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江苏省药品重点监测报备现状、问题与对策探讨

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药学与临床研究 2017年第5期25卷 465-468页

作者：孙骏于丹丹李明沈梦秋王新敏江苏省药品不良反应监测中心南京210002 南京中医药大学南京210023

为推进药品重点监测提供参考。分析2015年8月我省印发《江苏省药品重点监测报备工作程序的通知(试行)》后,对药品重点监测方案报备情况及主要问题,提出相应的改进措施。企业有意愿开展重点监测,但对重点监测目的和作用存在疑虑;可操作... 详细信息

为推进药品重点监测提供参考。分析2015年8月我省印发《江苏省药品重点监测报备工作程序的通知(试行)》后,对药品重点监测方案报备情况及主要问题,提出相应的改进措施。企业有意愿开展重点监测,但对重点监测目的和作用存在疑虑;可操作性与科学性的博弈贯穿重点监测全过程;方案伦理审查与患者知情同意是否执行,尚待形成共识。应做好政策间的衔接及说明工作;出台重点监测指南,明确技术标准;确定开展伦理审查,提高重点监测的科学性和伦理性。

关键词：上市药品药品重点监测报备

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粒径对青稞麸皮结构、理化及功能特性的影响

食品工业科技 2025年第3期46卷 101-109页

作者：王桐王雪青田亚凝杨京京党斌沈小刚王凤忠王丽丽中国农业科学院农产品加工研究所农业农村部农产品加工综合性重点实验室北京100193 青海省农林科学院青海省青藏高原农产品加工重点实验室青海西宁810016 山东玉皇粮油食品有限公司山东临沂276600

为研究粒径变化对青稞麸皮的结构、理化及功能特性的影响,本研究采用了不同强度的气流冲击磨(Airflow impact milling,AFIM)对粗青稞麸皮(Coarse highland barley bran,CHB)进行碾磨。获得了平均粒径为69.04μm的中青稞麸皮(Medium high... 详细信息

为研究粒径变化对青稞麸皮的结构、理化及功能特性的影响,本研究采用了不同强度的气流冲击磨(Airflow impact milling,AFIM)对粗青稞麸皮(Coarse highland barley bran,CHB)进行碾磨。获得了平均粒径为69.04μm的中青稞麸皮(Medium highland barley bran,MHB)、58.85μm的细青稞麸皮(Fine highland barley bran,FHB)和32.04μm的超微青稞麸皮(Ultrafine highland barley bran,UHB)。从粒径分布、微观结构、理化组成、孔隙特征以及功能特性等方面对这四种样品进行了多重表征。结果表明:随着青稞麸皮的粒径减小,部分不溶性膳食纤维(Insoluble dietary fiber,IDF)转化为可溶性膳食纤维(Soluble dietary fiber,SDF),导致SDF在总膳食纤维中的比例由7.18%(CHB)增加到8.50%(UHB)。显微结果与孔隙特征研究显示,随着粒径减小,青稞麸皮的堆积状态变得更加紧密,50 nm~10μm微孔在青稞麸皮孔隙中逐渐占据主导地位,从CHB组的31%提高至UHB组的69%。麸皮的组成和结构变化影响了其持水力、持油力等水合特性,相较于CHB,UHB的这两个指标分别降低了21%与7.64%。体外葡萄糖吸附实验表明,随着粒径减小,青稞麸皮对高浓度葡萄糖的吸附能力和抑制扩散的能力增强。综上所述,气流冲击磨通过物理改性有效降低了青稞麸皮的粒径分布,同时显著改变了麸皮的化学组成、微观结构、孔隙结构和颗粒间堆积状态,进而影响了其理化及功能特性的发挥。

关键词：青稞麸皮粒径孔隙特征水合特性体外降血糖能力

Basic science of water： Challenges and current status towards a molecular picture

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Nano Research 2015年第10期8卷 3085-3085,3086-3110页

