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Curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation

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Chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： xu Ben ZHANG Jia-en YE Lin yuan Chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTS18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(Col-I)and alpha-smooth muscle actin(α-SMA)mRNA and protein expressions were analyzed by real-time PCR(RT-PCR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dC,demethylation agent)for 72 *** of curcumin on extracellular matrix(ECM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTS18 small interfering RNA and grouped into a normal control,ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** Compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(P<0.01).Among the different concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(P<0.01).Immunochemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,Col-I andα-SMA(P<0.01).Curcumin and 5-zaz-dC had synergistic effects,promoting ADAMTS18 expression,removing ADAMTS18 methylation,and reducing ECM ***18 knockdown promoted ECM accumulation,and curcumin reversed this process(P<0.01).Conclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin Chinese medicine ADAMTS18 methylation modification

Segment differential aggregation representation and supervised compensation learning of ConvNets for human action recognition

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Science China(Technological Sciences) 2024年第1期67卷 197-208页

作者： REN ZiLiang ZHANG QieShi CHENG Qin xu ZhenYu yuan Shuai LUO DeLin School of Computer Science and Technology Dongguan University of TechnologyDongguan 523808China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin 541004China Department of the mechanical engineering Erlangen-Nuremberg UniversityErlangen 91508Germany School of Aerospace Engineering Xiamen UniversityXiamen 361102China

With more multi-modal data available for visual classification tasks,human action recognition has become an increasingly attractive ***,one of the main challenges is to effectively extract complementary features from different modalities for action *** this work,a novel multimodal supervised learning framework based on convolution neural networks(Conv Nets)is proposed to facilitate extracting the compensation features from different modalities for human action *** on information aggregation mechanism and deep Conv Nets,our recognition framework represents spatial-temporal information from the base modalities by a designed frame difference aggregation spatial-temporal module(FDA-STM),that the networks bridges information from skeleton data through a multimodal supervised compensation block(SCB)to supervise the extraction of compensation *** evaluate the proposed recognition framework on three human action datasets,including NTU RGB+D 60,NTU RGB+D 120,and *** results demonstrate that our model with FDA-STM and SCB achieves the state-of-the-art recognition performance on three benchmark datasets.

关键词： action recognition segment frame difference aggregation supervised compensation learning ConvNets

Morphological Evolution of Self-Assembled Sodium Dodecyl Sulfate/Dodecyltrimethylammonium Bromide@Epoxy-β-Cyclodextrin Supramolecular Aggregates Induced by Temperature

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Journal of Renewable Materials 2024年第4期12卷 629-641页

作者： Qingran meng Wenwen xu Zuobing Xiao Qinfei Ke Xingran Kou Key Laboratory of Textile Science&Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai201620China Collaborative Innovation Center of Fragrance Flavor and Cosmetics School of Perfume and Aroma Technology(Shanghai Research Institute of Fragrance&Flavour Industry)Shanghai Institute of TechnologyShanghaiChina

Bio-based cyclodextrins(CDs)are a common research object in supramolecular *** special cavity structure of CDs can form supramolecular self-assemblies such as vesicles and microcrystals through weak interaction with guest *** different forms of supramolecular self-assemblies can be transformed into each other under certain *** regulation of supramolecular self-assembly is not only helpful to understand the self-assembly principle,but also beneficial to its *** the present study,the self-assembly behavior of epoxy-β-cyclodextrin(EP-β-CD)and mixed anionic and cationic surfactant system(sodium dodecyl sulfate/dodecyltrimethylammonium bromide,SDS/DTAB)in aqueous solution was *** and particle size characterization found that the SDS/DTAB@EP-β-CD complex,as the basic building unit,self-assembled into worm-like micelles at lower temperatures and vesicles at higher *** magnetic resonance(NMR)and Fourier transform infrared spectroscopy(FT-IR)analysis revealed that the driving force for the formation of vesicles and worm-like micelles was the hydrogen bonds between EP-β-CD molecules,while water molecules played an important role in promoting vesicle formation between SDS/DTAB@EP-β-CD ***,the mechanism of the morphologic transformation of SDS/DTAB@EP-β-CD supramolecular aggregates induced by temperature was elucidated by exploring the self-assembly process,which may provide an excellent basis for the development of delivery carriers.

