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Effect of extracellular polymeric substances on Dolichospermum aggregation during temperature rise

Journal of Oceanology and Limnology 2023年第6期41卷 2208-2218页

作者： Dailan DENG Han meng You MA Yongqi GUO Zixuan WANG Huan HE Khan WAQAS Jin’e liu Limin ZHANG School of Environment Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and ApplicationNanjing Normal UniversityNanjing 210023China Green Economy Development Institute Nanjing University of Finance and EconomicsNanjing 210023China jiangsu Engineering Lab of Water and Soil Eco-remediation Nanjing 210023China

Dolichospermum,a typical model filamentous of cyanobacteria,has the potential to cause severely *** polymeric substances(EPSs)are considered to influence the aggregation of the algae,and temperature is a significant factor affecting EPSs ***,the mechanism of how EPSs affects the aggregation of Dolichospermum is still unclear because the structure and composition of EPSs are *** this study,the effects of EPSs on the aggregation of Dolichospermum during the rise of temperature(7-37℃)were *** results showed that the concentration of extracellular polysaccharides and proteins changed significantly with increasing temperature(P<0.01).Firstly,during the increasing temperature,the polysaccharide content of EPSs increased from 20.34 to 54.64 mg/L,and the polysaccharides in the soluble EPS(S-EPS)layer changed *** protein content reached maximum value at 21℃(14.52 mg/L)and varied significantly in S-EPS and loosely bound EPS(LB-EPS).In the EPSs matrix,humus substances and protein were main components of S-EPS and LB-EPS,and protein was the main component of tightly bound EPS(TB-EPS).Secondly,the cell density of Dolichospermum increased during the temperature rise while the aggregation ratio ***,zeta potential and surface thermodynamic analysis of Dolichospermum revealed that the interfacial free energy and electrostatic repulsion increased gradually with increasing temperature,which further reduced the aggregation of ***,principal component analysis(PCA)analysis showed the aggregation of Dolichospermum was directly related to the changes of protein in EPSs(especially S-EPS and LB-EPS)and zeta potential,and polysaccharides in EPSs inhibited the aggregation of *** on these results,it was illustrated that the composition and concentration of EPSs affected the cell surface properties of Dolichospermum with the change of temperature and thus affected the aggregation of D

关键词： temperature Dolichospermum extracellular polymeric substances aggregation

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Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer

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World Journal of Gastroenterology 2011年第16期17卷 2131-2136页

作者： jia-Qi Li Jie Chen Nan-Nan liu Li Yang Ying Zeng Bin Wang Xue-Rong Wang Key Laboratory of Reproductive Medicine Department of Pharmacology Nanjing Medical University Nan-jing 210029 Jiangsu Province China Department of General Surgery First Affiliated Hospitalof Nanjing Medical University. Nanjing 210029 Jiangsu Province China

AIM:To evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in ***:In this hospital-based case-control study of gastric cancer in jiangsu Province,China,we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk.A total of 241 patients with gastric cancer and 273 age-and sexmatched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length ***:The frequencies of genotypes GG,GT and TT were 65.6%,22.8% and 11.6% in gastric cancer cases,respectively,and 75.8%,17.6% and 6.6% in controls,*** were significant differences between gastric cancer and control groups in the distribution of their genotypes (P=0.03) and allelic frequencies (P=0.002) in the Ku80 promoter G-1401T ***:The T allele of Ku80 G-1401T may be associated with the development of gastric cancer.

关键词： Ku80 Gastric cancer Polymorphism Promoter Carcinogenesis

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基于数字孪生的电力设备实时巡检监控方法研究

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电子设计工程 2025年第1期33卷 137-141页

作者：胡周达钟漍标王凯刘嘉郑海波广东省能源集团贵州有限公司贵州贵阳550081

为进一步增强对新能源发电站的安全巡检能力,保障新能源发电站的安全稳定运转,提出了一种基于数字孪生的电力设备实时巡检监控方法。该方法在数字孪生技术的基础上对电力设备安全巡检系统进行了建模和仿真,使用5G网络切片技术确保电力... 详细信息

