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Efficacy of intra- tumor injection of Kang-Lai-Te in treating transplanted hepatoma in rats

Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 580-584页

作者： Li-Qun Wu, Yun Lu, Hua-Jun Lu, Zong-Gang zhao and meng yang Qingdao, China Department of Hepato-biliary-vascular Surgery, Qing- dao University Medical College, Qingdao 266003 , China Department of Hepato-biliary-vascular Surgery Qingdao University Medical College Qingdao 266003 China. jiaoqin@***

BACKGROUND: Non-operative therapy takes an impor- tant position in comprehensive therapy of liver cancer. De- spite some effects by using ethanol, acetic acid and heat sa- line for intra-tumor injection in the treatment of liver canc- er, it is difficult to attain a complete cure but bring about injury to the liver to some extent. Hence, searching for other drugs for the local treatment of liver tumor is an im- portant option. This study was designed to set up rat mo- dels of transplanted liver cancer, intra-tumor injection of Kang-Lai-Te (KLT), and negative control (saline) and positive control (ethanol). The effect of intra-tumor injec- tion of KLT in treating transplanted hepatoma in rats and its advantages and disadvantages were assessed and the pos- sibility of its use in treating patients with liver cancer was evaluated. METHODS: Forty rats were divided into 4 groups ( G1, G2, G3 and G4, 10 rats in each group). Different drugs were injected into their implanted hepatoma (G1 with 0.2 ml saline as control, G2 with 10 mg KLT, G3 with 20 mg KLT, G4 with 0.2 ml ethanol). After 3 and 8 days, the hepa- toma volume (HV), the serum levels of albumin, alanine aminotransferase(ALT), aspartate aminotransferase alkaline phosphatase( ALP) and creatinine, as well as the expression of proliferation cell nuclear antigen (PCNA) in hepatoma were detected. RESULTS: After 3 days, the HVs were smaller in G3 and G4 than in G1 (P <0.05), the serum levels of albumin were higher in G2 and G3 than in Gl and G4 (P <0.05), the se- rum levels of ALT and AST were lower in G2 and G3 than in G4 (P<0.05), the serum levels of ALP was lower in G2 and G3 than in Gl and G4 (P <0. 05), the PCNA labeling indexes (PCNA LI) were lower in G2 and G3 than in Gl and GA (P <0.05). After 8 days, the HVs were smaller in G2, G3 and G4 than in Gl (P <0.05), and the differences of HVs among G2, G3 and G4 were not significant. The serum levels of ALP were lower in G1, G2 and G3 than in G4 (P <0.05), and the PCNA

关键词： Kang-Lai-Te intra-tumor injection transplanted hepatoma rat

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan meng zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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Pulsed dynamic electrolysis enhanced PEMWE hydrogen production:Revealing the effects of pulsed electric fields on protons mass transport and hydrogen bubble escape

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Journal of Energy Chemistry 2025年第1期100卷 201-214页

作者： Xuewei Zhang Wei Zhou Yuming Huang Liang Xie Tonghui Li Huimin Kang Lijie Wang yang Yu Yani Ding Junfeng Li Jiaxiang Chen Miaoting Sun Shuo Cheng Xiaoxiao meng Jihui Gao Guangbo zhao School of Energy Science and Engineering Harbin Institute of Technology China Datang Technology Innovation Co. Ltd

