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电化学（中英文） 2024年第7期30卷 1-27页

作者： Fa-Dong Chen Zhuo-Yang Xie meng-ting li Si-Guo Chen Wei Ding li li Jing li Zi-Dong Wei State Key Laboratory of Advanced Chemical Power Sources(Chongqing University) College of Chemistry and Chemical EngineeringChongqing UniversityChongqing400044China

Two major challenges,high cost and short lifespan,have been hindering the commercialization process of lowtemperature fuel *** Wei's group has been focusing on decreasing cathode Pt loadings without losses of activity and durability,and their research advances in this area over the past three decades are briefly reviewed *** the Pt-based catalysts and the low Pt usage,they have firstly tried to clarify the degradation mechanism of Pt/C catalysts,and then demonstrated that the activity and stability could be improved by three strategies:regulating the nanostructures of the active sites,enhancing the effects of support materials,and optimizing structures of the three-phase *** Pt-free catalysts,especialiy carbon-based ones,several strategies that they proposed to enhance the activity of nitrogen-/heteroatom-doped carbon catalysts are firstly ***,an indepth understanding of the degradation mechanism for carbon-based catalysts is discussed,and followed by the corresponding stability enhancement ***,the carbon-based electrode at the micrometer-scale,faces the challenges such as low active-site density,thick catalytic layer,and the effect of hydrogen peroxide,which require rational structure design for the integral cathodic *** review finally gives a brief conclusion and outlook about the low cost and long lifespan of cathodic oxygen reduction catalysts.

关键词： Fuel cell Oxygen reduction reaction Pt-based catalyst Carbon-based catalyst

Identification of immune cell-related prognostic genes characterized by a distinct microenvironment in hepatocellular carcinoma

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World Journal of Clinical Oncology 2024年第2期15卷 243-270页

作者： meng-ting li Kai-Feng Zheng Yi-Er Qiu Department of Gastroenterology The Affiliated People's Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND The development and progression of hepatocellular carcinoma(HCC)have been reported to be associated with immune-related genes and the tumor ***,there are not enough prognostic biomarkers and models available for clinical *** on seven prognostic genes,this study calculated overall survival in patients with HCC using a prognostic survival model and revealed the immune status of the tumor microenvironment(TME).AIM To develop a novel immune cell-related prognostic model of HCC and depict the basic profile of the immune response in *** We obtained clinical information and gene expression data of HCC from The Cancer Genome Atlas(TCGA)and International Cancer Genome Consortium(ICGC)*** and ICGC datasets were used for screening prognostic genes along with developing and validating a seven-gene prognostic survival model by weighted gene coexpression network analysis and least absolute shrinkage and selection operator regression with Cox *** relative analysis of tumor mutation burden(TMB),TME cell infiltration,immune check-points,immune therapy,and functional pathways was also performed based on prognostic *** Seven prognostic genes were identified for signature *** receiver operating characteristic curve analysis showed the good performance of survival *** could be regarded as an independent factor in HCC survival *** was a significant difference in stromal score,immune score,and estimate score between the high-risk and low-risk groups stratified based on the risk score derived from the seven-gene prognostic *** immune checkpoints,including VTCN1 and TNFSF9,were found to be associated with the seven prognostic genes and risk *** combinations of checkpoint blockade targeting inhibitory CTLA4 and PD1 receptors and potential chemotherapy drugs hold great promise for specific HCC *** pathways,such as cell cycle regulat

关键词： Hepatocellular carcinoma Prognostic model Weighted gene coexpression network analysis Microenvironment Chemotherapy

Hard-carbon hybrid li-ion/metal anode enabled by preferred mesoporous uniform lithium growth mechanism

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Journal of Energy Chemistry 2024年第1期88卷 252-259,I0006页

作者： Fang Yan Yan liu Yuan li Yan Wang Zicen Deng meng li Zhenwei Zhu Aohan Zhou ting li Jingyi Qiu Gaoping Cao Shaobo Huang Biyan Wang Hao Zhang School of Chemistry and Biological Engineering University of Science and TechnologyBeijing 100083China Research Institute of Chemical Defense Beijing 100191China College of Physics and Engineering Henan University of Science and TechnologyLuoyang 471023HenanChina National Base for International Science&Technology Cooperation School of ChemistryXiangtan UniversityXiangtan 411105HunanChina Materials and Manufacturing Department Beijing University of TechnologyBeijing 100124China

To achieve high energy density in lithium batteries,the construction of lithium-ion/metal hybrid anodes is a promising *** particular,because of the anisotropy of graphite,hybrid anode formed by graphite/li metal has low transport kinetics and is easy to causes the growth of lithium dendrites and accumulation of dead li,which seriously affects the cycle life of batteries and even causes safety ***,by comparing graphite with two types of hard carbon,it was found that hybrid anode formed by hard carbon and lithium metal,possessing more disordered mesoporous structure and lithophilic groups,presents better *** indicate that the mesoporous structure provides abundant active site and storage space for dead *** the synergistic effect of this structure and lithophilic functional groups(–COOH),the reversibility of hard carbon/lithium metal hybrid anode is maintained,promoting uniform deposition of lithium metal and alleviating formation of lithium *** hybrid anode maintains a 99.5%Coulombic efficiency(CE)after 260 cycles at a specific capacity of 500 m Ah/*** work provides new insights into the hybrid anodes formed by carbon-based materials and lithium metal with high specific energy and fast charging ability.