关键词： Epoxy-β-cyclodextrin SDS/DTAB self-assembly temperature morphological evolution

Supramolecular Bonding Competition Enabled Nanostructure Evolution and Mechanical Reinforcement

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CCS Chemistry 2024年第1期6卷 157-164页

作者： Yuting Wang Peng meng Aidan Brock Yanan xu Hang meng Zixuan Liu Kan Zhang John McMurtrie Jingsan xu School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneQueensland 4000 Central Analytical Research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQueensland 4000 State Key Laboratory of Superhard Materials Department of Materials Science and Key Laboratory of Automobile MaterialsMOEJilin UniversityChangchun 130012

In this work,competition between different supramolecular interactions is investigated based on a fibrous crystal composed of hydrogen-bonded cyanuric acid(CA)and amidinothiourea(ADT).Melamine(M)is found to prevail over ADT and bond to CA due to its stronger triple H-bonding affiliation,forming hollow microtubes assembled by oriented CAM crystalline arrays,as guided by the directionality of peripheral hydrogen ***,competitive interaction between hydrogen bonding and ionic/covalent bonding is demonstrated by mixing Ag+ions with the CA-ADT fibers,where sulfur atoms are abstracted from ADT molecules to produce Ag_(2)S *** in situ-formed Ag_(2)S serves as a binding glue to generate CA-ADT/Ag_(2)S composites with significantly enhanced mechanical strength compared to the pristine CA-ADT fiber pellet.

关键词： supramolecular interaction hydrogen bonds chemical bond competition hollow crystal array organic-inorganic composite

Microstructures and mechanical properties of a commercial Mg-Al-Zn-Mn alloy with various hot-extrusion processes

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Rare Metals 2024年第3期43卷 1329-1336页

作者： He Ma Fan-Zhi meng Qiang Yang Ze-Feng Xie yuan-Ding Huang Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China MagIC-Magnesium Innovation Center Helmholtz-Zentrum Geesthacht21502GeesthachtGermany Engineering Research Center of Optoelectronic Functional Materials Ministry of EducationChangchun University of Science and TechnologyChangchun130022China

Mg-Al-Zn-Mn(AZ)system alloys have become widely used due to their good castability,excellent formability and outstanding corrosion resistance[1-6].However,their strength is still much lower than that of traditional Mg... 详细信息

关键词： alloys alloy corrosion

Single transition-metal atoms anchored on a novel Diracdispersive π-π conjugated holey graphitic carbon nitride substrate:computational screening toward efficient bifunctional OER/ORR electrocatalysts

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Rare Metals 2024年第8期43卷 3819-3832页

作者： Chun-Yao Fang Xi-Hang Zhang Qiang Zhang Di Liu Xiao-meng Cui Jing-Cheng xu Cheng-Long Shi meng-Yu Yang College of Science University of Shanghai for Science and Technology School of Materials and Chemistry University of Shanghai for Science and Technology

Nonprecious-metal-group single-metal-atom catalysts with bifunctional catalytic capabilities toward the oxygen evolution reaction（OER） and oxygen reduction reaction（ORR） are highly sought after in energy-conversion and storage ***,producing renewable and sustainable energy sources remains ***,single-transition metal atoms anchored on π-πconjugated two-dimensional（2D） graphitic carbon nitride substrates form π-d conjugated conductive channels that enhance the overall electrocatalytic ***,firstprinciples calculations were carried out to design and demonstrate a novel macropore graphitic carbon nitride(gC10N3) as a promising 2D electrocatalyst substrate to support single-transition metal（TM,from Sc to Au）.The "donation-acceptance" charge interaction in the TM-N2moiety effectively balances the adsorption strength of oxygenated intermediates in Ni@g-C10N3and Rh@gC10N3,making them effective bifunctional OER/ORR electrocatalysts with IrO2/Pt-beyond overpotentials being as low as 0.39/0.38 V and 0.54/0.44 V,***,they possess high stability and conductivity and are less susceptible to oxidation and corrosion under working *** guarantees high activity under ambient ***,the origin of the OER/ORR activity of TM@g-C10N3is explained using multilevel descriptors:intrinsic(p,Bader charge,integral crystal orbital Hamilton population（ICOHP）,bond length,and d-band center（εd）.In particular,for optimal Ni@g-C10N3,the clear hybridization between the Ni-d orbital and surface O-p orbital causes the paired electrons to occupy the bonding *** enables OH*to be adsorbed on the Ni@g-C10N3,thereby achieving the highest catalytic performance.

