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Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats

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Journal of Pharmaceutical Analysis 2011年第2期1卷 135-138页

作者： Hong-Ying Yang wen-meng zhang wen-wen Yang Ting Zhao Li-Xin Sun School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China Liaoning Institute of Pharmaceutical Industry Shenyang 110015 China

The pharmacokinetics of 16-dehydropregnenolone （16-DHP）, a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a single intramuscular administration （40 mg/kg）. The concentration of 16-DHP in rat plasma was determined by a high performance liquid chromatography （HPLC） method with UV detection. Levonorgestrel was used as the internal standard （IS）. The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a single intramuscular administration, the maximum plasma concentration （Cmax） was （289±25）ng/mL, time to reach Cmax（tmax） was （0.38±0.14） h, the elimination half-life （t1/z） was （2.5±1.1）h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration （AUC（0-t）） was （544± 73）ng· h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.

关键词： 16-dehydropregnenolone intramuscular administration pharmacokinetics high performance liquid chroma- tography

Consumption of garlic and risk of colorectal cancer:An updated meta-analysis of prospective studies

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World Journal of Gastroenterology 2014年第41期20卷 15413-15422页

作者： Ji-Yi Hu Yi-Wang Hu Jiao-Jiao Zhou meng-wen zhang Dan Li Shu Zheng Cancer Institute Key Laboratory of Cancer Prevention and InterventionChina National Ministry of Educationthe Second Affiliated HospitalSchool of MedicineZhejiang University

AIM: To conduct an updated meta-analysis of prospective studies addressing the association between garlic consumption and colorectal cancer.

关键词： Colorectal cancer Garlic Garlic supplement Cancer prevention Meta-analysis

DNA methylation in the tumor microenvironment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第5期18卷 365-372页

作者： meng-wen zhang Kenji FUJIWARA Xu CHE Shu ZHENG Lei ZHENG The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China The Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Department of Oncology Johns Hopkins University School of MedicineBaltimore 21231USA The Sidney Kimmel Cancer Center Johns Hopkins University School of MedicineBaltimore 21231USA

The tumor microenvironment （TME） plays an important role in supporting cancer progression. The TME is composed of tumor cells, the surrounding tumor-associated stromal cells, and the extracellular matrix （ECM）. Crosstalk between the TME components contributes to tumorigenesis. Recently, one of our studies showed that pancreatic ductal adenocarcinoma （PDAC） cells can induce DNA methylation in cancer-associated flbroblasts （CAFs）, thereby modifying tumor-stromal interactions in the TME, and subsequently creating a TME that supports tumor growth Here we summarize recent studies about how DNA methylation affects tumorigenesis through regulating tumor- associated stromal components including fibroblasts and immune cells. We also discuss the potential for targeting DNA methylation for the treatment of cancers.

关键词： Tumor microenvironment (TME) DNA methylation Cancer-associated fibroblasts Cancer-associated immune cells Epiqenetic therapy

RP-HPLC method for the simultaneous determination of daidzein,genistein and formonetin in Solanum Lyratum Thunb

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Journal of Pharmaceutical Analysis 2010年第3期22卷 156-159页

作者： Yu-Rong Jia1,wen-meng zhang1,Ting Zhao2,wen-wen Yang1,Li-Xin Sun1 1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016 2.Liaoning Academy of Pharmaceutical Industry,Shenyang 110016,China School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 China Liaoning Academy of Pharmaceutical Industry Shenyang 110016 China

A rapid method for the simultaneous determination of daidzein,genistein and formonetin in solanum Lyratum Thunb by high performance liquid chromatography(HPLC)was *** was achieved on a Diamonsil C18 column(250 mm×4.6 mm,5 μm)with isocratic elution,using a mobile phase of methanol-tetrahydrofuran-water(44∶3∶53,v/v).The wavelength was set at 260 nm and column was maintained at 35 ℃.The linear ranges of daidzein,genistein and formonetin were 1.0-40.0,0.1-4.0 and 0.1-4.0 μg/mL,*** average recoveries were between 98.4% and 101.3%.This method could be used for the quality control of Solanum lyratum Thunb due to its simplification,reliability,rapidity and excellent precision.