关键词： Hard carbon/li metal hybrid anode Mesoporous structure Surface oxygen functional group Fast charging lithium batteries

Compact broadband high-resolution Compton spectroscopy for laser-driven high-flux gamma rays

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Matter and Radiation at Extremes 2021年第1期6卷 5-14页

作者： Zhen-Chi Zhang Tao Yang Guang-Yue Hu meng-ting li Wen Luo Ning An Jian Zheng CAS Key Laboratory of Geospace Environment and Department of Engineering and Applied Physics University of Science and Technology of ChinaHefeiAnhui 230026China CAS Center for Excellence in Ultra-Intense Laser Science(CEULS) Shanghai 200031China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefeiAnhui 230026China Anhui Specreation Instrument Technology Co. Ltd.HefeiAnhui 230088China Collaborative Innovation Center of IFSA(CICIFSA) Shanghai Jiao Tong UniversityShanghai 200240China

A compact broadband Compton spectrometer with high spectral resolution has been designed to detect spectra of laser-driven high-flux gamma *** primary detection range of the gamma-ray spectrum is 0.5 MeV–13 MeV,although a secondary harder gamma-ray region of 13 MeV–30MeV can also be *** Compton-scattered electrons are spectrally resolved using a curved surface detector and a nonuniform magnetic field produced by a pair of step-like *** design allows a compact structure,a wider bandwidth,especially in the lower-energy region of 0.5 MeV–2 MeV,and optimum spectral *** spectral resolution is 5%–10%in the range 4 MeV–13 MeV and better than 25%in the range 0.5MeV–4MeV(with an Al converter of 0.25mmthickness and a collimator of 1 cm inner diameter).Low-Z plastic materials are used on the inner surface of the spectrometer to suppress noise due to secondary X-ray *** spectrometer can be adjusted flexibly via a specially designed mechanical *** algorithmbased on a regularizationmethod has also been developed to reconstruct the gamma-ray spectrum from the scattered electrons.

关键词： resolution scattered inner

De-biased knowledge distillation framework based on knowledge infusion and label de-biasing techniques

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Journal of Electronic Science and Technology 2024年第3期22卷 57-68页

作者： Yan li Tai-Kang Tian meng-Yu Zhuang Yu-ting Sun School of Economics and Management University of Electronic Science and Technology of ChinaChengdu611731China School of Economics and Management Beijing University of Posts and TelecommunicationBeijing100876China School of Electrical Engineering and Computer Science The University of QueenslandBrisbane4072Australia

Knowledge distillation,as a pivotal technique in the field of model compression,has been widely applied across various ***,the problem of student model performance being limited due to inherent biases in the teacher model during the distillation process still *** address the inherent biases in knowledge distillation,we propose a de-biased knowledge distillation framework tailored for binary classification *** the pre-trained teacher model,biases in the soft labels are mitigated through knowledge infusion and label de-biasing *** on this,a de-biased distillation loss is introduced,allowing the de-biased labels to replace the soft labels as the fitting target for the student *** approach enables the student model to learn from the corrected model information,achieving high-performance deployment on lightweight student *** conducted on multiple real-world datasets demonstrate that deep learning models compressed under the de-biased knowledge distillation framework significantly outperform traditional response-based and feature-based knowledge distillation models across various evaluation metrics,highlighting the effectiveness and superiority of the de-biased knowledge distillation framework in model compression.

关键词： De-biasing Deep learning Knowledge distillation Model compression

Tough Polymeric Hydrogels Based on Amino Acid Derivative Mediated Dynamic Metal Coordination Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1578-1588页

作者： meng li meng-Yuan Zhang Wu-Xuan Lei Zhu-ting Lv Qing-Hua Shang Zheng Zhao Jiang-Tao li Yi-Long Cheng Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University Polymer Materials & Engineering Department School of Materials Science & Engineering Chang'an University School of Electrical Engineering Xi'an Jiaotong University Department of Nuclear Medicine the First Affiliated Hospital of China Xi'an Jiaotong University

Abstract The development of physically crosslinked hydrogels with excellent mechanical and sensing properties is of importance for expanding the practical applications of intelligent soft hydrogel ***,after copolymerization of hydroxyl-containing amino acid derivative N-acryloyl serine （ASer） with acrylamide （AM）,we introduce Zr4+through an immersion strategy to construct metal ion-toughened non-covalent crosslinked hydrogels （with tensile strength of up to 5.73 MPa）.It is found that the synergistic coordination of hydroxyl and carboxyl groups with Zr4+substantially increases the crosslinking density of the hydrogels,thereby imparting markedly superior mechanical properties compared to hydroxyl-free Zr4+-crosslinked hydrogels,such as N-acryloyl alanine （AAla） copolymerized with AM hydrogels （with tensile strength of 2.98 MPa）Through the adjustment of the composition of the copolymer and the density of coordination bonds,the mechanical properties of the hydrogels can be modulated over a wide ***,due to the introduction of metal ions and the dynamic nature of coordination bonds,the hydrogels also exhibit excellent sensing performance and good self-recovery properties,paving the way for the development of flexible electronic substrates with outstanding comprehensive performances.

