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Chinese Physics B 2024年第2期33卷 238-246页

作者：王梦蛟辜玲芳 School of Automation and Electronic Information Xiangtan UniversityXiangtan 411105China

Memristor-based chaotic systems with infinite equilibria are interesting because they generate extreme *** initial state-dependent dynamics can be explained in a reduced-dimension model by converting the incremental integration of the state variables into system ***,this approach cannot solve memristive systems in the presence of nonlinear terms other than the memristor *** addition,the converted state variables may suffer from a degree of *** allow simpler mechanistic analysis and physical implementation of extreme multistability phenomena,this paper uses a multiple mixed state variable incremental integration(MMSVII)method,which successfully reconstructs a four-dimensional hyperchaotic jerk system with multiple cubic nonlinearities except for the memristor term in a three-dimensional model using a clever linear state variable mapping that eliminates the divergence of the state ***,the simulation circuit of the reduced-dimension system is constructed using Multisim simulation software and the simulation results are consistent with the MATLAB numerical simulation *** results show that the method of MMSVII proposed in this paper is useful for analyzing extreme multistable systems with multiple higher-order nonlinear terms.

关键词： extreme multistability hyperchaotic jerk system nonlinearity

Modeling human gastric cancers in immunocompetent mice

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Cancer Biology & Medicine 2024年第7期21卷 553-570页

作者： Weihong Zhang Shilong wang Hui Zhang Yan meng Shi jiao Liwei An Zhaocai Zhou Department of Stomatology Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University Cancer Center Tongji University School of Medicine State Key Laboratory of Genetic Engineering School of Life Sciences Zhongshan Hospital Fudan University Collaborative Innovation Center for Cancer Personalized Medicine School of Public Health Nanjing Medical University

Gastric cancer(GC) is a major cause of cancer-related mortality worldwide. GC is determined by multiple(epi)genetic and environmental factors; can occur at distinct anatomic positions of the stomach; and displays high heterogeneity, with different cellular origins and diverse histological and molecular features. This heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient therapeutics. In the past decade, great progress has been made in the study of GC, particularly in molecular subtyping, investigation of the immune microenvironment, and defining the evolutionary path and dynamics. Preclinical mouse models, particularly immunocompetent models that mimic the cellular and molecular features of human GC, in combination with organoid culture and clinical studies, have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion, and the development of novel therapeutic strategies. Herein, we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models, emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

关键词： GEMM Gastric cancer heterogeneity immunocompetent mouse model

A pseudoclassical theory for the wavepacket dynamics of the kicked rotor model

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 34-43页

作者： Zhixing Zou jiao wang Department of Physics and Key Laboratory of Low Dimensional Condensed Matter Physics(Department of Education of Fujian Province) Xiamen UniversityXiamen 361005China Lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China

In this study, we propose a generalized pseudoclassical theory for the kicked rotor model in an attempt to discern the footprints of the classical dynamics in the deep quantum regime. Compared with the previous pseudoclassical theory that applies only in the neighborhoods of the lowest two quantum resonances, the proposed theory is applicable in the neighborhoods of all quantum resonances in principle by considering the quantum effect of the free rotation at a quantum resonance. In particular, it is confirmed by simulations that the quantum wavepacket dynamics can be successfully forecasted based on the generalized pseudoclassical dynamics, offering an intriguing example where it is feasible to bridge the dynamics in the deep quantum regime to the classical dynamics. The application of the generalized pseudoclassical theory to the PT-symmetric kicked rotor is also discussed.

关键词： quantum-classical correspondence kicked rotor model pseudoclassical theory wavepacket dynamics

Naringin ameliorates H_(2)O_(2)-induced oxidative damage in cells and prolongs the lifespan of female Drosophila melanogaster via the insulin signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1231-1245页

作者： Xiaomei Du Kexin wang Xiaoyan Sang Xiangxing meng jiao Xie Tianxin wang Xiaozhi Liu Qun Huang Nan Zhang Hao wang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and TechnologyTianjin 300457China The key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuizhou 550025China Department of neurosurgery the Fifth Central Hospital of TianjinTianjin 300450China Tianjin Key Laboratory of Epigenetics for Organ Department in Preterm Infants the Fifth Central Hospital of TianjinTianjin 300450China

Naringin exists in a wide range of Chinese herbal medicine and has proven to possess several pharmacological *** this study,PC12,HepG2 cells,and female Drosophila melanogaster were used to investigate the antioxidative and anti-aging effects of naringin and explore the underlying *** results showed that naringin inhibited H_(2)O_(2)-induced decline in cell viability and decreased,the content of reactive oxygen species in ***,naringin prolonged the lifespan of flies,enhanced the abilities of climbing and the resistance to stress,improved the activities of antioxidant enzymes,and decreased malondialdehyde *** also improved intestinal barrier dysfunction and reduced abnormal proliferation of intestinal stem ***,naringin down-regulated the mRNA expressions of inr,chico,pi 3k,and akt-1,and up-regulated the mRNA expressions of dilp2,dilp3,dilp5,and foxo,thereby activating autophagy-related genes and increasing the number of ***,the mutant stocks assays and computer molecular simulation results further indicated that naringin delayed aging by inhibiting the insulin signaling(IIS)pathway and activating the autophagy pathway,which was consistent with the result of network pharmacological predictions.