关键词： Solanum lyratum Thunb daidzein genistein formonetin determination RP-HPLC

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中国标准动车组前端三维蒙皮件冲压成形

吉林大学学报（工学版） 2017年第3期47卷 869-875页

作者：谷诤巍吕萌萌张文学雷娇娇徐虹吉林大学材料科学与工程学院长春130022

以中国标准动车组前端三维蒙皮件为例,利用通用有限元软件Autoform对该类厚度大、拉延深度浅、空间结构复杂、非对称的V型截面蒙皮件的成形过程进行了模拟分析。研究了压边力、拉延筋、凹模圆角、拉延深度、摩擦因数及模具间隙等工艺和... 详细信息

以中国标准动车组前端三维蒙皮件为例,利用通用有限元软件Autoform对该类厚度大、拉延深度浅、空间结构复杂、非对称的V型截面蒙皮件的成形过程进行了模拟分析。研究了压边力、拉延筋、凹模圆角、拉延深度、摩擦因数及模具间隙等工艺和结构参数对蒙皮件成形的影响。分析了该类构件拉伸不足及轮廓精度差等成形缺陷的成因,并提出了相应的控制方法。结果表明:拉伸不足主要由成形过程中板料的流动阻力不足引起,可通过增大压边力、设置拉延筋进行控制,对于本文所研究的长条形蒙皮件而言,采用变强度拉延筋可以有效控制拉伸不足;轮廓精度差主要由回弹量大引起,优化成形工艺参数可一定程度上提高蒙皮件轮廓精度,工艺参数对轮廓精度的影响程度按照从大到小排序为:凹模圆角、摩擦因数、模具间隙、拉延深度;基于回弹量对模具型面进行补偿可以有效控制蒙皮件的轮廓精度;对于4 mm厚5083-H111铝合金蒙皮件而言,回弹补偿系数取1.2时,蒙皮件的轮廓精度最好。基于模拟结果开展了成形试验,得到合格的成形件,验证了缺陷控制措施的有效性。

关键词：材料合成与加工工艺中国标准动车组三维蒙皮数值模拟工艺参数缺陷控制

Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： meng Zheng Lei zhang Wei Liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： wen Jin LIU Zhanzhi WU Zhengwei PAN Yu zhang Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

切向气流作用下激光辐照对尼龙材料的热烧蚀规律

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光学精密工程 2017年第2期25卷 351-357页

作者：蒙文张文杰李云霞方英武韩晓飞空军工程大学信息与导航学院中国人民解放军95007部队

为了研究切向气流对激光毁伤低慢小目标的影响,采用仿真分析和实验相结合的方法研究了在激光辐照典型低慢小目标材料尼龙66过程中切向气流对激光烧蚀作用的影响。建立了激光烧蚀尼龙的简化物理模型,利用红外热像仪分别研究了1.5s和4s两... 详细信息

为了研究切向气流对激光毁伤低慢小目标的影响,采用仿真分析和实验相结合的方法研究了在激光辐照典型低慢小目标材料尼龙66过程中切向气流对激光烧蚀作用的影响。建立了激光烧蚀尼龙的简化物理模型,利用红外热像仪分别研究了1.5s和4s两个时刻激光辐照下尼龙材料的温度场分布和烧蚀形貌,并与无气流条件下的结果进行对比。实验表明,切向气流对激光烧蚀尼龙材料过程的影响主要分两个阶段,在辐照前段时间切向气流减缓了激光辐照下尼龙66材料的温升,抑制了激光对尼龙材料的烧蚀作用;但随着温度的升高,热分解产物增多使激光屏蔽作用增强,切向气流减轻了目标材料表面热分解产物对激光的衰减,并为尼龙材料的氧化烧蚀提供更多氧气,促进了烧蚀作用。最后对切向气流下激光烧蚀尼龙的过程进行了ANSYS仿真,实验结果和仿真结果基本一致,从而验证了理论的可靠性。

关键词：激光烧蚀激光辐照热烧蚀尼龙66 切向气流 ANSYS仿真