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Study on the effect and mechanism of Swertia mussotii Franch. in the treatment of primary biliary cholangitis based on bioinformatics and in vitro experiments

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Traditional Medicine Research 2024年第3期9卷 32-42页

作者： Xing-Fang Zhang meng-meng yang Yi-Chen Guo meng-Yuan Wang Hong-Xia yang Ming Zhang Cen Li Li-Xin Wei Hong-Tao Bi Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation Northwest Institute of Plateau BiologyChinese Academy of ScienceXining 810008China Medical College Qinghai UniversityXining 810001China College of Eco-Environmental Engineering Qinghai UniversityXining 810016China CAS Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China

Background:Primary biliary cholangitis(PBC)is a chronic biliary autoimmune liver disease characterized by intrahepatic cholestasis.Swertia mussotii Franch.(SMF)is a Tibetan medicine with hepatoprotective and anti-inflammatory activities.In this study,the therapeutic effect and potential mechanisms of SMF on PBC were investigated by bioinformatics analysis and in vitro experimental validation,with the aim of promoting the progress of SMF and PBC research.Methods:We first explored the therapeutic effects and key targets of SMF on PBC using a network pharmacology approach,further screened the core targets using the GSE79850 dataset,and finally validated the results using molecular docking techniques and in vitro experiments.Results:By bioinformatics analysis,we identified core targets of SMF for PBC treatment(STAT3,JAK2,TNF-α,and IL-1β)and important signaling pathways:JAK-STAT,TNF,and PI3K-AKT.The molecular docking results showed that the significant components of SMF had good binding properties to the core targets.In vitro experiments showed that SMF extracts improved the extent of epithelial-mesenchymal transition in human intrahepatic biliary epithelial cells and had a significant reversal effect on epithelial-mesenchymal transition process markers and potential targets in PBC.Conclusion:SMF may exert its therapeutic effects on PBC by acting on important targets such as STAT3,JAK2,TNF-α,IL-1β,Vimentin,and E-cadherin and the pathways in which they are involved.

关键词： Swertia mussotii Franch. primary biliary cholangitis bioinformatics in vitro experiments

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Natural marmatite photocatalyst for treatment of mineral processing wastewater to help zero wastewater discharge

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Journal of Environmental Sciences 2024年第8期142卷 83-91页

作者： Meirong Wu Wei Sun Xiangsong meng Jianhua Kang Yue yang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

Mineral processing wastewater(MPW)with large discharge and high toxicity affects environmental safety,and the realizing zero discharge of MPW is of great significance for reducing environmental pollution,saving water resources,and promoting the sustainable development of the mining industry.In this study,we reported natural marmatite(NM)as a low-cost and efficient photocatalyst for the treatment of MPW to help zero wastewater discharge.The photocatalytic activity of NM was evaluated by the removal of total organic carbon(TOC)from MPW under visible-light illumination,and the optimal degradation conditions were discussed.Results showed that superoxide free radicals(^(·)O_(2)^(-))were the dominant active species responsible for organic pollutants degradation,and 74.25%TOC removal was obtained after 120 min reaction under the optimum treatment conditions.Meanwhile,the wastewater treated by NM photocatalysis can be reused in the flotation system without adverse impact on the product index.Based on these findings,a model of zero wastewater discharge for flotation with the help of photocatalytic treatment was established,it indicated that the water of the whole system can be balanced without affecting the ore dressing index,which showed that visible light-driven photocatalyst has a promising application prospect in the treatment and recycling of industrial wastewater.

关键词： Natural mineral Photocatalysis Industrial wastewater Wastewater recycling Water balance

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Maximizing Submodular+Supermodular Functions Subject to a Fairness Constraint

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Tsinghua Science and Technology 2024年第1期29卷 46-55页

作者： Zhenning Zhang Kaiqiao meng Donglei Du yang Zhou Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFredericton E3B 5A3Canada School of Mathematics and Statistics Shandong Normal UniversityJinan 250014China

We investigate the problem of maximizing the sum of submodular and supermodular functions under a fairness constraint.This sum function is non-submodular in general.For an offline model,we introduce two approximation algorithms:A greedy algorithm and a threshold greedy algorithm.For a streaming model,we propose a one-pass streaming algorithm.We also analyze the approximation ratios of these algorithms,which all depend on the total curvature of the supermodular function.The total curvature is computable in polynomial time and widely utilized in the literature.

