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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-Jin WU Zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting zeng Xin HAO Hua-Bin su Qiang su Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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Protect the oceans from Japan's radioisotope dumping

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Environmental Science and Ecotechnology 2024年第4期20卷 16-17页

作者： Chengjun Li Huan Zhong Lingyu meng mengjie Wu Wenjing Ning su Shiung Lam Jun Luo Christian Sonne Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China School of Environment Nanjing UniversityNanjingChina Department of Civil Engineering Nagoya Institute of TechnologyJapan Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjingChina Universiti Malaysia Terengganu TerengganuMalaysia Center for Global Health Research(CGHR) Saveetha Institute of Medical and Technical Sciences(SIMATS)Saveetha UniversityChennaiIndia Aarhus University RoskildeDenmark sustainability Cluster School of EngineeringUniversity of Petroleum&Energy StudiesDehradunUttarakhandIndia

In August 2023,Japan started to dump its 1.3 million tons of radioactive wastewater into the oceans[1,2].Most radioisotopes are claimed to be removed from the wastewater except tritium,which needs further dilution before ***,this dilution does not effectively remove any tritium from the wastewater but serves as a measure to bring its abnormally high concentration down to meet emission *** most worrisome situation is that many more bioaccumulative long-lived radioisotopes(BLLRs),such as carbon-14 and cobalt-60,slip through the treatment *** are attempts to reduce the concentrations of BLLRs via repurification to meet the regulatory standards[3];however,even low levels of these BLLRs can undergo biomagnification of up to 50,000 folds in marine fish species[4].

关键词： wastewater Japan removed

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Analysis of Characteristics of a Heavy Rainstorm Process in Nanchang City on July 7,2020

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Meteorological and Environmental Research 2024年第1期15卷 1-7,11页

作者： Fengling zeng Landi ZHONG Minghua meng Chongqing Branch Southwest Air Traffic Management BureauCivil Aviation Administration of ChinaChongqing 401120China Nanchang Meteorological Bureau Nanchang 330038China

Based on the conventional observation data,dual polarization radar data and NCEP reanalysis data,the large-scale circulation background field,mesoscale conditions and formation causes of a heavy rainstorm in Nanchang on July 7,2020 were *** was found that this heavy rainstorm occurred under the weather background of the confrontation between the northward air flow behind the trough and the strong southwest warm and humid air flow to the northwest of the subtropical *** divergence at the upper level,the shear in the middle and low levels,the southward movement of cold air at the low level,unusually abundant water vapor and high unstable energy caused the heavy rainstorm *** this process,under the influence of continuous eastward movement of several strong echo cells,an obvious"train effect"was formed in Nanchang,so that the local rainfall was continuous and ***,the average of VIL was about 17 kg/m 2,and its variation characteristics were consistent with the variation trend of 5-min rainfall intensity,which had a certain indicator effect on short-term heavy *** topography of the Meiling Mountain in the west of Nanchang had a great influence on the formation and precipitation distribution of the heavy rain *** was a strong rainstorm center near the mountain,and the precipitation was obviously larger than that in the plain area.

关键词： Short-term heavy precipitation Mesoscale system Train effect Meiling landform

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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The transition from 2G to 3G-feedstocks enabled efﬁcient production of fuelsand chemicals

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Green Energy & Environment 2024年第11期9卷 1759-1770页

作者： Kai Wang Changsheng su Haoran Bi Changwei Zhang Di Cai Yanhui Liu meng Wang Biqiang Chen Jens Nielsen Zihe Liu Tianwei Tan College of Life Science and Technology Beijing University of Chemical TechnologyBeijing Advanced Innovation Center for Soft Matter Science and EngineeringNo.15 North 3rd Ring Rd EastBeijing100029China National Energy R&D Center for Biorefnery Beijing Key Lab of BioprocessBeijing University of Chemical TechnologyNo.15 North 3rd Ring Rd EastBeijing100029China Department of Life Sciences Chalmers University of TechnologyGothenburgSE41296Sweden

For decades micoorganisms have been engineered for the utilization of lignocellulose-based second-generation (2G) feedstocks, but with theconcerns of increased levels of atmospheric CO_(2) causing global warming there is an emergent need to transition from the utilization of 2Gfeedstocks to third-generation (3G) feedstocks such as CO_(2) and its derivatives. Here, we established a yeast platform that is capable ofsimultaneously converting 2G and 3G feedstocks into bulk and value-added chemicals. We demonstrated that by adopting 3G substrates such asCO_(2) and formate, the conversion of 2G feedstocks could be substantially improved. Speciﬁcally, formate could provide reducing power andenergy for xylose conversion into valuable chemicals. Simultaneously, it can form a concentrated CO_(2) pool inside the cell, providing thermodynamically and kinetically favoured amounts of precursors for CO_(2) ﬁxation pathways, e.g., the Calvin–Benson–Bassham (CBB) ***, we demonstrated that formate could directly be utilized as a carbon source by yeast to synthesize endogenous amino acids. Theengineered strain achieved a one-carbon (C1) assimilation efﬁciency of 9.2%, which was the highest efﬁciency observed in the co-utilization of2G and 3G feedstocks. We applied this strategy for productions of both bulk and value-added chemicals, including ethanol, free fatty acids(FFAs), and longifolene, resulting in yield enhancements of 18.4%, 49.0%, and ~100%, respectively. The strategy demonstrated here for coutilization of 2G and 3G feedstocks sheds lights on both basic and applied research for the up-coming establishment of 3G bioreﬁneries.

