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Adjuvant therapy for gastric cancer:Current and future directions

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World Journal of Gastroenterology 2014年第38期20卷 13718-13727页

作者： marcus Foo Trevor Leong Division of Radiation Oncology and Cancer Imaging and Cancer Imaging Peter MacCallum Cancer Centre University of Melbourne

The management of gastric cancer continues to evolve. Whilst surgery alone is effective when tumours present early,a large proportion of patients are diagnosed with loco-regionally advanced disease,resulting in high locoregional and distant relapse rates,with subsequent poor survival. Early attempts at improving outcomes following resection were disappointing;however,randomized trials have now established either post-operative chemoradiotherapy(INT0116) or peri-operative chemotherapy as standard adjuvant therapies in the Western world. There remain,however,significant differences in the approach to management between the West and East. In Asia,where there is the highest incidence of gastric cancer,extended resection followed by adjuvant chemotherapy represents the standard of care. This review discusses current standard adjuvant therapy in gastric adenocarcinoma,as well as recent and ongoing trials investigating novel(neo)adjuvant approaches,which hope to build on the successes of previous studies.

关键词： Adjuvant Gastric Stomach Cancer Chemoradiation Chemoradiotherapy Chemotherapy Peri-operative Neo-adjuvant

Collective Computation,Information Flow,and the Emergence of Hunter-Gatherer Small-Worlds

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Journal of Social Computing 2022年第1期3卷 18-37页

作者： marcus J.Hamilton the Department of Anthropology University of Texas at San AntonioSan AntonioTX 78249USA.

Two key features of human sociality are anatomically complex brains with neuron-dense cerebral cortices,and the propensity to form complex social networks with *** brains and complex social networks facilitate flows of fitness-enhancing energy and information at multiple scales of social ***,we consider how these flows interact to shape the emergence of macroscopic regularities in hunter-gatherer macroecology relative to other mammals and non-human *** computation is the processing of information by complex adaptive systems to generate inferences in order to solve adaptive *** hunter-gatherer societies the adaptive problem is to resolve uncertainty in generative models used to predict complex environments in order to maximize inclusive *** macroecological solution is to link complex brains in social networks to form collective brains that perform collective *** developing theory and analyzing data,the author shows hunter-gatherers bands of~16 people,or~4 co-residing families,form the largest collective brains of any social ***,because individuals,families,and bands interact at multiple time scales,these fission-fusion dynamics lead to the emergence of the macroscopic regularities in hunter-gatherer macroecology we observe in cross-cultural *** results show how computation is distributed across spatially-extended social networks forming decentralized knowledge systems characteristic of hunter-gatherer *** flow of information at scales far beyond daily interactions leads to the emergence of small-worlds where highly clustered local interactions are embedded within much larger,but sparsely connected multilevel metapopulations.

关键词： complex adaptive systems hierarchically modular networks collective brains macroecology allometry mammals primates

Individual variation in dispersal associated behavioral traits of the invasive Chinese mitten crab （Eriocheir sinensis, H. Milne Edwards, 1854） during initial invasion of Lake V^inern, Sweden

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Current Zoology 2014年第3期60卷 410-416页

作者： Tomas BRODIN marcus K. DROTZ Department of Ecology and Environmental Science Umea University Sweden Lake Vanem Museum of Natural and Cultural History Framnisvsgen 2 53154 Lidkoping Sweden

Understanding and predicting species range-expansions and biological invasions is an important challenge in modem ecology because of rapidly changing environments. Recent studies have revealed that consistent within-species variation in behavior （i.e. animal personality） can be imperative for dispersal success, a key stage in the invasion process. Here we investigate the composition and correlation of two important personality traits associated with invasion success, activity and boldness, and how they are connected to sex and individual size in a newly colonised population of the Chinese mitten crab Eriocheir sinensis in Lake Vanem, Sweden. We found no effect of sex or size on behavioral expressions orE. sinensis but a clear positive correlation between boldness and activity. In addition, this study generates important baseline data for monitoring behavioral develop ment, and thereby changing ecological impact, of an invading population over time. This has implications for predicting ecological effects of invasive species as well as for managing ecological invasions.

关键词： Eriocheir sinensis Biological invasion Behavior Boldness Activity Invasion front

On Local Nonreflecting Boundary Conditions for Time Dependent Wave Propagation

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 589-606页

作者： marcus J. GROTE Imbo SIM Department of Mathematics University of Basel

The simulation of wave phenomena in unbounded domains generally requires an artificial boundary to truncate the unbounded exterior and limit the computation to a finite *** the artificial boundary a boundary condition is then needed,which allows the propagating waves to exit the computational domain without spurious *** 1977,Engquist and Majda proposed the first hierarchy of absorbing boundary conditions,which allows a systematic reduction of spurious reflection without moving the artificial boundary farther away from the *** pioneering work,which initiated an entire research area,is reviewed here from a modern *** developments such as high-order local conditions and their extension to multiple scattering are also ***,the accuracy of high-order local conditions is demonstrated through numerical experiments.