关键词： submodular function supermodular function fairness constraint greedy algorithm threshold greedy algorithm streaming algorithm

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Double Moving Extremes Ranked Set Sampling Design

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 75-90页

作者： meng Chen Wang-xue Chen Rui yang Department of Mathematics and Statistics Jishou UniversityJishou416000China

The traditional simple random sampling(SRS)design method is inefficient in many cases.Statisticians proposed some new designs to increase efficiency.In this paper,as a variation of moving extremes ranked set sampling(MERSS),double MERSS(DMERSS)is proposed and its properties for estimating the population mean are considered.It turns out that,when the underlying distribution is symmetric,DMERSS gives unbiased estimators of the population mean.Also,it is found that DMERSS is more efficient than the SRS and MERSS methods for usual symmetric distributions(normal and uniform).For asymmetric distributions considered in this study,the DMERSS has a small bias and it is more efficient than SRS for usual asymmetric distribution(exponential)for small sample sizes.

关键词： double moving extremes ranked set sampling symmetric distribution efficiency

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Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-Yao Sheng Zi-Fan meng Qiao Li Yong-Sheng yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China Jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with cirrhosis.Although primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related contraindications.With recent advances in precision medicine,precise drug treatment provides better treatment efficacy.Data sources:Literature search was conducted in PubMed,MEDLINE and Web of Science for relevant articles published up to May 2022.Information on clinical trials was obtained from https://clinicaltrials.gov/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising drugs.According to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and others.All these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.Conclusions:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

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Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

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Journal of Integrative Medicine 2024年第2期22卷 188-198页

作者： meng Li yang Zhou Hui Zhu Lie-ming Xu Jian Ping Institute of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Preventive Treatment Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437 China Department of Gastroenterology Suzhou Traditional Chinese Medicine HospitalSuzhou 215000Jiangsu ProvinceChina Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China Key Laboratory of Liver and Kidney Diseases(Ministry of Education) Shanghai 201203China

Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver fibrosis.Methods:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver fibrosis.DHQ was administered orally for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-related proteins.Real-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphorylation in the liver tissue of Mdr2-/-mice.In addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 expression.Cholangiocytes overexpressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell activation.The intervention effect of DHQ on these processes was also investigated.HSCs overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of DHQ.Results:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19expression,STAT3 expression and STAT3 phosphorylation.This formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in HSCs.The overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphorylation and HSC activation,and DHQ was able to successfully inhibit these effects.Conclusion:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Mdr2-/-mice by inhibiting H19 upregulation in chol

关键词： Liver cirrhosis biliary Long non-coding RNA H19 Danhongqing formula Cholangiocyte Hepatic stellate cells STAT3 transcription factor

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Applications of single-cell RNA sequencing in spermatogenesis and molecular evolution

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Zoological Research 2024年第3期45卷 575-585页

作者： Wen-Bo Chen meng-Fei Zhang Fan yang Jin-Lian Hua College of Veterinary Medicine Shaanxi Centre of Stem Cells Engineering&TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China

Spermatogenic cell heterogeneity is determined by the complex process of spermatogenesis differentiation.However,effectively revealing the regulatory mechanisms underlying mammalian spermatogenic cell development and differentiation via traditional methods is difficult.Advances in technology have led to the emergence of many single-cell transcriptome sequencing protocols,which have partially addressed these challenges.In this review,we detail the principles of 10x Genomics technology and summarize the methods for downstream analysis of single-cell transcriptome sequencing data.Furthermore,we explore the role of single-cell transcriptome sequencing in revealing the heterogeneity of testicular ecological niche cells,delineating the establishment and disruption of testicular immune homeostasis during human spermatogenesis,investigating abnormal spermatogenesis in humans,and,ultimately,elucidating the molecular evolution of mammalian spermatogenesis.

