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Community-centered Disease Severity Assessment of Metabolic Dysfunction-associated Fatty Liver Disease

Journal of Clinical and Translational Hepatology 2023年第5期11卷 1061-1068页

作者： Jee-Fu Huang Pei-Chien Tsai Ming-Lun Yeh Chung-Feng Huang Ching-I Huang Mei-hsuan Lee Po-Yau Hsu Chih-Wen Wang Yu-Ju Wei Po-Cheng Liang Yi-Hung Lin meng-hsuan hsieh Jeng-Fu Yang Ming-Yen hsieh Tyng-Yuan Jang Ming-Jong Bair Zu-Yau Lin Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung Graduate Institute of Clinical Medicine Kaohsiung Medical UniversityKaohsiung Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung Center for Liquid Biopsy and Cohort Research Kaohsiung Medical UniversityKaohsiung Institute of Clinical Medicine National Yang Ming Chiao Tung UniversityTaipei Department of Preventive Medicine Kaohsiung Medical University HospitalKaohsiung Division of Gastroenterology Department of Internal MedicineTaitung Mackay Memorial HospitalTaitung Mackay Medical College New Taipei City School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of MedicineNational Sun Yat-sen UniversityKaohsiung Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat-sen UniversityKaohsiung

Background and Aims:Disease severity across the different diagnostic categories of metabolic dysfunction-associated fatty liver disease(MAFLD)remains *** study assessed the fibrosis stages and features of MAFLD between different *** also aimed to investigate the associations between advanced fibrosis and risk ***:This multicenter cross-sectional study enrolled adults participating in liver disease screening in the *** were stratified following MAFLD diagnostic criteria,to group A(395 patients)for type 2 diabetes,group B(1,818 patients)for body mass index(BMI)>23 kg/m^(2),and group C(44 patients)for BMI≤23kg/m^(2) with at least two metabolic *** fibrosis was defined as a fibrosis-4 index>***:Between 2009 and 2020,1,948 MAFLD patients were recruited,including 478 with concomitant liver *** fibrosis was observed in 125 patients.A significantly larger proportion of patients in group C(25.0%)than in group A(7.6%)and group B(5.8%)had advanced fibrosis (p<0.01).Logistic regression analysis found that hepatitis B virus(HBV)/hepatitis C virus(HCV)coinfection(odds ratio[OR]:12.14,95%confidence interval[CI]:4.04-36.52;p<0.01),HCV infection(OR:7.87,95%CI:4.78-12.97;p<0.01),group C(OR:6.00,95%CI:2.53-14.22;p<0.01),and TC/LDL-C(OR:1.21,95%CI:1.06-1.38;p<0.01)were significant predictors of advanced ***:A higher proportion of lean MAFLD patients with metabolic abnormalities had advanced *** infection was significantly associated with advanced fibrosis.

关键词： Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Advanced fibrosis Community screening Viral hepatitis

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Outreach onsite treatment with a simplified pangenotypic directacting anti-viral regimen for hepatitis C virus micro-elimination in a prison

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World Journal of Gastroenterology 2022年第2期28卷 263-274页

作者： Chun-Ting Chen Ming-Ying Lu meng-hsuan hsieh Pei-Chien Tsai Tsai-Yuan hsieh Ming-Lun Yeh Ching-I Huang Yi-Shan Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yu-Ju Wei Po-Yao Hsu Cheng-Ting Hsu Tyng-Yuan Jang Ta-Wei Liu Po-Cheng Liang Ming-Yen hsieh Zu-Yau Lin Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Yu-Lueng Shih Ming-Lung Yu Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General Hospital Penghu BranchNational Defense Medical CenterPenghu County 88041Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Hepatobiliary Department of Internal Medicine and Hepatitis CenterKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of Medicine and Hepatitis Research Center College of Medicineand Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung 80708Taiwan National Pingtung University of Science and Technology Pingtung 912Taiwan

