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Electrochemical response of MoS_(2) nanosheets/SiO_(2)-NH_(2) nanoparticles modified glassy carbon electrode to phenylacetic acid

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Rare Metals 2023年第12期42卷 4142-4152页

作者： Tian-Yao Qi zhen-Yu Yuan Fan-Li meng College of Information Science and Engineering Northeastern UniversityShenyang 110819China Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology Qinhuangdao 066004China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationShenyang 110819China

Phenylacetic acid(PAA)is a primary raw material for illegal Methamphetamine(MATM)synthesis under the strong precursor chemicals supervisions of safrole and ***,trace detection of PAA at ultra-low concentration is a strategic technique and an urgent issue in the field of drug *** this paper,trace determination of PAA at sub-nmol-L-1 concentration level is achieved by hydrogen bond adsorption and electrochemical catalysis through the prepared aminated SiO_(2)nanoparticles(SiO_(2)-NH_(2) NPs)and MoS_(2) nanosheets(NSs)modified glassy carbon electrode(GCE).The prepared MoS_(2) NS s/SiO_(2)-NH_(2) NPs modified electrode represents a detecting limit of 0.0989 nmol·L^(-1)and an obvious increasing linear range before the concentration increasement up to 60 nmol·L^(-1)in square wave voltammetry(SWV)responses of *** SWV response of the modified electrode to PAA in the concentration range within 100 nmol·L^(-1)is higher than phenol,acetic acid(HOAc)and benzoic Acid(BEN).This electrochemical method for trace detection of PAA in aqueous solution with desired performance provides a feasible scheme for the detection of other drugs and aromatic precursor chemicals.

关键词： Phenylacetic acid detection Modified electrode MoS_(2)nanosheet Square wave voltammetry

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng zhen Zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Uncertainty evaluation and correlation analysis of single-particle energies in phenomenological nuclear mean field:an investigation into propagating uncertainties for independent model parameters

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Nuclear Science and Techniques 2021年第2期32卷 45-57页

作者： zhen-zhen Zhang Hua-Lei Wang Hai-Yan meng Min-Liang Liu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

Based on the Monte Carlo approach and conventional error analysis theory,taking the heaviest doubly magic nucleus 208Pb as an example,we first evaluate the propagated uncertainties of universal potential parameters for three typical types of single-particle energy in the phenomenological Woods–Saxon mean *** the Woods–Saxon modeling with uncorrelated model parameters,we found that the standard deviations of singleparticle energy obtained through the Monte Carlo simulation and the error propagation rules are in good *** seems that the energy uncertainty of the single-particle levels regularly evoluate with certain quantum numbers to a large extent for the given parameter ***,the correlation properties of the single-particle levels within the domain of input parameter uncertainties are statistically analyzed,for example,with the aid of Pearson’s correlation *** was found that a positive,negative,or unrelated relationship may appear between two selected single-particle levels,which will be extremely helpful for evaluating the theoretical uncertainty related to the single-particle levels(e.g.,K isomer)in nuclear structural calculations.

关键词： Uncertainty propagation Correlation effect Woods-Saxon potential

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Time-decay Estimates for Keller-Segel System

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Acta Mathematica Sinica,English Series 2021年第4期37卷 666-674页

作者： zhen Bin CAO Xiao Feng LIU meng WANG School of Mathematical Sciences Zhejiang UniversityHangzhou 310027P.R.China College of Science Institute for Nonlinear SciencesDonghua UniversityShanghai 201620P.R.China

For the Cauchy problem to Keller–Segel system,we show well-posedness and time-decay estimates in the critical scaling-invariant Besov spaces by using Littlewood–Paley analysis together with the decay estimates of he... 详细信息

关键词： Chemotaxis parabolic system global solutions long time asymptotic behavior

Assessment of water-based cutting fluids with green additives in broaching

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Friction 2020年第6期8卷 1051-1062页

作者： Jing NI Kai FENG Lihua HE Xiaofan LIU zhen meng School of Mechanical Engineering Hangzhou Dianzi UniversityHangzhou 310018China

In order to improve the cutting performance in broaching,the lubrication and cleaning effects offered by water-based cutting fluids with green additives need to be studied from the viewpoint of green ***,water-based solutions with castor oil,surfactant(linear alkylbenzene sulfonate,LAS),and nanographite were prepared by ultrasonic agitation and sprayed into the zone of broaching via *** performances of the cutting fluids,in terms of the viscosity,specific heat,wetting angle,and droplet size,were evaluated to discuss their effects on the broaching *** the fluids,the addition of LAS into oil-in-water(WO-S),where its cutting fluid with 10 wt.%castor oil and 1.5 wt.%surfactant,exhibited the lowest broaching *** regard to the lubricating and cleaning mechanisms,WO-S has good wettability and permeability,and hence,can lubricate the cutting edge of the tool to decrease the cutting load,cool the cutting edge to keep it sturdy,and clean the surface of the cutting edge to keep it *** results reveal that the simultaneous addition of castor oil and LAS had remarkable effects on the lubrication and cleaning,and resulted in a broaching load reduction of more than 10%compared to commercial cutting ***,the addition of nanographite could not improve the lubrication owing to its agglomeration.