作者： sheng meng Lauren F. Greenlee Yuen Ron shen Enge wang BeijingNationalLabforCondensedMatterPhysics InstituteofPhysicsChineseAcademyofSciencesBeijing100190China AppliedChemicalsandMaterialsDivision NationalInstituteofStandardsandTechnology325BroadwayMS647BoulderCO80305USA DepartmentofPhysics UniversityofCaliforniaBerkeleyCA94720USA InternationalCenterforQuantumMaterials SchoolofPhysicsPekingUniversityBeijing100871China

Rapid developments in both fundamental science and modern technology that target water-related problems, including the physical nature of our planet and environment, the origin of life, energy production via water splitting, and water purification, all call for a molecular-level understanding of water. This invokes relentless efforts to further our understanding of the basic science of water. Current challenges to achieve a molecular picture of the peculiar properties and behavior of water are discussed herein, with a particular focus on the structure and dynamics of bulk and surface water, the molecular mechanisms of water wetting and splitting, application-oriented research on water decontamination and desalination, and the development of complementary techniques for probing water at the nanoscale.

关键词： water molecular structure surface water water treatment nanotechnology water properties

SEL1L-mediated endoplasmic reticulum associated degradation inhibition suppresses proliferation and migration in Huh7 hepatocellular carcinoma cells

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World Journal of Gastroenterology 2025年第10期31卷 118-133页

作者： Jia-Nan Chen Li wang Yu-Xin He Xiao-Wei Sun Long-Jiao Cheng Ya-Nan Li Sei Yoshida Zhong-Yang shen School of Medicine Nankai UniversityTianjin 300071China Department of Organ Transplant Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesFrontiers Science Center for Cell ResponsesNankai UniversityTianjin 300071China Research Institute of Transplant Medicine Nankai UniversityTianjin 300192China Nankai International Advanced Research Institute Shenzhen 518045Guangdong ProvinceChina Tianjin Key Laboratory for Organ Transplantation Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Proteins play a central role in regulating biological functions,and various pathways regulate their synthesis and *** reticulum-associated protein degradation(ERAD)is crucial for monitoring protein synthesis and processing unfolded or misfolded proteins in actively growing tumor ***,the role of the multiple ERAD complexes in liver cancer remains *** To elucidate the effects of SEL1L-mediated ERAD on Huh7 and explore the underlying mechanisms in vivo and in *** Huh7 cells were treated with ERAD inhibitor to identify ERAD’s *** counting kit-8,5-ethynyl-2’-deoxyuridine and colony formation experiments were *** level and migration ability were assessed using fluorescence activated cell sorting and Transwell assay,***7 SEL1L knockout cell line was established via clustered regularly interspaced short palindromic repeats,proliferation,apoptosis,and migration were assessed through previous *** role of SEL1L in vivo and the downstream target of SEL1L were identified using Xenograft and mass spectrometry,*** The ERAD inhibitor suppressed cell proliferation and migration and promoted ***1L-HRD1 significantly influenced Huh7 cell ***1L knockout suppressed tumor cell proliferation and migration and enhanced *** spectrometry revealed EXT2 is a primary substrate of ***1L knockout significantly increased the protein expression of ***,EXT2 knockdown partially restored the effect of SEL1L *** ERAD inhibition suppressed the proliferation and migration of Huh7 and promoted its ***2 plays an important role and ERAD might be a potential treatment for Huh7 hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Endoplasmic reticulum stress Endoplasmic reticulum-associated protein degradation SEL1L EXT2

HER2 changes to positive after neoadjuvant chemotherapy in breast cancer: A case report and literature review

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World Journal of Clinical Cases 2022年第1期10卷 260-267页