BACKGROUND Prisoners are at risk of hepatitis C virus(HCV)infection,especially among the people who inject drugs(PWID).We implemented an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic direct-acting antivirals(DAA)regimen,12 wk of sofosbuvir/velpatasvir,in a PWID-dominant prison in *** To implement an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic DAA regimen in a PWID-dominant prison in *** HCV-viremic patients were recruited for onsite treatment program for HCV micro-elimination with a pangenotypic DAA regimen,12 wk of sofosbuvir/velpatasvir,from two cohorts in Penghu Prison,either identified by mass screen or in outpatient clinics,in September *** group of HCV-viremic patients identified sporadically in outpatient clinics before mass screening were enrolled as a control *** primary endpoint was sustained virological response(SVR12,defined as undetectable HCV ribonucleic acid(RNA)12 wk after end-of-treatment).RESULTS A total of 212 HCV-viremic subjects were recruited for HCV micro-elimination campaign;91 patients treated with sofosbuvir/Ledipasvir or glecaprevir/pibrentasvir before mass screening were enrolled as a *** HCV microelimination group had significantly lower proportion of diabetes,hypertension,hyperlipidemia,advanced fibrosis and chronic kidney diseases,but higher levels of HCV *** SVR12 rate was comparable between the HCV microelimination and control groups,95.8%(203/212)vs 94.5%(86/91),respectively,in intent-to-treat analysis,and 100%(203/203)vs 98.9%(86/87),respectively,in perprotocol *** was no virological failure,treatment discontinuation,and serious adverse event among sofosbuvir/velpatasvir-treated patients in the HCV micro-elimination *** Outreach mass screening followed by immediate onsite treatment with a simplified pange

关键词： Direct-acting antivirals Sofosbuvir Velpatasvir People who inject drugs Universal screen

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Treatment efficacy for patients with chronic hepatitis C and preexisting hepatocellular carcinoma by directly acting antivirals

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Hepatoma Research 2020年第4期6卷 30-38页

作者： Chia-Yen Dai Chung-Feng Huang meng-hsuan hsieh Ching-I Huang Ming-Lun Yeh Pei-ChienTsai Ching-Chih Lin meng-Szu Lee Jeng-Fu Yang Po-Yao Hsu Yu-Ju Wei Cheng-Ting Hsu Po-Cheng Liang Yi-Hung Lin Jee-Fu Huang Wan-Long Chuang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Health Management Center&Department of Community Medicine Kaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung 807Taiwan Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung 807Taiwan Department of Biological Science and Technology College of Biological Science and TechnologyNational Chiao Tung UniversityHsin-ChuKaohsiung 807Taiwan

Aim:Despite the high cure rate of interferon-free directly acting antivirals(DAAs)for chronic hepatitis C(CHC)patients,the treatment efficacy for patients with preexisting hepatocellular carcinoma(HCC)remains *** aimed in the present study to address the issue by using novel DAAs in treating CHC patients who were adherent to treatment in ***:CHC patients with or without HCC were consecutively *** primary objective was sustained virological response(SVR)defined as undetectable HCV RNA throughout 12 weeks of a post-treatment follow-up period(SVR12).Only patients with available SVR12 were enrolled for final ***:A total of 1237 patients(1113 non-HCC,101 inactive HCC and 23 active HCC)were *** overall SVR12 rate was 98.9%,and was similar between HCV patients with and without pre-existing HCC(98.4%vs.98.9%,P=0.64).While HCC patients were classified as those who had active or inactive HCC,the SVR12 was also similar between patients with and without active HCC(95.7%vs.99.0%,P=0.34).Among the 101 patients without viable HCC at the time of DAA initiation,eighty-four patients exhibited curative therapy and the other 17 ;patients experienced HCC recurrence before *** the 23 patients with viable HCC at the time of DAA treatment,10 patients had received curative therapy for HCC whereas the remaining 13 patients had HCC that was never *** SVR12 rates were also similar among the four subpopulations,being 98.8%(83/84),100%(17/17),90%(9/10)and 100%(13/13)***:CHC patients with HCC who were adherent to potent DAAs achieved similar SVR12 rate compared to those without HCC and could be effectively treated.

关键词： Directly acting antiviral chronic hepatitis C hepatitis C virus hepatocellular carcinoma sustained virological response

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GPS Vector Tracking Loop with Fault Detection and Exclusion

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Computers, Materials & Continua 2021年第8期68卷 1785-1805页

作者： Dah-Jing Jwo meng-Hsien hsieh Department of Communications Navigation and Control EngineeringTaiwan Ocean UniversityKeelung202301Taiwan

In this paper,both the integrity monitoring and fault detection and exclusion(FDE)mechanisms are incorporated into the vector tracking loop(VTL)architecture of the Global Positioning System(GPS)receiver for reliability *** the VTL,the tasks of signal tracking and navigation state estimation no longer process separately and a single extended Kalman filter(EKF)is employed to simultaneously track the received signals and estimate the receiver’s position,velocity,*** contrast to the scalar tracking loop(STL)which utilizes the independent parallel tracking loop approach,the VTL technique is beneficial from the correlation of each satellite signal and user *** VTL approach provides several important *** of the merits is that the tracking loop can be assisted for overcoming the problem of signal *** the VTL architectures provide several important advantages,they suffer some fundamental *** example,the errors in the navigation solutions may degrade the tracking *** most significant drawback is that failure of tracking in one channel may affect the entire tracking loop and possibly lead to loss of *** reliability enhancement,the EKF based integrity monitoring and FDE algorithms are developed to prevent the error from spreading into the entire tracking *** integrity monitoring is utilized to check the possible fault in the pseudorange and the pseudorange rate,followed by the FDE mechanism employed to exclude the abnormal satellite *** assessment and evaluation for the proposed approach will be presented.