关键词： Amino acid Flexible sensor Hydrogel Mechanical performance Metal coordination

Therapeutic Effect of Prolyl Endopeptidase Inhibitor in High-fat Diet-induced Metabolic Dysfunction-associated Fatty liver Disease

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1035-1049页

作者： Jian-Bin Zhang meng-ting li Shuang-Zhe lin Yu-Qing Cheng Jian-Gao Fan Yuan-Wen Chen Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiChina Department of Gastroenterology Huadong HospitalFudan UniversityShanghaiChina Department of Gastroenterology The Affiliated People's Hospital of Ningbo UniversityNingboZhejiangChina Department of Geriatrics Huadong HospitalFudan UniversityShanghaiChina

Background and Aims:Prolyl endopeptidase(PREP)is a serine endopeptidase that participates in many pathological processes including inflammation,oxidative stress,and *** previous studies found that PREP knockout exhibited multiple benefits in high-fat diet(HFD)or methionine choline-deficient diet-induced metabolic dysfunctionassociated fatty liver disease(MAFLD).However,cumulative studies have suggested that PREP performs complex functions during disease ***,further understanding the role of PREP in MAFLD development is the foundation of PREP ***:In this study,an HFD-induced MAFLD model at different time points(4,8,12,and 16 weeks)was used to explore dynamic changes in the PREP proline-glycine-proline(PGP)/N-acetyl-seryl-aspartyllysyl-proline(AcSDKP)*** explore its potential value in MAFLD treatment,saline,or the PREP inhibitor,KYP-2047,was administered to HFD-induced MAFLD mice from the 10th to 16th ***:PREP activity and expression were increased in HFD-mice compared with control mice from the 12th week onwards,and increased PREP mainly resulted in the activation of the matrix metalloproteinase 8/9(MMP8/9)-PREP-PGP axis rather than the thymosin B4-meprin a/PREP-AcSDKP *** addition,KYP-2047 reduced HFD-induced liver injury and oxidative stress,improved lipid metabolism through the suppression of lipogenic genes and the induction of B-oxidation-related genes,and attenuated hepatic inflam-mation by decreasing MMP8/9 and ***,KYP2047 restored HFD-induced impaired autophagy and this was veri-fied in HepG2 ***:These findings suggest that increased PREP activity/expression during MAFLD de-velopment might be a key factor in the transition from sim-ple steatosis to steatohepatitis,and KYP-2047 might possess therapeutic potential for MAFLD treatment.

关键词： Metabolic dysfunction-associated fatty liver disease Prolyl endopeptidase KYP-2047 Proline-glycine-proline N-acetyl-seryl-aspartyl-lysylproline

Strategies that regulate LSD1 for novel therapeutics

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： meng li mengge Dai Bing Cheng Shaotong li Enhui Guo Junwei Fu ting Ma Bin Yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

A high li-ion diffusion kinetics in multidimensional and compact-structured electrodes via vacuum filtration casting

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Journal of Energy Chemistry 2024年第6期93卷 368-376,I0010页

作者： Jieqiong li ting Ouyang Lu liu Shu Jiang Yongchao Huang M.-Sadeeq Balogun College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082HunanChina Institute of Environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina

Manufacturing process,diffusion co-efficient and areal capacity are the three main criteria for regulating thick electrodes for lithium-ion batteries(liBs).However,simultaneously regulating these criteria for liBs is desirable but remains a significant *** this work,niobium pentoxide(Nb_(2)O_(5))anode and lithium iron phosphate(liFePO_(4))cathode materials were chosen as the model materials and demonstrate that these three parameters can be simultaneously modulated by incorporation of micro-carbon fibers(MCF)and carbon nanotubes(CNT)with both Nb_(2)O_(5) and LFP via vacuum filtration *** as-prepared MNC-20 anode and MLC-20 cathode achieves high reversible areal capacity of≈5.4 m A h cm^(-2)@0.1 C and outstanding li-ion diffusion coefficients of≈10~(-8)cm~2 s~(-1)in the half-cell *** assembled MNC-20‖MLC-20 full cell liB delivers maximum energy and power densities of244.04 W h kg^(-1)and 108.86 W kg^(-1),*** excellent electrochemical properties of the asprepared thick electrodes can be attributed to the highly conductive,mechanical compactness and multidimensional mutual effects of the MCF,CNT and active materials that facilitates rapid li-ion diffusion ***,electrochemical impedance spectroscopy(EIS),symmetric cells analysis,and insitu Raman techniques clearly validates the enhanced li-ion diffusion kinetics in the present architecture.

关键词： Thick electrodes Carbon nanotubes li-ion diffusion co-efficient Vacuum filtration technique High areal capacity lithium-ion batteries

Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru Zhang Qiong Wu Yong Zhang Xi-Fei li ting Xie Yu-Cheng Wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials lithium-ion batteries