为进一步增强对新能源发电站的安全巡检能力,保障新能源发电站的安全稳定运转,提出了一种基于数字孪生的电力设备实时巡检监控方法。该方法在数字孪生技术的基础上对电力设备安全巡检系统进行了建模和仿真,使用5G网络切片技术确保电力设备数据在巡检系统中的传输速度。同时,还设计了一种轻量级残差密集卷积神经网络,并将其与能谱图结合,实现了对电力设备故障的快速、精准识别。实验结果表明,所提出的实时巡检监控技术方案具有良好的综合性能,识别准确率可达98.32%,相比于仿真性能最优的SENet仍高出5.11%,从采集数据到回传识别结果所需的时间仅为2.1~3.3 s。

关键词：数字孪生电力设备巡检 5G网络切片深度学习

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Membrane-based acoustic metamaterial with near-zero refractive index

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Chinese Physics B 2017年第1期26卷 237-242页

作者： Yi-Feng Li Jun Lan Hui-Yang Yu Xiao-Zhou liu jia-Shu Zhang Department of Computer Science and Technology Nanjing Technology University Nanjing 211800 China Key Laboratory of Modern Acoustics Ministry of Education Nanjing University Nanjing 210093 China Key Laboratory of Modem Acoustics Ministry of Education Institute of Acoustics and School of Physics Nanjing University Nanjing 210093 China Department of Electronic and Electrical Engineering The University of Sheffield Sheffield S102TN UK

We investigate a one-dimensional acoustic metamaterial with a refractive index of near zero（RINZ） using an array of very thin elastic membranes located along a narrow waveguide pipe. The characteristics of the effective density, refractive index, and phase velocity of the metamaterial indicate that, at the resonant frequency fm, the metamaterial has zero mass density and a phase transmission that is nearly uniform. We present a mechanism for dramatic acoustic energy squeezing and anomalous acoustic transmission by connecting the metamaterial to a normal waveguide with a larger cross-section. It is shown that at a specific frequency f1, transmission enhancement and energy squeezing are achieved despite the strong geometrical mismatch between the metamaterial and the normal waveguide. Moreover, to confirm the energy transfer properties, the acoustic pressure distribution, acoustic wave reflection coefficient, and energy transmission coefficient are also calculated. These results prove that the RINZ metamaterial provides a new design method for acoustic energy squeezing,super coupling, wave front transformation, and acoustic wave filtering.

关键词： acoustic metamaterial refractive index of near zero(RINZ) energy squeezing transmission enhancement

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Geochronology and Geochemical Characteristics of Intrusion in the Jinchangliang Gold Deposit,Inner Mongolia and Their Tectonic Significance

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Acta Geologica Sinica(English Edition) 2015年第6期89卷 1947-1962页

作者： SUN Zhenjun SUN Guosheng YU Henan TIAN Yi liu Shanli XIANG Zhu meng jian XUE Huaiyu LU Lina Department of Earthquake Science Institute of disaster prevention Science and Technology College of Earth Sciences Jilin University Liaoning Survey Academy of Geology and Mineral Resources Geophysical Research Institute of Jilin Province

Discovered and mined in recent years, the Jinchangliang gold deposit has not yet been studied in its genetic type. In this paper, the geological features of ore deposit, S isotopic composition, metallogenic age and elements geochemical of the granite closely related to mineralization were discussed. The results of the geological features of ore deposit and S isotopic composition show that ore-bearing hydrothermal solution was closely related with the intrusion of magmatic. The granite is characteristic of high silica SiO2=72.38%–72.98%, high aluminum and Al2O3=14.22%–14.35%, low calcium CaO=0.16% –0.26%, and low value of FeOT/MgO（6.86–7.73）, and rich in alkalis Na2O+K2O=9.11%–9.24%, suggesting that it is high-K calc-alkaline, highly fractionated, weak aluminum A-type granite. The REE patterns are inclined to right and show intense fractionation between LREE and HREE, without obvious negative Eu anomaly（δEu=0.80–0.84）. The primitive mantle-normalized spidergrams are characterized by depletion of Ba, U, Ta, Nb, Zr, Ti and P, which implies that the granite has the characteristics of the crust-mantle mixing. S isotopes also indicate that the material source of gold deposit is closely related to the granite rocks. The LA-ICP-MS Zircon UPb age of the Damiao rock mass medium-fine grained monzogranite（belonging to the early IndoChina） is（245±1） Ma. It shows that Jinchangliang gold deposit was not formed in Yanshanian, but the early Indo-China. Specifically speaking, the deposit was formed in the collision stage of the North China plate and the Siberian plate.