关键词： Global Positioning System vector tracking loop signal blockage integrity fault detection and exclusion

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Factor analysis for the statistical modeling of earthquake-induced landslides

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 123-126页

作者： Jeng-Wen LIN meng-Hsun hsieh Yu-Jen LI Department of Civil Engineering Feng Chia UniversityTaichung 40724China School of Management Fujian University of TechnologyFuzhou 350118China Ruentex Engineering&Construction Co. Ltd.Taipei 10492China

Earthquake-induced landslides are difficult to assess and predict owing to the inherent unpredictability of *** most existing studies,the landslide potential is statistically assessed by collecting and analyzing the data of historical landslide events and earthquake observation *** rainfall-induced landslides,earthquake-induced landslides cannot be predicted in advance using real-time monitoring systems,and the development of the models for these landslides should instead depend on early earthquake warnings and ***,in this study,factor analysis was performed and the frequency distribution method was employed to investigate the potential risk of the landslides caused by *** such as the slope gradient,lithology(geology),aspect,and elevation were selected and classified as influential factors to facilitate the construction of a landslide database for the area of study.

关键词： earthquake factor analysis slope landslides statistical modeling

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Ocular hypertension and severe intraocular pressure elevation after posterior subtenon injection of triamcinolone acetonide for various diseases

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 946-951页

作者： Yun-Hsiang Yang Hua-hsuan Kuo Wei-Cherng Hsu Yi-Ting hsieh Department of Ophthalmology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei 231TaiwanChina School of Medicine Tzu Chi UniversityHualien 970TaiwanChina Department of Ophthalmology National Taiwan University HospitalTaipei 10002TaiwanChina

AIM:To evaluate and compare the incidences of ocular hyper tension and severe intraocular pressure(IOP)elevation after posterior subtenon injection of triamcinolone acetonide(PSTA)for various ***:Totally 179 eyes that had received PSTA for diabetic macular edema(n=108),pseudophakic cystoid macular edema(n=20),branch retinal vein occlusion(n=16),central retinal vein occlusion(CRVO,n=14),choroidal neovascularization(n=14)or noninfectious uveitis(n=7)were retrospectively *** primary outcomes included ocular hypertension defined as an IOP>21 mm Hg,and severe IOP elevation defined as a rise of 10 mm Hg or more in IOP compared with *** regression models were used to analyze the hazard ratios(HRs)among different ***:After PSTA,the mean IOPs from month 1 to month 6 all significantly increased(P<0.05).Ocular hypertension occurred in 30.7%of eyes(median time:8 wk),and severe IOP elevation occurred in 16.2%of eyes(median time:9 wk).Patients receiving PSTA for CRVO or uveitis had a significantly higher risk for ocular hypertension(HR=3.049,P=0.004 for CRVO;HR=5.464,P=0.019 for uveitis)and severe IOP elevation(HR=2.913,P=0.034 for CRVO;HR=7.650,P=0.009 for uveitis).CONCLUSION:IOP significantly increases within 6 mo after PSTA,with the onset of ocular hypertension happening mostly at 2 to 3 *** of CRVO or noninfectious uveitis have a higher risk of ocular hypertension or severe IOP elevation after PSTA and should be monitored for IOP more carefully.

关键词： intraocular pressure ocular hypertension uveitis retinal vein occlusion triamcinolone acetonide

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Characterization of horseshoe vortex in a developing scour hole at a cylindrical bridge pier

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International Journal of Sediment Research 2019年第2期34卷 118-124页

作者： Dawei Guan Yee-meng Chiew Maoxing Wei Shih-Chun hsieh College of Harbour Coastal and Offshore EngineeringHohai University School of Civil and Environmental Engineering Nanyang Technological University

Since local scour at bridge piers in rivers and estuaries is a major cause of bridge failure,estimation of the maximum local scour depth is of great importance to hydraulic and coastal *** numerous studies that focus on scour-depth prediction have been done and published,understanding of the flow and turbulence characteristics of the horseshoe vortex that drives the scour mechanism in a developing scour hole still is *** study aims to quantify the detailed turbulent flow field in a developing clear-water scour hole at a circular pier using Particle Image Velocimetry(PIV).The distributions of velocity fields,turbulence intensities,and Reynolds shear stresses of the horseshoe vortex that form in front of the pier at different scour stages(t = 0,0.5,1,12,24,and 48 h)are presented in this *** scour development,the horseshoe vortex system was found to evolve from one initially small vortex to three *** strength and size of the main vortex are found to increase with increasing scour *** regions of both the maximum turbulence intensity and Reynolds shear stress are found to form at a location upstream of the main vortex,where the large turbulent eddies have the highest possibility of *** from this study not only provide new insight into the complex flow-sediment interaction at bridge piers,but also provide valuable experimental databases for advanced numerical simulations.