关键词： transition utilized Benson

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The Optical Variability Properties of TeV Blazars

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Research in Astronomy and Astrophysics 2024年第9期24卷 66-75页

作者： Zi-An su Wen-Xin Yang Xiang-Tao zeng Le-Jian Ou Ze-Lin Li Jiang-He Yang Jun-Hui Fan Department of Physics School of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Greater Bay Brand Center of the National Astronomical Data Center Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China College of Microelectronics Feicuihu Campus of Hefei University of TechnologyHefei 230601China College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China

Variability is one of the typical observational properties of blazars and the spectral changes are usually associated with variability,although this kind of association is unclear *** this work,we used data from the Steward Observatory blazar monitoring program to investigate the optical variability properties including the short-term timescale,the brightness-dependent spectral property,the correlation between the the brightness variation and the polarization,and then estimate the Doppler factors based on the obtained short timescale to study the polarization property for a sample of 20 TeV *** analyses arrive at the following results:(1)The largest variation amplitude in R-band,ΔR_(M),covers a range from ΔR_(M)=0.29 mag(1ES 2344+514)to ΔR_(M)=4.66 mag(3C 279).(2)Intra-day variability was found from five sources with timescales from 0.14 day for S50716+714 to 0.98 day for PKS *** sources show spectra that are bluer when they become brighter,suggesting a common bluer-when-brighter property.(3)The plot of the polarization versus estimated Doppler factor is consistent with the Doppler factor dependent formula of polarization.(4)The largest polarization is correlated with the largest optical variation,suggesting that the high polarization and high amplitude variation are both the indicator of beaming effect.

关键词： galaxies:active galaxies:jets radiation mechanisms:non-thermal

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Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang Chun-Hong Gu Jia zeng Xiao-Hui Wei Mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

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Two-dimensional materials for tunable and nonlinear metaoptics

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Advanced Photonics 2024年第3期6卷 16-34页

作者： zeng Wang Kandammathe Valiyaveedu Sreekanth meng Zhao Jinpeng Nong Yincheng Liu Jinghua Teng Agency for Science Technology and Research(A^(*)STAR)Institute of Materials Research and Engineering(IMRE)Singapore

Metaoptics formed by ultrathin and planar building blocks enable compact and efficient optical devices that manipulate light at the *** development of tunable metaoptics holds the promise of miniaturized and efficient optical systems that can dynamically adapt to changing conditions or requirements,propelling innovations in fields ranging from telecommunication and imaging to quantum computing and ***-dimensional(2D)materials show strong promise in enabling tunable metaoptics due to their exceptional electronic and optical properties from the quantum confinement within the atomically thin *** this review,we discuss the recent advancements and challenges of 2D material-based tunable metaoptics in both linear and nonlinear regimes and provide an outlook for prospects in this rapidly advancing area.

关键词： metaoptics tunable metaoptics two-dimensional optoelectronics nonlinear optics excitons polaritons

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Differential mode-gain equalization via femtosecond laser micromachining-induced refractive index tailoring

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Light(Advanced Manufacturing) 2024年第2期5卷 24-32页

作者： Cong Zhang Senyu Zhang Yan zeng Yue Wang meng Xiang Di Lin Songnian Fu Yuwen Qin Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of TechnologyGuangzhou510006China Key Laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of Education of ChinaGuangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Information Photonic Technology Guangdong University of TechnologyGuangzhou 510006China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

The mode-division multiplexing technique combined with a few-mode erbium-doped fiber amplifier(FM-EDFA)demonstrates significant potential for solving the capacity limitation of standard single-mode fiber(SSMF)transmission ***,the differential mode gain(DMG)arising in the FM-EDFA fundamentally limits its transmission capacity and ***,an innovative DMG equalization strategy using femtosecond laser micromachining to adjust the refractive index(RI)is *** mode-dependent attenuations can be achieved according to the DMG profile of the FM-EDFA,enabling DMG *** validate the proposed strategy,DMG equalization of the commonly used FM-EDFA configuration was *** results revealed that by optimizing both the length and RI modulation depth of the femtosecond laser-tailoring area,the maximum DMG(DMGmax)among the 3 linear-polarized(LP)mode-group was mitigated from 10 dB to 1.52 dB,whereas the average DMG(DMGave)over the C-band was reduced from 8.95 dB to 0.78 ***,a 2-LP mode-group DMG equalizer was experimentally demonstrated,resulting in a reduction of the DMGmax from 2.09 dB to 0.46 dB,and a reduction of DMGave over the C band from 1.64 dB to 0.26 dB,with only a 1.8 dB insertion ***,a maximum range of variable DMG equalization was achieved with 5.4 dB,satisfying the requirements of the most commonly used 2-LP mode-group amplification scenarios.

关键词： Mode-division multiplexing Few-mode Erbium-doped fiber amplifier Differential mode gain Femtosecond laser micromachining

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Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1204-1221页

作者： Xiaohui Chen Meichun Gao Yongzhen Xia Xin Wang Jingbo Qin Hongying He Weirong Liu Xiaowei Zhang Shuangzhou Peng Zhiping zeng Ying su Xiaokun Zhang School of Pharmaceutical Science Fujian Provincial Key Laboratory of Innovative Drug Target ResearchXiamen UniversityXiamen 361002China NucMito Pharmaceuticals Co. Ltd.Xiamen 361000China Department of Clinical Laboratory the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor *** pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to *** Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer ***,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 *** vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent *** studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related ***,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 ***,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria.

关键词： XS561 Nur77 Bcl-2 Apoptosis Mitochondria Phase separation TNBC TAMR

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