作者： Luo wang Qi Jiang meng-Ye He Peng shen Department of Medical Oncology The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND As the most common cancer in women,breast cancer is the leading cause of *** patients are initially diagnosed as stage *** those without distant metastases,64%are local tumors and 27%are regional *** in stage IIA-IIIC and those who meet the breast-conserving criterion with the exception of tumor size can consider neoadjuvant chemotherapy(NACT).It is worth noting that the status of tumor cell biomarkers is not consistently ***-related estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2)encoded by erythroblastic leukemia viral oncogene homolog 2 gene can all alter from positive to negative or vice versa,especially in luminal B subtype after *** addition,determination of HER2 status currently mainly relies on immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),but FISH is commonly used when the result of IHC is ***2 is regarded as negative when the IHC result is 0/1+without the addition of *** the best of our knowledge,this is the first report of a case harboring HER2 status transformation and IHC1+with positive amplification by FISH after *** SUMMARY A 49-year-old woman discovered a mass in her right breast and underwent diagnostic *** of the right breast lesion and axillary lymph nodes were *** results pointed to invasive ductal carcinoma with the IHC result for ER(80%),PR(60%),Ki-67(20%)and ambiguous expression of HER2(IHC 2+)with negative amplification by FISH(HER2/CEP17 ratio of 1.13).She underwent surgery after *** pathological findings of the surgically resected sample supported invasive ductal carcinoma with the tumor measuring 1.1 cm×0.8 cm×0.5 cm and had spread to one of fifteen dissected lymph *** of the specimen showed that the tumor was positive for ER(2+,85%)and PR(2+,10%)but negative for HER2 by IHC(1+).Also Ki-67 had dropped to 2%.The patient was regularly monitored every 3 mo wit

关键词： Carcinoma Ductal Breast Neoadjuvant therapy Biomarkers,Tumor Case report

Geochemical characteristics of light hydrocarbons in natural gases from the Turpan-Hami Basin and identification of low-mature gas

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Chinese Science Bulletin 2010年第29期55卷 3324-3328页

作者： shen Ping wang XiaoFeng wang ZhiYong meng QianXiang XU YongChang State Key Laboratory of Oil and Gas Resources Research Chinese Academy of Sciences Lanzhou 730000 China Institute of Exploration and Development Tu-Ha Oilfield Company of China Hami 839009 China

Theoretical and practical knowledge regarding low-mature gasses is of significant importance to identifying potential natural gas *** hydrocarbon parameters and C and H isotopes are useful tools to identify low-mature *** gas samples were collected from the Turpan-Hami Basin for light hydrocarbon *** results showed that the light hydrocarbon components of natural gases contain high methylcycloxane,high isoparaffin and low *** implies that the gas-generating parent materials are of typical humus type and the paleoenvironment is a fresh water sedimentary *** features are consistent with the geological setting of the *** studies of isoheptane,heptane,and the carbon isotopic compositions of methane in natural gases,and other maturity indices indicated that natural gases in the Turpan-Hami Basin are dominated by low-mature gas formed during the low evolution stage of Jurassic coal *** parent materials are of type III,and the maturation degree was in the low evolution *** are the fundamental characteristics of low-mature *** of light hydrocarbon research provided further evidence to suggest that the Turpan-Hami Basin is a large-scale gas producer of low-mature gas in *** is likely that this resource will play an important role in future exploration and development of low-mature gas in China.

关键词：天然气资源地球化学特征吐哈盆地轻烃参数低熟气碳同位素组成鉴定母质类型

深化考试评价改革服务教育强国建设——第一届教育考试与评价改革论坛会议综述

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中国考试 2025年第1期 104-110页

作者：申继亮王辉陈红艳北京师范大学中国教育与社会发展研究院北京100875 北京师范大学出版集团北京100088

2024年11月18至19日,北京师范大学中国教育与社会发展研究院举办的第一届教育考试与评价改革论坛在北京召开,论坛主题为“深化考试评价改革,服务教育强国建设”。会议由教育考试评价能力建设研究中心揭牌仪式、特邀嘉宾主旨报告及四场... 详细信息

2024年11月18至19日,北京师范大学中国教育与社会发展研究院举办的第一届教育考试与评价改革论坛在北京召开,论坛主题为“深化考试评价改革,服务教育强国建设”。会议由教育考试评价能力建设研究中心揭牌仪式、特邀嘉宾主旨报告及四场高规格的教育考试评价专题分论坛组成。主旨报告和分论坛主要围绕考试评价能力建设、拔尖创新人才选拔培养、综合素质评价实践、基于核心素养的命题改革,以及教育考试评价技术发展趋势等前沿热点问题展开交流研讨,主题鲜明、内容丰富,有助于推动教育评价改革进一步深化,服务教育强国建设。本次论坛共有来自全国各地教育领域的专家、学者、行业精英及相关从业人员等300余名代表参会。