关键词： Drosophila melanogaster Insulin signaling(IIS)pathway Naringin PC12 cell HepG2 cell

Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

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Journal of Environmental Sciences 2024年第3期137卷 500-514页

作者： Shan Cao meng wang jiao Pan Dengjie Luo Samavia Mubeen Caijin wang jiao Yue Xia Wu Qijing Wu Hui Zhang Canni Chen Muzammal Rehman Sichen Xie Ru Li Peng Chen Guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1 was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HcZIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HcZIP2

One-Pot Upgrading Polyethylene and CO_(2)to Aromatics via Tandem Catalysis

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CCS Chemistry 2024年第6期6卷 1422-1429页

作者： Wenjun Chen Yuchen jiao Yue Liu meng wang Fan Zhang Ding Ma National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan) College of ChemistrySichuan UniversityChengdu 610064Sichuan Beijing National Laboratory for Molecular Sciences New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

Polyolefins have the largest share in plastic waste,so it is vital to transform these end-of-life wastes into highly valued *** present here a new catalytic method to produce aromatics using PE as a carbon *** results indicate that polyethylene(PE)and CO_(2)can be converted into aromatics and CO simultaneously,achieving a high transformation rate and a 64.0%selectivity toward aromatics below 400°C by Cu-Fe_(3)O_(4)and Zn/ZSM-5 tandem ***,the established theoretical limit of 50%selectivity toward aromatics in PE aromatization is *** is attributed to the coexistence of reverse water-gas shift,which converts another feed,CO_(2),with hydrogen to produce valuable CO,confirmed by^(13)C isotope *** consumes excessive hydrogen generated during PE aromatization to produce CO and mitigates the production of light alkanes from hydrogen transfer reactions,thereby augmenting the formation of aromatic *** research offers a new approach to valorizing two prevalent waste carbon sources:waste plastic and CO_(2),which is useful for designing a new strategy for upcycling waste carbon resources.

关键词： polyethylene CO_(2) tandem catalysis upgrading aromatics

Reduction of the oxidative damage to H_(2)O_(2)-induced HepG2 cells via the Nrf2 signalling pathway by plant flavonoids Quercetin and Hyperoside

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Food Science and Human Wellness 2024年第4期13卷 1864-1876页

作者： Meijing Zhang Gaoshuai Zhang Xiangxing meng Xinxin wang jiao Xie Shaoshu wang Biao wang Jilite wang Suwen Liu Qun Huang Xu Yang Jing Li Hao wang State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology(TUST)Tianjin 300457China Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuiyang 550025China College of Chemical Engineering and Materials Science Tianjin University of Science and Technology(TUST)Tianjin 300457China Department of Agriculture Hetao CollegeBayannur 015000China College of Food Science&Technology Hebei Normal University of Science and TechnologyQinhuangdao 066004China National Center of Supervision and Inspection for Processed Food Quality Tianjin Institute for Food Safety Inspection TechnologyTianjin 300457China

Hyperoside and quercetin are similar in molecular *** this study,the antioxidant regulatory targets of hyperoside and quercetin are mainly in the nuclear factor(erythroid-2-derived)-related factor 2(Nrf2)pathway predicted by network *** the antioxidant effect and mechanism of hyperoside and quercetin were measured and compared in H_(2)O_(2)-induced Hep G2 cells and Caenorhabditis *** findings indicated that quercetin was more effective than hyperoside in reducing oxidative damage,which was proved by improved cell viability,decreased reactive oxygen species(ROS)production,decreased cellular apoptosis,and alleviated mitochondrial *** addition,quercetin was more efficient than hyperoside in enhancing the expression of Nrf2-associated m RNAs,increasing the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and catalase(CAT),and reducing the cellular malondialdehyde(MDA)*** was superior to hyperoside in prolonging the lifespan of worms,decreasing the accumulation of lipofuscin,inhibiting ROS production,and increasing the proportion of skn-1 in the *** the Nrf2 inhibitor ML385,we verified that quercetin and hyperoside primarily protected the cells against oxidative damage via the Nrf2 signalling ***,molecular docking and dynamics simulations demonstrated that the quercetin-Kelch-like ECH-associated protein 1(Keap1)complex was more stable than the hyperoside-Keap1 *** stable structure of the complex might hinder the binding of Nrf2 and Keap1 to release Nrf2 and facilitate its entry into the nucleus to play an antioxidant ***,quercetin had a better antioxidant than hyperoside.

