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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Enhanced bioavailability and biosafety of cannabidiol nanomicelles for effective anti-inflammatory therapy

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Particuology 2022年第10期20卷 1-9页

作者： yuan Rao Runwei Li Saixing liu Linchao meng Qilin Wu Qipeng yuan Hao Liang meng Qin College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China StarHealth Botanical Technology Corporation Beijing 100005China

Cannabidiol(CBD)shows great anti-inflammatory potential;however,the hydrophobicity and strong first-pass effect of CBD leads to its extremely low oral *** 407(P407)is a tri-block copolymer composed of(poly)ethylene oxide(PEO)and(poly)propylene oxide(PPO)*** has a PEO-PPO-PEO structure,which is widely used in the preparation of drug delivery systems that are highly *** it reaches a certain concentration in water,P407 can self-assemble into a micelle structure containing a hydrophobic core and a hydrophilic shell.A potential approach to enhanc-ing the oral bioavailability of hydrophobic drugs incorporating them into the hydrophilic *** prepared CBD nanomicelles with a drug loading of 14.29%by a cosolvent evaporation method using P407 with appropriate *** experiments indicated that anti-inflammatory markers(IL-4 and IL-10)increased,while inflammatory markers(TNF-αand IL-6)***,animal experiments showed that inflammatory cells were inhibited by CBD nanomicelles,and the anti-inflammatory effect of micelles was better than that of CBD,while no obvious evidence indicated toxicity to the liver and kidney.

关键词： CBD Poloxamer 407 Polymeric micelle Anti-inflammatory Cytotoxicity

On the Positivity of Linear Weights in WENO Approximations

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Acta Mathematicae Applicatae Sinica 2009年第3期25卷 503-538页

作者： yuan-yuan liu Chi-wang Shu meng-ping Zhang Department of Mathematics University of Science and Technology of China Hefei 230026 China Division of Applied Mathematics Brown University Providence RI 02912 USA

High order accurate weighted essentially non-oscillatory （WENO） schemes have been used extensively in numerical solutions of hyperbolic partial differential equations and other convection dominated problems. However the WENO procedure can not be applied directly to obtain a stable scheme when negative linear weights are present. In this paper, we first briefly review the WENO framework and the role of linear weights, and then present a detailed study on the positivity of linear weights in a few typical WENO procedures, including WENO interpolation, WENO reconstruction and WENO approximation to first and second derivatives, and WENO integration. Explicit formulae for the linear weights are also given for these WENO procedures. The results of this paper should be useful for future design of WENO schemes involving interpolation, reconstruction, approximation to first and second derivatives, and integration procedures.

关键词： Weighted essentially non-oscillatory (WENO) scheme hyperbolic partial differential equations WENO interpolation WENO reconstruction WENO approximation to derivatives WENO integration

延胡索挥发油的红外光谱法与气相色谱-质谱分析

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中南药学 2017年第1期15卷 99-102页

作者：王媚史亚军郭东艳孟凡刘园园陕西中医药大学药学院陕西咸阳712046

目的研究延胡索挥发油的红外光谱和化学成分,以控制其质量。方法采用索氏提取器提取样品挥发油后,利用傅里叶变换红外光谱法与气相色谱-质谱分析法进行分析,再用峰面积归一化法计算各组分的相对含量。结果延胡索对照药材挥发油和3批延... 详细信息

目的研究延胡索挥发油的红外光谱和化学成分,以控制其质量。方法采用索氏提取器提取样品挥发油后,利用傅里叶变换红外光谱法与气相色谱-质谱分析法进行分析,再用峰面积归一化法计算各组分的相对含量。结果延胡索对照药材挥发油和3批延胡索挥发油的红外光谱图中,有15个共有峰;气相色谱-质谱分离出31种主要成分,鉴别出24种化学成分,主要含有高级烷烃类、烯类、醇和酮类等。其中的8种主要成分共约占总成分的74.77%~80.06%,丹皮酚的含量在24.52%~26.9%。结论延胡索挥发油的化学成分复杂,红外光谱法能准确的鉴别延胡索,气相色谱-质谱能以特征成分为指标精确地控制延胡索的质量。

关键词：延胡索挥发油傅立叶变换红外光谱法气相色谱-质谱法化学成分

Impaired SWEET-mediated sugar transportation impacts starch metabolism in developing rice seeds

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The Crop Journal 2022年第1期10卷 98-108页

作者： Pei Li Lihan Wang Hongbo liu meng yuan National Key Laboratory of Crop Genetic Improvement National Center of Plant Gene Research(Wuhan)Huazhong Agricultural UniversityWuhan 430070HubeiChina

