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Nuclear Science and Techniques 2018年第4期29卷 155-162页

作者： meng-ge dong Xiang-Xin Xue V.P.Singh He Yang Zhe-Fu Li M.I.Sayyed Department of Resource and Environment School of Metallurgy Northeastern University Shenyang 110819China Department of Physics Karnatak UniversityDharwad 580003 India Shanghai Institute of Applied Physics Shanghai 201800China Physics Department University of Tabuk Tabuk Saudi Arabia

In this study, the mass attenuation coefficient of boron-containing ores in the Liaoning province of China was calculated using Win XCOM software to investigate the shielding effectiveness of these ores against gamma rays. The mass attenuation coefficients were also calculated using MCNP-4 B code and compared with Win XCOM results; consequently, a good consistency between the results of Win XCOM and MCNP-4 B was observed. Furthermore, the G-P fitting method was used to evaluate the values of exposure buildup factor(EBF) in the energy range of 0.015–15 Me V up to 40 mean free paths. Among the selected ores, boron-bearing iron concentrate ore(M3)was determined to be the best gamma ray shielding ore owing to its higher values of mass attenuation coefficient and equivalent atomic number and lower value of ***, American Evaluated Nuclear Data File(ENDF/B-VII) was used to analyze the shielding effectivenessagainst thermal neutrons. It was determined that Szaibelyite(M2) is the best thermal neutron shielding *** study would be useful for demonstrating the potential of boron-containing ores for applications in the field of nuclear engineering and technology.

关键词： Exposure buildup factors Gamma ray Neutron Boron-containing ores G-P fitting method

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

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液压挖掘机履带行走装置的合理预张紧力

吉林大学学报（工学版） 2018年第2期48卷 486-491页

作者：刘汉光王国强孟东阁赵寰宇江苏徐州工程机械研究院江苏徐州221004 徐工集团高端工程机械智能制造国家重点实验室江苏徐州221004 吉林大学机械科学与工程学院长春130022

针对液压挖掘机履带行走装置的合理预张紧力进行了分析研究。在多体动力学软件RecurDyn中建立了挖掘机的虚拟样机模型,并通过实验测得了在直行、原地转向以及差速转向3种工况下的履带行走装置张紧力的曲线,与仿真结果进行对比,验证了虚... 详细信息

针对液压挖掘机履带行走装置的合理预张紧力进行了分析研究。在多体动力学软件RecurDyn中建立了挖掘机的虚拟样机模型,并通过实验测得了在直行、原地转向以及差速转向3种工况下的履带行走装置张紧力的曲线,与仿真结果进行对比,验证了虚拟样机模型的准确。通过对直行、爬坡以及原地转向3种典型工况下的仿真分析,得到了在改变履带行走装置预张紧力情况下,履带行驶时张紧力的变化情况,通过张紧力曲线的标准差来判断其波动情况,进而得到合理的预张紧力与车重的比例系数。

关键词：机械工程液压挖掘机虚拟样机仿真预张紧力

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

基于AutoLISP的偏置圆柱蜗杆传动副的三维建模

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机械制造与自动化 2011年第5期40卷 77-78,94页

作者：孟东阁范元勋南京理工大学机械工程学院江苏南京210094

偏置圆柱蜗杆传动副中面蜗轮的齿面复杂,直接进行三维建模比较困难。在AutoCAD中,利用AutoLISP语言编制程序模拟滚刀加工面蜗轮的过程,完成了偏置圆柱蜗杆传动副的三维建模。得到的三维造型可进行啮合仿真、有限元分析等操作。

关键词：偏置圆柱蜗杆传动副 AutoLISP 实体造型

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong Chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

High-resolution imaging through dynamic scattering media: Iterative optimization based on polarimetric characteristics

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Science China Technological Sciences 2025年第1期 82-84页

作者： meng XIANG Kai DENG Tianyu WANG Jinpeng LIU Xue dong Teli XI Fei LIU Xiaopeng SHAO School of Optoelectronic Engineering Xidian University Xi'an Key Laboratory of Computational Imaging National Key Laboratory of Infrared Detection Technologies

High-resolution imaging through randomly dynamic scattered fields and highly scattered walls is an extensively sought-after capability with potential applications in various fields such as underwater imaging, biomedical imaging, and seeing through fog. Numerous methods have been proposed to unscramble object information from degraded scattered images, resulting in considerable improvements in image contrast in degraded scenarios [1].

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履带驱动轮系统失效机理研究

筑路机械与施工机械化 2017年第6期34卷 91-94页

作者：刘汉光孟东阁李海龙李刚江苏徐州工程机械研究院江苏徐州221004 徐工集团高端工程机械智能制造国家重点实验室江苏徐州221004 吉林大学机械科学与工程学院吉林长春130022

为了解决液压挖掘机履带驱动轮连接螺栓易失效的问题,分析了驱动轮连接螺栓在工作过程中的受力状态,证实了失效的根本原因是预紧力不足。应用Hyperworks仿真方法验证了分析结论,提出扭矩控制并增加内齿圈锁紧垫片的螺栓连接改进方案,以... 详细信息

为了解决液压挖掘机履带驱动轮连接螺栓易失效的问题,分析了驱动轮连接螺栓在工作过程中的受力状态,证实了失效的根本原因是预紧力不足。应用Hyperworks仿真方法验证了分析结论,提出扭矩控制并增加内齿圈锁紧垫片的螺栓连接改进方案,以提高驱动轮系统可靠性。以上研究方法可以分析评价其他型号液压挖掘机的履带驱动轮连接螺栓的安装扭矩及结构设计安全。

关键词：驱动轮系统连接螺栓预紧力失效机理

Enhanced solid-electrolyte interface efficiency for practically viable hydrogen-air fuel cell systems

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Journal of Energy Chemistry 2025年第1期100卷 356-368页

作者： Venkitesan Sakthivel dong Jin Yoo Graduate School Department of Energy Storage/Conversion Engineering (BK21 FOUR) Hydrogen and Fuel Cell Research Center Jeonbuk National University Jeonju Department of Life Science Jeonbuk National University

Proton exchange membrane fuel cells （PEMFCs） provide an appealing sustainable energy system,with the solid-electrolyte membrane playing a crucial role in its overall ***,sulfonated poly（1,4-phenylene ether-ether sulfone）(SPEES),an aromatic hydrocarbon polymer,has garnered considerable attention as an alternative to Nafion ***,the long-term durability and stability of SPEES present a significant *** this context,we introduce a potential solution in the form of an additive,specifically a core–shell-based amine-functionalized iron titanate （A–Fe2TiO5）,which holds promise for improving the lifetime,proton conductivity,and power density of SPEES in *** modified SPEES/A–Fe2TiO5composite membranes exhibited notable characteristics,including high water uptake,enhanced thermomechanical stability,and oxidative ***,the SPEES membrane loaded with 1.2 wt%of A–Fe2TiO5demonstrates a maximum proton conductivity of 155 mS cm-1,a twofold increase compared to the SPEES membrane,at 80°C under 100%relative humidity （RH）.Furthermore,the 1.2 wt%of A–Fe2TiO5/SPEES composite membranes exhibited a maximum power density of 397.37 mW cm-2and a current density of 1148 mA cm-2at 60°C under 100%RH,with an opencircuit voltage decay of 0.05 m V/h during 103 h of continuous *** study offers significant insights into the development and understanding of innovative SPEES nanocomposite membranes for PEMFC applications.

关键词： Composite membranes