关键词： Absorbing boundary conditions Scattering problems Wave equation

Part-based methods for handwritten digit recognition

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Frontiers of Computer Science 2013年第4期7卷 514-525页

作者： Song WANG Seiichi UCHIDA marcus LIWICKI Yaokai FENG Department of Intelligent Systems Graduate School of Information Science and Electrical Engineering Kyushu University Fukuoka 819-0395 Japan German Research Center for Artificial Intelligence (DFKI) Kaiserslautern D-67663 Germany

In this paper, we intensively study the behavior of three part-based methods for handwritten digit recognition. The principle of the proposed methods is to represent a handwritten digit image as a set of parts and recognize the image by aggregating the recognition results of individual parts. Since part-based methods do not rely on the global structure of a character, they are expected to be more robust against various delormations which may damage the global structure. The proposed three methods are based on the same principle but different in their details, for example, the way of aggregating the individual results. Thus, those methods have different performances. Experimental results show that even the simplest part-based method can achieve recognition rate as high as 98.42% while the improved one achieved 99.15%, which is comparable or even higher than some state-of-the-art method. This result is important because it reveals that characters can be recognized without their global structure. The results also show that the part-based method has robustness against deformations which usually appear in handwriting.

关键词： handwritten digit recognition local features,part-based method

BIM-Based Indoor-Emergency-Navigation-System for Complex Buildings

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Tsinghua Science and Technology 2008年第S1期13卷 362-367页

作者： Uwe Rueppel Kai marcus Stuebbe Institute of Numerical Methods and Informatics in Civil Engineering Department of Civil Engineering and Geodesy Technische Universitaet Darmstadt

The imminence of terrorist activities and the necessity of the maximum possible disaster preparedness in the sense of indoor-navigation support have been brought to evidence by several catastrophes, e.g., the fire at Istanbul Airport in May 2006 or the terror attacks on the London Underground on July 7, 2005. Since 2001 ten terror attacks have been thwarted only in Great Britain. For that reason the aim of the presented research project is to develop a solution for response and recovery to support rescuers in finding the shortest way within a public building and provide them with important information in their particular spa-tial context. Existing building information models (BIM) are used for displaying plans on mobile devices and for routing purposes. The indoor navigation system is based on wireless LAN (WLAN), ultra-wide-band (UWB), and radio frequency identification (RFID). These technologies are described in detail and an overview on data formats which are used to retrieve building data out of the BIM for generating routing networks is given.

关键词： indoor positioning RFID UWB WLAN disaster preparedness response and recovery BIM

Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer's disease

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Neural Regeneration Research 2021年第8期16卷 1548-1549页

作者： marcus Augusto-Oliveira Alexei Verkhratsky Laboratório de Farmacologia Molecular Instituto de Ciências BiológicasUniversidade Federal do Pará66075-110 BelémBrasil Faculty of Biology Medicine and HealthThe University of ManchesterManchesterM139PTUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for Science48011 BilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain

Alzheimer's disease(AD) is the widespread and the most feared neurodegenerative disorder leading to dementia in the *** by eliminating intelligence,diminishes a man to helpless body,places an unbearable strain on patients,families,and fuels socioeconomic healthcare crises around the *** main histopathological hallmarks of AD are the accumulation of extracellular amyloid depositions known as senile plaques and intracellular neurofibrillary to ngles,together with severe dysfunctional synaptic connectivity and neuronal death leading to brain atrophy.

关键词： Alzheimer senile eliminating

Chronic Pain 2nd ed. 2009

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A survey on artificial intelligence trends in spacecraft guidance dynamics and control

丛书名： Current Clinical Practice

2009年

作者： Dawn marcus

来源：畅想之星图书光盘版（南... 评论

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Astrodynamics 2019年第4期3卷 287-299页

作者： Dario Izzo marcus Martens Binfeng Pan Furopean Space Agency Noorduijk2201 A ZThe Netherlands Northwestern Polytechnical University Xi'anShaanxi 710072China

The rapid developments of artificial intelligence in the last decade are influencing aerospace engineering to a great extent and research in this context is *** share our observations on the recent developments in the area of spacecraft guidance dynamics and control,giving selected examples on success stories that have been motivated by mission *** focus is on evolutionary optimisation,tree searches and machine learning,including deep learning and reinforcement learning as the key technologies and drivers for current and future research in the *** a high-level perspective,we survey various scenarios for which these approaches have been successfully applied or are under strong scientific *** possible,we highlight the relations and synergies that can be obtained by combining different techniques and projects towards future domains for which newly emerging artificial intelligence techniques are expected to become game changers.

关键词： guidance control AI deep learning machine learning evolutionary computing genetic algorithms interplanetary