关键词： Geochemistry LA-ICP-MS zircon U-Pb dating Early Indo-China diagenesis and metallogenic Aohanqi Inner Mongolia

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Discovery of natural BH3 mimetics and research on related mechanism

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中国药理学与毒理学杂志 2018年第4期32卷 281-282页

作者： Si-meng GU Shuai-shuai liu Yue ZHANG Xue-jun LI Department of Pharmacology School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China

In the past two decades,with the increase of smoking population,more and more people are suffering from small cell lung cancer(SCLC).Besides,it is difficult to find an effective way to cure SCLC,since patience can easily develop drug *** the other hand,with the development of science and technology,people began to study the anti-cancer strategy to increase apoptosis,such as inhibiting the overexpression of survival *** these survival factors,BCL-2 family has attracted a lot of ***3-only protein is a member of BCL-2 family and it can directly inhibit the expression of BCL-2 protein,thereby prompting *** the BH3-only protein itself is difficult to become a clinical drug,to find alternatives BH3-only protein-BH3 mimetics is particularly ***,more and more researchers have paid attention on the natural BH3 mimetic since it has less side-effect than artificial BH3 *** find possible BH3 mimetics,we made a primary screening with this *** on a small molecular compounds library via Discovery Studio *** then MTS assay were introduced to verify the activity of *** that,we use Western Blot and Co-IP *** to test the effect of BH3 *** finally use CDOCKER to predict the further mechanism on autophagy and *** our studies,we found 3 possible BH3 mimetics compounds from 170,000 natural small molecular compounds via pharmacophore-based virtual ***,we *** AD23,one of the 3 possible natural BH3 mimetics,induced autophagy and apoptosis *** in dose-time dependence in SCLC cell ***,we use Molecular Docking to predict the further mechanism on autophagy and *** believe our works would provide evidences and clues for the structural optimizing and further study of new drugs in the future.

关键词：小细胞肺癌耐药性治疗方法临床分析

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Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease

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Science China(Life Sciences) 2019年第12期62卷 1630-1637页

作者： jiacheng Li Chaoxia Lu Wei Wu Yaping liu Rongrong Wang Nuo Si Xiaolu meng Shuyang Zhang Xue Zhang McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100005China Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Laboratory of Clinical Genetics Peking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China

Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations.

关键词： Marfan syndrome FBN1 mutation next-generation sequencing genotype-phenotype correlations

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Will male semen quality improve with environmental quality?

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Asian Journal of Andrology 2023年第2期25卷 252-258页

作者： Xu-Chao Dai meng-Qi Zhang Gang Chen Kun Mei Yan-Long liu Hong Huang Zhi-Gang Wu School of Public Health and Management Wenzhou Medical UniversityWenzhou 325035China School of Geography Science and Geomatics Engineering Suzhou University of Science and TechnologySuzhou 215009China School of Mental Health Wenzhou Medical UniversityWenzhou 325035China Research Center for Healthy China Wenzhou Medical UniversityWenzhou 325035China Zhejiang Provincial Key Laboratory of Watershed Sciences and Health Wenzhou 325035China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Reproductive Health Research Center Health Assessment Center of Wenzhou Medical UniversityWenzhou 325000China

Wenzhou has improved its environmental quality because of comprehensive environmental remediation;nevertheless,the semen quality of infertile males remains *** study determined whether better environmental quality improved semen quality in this *** recorded semen quality data from 22962 infertile males from January 2014 to November 2019 at the Center for Reproductive Health of The First Affiliated Hospital of Wenzhou Medical University(Wenzhou,China).Patients were predominantly 30–35 years old(33.1%)and workers(82.0%),with high school education or lower(77.6%);more than a half of the patients(52.6%)were Wenzhou household registration;and most patients(77.5%)had abnormal semen *** who were older than 40 years and workers,and those with Wenzhou household registration,had significantly worse semen quality(all P<0.05).From 2014 to 2019,progressive sperm motility,total sperm motility,and semen volume showed increasing linear trends in all patients(P=0.021,0.030,and 0.005,respectively),yet normal sperm morphology showed a linearly decreasing trend(P=0.046).Sensitivity analyses for subgroups yielded similar *** conclusion,the improvement of environmental quality and better function of the accessory glands are associated with progressive sperm motility,total sperm motility,and semen *** sperm morphology is influenced by occupational exposures and personal lifestyle and does not improve with environmental quality.