Sugar transportation and sugar-to-starch metabolism are considered important processes in seed development and embryo viability.A few plant SWEET proteins acting as sugar transporters have been reported to function in inflorescence and/or seed ***,we identified seven members of the 21 Os SWEET genes in rice that play essential roles in sugar transportation and sugar-to-starch conversion in seed *** Os SWEET genes exhibiting different expression patterns during inflorescence and seed development were knocked out individually by CRISPR/*** third of the mutants showed decreased fertile pollen viability and shriveled mature caryopses,resulting in weakened seed *** fill-related genes but not representative grain shape-regulating genes showed attenuated expression in the *** of each of these mutants accumulated more sucrose,glucose or fructose but less *** all Os SWEET genes,Os SWEET4 and Os SWEET11 had major effects on caryopsis *** sugar-to-starch metabolic pathway was significantly altered in ossweet11 mutants based on differential expression analysis in RNA sequencing assays,confirming that Os SWEET11 functions as a sugar transporter with a key role in seed *** results help to decipher the multiple functions of Os SWEET genes and to show how they might be used in genetic improvement of rice.

关键词： Oryza sativa Sugar transporter SWEET Sugar Starch

Fate and risk assessment of emerging contaminants in reclaimed water production processes

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 295-310页

作者： yuan meng Weiyi liu Heidelore Fiedler Jinlan Zhang Xinrui Wei Xiaohui liu meng Peng Tingting Zhang Department of Environmental Science and Engineering Research Centre for Resource and EnvironmentBeijing University of Chemical TechnologyBeijing100029China MTM Research Centre School of Science and TechnologyOrebro UniversityOrebroSE-70182Sweden State Key Laboratory of Environmental Criteria and Risk Assessment National Engineering Laboratory for Lake Pollution Control and Ecological RestorationResearch Centre of Lake EnvironmentChinese Research Academy of Environmental SciencesBeijing100012China School of Environment Tsinghua UniversityBeijing100084China

Reclaimed water has been widely applied in irrigation and industrial *** the behavior of emerging contaminants in the production process of reclaimed water is the first prerequisite for developing relevant water quality *** study investigated 43 emerging contaminants,including 22 pharmaceuticals and personal care products(PPCPs),11 organophosphorus flame retardants(OPFRs),and 10 antibiotic resistance genes(ARGs)in 3 reclaimed wastewater treatment plants(RWTPs)in *** composition profiles and removal efficiencies of these contaminants in RWTPs were *** results indicated that the distribution characteristics of the different types of contaminants in the three RWTPs were ***,sul2 and tris(1-chloro-2-propyl)phosphate were the dominant substances in the wastewater,and their highest concentrations were 27104 ng/L,1.4×10^(7) copies/mL and 262 ng/L,*** and sul2 were observed to be the dominant substances in the sludge,and their highest concentrations were 5419 ng/g and 3.7×10^(8) copies/g,***/anoxic/oxic system combined with the membrane bioreactor process achieved a relatively high aqueous removal of PPCPs(87%).ARGs and OPFRs were challenging to remove,with average removal rates of 6.5%and 31%,*** meta-analysis indicated that tertiary treatment processes performed better in emerging contaminant removal than secondary *** exhibited the highest mass load discharge,with 33.5 mg/d per 1000 *** and tris(2-ethylhexyl)phosphate posed high risks(risk quotient>1.0)to aquatic *** study provides essential evidence to screen high priority pollutants and develop corresponding standard in RWTPs.

关键词： Trace organic pollution Antibiotic resistance genes Reclaimed wastewater Sludge Risk assessment Mass load

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin yuan Weicheng Kong Pengcheng Xia yuanrong Li Yuewei Chen Nian liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Fine-Grained Resource Provisioning and Task Scheduling for Heterogeneous Applications in Distributed Green Clouds

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1380-1393页

作者： Haitao yuan meng Chu Zhou Qing liu Abdullah Abusorrah Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA Department of Electrical and Computer Engineering Faculty of Engineeringand the Center of Research Excellence in Renewable Energy and Power SystemsKing Abdulaziz UniversityJeddah 21589Saudi Arabia IEEE

An increasing number of enterprises have adopted cloud computing to manage their important business applications in distributed green cloud(DGC)systems for low response time and high cost-effectiveness in recent *** scheduling and resource allocation in DGCs have gained more attention in both academia and industry as they are costly to manage because of high energy *** factors in DGCs,e.g.,prices of power grid,and the amount of green energy express strong spatial *** dramatic increase of arriving tasks brings a big challenge to minimize the energy cost of a DGC provider in a market where above factors all possess spatial *** work adopts a G/G/1 queuing system to analyze the performance of servers in *** on it,a single-objective constrained optimization problem is formulated and solved by a proposed simulated-annealing-based bees algorithm(SBA)to find SBA can minimize the energy cost of a DGC provider by optimally allocating tasks of heterogeneous applications among multiple DGCs,and specifying the running speed of each server and the number of powered-on servers in each GC while strictly meeting response time limits of tasks of all *** databased experimental results prove that SBA achieves lower energy cost than several benchmark scheduling methods do.

关键词： Bees algorithm data centers distributed green cloud(DGC) energy optimization intelligent optimization simulated annealing task scheduling machine learning