao School of Electronics and Information Engineering Beihang UniversityBeijing 100191China

Achieving higher accuracy positioning results in urban environments at a lower cost has been an important pursuit in areas such as autonomous driving and intelligent *** Inertial Navigation System and Global Navigation Satellite System(INS/GNSS)integrated navigation systems have been an important means of fulfilling the above quest due to the complementary error characteristics between INS and *** complex urban driving environment requires the system sufficiently adaptive to keep up with the time-varying measurement noise and sufficiently robust to cope with measurement outliers and prior ***,many efforts lack a balance between adaptability and *** this paper,a novel positioning method with both adaptability and robustness is proposed by coupling the Mahalanobis distance method,the Variational Bayesian method and the student’s t-distribution in one process(M-VBt method).This method is robust against non-Gaussian noise and priori uncertainties,plus adaptive against measurement noise uncertainty and time-varying *** field test results show that the M-VBt method(especially the Mahalanobis distance part)has significantly improved the system performance in the complex urban driving environment.

关键词： Urban environments Mahalanobis distance Adaptability Robustness Integrated navigation

Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix

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Biomedical and Environmental Sciences 2024年第6期37卷 565-580页

作者： meng Wu Jialu Zhou zhe Zhang Yuanguang meng School of Medicine Nankai UniversityTianjin 300071China Department of Obstetrics and Gynecology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology Chinese PLA Medical SchoolBeijing 100853China Department of Obstetrics and Gynecology The Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC *** Sequencing was performed to analyze neoantigen *** Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in *** mutations were the most frequent types of somatic mutation in the coding sequence *** signature analysis detected signature 2,signature 6,and signature 7 in CSCC ***3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported *** variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related *** The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

关键词： Cervical squamous cell carcinoma Genome alteration Neoantigens Immunotherapy