关键词： Sediment transport Scour Bridge pier PIV Horseshoe vortex Turbulence Scour hole

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Myoepithelial carcinoma of the stomach: A diagnostic pitfall

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World Journal of Gastroenterology 2015年第14期21卷 4391-4396页

作者： Chih-En Tseng Yu-Hsi hsieh Chang-Kuo Wei hsuan-Ying Huang Chen-Lin Chi Department of Pathology Buddhist Dalin Tzu Chi Hospital School of Medicine Tzu Chi University Department of Gastroenterology Buddhist Dalin Tzu Chi Hospital Department of General Surgery Buddhist Dalin Tzu Chi Hospital Department of Anatomical Pathology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine

Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral *** report describes a case of a rare low-grade myoepithelial carcinoma of the stomach.A61-year-old female patient presented with postprandial abdominal *** revealed a 1.1 cm submucosal *** excision was performed after malignancy was confirmed by *** resection margin is free of tumor and she received no adjuvant *** tumor was characterized by multinodular growth with biphasic epithelioid and spindle *** margin and nuclear pleomorphism are *** cells were positive for both epithelial and myoepithelial *** of epithelial differentiation was confirmed by electron *** EWSR1 rearrangement was *** final diagnosis was low-grade myoepithelial gastric *** patient is currently well, and no evidence of recurrence or metastasis was found after ten-month of *** carcinoma should be considered in the differential diagnosis of a biphasic gastric tumor.

关键词： Myoepithelioma Myoepithelial carcinoma Stomach

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Estimating nutrient budgets in a coastal lagoon

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Chinese Science Bulletin 2010年第6期55卷 484-492页

作者： hsieh WeiChun LEE HungJen TEW KweeSiong LIN Chitsan FAN KuoShuh meng PeiJie Graduate Institute of Engineering Science and Technology Kaohsiung First University of Science and Technology Kaohsiung 824 Taiwan China Department of Marine Environmental Informatics Taiwan Ocean University Keelung 202-24 Taiwan China Museum of Marine Biology and Aquarium Pingtung 944 Taiwan China Department of Marine Environmental Engineering Kaohsiung Marine University Kaohsiung 811 Taiwan China Institute of Marine Biodiversity and Evolutionary Biology Dong Hwa University Pingtung 944 Taiwan China

To estimate nutrient budgets,water samples were collected at 16 sites in Tapong lagoon from January 2004 through April 2005 and the parameters of water quality were analyzed immediately after *** data were used to build a box model for calculating nutrient budgets of the *** estimated the net amount of nutrient fluxes into (coming from creeks) and out (from tidal inlet) of the lagoon and calculated the total amount of nutrient that deposits into the sediment in a full tidal *** January and April,nutrients (including nitrate,nitrite and ammonia) accumulated in the lagoon,but phosphate,total phosphate and suspended solids were flushed out of the lagoon from the tidal *** addition,a huge amount of suspended solids (13-15 tons per tidal cycle) flew from the lagoon to the adjacent ocean through the inlet-outlet channel.

关键词：泻湖养分预算估计沿海潮汐周期亚硝酸盐悬浮固体

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Anti-Helicobacter pylori therapy significantly reduces Helicobacter py/ori-Induced gastric mucosal damage in Mongolian gerbils

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World Journal of Gastroenterology 2005年第7期11卷 982-985页

作者： Sheng-hsuan Chen Gi-Shih Lien Yuarn-Jang Lee Horng-Yuan Lou Ching-Ruey hsieh Chia-Lang Fang Shiann Pan Department of Internal Medicine

AIM: To investigate the effectiveness of 4 d' anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes. METHODS: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2×108 CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d' anti-H pylori triple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected & H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E2 level. RESULTS: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE2 levels were significantly higher in H pylori-infected group than those in the other two groups. CONCLUSION: Four days' anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

关键词： Helicobacter pylori anti-H pylori therapy Mongolian gerbils Gastritis

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