关键词： environmental quality male infertility semen quality time trend

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Enhancing betavoltaic nuclear battery performance with 3D P^(+)PNN^(+)multi-groove structure via carrier evolution

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Nuclear Science and Techniques 2023年第12期34卷 1-16页

作者： Hou‑Jun He Yun‑Cheng Han Xiao‑Yu Wang Yu‑Min liu jia‑Chen Zhang Lei Ren Ming‑Jie Zheng Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China School of Nuclear Technology and Chemistry and Biology Hubei University of Science and TechnologyXianning 437100China

Betavoltaic nuclear batteries offer a promising alternative energy source that harnesses the power of beta particles emitted by *** satisfy the power demands of microelectromechanical systems(MEMS),3D structures have been proposed as a potential ***,this paper introduces a novel 3D^(63)Ni–SiC-based P^(+)PNN^(+)structure with a multi-groove design,avoiding the need for PN junctions on the inner surface,and thus reducing leakage current and power *** Carlo simulations were performed considering the fully coupled physical model to extend the electron–hole pair generation rate to a 3D structure,enabling the efficient design and development of betavoltaic batteries with complex 3D *** a result,the proposed model produces the significantly higher maximum output power density of 19.74μW/cm^(2) and corresponding short-circuit current,open-circuit voltage,and conversion efficiency of 8.57μA/cm^(2),2.45 V,and4.58%,respectively,compared with conventional planar *** analysis of the carrier transport and collection characteristics using the COMSOL Multiphysics code,we provide deep insights regarding power increase,and elucidate the discrepancies between the ideal and simulated performances of betavoltaic *** work offers a promising approach for the design and optimization of high-output betavoltaic nuclear batteries with a unique 3D design,and serves as a valuable reference for future device fabrication.

关键词： Betavoltaic nuclear battery High-output power density Three-dimensional structure Carrier drift–diffusion Carrier recombination Carrier collection efficiency

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Regulating ion transport behaviors toward dendrite-free potassium metal batteries:recent advances and perspectives

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Rare Metals 2024年第4期43卷 1435-1460页

作者： Lu-Kang Zhao Xuan-Wen Gao Tian-Zhen Ren Da Wang Da-Wei Wang Zhao-meng liu Hong Chen Wen-Bin Luo School of Metallurgy Northeastern UniversityShenyang110819China School of Chemical Engineering The University of New South WalesSydneyNSW2052Australia

With abundant potassium resources and high capacity,potassium metal batteries(PMBs)present a compelling option for the next generation of energy storage ***,PMBs suffer from an unstable anode interface caused by uncontrolled dendrite growth,which results in unsatisfactory cyclability and safety *** investigations suggest that significant progress has been made in enhancing the interfacial stability of *** various effective strategies for stabilizing interfaces can ultimately be attributed to the regulation of the sluggish ion transfer kinetics and irregular deposition,i.e.,the arrangement of ion transport behaviors at the *** modulation of ions transport rate and ions deposition directions makes it possible to obtain a dendrite-free and smooth deposition ***,the influencing factors and action mechanism of K^(+)interface transport behaviors are discussed to understand the nature of material design for constructing stable anode interfaces,including regulating the solvation and desolvation structures,accelerating K^(+)transport kinetics and controlling K^(+)deposition *** addition,the deficiencies and prospects of the research on electrolyte,separators and designed electrode involved in the manufacturing and testing and ion transport process of PMBs are *** review is expected to provide some possible directions for constructing dendrite-free interfaces in advanced PMBs-related research and offer significant insights for prospective experimental research and commercial applications.

关键词： Ion transport rate Ion transport direction Interface Potassium metal batteries Dendrites growth

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