关键词： First-principles calculation Oxygen evolution reaction Oxygen reduction reaction Bifunctional electrocatalysts Single-metal-atom electrocatalysts

All-dielectric terahertz metasurface governed by bound states in the continuum with high-Q factor

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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 44-54页

作者： Li Kun Zhao xu Wang meng Jia Xingning Zhao Ruiqi Lu Guizhen School of Integrated Circuit Science and Engineering Tianjin University of TechnologyTianjin 300384China School of Electronic and Electrical Engineering Ningxia UniversityYinchuan 750021China QILU Aerospace Information Research Institute Chinese Academy of Sciences(CAS)Jinan 250101China State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing 100024China

The method of terahertz(THz)resonance with a high-quality(high-Q)factor offers a vital physical mechanism for metasurface sensors and other high-Q factor ***,it is challenging to excite the resonance with a high-Q factor in metasurfaces with proper sensitivity as well as figure of merit(FOM)***,an all-dielectric metasurface composed of two asymmetrical rectangular blocks is *** and silicon are the materials applied for the substrate and cuboids *** distinct resonance governed by bound states in the continuum(BIC)is excited by forming an asymmetric cluster by a novel hybrid method of cutting and moving the *** investigation focuses on analyzing the transmission spectra of the metasurface under different variations in structural parameters and the loss of silicon refractive *** the proposed defective metasurface serves as a transmittance sensor,it shows a Q factor of 1.08×10^(4)and achieves an FOM up to 4.8×10^(6),which is obtained under the asymmetric parameter equalling 1μ***,the proposed defective metasurface is sensitive to small changes in refractive *** the thickness of the analyte is 180μm,the sensitivity reaches a maximum value of 578 GHz/***,the proposed defective metasurface exhibits an extensive number of possible applications in the filters,biomedical diagnosis,security screening,and so on.

关键词： terahertz(THz)metasurface high-quality(high-Q)factor bound states in the continuum figure of merit(FOM)

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A New Method to Identify the Maximum Time Interval between Individual Events in Compound Rainstorm and Heatwave Events

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International Journal of Disaster Risk Science 2024年第3期15卷 453-466页

作者： Junlin Zhang Wei xu Yu Qiao Xinli Liao Chenna meng Qinmei Han Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Faculty of Geographical Science Beijing Normal University Academy of Disaster Reduction and Emergency Management Ministry of Emergency Management and Ministry of Education Beijing Normal University State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal University National Climate Center China Meteorological Administration

Growing evidence indicates that extreme heat and rain may occur in succession within short time periods and cause greater impacts than individual events separated in time and space. Therefore, many studies have examined the impacts of compound hazard events on the social-ecological system at various scales. The definition of compound events is fundamental for such research. However, there are no existing studies that support the determination of time interval between individual events of a compound rainstorm and heatwave(CRH) event, which consists of two or more potentially qualifying component heatwave and rainstorm events. To address the deficiency in defining what individual events can constitute a CRH event, this study proposed a novel method to determine the maximum time interval for CRH events through the change in CRH event frequency with increasing time interval between individual events, using southern China as a case study. The results show that the threshold identified by the proposed method is reasonable. For more than 90% of the meteorological stations, the frequency of CRH events has reached a maximum when the time interval is less than or equal to the threshold. This study can aid in time interval selection, which is an important step for subsequent study of CRH events.

关键词： Compound extreme weather event Rainstorm and heatwave Southern China Threshold Time interval

Effects of diamond particle size on microstructure and properties of diamond/Al-12Si composites prepared by vacuum-assisted pressure infiltration

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China Foundry 2024年第4期21卷 360-368页

作者： Jia-ping Fu Can-xu Zhou Guo-fa Mi yuan Liu School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Diamond/aluminium composites have attracted attention in the field of thermal management of electronic packaging for their excellent *** order to solve the interfacial problem between diamond and aluminium,a novel process combining pressure infiltration with vacuum-assisted technology was proposed to prepare diamond/aluminum *** effect of diamond particle size on the microstructure and properties of the diamond/Al-12Si composites was *** results show that the diamond/Al-12Si composites exhibit high relative density and a uniform *** thermal conductivity and coefficient of thermal expansion increase with increasing particle size,while the bending strength exhibits the opposite *** the average diamond particle size increases from 45μm to 425μm,the thermal conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),while the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-quality composites can be prepared by the vacuum-assisted pressure infiltration process and the thermal conductivity of the composites can be effectively improved by increasing the diamond particle size.

关键词： diamond/aluminum composites thermal conductivity electronic packaging vacuum-assisted pressure infiltration