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N-linked glycoproteomic profiling in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第29期28卷 3869-3885页

作者： Qi-Wei liu Hao-Jie Ruan Wei-Xia Chao meng-xiang li Ye-lin Jiao Douglas G Ward She-Gan Gao Yi-Jun Qi Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment/Henan Key Laboratory of Cancer Epigenetics/Cancer Hospital The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471003Henan ProvinceChina Department of Pathology The First People’s Hospital of Luo YangLuoyang 471000Henan ProvinceChina Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND Mass spectrometry-based proteomics and glycomics reveal post-translational modifications providing significant biological insights beyond the scope of genomic *** To characterize the N-linked glycoproteomic profile in esophageal squamous cell carcinoma(ESCC)via two complementary *** Using tandem multilectin affinity chromatography for enrichment of N-linked glycoproteins,we performed N-linked glycoproteomic profiling in ESCC tissues by two-dimensional gel electrophoresis(2-DE)-based and isobaric tags for relative and absolute quantification(iTRAQ)labeling-based mass spectrometry quantitation in parallel,followed by validation of candidate glycoprotein biomarkers by Western *** 2-DE-based and iTRAQ labeling-based quantitation identified 24 and 402 differentially expressed N-linked glycoproteins,respectively,with 15 in common,demonstrating the outperformance of iTRAQ labeling-based quantitation over 2-DE and complementarity of these two *** showed the distinct compositions of functional categories between proteins and glycoproteins with differential expression associated with *** blot analysis validated the up-regulation of total procathepsin D and high-mannose procathepsin D,and the downregulation of total haptoglobin,high-mannose clusterin,and GlcNAc/sialic acid-containing fraction of 14-3-3ζ in ESCC *** serum levels of glycosylated fractions of clusterin,prolinearginine-rich end leucine-rich repeat protein,and haptoglobin in patients with ESCC were remarkably higher than those in healthy *** Our study provides insights into the aberrant N-linked glycoproteome associated with ESCC,which will be a valuable resource for future investigations.

关键词： Esophageal squamous cell carcinoma N-linked glycoprotein Post-translational modification Lectin Cathepsin D Haptoglobin 14-3-3ζ

基于参数识别视速度的双矢量粗对准方法(英文)

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中国惯性技术学报 2016年第6期24卷 730-735页

作者：孟翔飞李鑫常熟理工学院电气与自动化工程学院常熟215500

针对传统基于视速度双矢量粗对准中,由于传感器随机噪声的影响,存在对准精度差,收敛速度慢的缺点,提出了一种新型自适应Kalman滤波的参数识别粗对准方法。该方法通过对视速度运动进行建模,设计采用自适应Kalman滤波对模型参数进行参数识... 详细信息

针对传统基于视速度双矢量粗对准中,由于传感器随机噪声的影响,存在对准精度差,收敛速度慢的缺点,提出了一种新型自适应Kalman滤波的参数识别粗对准方法。该方法通过对视速度运动进行建模,设计采用自适应Kalman滤波对模型参数进行参数识别,从而有效地消除视运动中的随机噪声,提高粗对准的精度和收敛速度。由于自适应滤波的特点,新方法不需要对传感器误差进行统计,使其在实际系统中具有更加广泛的应用价值。针对双矢量粗对准的计算特点,设计了一种矢量重构算法,从而尽可能地规避双矢量共线性问题,加快了粗对准的收敛过程。仿真与转台实验表明,与传统方法对比,新方法在相同的对准时间内具有更高的对准精度,在相同的对准精度下,具有更高的收敛速度。转台实验的最终对准精度为-0.1391°,标准差为0.012°。

关键词：捷联惯导系统粗对准改良Kalman滤波参数辨识双矢量姿态确定

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

O_3分子在CuO(110)面吸附的密度泛函理论研究

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高等学校化学学报 2009年第1期30卷 164-169页

作者：覃吴李欣孟祥丽强亮生哈尔滨工业大学应用化学系哈尔滨150090

应用密度泛函理论研究了O3分子在2×1CuO(110)面(S1)和掺杂一个Fe原子的2×1CuO(110)面(S2)的吸附过程和电子特性.计算结果表明,O3分子与表面S1和S2有很强的相互作用,O3分子在表面吸附反应的活化能和反应能均为负值,反应很容易进行.态... 详细信息

应用密度泛函理论研究了O3分子在2×1CuO(110)面(S1)和掺杂一个Fe原子的2×1CuO(110)面(S2)的吸附过程和电子特性.计算结果表明,O3分子与表面S1和S2有很强的相互作用,O3分子在表面吸附反应的活化能和反应能均为负值,反应很容易进行.态密度和电荷密度分析结果进一步证实了O3分子在S1上吸附是桥位化学吸附,形成表面臭氧化物,在S2上吸附分解为1个被吸附的表面氧原子和1个自由氧分子.电子特性分析表明,O3分子与S1和S2相互作用的本质是O3分子的价轨道2p与CuO(110)表面杂化轨道的相互作用.