关键词： Hyperoside Quercetin HepG2 cell Oxidative damage Nrf2 signalling pathway

Optimal retrofitting scenarios of multi-objective energy-efficient historic building under different national goals integrating energy simulation,reduced order modelling and NSGA-II algorithm

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Building Simulation 2024年第6期17卷 933-954页

作者： Hailu Wei Yuanhao jiao Zhe wang Wei wang Tong Zhang School of Architecture Southeast UniversityNanjingJiangsu Province210096China Key Laboratory of Urban and Architectural Heritage Conservation(Southeast University) Ministry of EducationNanjingChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhenChina

Retrofitting a historic building under different national goals involves multiple objectives,constraints,and numerous potential measures and packages,therefore it is time-consuming and challenging during the early design *** study introduces a systematic retrofitting approach that incorporates standard measures for the building envelope(walls,windows,roof),as well as the heating,cooling,and lighting *** retrofit objectives are delineated based on prevailing Chinese *** retrofit measures function as genes to optimize energy-savings,carbon emissions,and net present value(NPV)by employing a log-additive decomposition approach through energy simulation techniques and NSGA-II,yielding 185,163,and 8 ***,a weighted sum method is proposed to derive optimal solutions across multiple *** framework is applied to a courtyard building in Nanjing,China,and the outcomes of the implementation are scrutinized to ascertain the optimal retrofit package under various *** this retrofit,energy consumption can be diminished by up to 63.62%,resulting in an NPV growth of 151.84%,and maximum rate of 60.48%carbon *** three result values not only indicate that the optimal values are achieved in these three aspects of energy saving,carbon reduction and economy,but also show the possibility of possible equilibrium in this multi-objective optimization *** framework proposed in this study effectively addresses the multi-objective optimization challenge in building renovation by employing a reliable optimization algorithm with a computationally efficient reduced-order *** provides valuable insights and recommendations for optimizing energy retrofit strategies and meeting various performance objectives.

关键词： historic building energy-efficient retrofitting building energy simulation log-additive decomposition approach NSGA-II

Feedback Mechanism-driven Mutation Reptile Search Algorithm for Optimizing Interpolation Developable Surfaces

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Journal of Bionic Engineering 2024年第1期21卷 527-571页

作者： Gang Hu jiao wang Xiaoni Zhu Muhammad Abbas Department of Applied Mathematics Xi'an University of TechnologyXi'an 710054China School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China Department of Mathematics University of SargodhaSargodha 40100Pakistan

Curvature lines are special and important curves on *** is of great significance to construct developable surface interpolated on curvature lines in engineering *** this paper,the shape optimization of generalized cubic ball developable surface interpolated on the curvature line is studied by using the improved reptile search ***,based on the curvature line of generalized cubic ball curve with shape adjustable,this paper gives the construction method of SGC-Ball developable surface interpolated on the ***,the feedback mechanism,adaptive parameters and mutation strategy are introduced into the reptile search algorithm,and the Feedback mechanism-driven improved reptile search algorithm effectively improves the solving *** IEEE congress on evolutionary computation 2014,2017,2019 and four engineering design problems,the feedback mechanism-driven improved reptile search algorithm is compared with other representative methods,and the result indicates that the solution performance of the feedback mechanism-driven improved reptile search algorithm is *** last,taking the minimum energy as the evaluation index,the shape optimization model of SGC-Ball interpolation developable surface is *** developable surface with the minimum energy is achieved with the help of the feedback mechanism-driven improved reptile search algorithm,and the comparison experiment verifies the superiority of the feedback mechanism-driven improved reptile search algorithm for the shape optimization problem.

关键词： Reptile search algorithm Feedback mechanism Adaptive parameter Mutation strategy SGC-Ball interpolation developable surface Shape optimization

Progress and challenges of electrolyte modulation in aqueous zinc-ion batteries

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Rare Metals 2024年第7期43卷 2940-2967页

作者： Qi-Hang Yang Lu-Fei wang Xiao-Yu wang meng-meng Zhen Tianjin Key Laboratory of Clean Energy and Pollution Control School of Energy and Environmental EngineeringHebei University of Technology

As a new type of green battery system,aqueous zinc-ion batteries（AZIBs） have gradually become a research hotspot due to their low cost,high safety,excellent stability,high theoretical capacity(820 mAh·g-1) of zinc anode,and low redox potential(-0.76 V *** hydrogen electrode（SHE）).AZIBs have been expected to be an alternative to lithium-ion batteries for large-scale commercial energy storage ***,they are facing thorny issues such as degradation of cycling performance,zinc dendrites,and side *** the same time,these problems cause short cycling life of batteries,thus severely limiting their commercial *** recent years,many more researches have been conducted on the modification of anode and cathode materials of AZIBs,but there is a lack of in-depth discussion on the characteristics and mechanism of electrolyte *** this review,we will make a systematic summary of the current problems with two electrodes in AZIBs,as well as the types and functions of electrolyte ***,we further systematically describe the modulation mechanism of electrolyte additives in the performance of the cathode and *** prospects and development directions of additive modulation strategies for AZIBs electrolytes are prospected.

关键词： Electrolyte additives Aqueous zinc-ion batteries Zinc anode protection Cathode chemistry