关键词：教育考试评价改革拔尖创新人才综合素质评价核心素养评价技术

Application of nanozymes in problematic biofilm control:progress,challenges and prospects

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Frontiers of Environmental Science & Engineering 2024年第11期18卷 65-84页

作者： Junzheng Zhang Tong Dou Yun shen Wenrui wang Luokai wang Xuanhao Wu meng Zhang Dongsheng wang Pingfeng Yu College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310058China Innovation Center of Yangtze River Delta Zhejiang UniversityJiashan 314100China Department of Civil and Environmental Engineering The George Washington UniversityWashingtonDC 20052USA

Current microbial control strategies face challenges in keeping up with the escalation of microbial problems due to the presence of ***,there is an urgent need to develop effective and robust strategies to control problematic biofilms in water treatment and reuse ***,which have intrinsic biocatalytic activity and broad antibacterial spectra,hold promise for controlling resilient *** review summarizes the milestones of nanozyme studies and their applications as antibiofilm *** mechanisms behind the antibacterial,quorum quenching,and depolymerizing properties of nanozymes with different enzyme activities are ***,the surface and composition of nanozymes are crucial for their efficacy in biofilm control;thus,rationally designed nanozymes can increase their ***,the challenges of nanozymes as antibiofilm agents in realistic scenarios are investigated along with proposed strategies to overcome these *** of nanozyme-based biofilm control,such as machine learning-assisted nanozyme design,are also ***,this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.

关键词： Nanozymes Biofilm Antibacterial mechanisms Rational design Machine learning

Marine sources of formaldehyde in the coastal atmosphere

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Science Bulletin 2025年第1期70卷 96-103页

作者： Hengqing shen Likun Xue Gen Zhang Yujiao Zhu Min Zhao Xuelian Zhong Yanqiu Nie Jinghao Tang Yuhong Liu Qi Yuan Huiwang Gao Tao wang Wenxing wang Environment Research Institute Shandong UniversityQingdao 266237China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry of CMA Institute of Atmospheric CompositionChinese Academy of Meteorological SciencesBeijing 100081China Key Laboratory of Marine Environment and Ecology Ministry of Education of ChinaOcean University of ChinaQingdao 266100China Marine Ecology and Environmental Science Laboratory Laoshan LaboratoryQingdao 266071China

Elevated concentrations of formaldehyde and other carbonyl compounds are frequently observed in the marine atmosphere but are often significantly underestimated by atmospheric *** evaluate the potential impact of marine sources on atmospheric formaldehyde,high-resolution measurements were conducted at a coastal site(~15 m from the sea)during the summer in Qingdao,*** formaldehyde levels averaged 2.4±0.9 ppbv(1 ppbv=10^(-9)L L^(-1)),with peaks reaching 6.8 *** trajectories indicate that formaldehyde concentrations remained high in marine air *** exhibited weak correlations with primary pollutants such as NO and CO but showed strong correlations with marine tracers,notably methyl ethyl ketone and *** experiments confirmed that the photodecomposition of Enteromorpha released large amounts of formaldehyde and marine tracer *** normalized to acetylene,the levels of formaldehyde,1-butene,and MEK increased by factors of 3.8,8.1,and 3.5,*** from an observation-based chemical box model simulation,which utilizes the Master Chemical Mechanism(MCM),revealed that formaldehyde contributes 56% to the primary source of HO_(2)radicals,while neglecting formaldehyde chemistry would lead to a 15% reduction in coastal ozone production *** study interlinks oceanic biology and atmospheric chemistry,advancing the understanding of the ocean’s role as a significant source of organic compounds and its contribution to carbon cycling.

关键词： Formaldehyde Coastal atmosphere Enteromorpha Marine Ozone