The transition of hydrogen sourcing from carbon-intensive to water-based methodologies is underway,with renewable energy-powered proton exchange membrane water electrolysis （PEMWE） emerging as the preeminent pathway for hydrogen *** remarkable advancements in this field,confronting the sluggish electrochemical kinetics and inherent high-energy consumption arising from deteriorated mass transport within PEMWE systems remains a formidable *** impediment stems primarily from the hindered protons mass transfer and the untimely hydrogen bubbles *** address these challenges,we harness the inherent variability of electrical energy and introduce an innovative pulsed dynamic water electrolysis *** to constant voltage electrolysis (hydrogen production rate:51.6 m L h-1,energy consumption:5.37 kWh Nm-3H2),this strategy (hydrogen production rate:66 m L h-1,energy consumption:3.83 kWh Nm-3H2) increases the hydrogen production rate by approximately 27%and reduces the energy consumption by about 28%.Furthermore,we demonstrate the practicality of this system by integrating it with an off-grid photovoltaic （PV） system designed for outdoor operation,successfully driving a hydrogen production current of up to 500 mA under an average voltage of approximately 2 *** combined results of in-situ characterization and finite element analysis reveal the performance enhancement mechanism:pulsed dynamic electrolysis （PDE） dramatically accelerates the enrichment of protons at the electrode/solution interface and facilitates the release of bubbles on the electrode *** such,PDE-enhanced PEMWE represents a synergistic advancement,concurrently enhancing both the hydrogen generation reaction and associated transport *** promising technology not only redefines the landscape of electrolysis-based hydrogen production but also holds immense potential for broadening its application across a diverse spectrum of electrocatalytic endeavors.

关键词： Electrolysis

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： Yingjie zhao Yicheng Sun Chaoxin Pei Xing Yin Xinyi Li Yi Hao mengru Zhang meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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疫情常态化防控期间剧场管理规范及应急处置流程——以中央戏剧学院教学实习演出中心为例

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演艺科技 2020年第11期 37-40页

作者：赵孟阳中央戏剧学院北京102209

以中央戏剧学院教学实习演出中心为例,探讨疫情常态化防控期间高校剧场管理规范,并提出应急处置流程及工作要点,是疫情常态化防控期间剧场管理规范的可参考案例。

关键词：新冠肺炎疫情常态化防控高校剧场剧场管理应急处置

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Subnetwork-based federated few-shot semantic segmentation of organ images

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Optoelectronics Letters 2025年

作者： Wu Junpeng zhao meng Zhang Huanping Key Laboratory of Computer Vision and System of Ministry of Education， School of Computer Science and Engineering， Tianjin University of Technology

Federated learning(FL)， as a distributed learning paradigm， allows multiple medical institutions to collaborate on learning without the need to centralize all client data. However， existing methods pay little attention to more challenging medical image semantic segmentation tasks， especially in the scenario of the imbalanced dataset in federated few-shot learning. In this paper， we propose a subnetwork-based federated few-shot organ image segmentation method. Firstly， individual clients train using local training samples and then upload local model gradients to the server. The server utilizes their respective local model gradients to update the subnetwork maintained on the server and generate aggregation weights for forming personalized model parameters. Through this method， we can learn the similarities between different clients to address data heterogeneity issues. In addition， to enhance the communication efficiency between clients and the server， we have also designed a personalized layer aggregation strategy， which only transmits partial layer model parameters during the communication process to improve communication efficiency. Finally， we conducted experiments on ABD-MRI and ABD-CT datasets to demonstrate the effectiveness of our method.

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玻璃体切除联合内界膜剥除翻转填塞治疗特发性黄斑裂孔的短期疗效及影响因素

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眼科 2018年第6期27卷 447-450页

作者：汪晓磊孟照洋赵露王艳玲首都医科大学附属北京友谊医院眼科 100050

目的观察玻璃体切除联合内界膜剥除翻转填塞治疗特发性黄斑裂孔的疗效和预后影响因素。设计回顾性病例系列。研究对象特发性黄斑裂孔患者36例(37眼)。方法所有患者行玻璃体切除联合内界膜剥除翻转填塞手术。术后随访时间4个月。观察眼... 详细信息