关键词： cutting fluid castor oil linear alkylbenzene sulfonate nanographite broaching

Failure Envelopes of Single-Plate Rigid Helical Anchors for Floating Offshore Wind Turbine

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China Ocean Engineering 2023年第6期37卷 1000-1010页

作者： CHEN Hong-zhen WANG Le TIAN Ying-hui ZHANG Chun-hui SHEN Zhi-chao LIU meng-meng State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China Department of Infrastructure Engineering Faculty of Engineering and Information Technology The University of MelbourneVictoria 3010Australia School of Civil Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Hebei Technological Innovation Center of Disaster Prevention and Mitigation Engineering of Geotechnical and Structural System Shijiazhuang 050018China School of Marine Science and Engineering South China University of TechnologyGuangzhou 511442China Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China

Helical anchor is a kind of novel foundation for floating offshore wind turbines,which should be subjected to combined tensile loading caused by wind,wave and ***,the research about the capacity of helical anchor was mainly examined under uniaxial loading and scarcely explored under combined *** this study,three-dimensional finite element limit analysis is adopted to assess the bearing capacities of single-plate rigid helical anchors with different ratios of helix to shaft diameter,D_(H)/D_(S) and embedment ratios L/D_(S).Result shows that the vertical,horizontal and moment bearing capacities increase with increasing D_(H)/D_(S) and L/D_(S).The normalized V-H failure envelopes expands with increasing L/D_(S),while the normalized V-M failure envelopes tend to contract with the increase of D_(H)/D_(S).With increasing D_(H)/D_(S) or decreasing L/D_(S),the normalized H-M failure envelopes expand when the horizontal and moment loading act in the same direction and contract when they act in the opposite *** effect of D_(H)/D_(S) and L/D_(S) on the shape of H-M failure envelope become insignificant when L/D_(S)≥4.A series of failure mechanisms under different loading conditions were observed and can be used to explain the ***,a series of approximate expressions were proposed to fit the uniaxial bearing capacities and the failure envelopes.

关键词： helical anchors bearing capacity failure envelope clay

Mechanical anisotropy and electronic properties of X2N2(XH2):first-principles calculations

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Communications in Theoretical Physics 2020年第11期72卷 109-120页

作者： Xiao-zhen Li meng-Jiang Xing Department of Information and Technology Kunming UniversityKunming650214China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China

The mechanical anisotropy,structural properties,electronic band structures and thermal properties of C2N2(CH2),Si2N2(SiH2)and Ge2N2(GeH2)are detailed and investigated in this *** novel silicon nitride phase Si2N2(SiH2)and germanium nitride phase Ge2N2(GeH2)in the Cmc21 structure are proposed in this *** novel proposed Si2N2(SiH2)and Ge2N2(GeH2)are both mechanically and dynamically *** electronic band calculation of the HSE06 hybrid functional shows that C2N2(CH2),Si2N2(SiH2)and Ge2N2(GeH2)are all wide band gap semiconductor materials,and C2N2(CH2)and Si2N2(SiH2)are direct band gap semiconductor materials,while Ge2N2(GeH2)is a quasi-direct band gap semiconductor material,the band gap of C2N2(CH2),Si2N2(SiH2)and Ge2N2(GeH2)are 5.634 eV,3.013 eV,and2.377 eV,*** three-dimensional and plane distributions of Young’s modulus,shear modulus and Poisson’s ratio of C2N2(CH2),Si2N2(SiH2)and Ge2N2(GeH2)show that these materials have different degrees of mechanical *** order of Young’s modulus of Si2N2(SiH2)and Ge2N2(GeH2)in different directions is different from that of C2N2(CH2).When the tensile axis is in a particular direction,the order of the Young’s modulus of Si2N2(SiH2):E[110]

关键词： X2N2(XH2) mechanical anisotropy wide band gap semiconductor Young’s modulus

Adaptive sliding mode output tracking control based-FODOB for a class of uncertain fractional-order nonlinear time-delayed systems

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Science China(Technological Sciences) 2020年第9期63卷 1854-1862页

作者： WANG zhen WANG XinHe XIA JianWei SHEN Hao meng Bo College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao266590China School of Mathematics Science Liaocheng UniversityLiaocheng252059China School of Electrical Engineering and Information Anhui University of TechnologyMaanshan243002China

An adaptive sliding mode control(ASMC) method, based on fractional-order disturbance-observer(FODOB), is presented for a class of fractional-order nonlinear time-delay systems(FONTDS) with uncertainties to solve the target output tracking *** external disturbances are estimated by FODOB, and the unknown internal perturbations of the system are adaptively estimated by sliding mode control(SMC). Furthermore, Gronwall's inequality approach is used to ensure that the output tracking error is uniformly bounded for FONTDS. Firstly, a fractional-order sliding mode control(FOSMC) based FODOB is proposed for a fractional-order linear time-delay system(FOLTDS). Secondly, combined with adaptive estimation, the ASMC of FONTDS is studied. Finally, a numerical example of FONTDS is used to verify the effectiveness of the proposed methods.

关键词： adaptive sliding mode control fractional-order disturbance-observer time-delay uncertainty