关键词： O3 CuO(110)面表面吸附密度泛函理论

基于计算机仿真技术的矿井救援密封舱盾构土压平衡问题研究

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煤炭技术 2014年第1期33卷 131-133页

作者：孟祥丽德州职业技术学院山东德州253000

井下救援密封舱是煤矿安全生产的保障,是危机时刻矿工的最后一道生命线。随着煤矿开拓推进,密封舱会受到掘进机扰动而发生围岩压力变化,影响了密封舱的稳定性。文章基于以上问题建立了密封舱压力场分布模型和压力控制模型。根据模型制... 详细信息

井下救援密封舱是煤矿安全生产的保障,是危机时刻矿工的最后一道生命线。随着煤矿开拓推进,密封舱会受到掘进机扰动而发生围岩压力变化,影响了密封舱的稳定性。文章基于以上问题建立了密封舱压力场分布模型和压力控制模型。根据模型制定了密封舱周围开拓扰动影响的控制策略,利用计算机仿真技术验证了模型和控制策略的有效性。此研究为井下救援密封舱及巷道布置研究提供了科学依据。

关键词：计算机仿真救援密封舱盾构土压平衡

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun Fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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圜道观视域下的“肺主治节”探析

中华中医药杂志 2022年第5期37卷 2651-2653页

作者：孟祥丽张庆祥山东中医药大学中医学院济南250355

圜道观是中国古老的传统观念形态之一,其周而复始的环周运动思维模式中隐含了恒动循环观、系统整体观和自和稳态观等诸多观念,促使圜道观几乎渗透到了中国传统文化中精神文明的各个方面。中医学作为最具有中国思维特色的传统科学之一,... 详细信息

圜道观是中国古老的传统观念形态之一,其周而复始的环周运动思维模式中隐含了恒动循环观、系统整体观和自和稳态观等诸多观念,促使圜道观几乎渗透到了中国传统文化中精神文明的各个方面。中医学作为最具有中国思维特色的传统科学之一,离不开圜道观的影响与渗透。文章以肺主治节理论为例,从圜道观视角进行解读探析,以期将中国传统思维方式更好地应用于现代中医理论的认识与理解,为中医学理论的基础研究及临床实践提供启发和参考。

关键词：圜道观肺主治节恒动循环系统整体自和稳态中医基础理论

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang liu xiang li Shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

不同产地浮萍中5种黄酮成分量及抗氧化活性的化学模式识别研究

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中草药 2017年第5期48卷 985-990页

作者：蒋祥亮刘聪燕陈彦黄萌萌王理想李萍安徽中医药大学安徽合肥230012 江苏省中医药研究院中药组分与微生态研究中心江苏南京210028

目的测定不同产地浮萍Spirodela polyrriza中5个黄酮类成分的量,并对其抗氧化活性进行评价。方法采用HPLC法,以乙腈-0.1%甲酸为流动相测定8个产地17批浮萍药材中荭草素、牡荆素、木犀草苷、大波斯菊苷、木犀草素的量;采用DPPH清除率法... 详细信息

目的测定不同产地浮萍Spirodela polyrriza中5个黄酮类成分的量,并对其抗氧化活性进行评价。方法采用HPLC法,以乙腈-0.1%甲酸为流动相测定8个产地17批浮萍药材中荭草素、牡荆素、木犀草苷、大波斯菊苷、木犀草素的量;采用DPPH清除率法比较不同产地浮萍的抗氧化活性,并结合聚类分析和主成分分析等化学模式识别技术对浮萍质量进行评价。结果不同产地浮萍中5个黄酮类成分量存在一定差异,聚类分析和主成分分析均可将不同产地浮萍分为3类,且分类结果一致。其中陕西和山西产地的浮萍中荭草素、牡荆素、木犀草苷的量均较其他产地明显偏高;相关性分析表明,氧化清除率与黄酮类成分量呈显著正相关。结论陕西和山西产地的浮萍黄酮类成分量高,抗氧化能力较强。所建立的分析方法稳定可靠,可为浮萍药材的产地识别和质量控制提供参考。

关键词：浮萍黄酮类荭草素牡荆素木犀草苷大波斯菊苷木犀草素聚类分析主成分分析抗氧化活性