目的观察玻璃体切除联合内界膜剥除翻转填塞治疗特发性黄斑裂孔的疗效和预后影响因素。设计回顾性病例系列。研究对象特发性黄斑裂孔患者36例(37眼)。方法所有患者行玻璃体切除联合内界膜剥除翻转填塞手术。术后随访时间4个月。观察眼压、最佳矫正视力(best-corrected visual acuity, BCVA)、裂隙灯、间接检眼镜、眼轴长度(axial length, AL)、黄斑裂孔直径;频域相干光断层扫描(spectral domain optical coherence tomography, SD-OCT)测量术前及术后黄斑区视网膜各层厚度,包括视网膜神经纤维层(retinal nerve fiber layer, RNFL)、视网膜神经节细胞层(ganglion cell layer, GCL)、内丛状层(inner plexiform layer, IPL)、内核层(inner nuclear layer, INL)、外丛状层(outer plexiform layer, OPL)、外核层(outer nuclear layer, ONL)、视网膜色素上皮层(retinal pigment epithelium, RPE);Spearman相关性分析术后BCVA与术前BCVA、AL、年龄、黄斑裂孔大小等的关系。主要指标裂孔闭合率,BCVA,视网膜厚度。结果术后黄斑裂孔闭合率100%。术前、术后平均BCVA(LogMRA)分别为1.23±0.64和0.28±0.17(P0.05)。术后BCVA与术前BCVA(r=0.641)、黄斑裂孔最小直径(r=0.662)、白内障手术(r=0.438)、黄斑区鼻侧RNFL厚度变化(r=0.349)、黄斑区鼻侧IPL厚度变化(r=0.383)有相关性(P均<0.05)。结论玻璃体切除联合内界膜剥除翻转填塞治疗黄斑裂孔能改善术后BCVA。术前BCVA、黄斑裂孔最小直径、白内障手术、黄斑区鼻侧RNFL厚度变化、黄斑区鼻侧IPL厚度变化是影响术后BCVA的因素。

关键词：特发性黄斑裂孔玻璃体切除内界膜剥除内界膜翻转填塞疗效

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构建学习化社会的几点思考

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三门峡职业技术学院学报 2003年第2期2卷 16-18页

作者：孟昭阳三门峡职业技术学院河南三门峡472000

建立一个全民学习、终身学习的学习社会,是全面建设小康社会的重要目标,也是我国社会持续不断发展的需要。在建立学习化社会的过程中,我们如何更新观念,正确认识学习化社会,如何构建学习化社会,都是摆在我们面前的迫切需要思考的问题。

关键词：学习化社会终身教育构建思考

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炼钢闭路循环冷却水变频补水系统工艺与控制

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天津冶金 2014年第2期 110-113页

作者：孟召阳天津钢管集团股份有限公司能源部天津300301

分析了天津钢管公司三炼钢厂水处理的恒压补水系统的生产工艺、过程控制,系统设计原理,控制要求及实现。该系统对公司三炼钢所有闭路水系统进行系统补水,可满足各个闭路水正常运行的要求,节约了电耗和水耗。

关键词：变频器恒压供水自动控制工业以太网

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曳引式电梯上行超速保护装置日常维护和检验疏漏分析

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机电工程技术 2019年第8期48卷 305-307页

作者：孟照阳广州特种机电设备检测研究院

电梯作为现代生活的交通工具,其安全运行关系每个公民的人身安全,对电梯的日常维护和安全检查必不可少。根据相关规定对曳引式电梯上行超速保护装置日常维护和检验中存在的疏漏进行分析,主要讲述夹绳器与轿厢上行安全钳装置,并给出实际... 详细信息

电梯作为现代生活的交通工具,其安全运行关系每个公民的人身安全,对电梯的日常维护和安全检查必不可少。根据相关规定对曳引式电梯上行超速保护装置日常维护和检验中存在的疏漏进行分析,主要讲述夹绳器与轿厢上行安全钳装置,并给出实际案例解释了造成日常维护疏漏的原因,参考关于电梯结构原理的图书,并结合相关的工作经验,提出相应的整改方法及措施,以期提高对电梯日常维护和安全运行检查的质量。

关键词：电梯上行超速保护装置日常维护检验疏漏

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