关键词： Single-cell RNA sequencing(scRNA-seq) Spermatogenesis Molecular evolution Sertoli cell

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Improving photochemical indicators for attributing ozone sensitivities in source apportionment analysis

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Journal of Environmental Sciences 2024年第9期143卷 235-246页

作者： Xiaohui Du Wei Tang Zhongzhi Zhang yang Yu yang Li Ling Huang Greg Yarwood Fan meng Atmospheric Environment Institute Chinese Research Academy of Environmental SciencesBeijing 100012China College of Water Sciences Beijing Normal UniversityBeijing 100857China Asia Center for Air Pollution Research United Nations Environment Programme Asia and the Pacific OfficeNishi-kuNiigata-shi 9502144Japan School of Environmental and Chemical Engineering Shanghai UniversityShanghai 200444China Ramboll NovatoCalifornia 94945USA

Comprehensive Air Quality Model with extensions(CAMx)-Decoupled Direct Method(DDM)simulations of first-order ozone(O_(3))sensitivity to nitrogen oxides(NO_(x))and volatile organic compounds(VOCs)emissions were performed and combined with modelled P_(H_(2)O_(2))/P_(HNO_(3))ratios to obtain a range of thresholds for determining O_(3)-sensitivity regimes for different areas of China.Utilising the new threshold ranges for photochemical indicators,the method for determining O_(3)formation in the Ozone Source Apportionment Technology(OSAT)module within CAMx was improved by a dynamically varied threshold of P_(H_(2)O_(2))/P_(HNO_(3))ratio.The O_(3)concentration contributions in the newly added transition regime were apportioned to NO_(x)and VOCs emissions in proportion to the relationship between the P_(H_(2)O_(2))/P_(HNO_(3))ratio and first-order O_(3)sensitivity.The source contributions of O_(3)concentrations from different emission sectors from June to September 2019 were compared using the original and improved CAMx-OSAT.The results showed that the O_(3)concentration contributions changed significantly in the NO_(x)-limited regime,with a maximum decrease of 21.89%,while the contributions increased by up to 7.57%in the VOC-limited regime,and were within 15μg/m^(3)in the transition regime.The modified OSAT module enabled a more sophisticated attribution of O_(3)to precursor emissions and may have far-reaching implications for informing O_(3)pollution control policy.

关键词： O_(3) modeling O_(3)-sensitivity regimes Ozone source apportionment technology Photochemical indicators

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Advances and challenges in artificial intelligence text generation

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 64-83页

作者： Bing LI Peng yang Yuankang SUN Zhongjian HU meng YI School of Computer Science and Engineering Southeast UniversityNanjing 210000China Key Laboratory of Computer Network and Information Integration Ministry of EducationSoutheast UniversityNanjing 210000China

Text generation is an essential research area in artificial intelligence(AI)technology and natural language processing and provides key technical support for the rapid development of AI-generated content(AIGC).It is based on technologies such as natural language processing,machine learning,and deep learning,which enable learning language rules through training models to automatically generate text that meets grammatical and semantic requirements.In this paper,we sort and systematically summarize the main research progress in text generation and review recent text generation papers,focusing on presenting a detailed understanding of the technical models.In addition,several typical text generation application systems are presented.Finally,we address some challenges and future directions in AI text generation.We conclude that improving the quality,quantity,interactivity,and adaptability of generated text can help fundamentally advance AI text generation development.

关键词： AI text generation Natural language processing Machine learning Deep learning

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Wettability Gradient-Induced Diode:MXene-Engineered Membrane for Passive-Evaporative Cooling

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Nano-Micro Letters 2024年第8期16卷 382-397页

作者： Leqi Lei Shuo meng Yifan Si Shuo Shi Hanbai Wu Jieqiong yang Jinlian Hu Department of Biomedical Engineering City University of Hong KongHong Kong S.A.R 999077China

Thermoregulatory textiles,leveraging high-emissivity structural materials,have arisen as a promising candidate for personal cooling management;however,their advancement has been hindered by the underperformed water moisture transportation capacity,which impacts on their thermophysiological comfort.Herein,we designed a wettability-gradient-induced-diode(WGID)membrane achieving by MXene-engineered electrospun technology,which could facilitate heat dissipation and moisture-wicking transportation.As a result,the obtained WGID membrane could obtain a cooling temperature of 1.5℃ in the“dry”state,and 7.1℃ in the“wet”state,which was ascribed to its high emissivity of 96.40%in the MIR range,superior thermal conductivity of 0.3349 W m^(-1) K^(-1)(based on radiation-and conduction-controlled mechanisms),and unidirectional moisture transportation property.The proposed design offers an approach for meticulously engineering electrospun membranes with enhanced heat dissipation and moisture transportation,thereby paving the way for developing more efficient and comfortable thermoregulatory textiles in a high-humidity microenvironment.

关键词： Passive-evaporative cooling MXene Electrospun membrane Wettability gradient Diode

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