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Preparation of Tolterodine Metabolite Loaded Biodegradable PLGA Microspheres

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Chemical Research in Chinese Universities 2010年第1期26卷 75-80页

作者： TENG Le-sheng JIANG Chao-jun liN Xiang-you DONG Yuan-chen li Chun-mei meng Qing-fan li You-xin College of life Science Jilin University Changehun 130012 P. R. China

Biodegradable polymer poly（lactic-co-glycolic acid）（PLGA） was used to encapsulate the pharmacological activity metabolite of tolterodine by means of O/W emulsion solvent evaporation method via homogenization in the emulsification process. The influences of preparation parameters were investigated. The results indicate that increa- sing PLGA concentration from 15% to 40% made the encapsulation efficiency of 5-hydroxymethyl derivative of tol- terodine（5-HMT） increased from 55.39% to 76.32%, and the particle size increased from 34.33 μm to 70,78 lain. In addition, when homogenization speed increased from 850 r/min to 2300 r/min, both particle size and encapsulation efficiency of microspheres decreased. An increase in the volume of aqueous phase led to higher encapsulation efficiency and bigger particle size. Increasing temperature made encapsulation efficiency and particle size change significantly. While reaction temperature increased from 20 ℃ to 50 ℃, the encapsulation efficiency decreased from 70.44% to 24.07%, and particle size increased from 38.66 μm to 69.38 μm. High reaction temperature（over 40 ℃） may lead to porous surface of microspheres. Porous surface, encapsulation efficiency and particle size influenced on the in vitro release of 5-HMT together.

关键词： Poly(lactic-co-glycolic acid) Microsphere Tolterodine Tolterodine metabolite

Catalytic Enantioselective Construction of 6-4 Ring-Junction All-Carbon Stereocenters and Mechanistic Insights

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Chinese Journal of Chemistry 2022年第15期40卷 1767-1776页

作者： Jia-Yin Wang Chen-Long li Ting Xu meng-fan li Wen-Juan Hao Shu-Jiang Tu Jianyi Wang Guigen li Zhi-Xiang Yu Bo Jiang School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhouJiangsu 221116China College of Chemistry Peking UniversityBeijing 100871China Medical College Guangxi UniversityNanningGuangxi 530004China Institute of Chemistry&Biomedical Sciences Nanjing UniversityNanjingJiangsu 210093China Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTexas 79409-1061United States

Comprehensive Summary Developing reactions for the synthesis of 6-6-4 and 6-4 carbocyclic scaffolds with a chiral quaternary center at the bridgehead position is highly desired,considering the existence of such skeletons in natural products with biological activities and the potential of using these molecules for downstream studies in chemical biology and medicinal *** here is accessing these target skeletons with high chemo-,regio-and enantio-selectivities through Pd(ll)/chiral N,N'-disulfonyl bisimidazoline(Bim)ligand-catalyzed asymmetric reaction of yne-allenones and arylboronic acids.

关键词： Asymmetric catalysis Palladium Michael addition Chiral cyclobutenes Mechanism

Stereoselective construction of azepine-containing bridged scaffolds via organocata-lytic bicyclization of yne-allenone esters with nitrones

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Chinese Chemical Letters 2023年第4期34卷 309-312页

作者： meng-fan li Shao-Qing Shi Ting Xu Qian Zhang Wen-Juan Hao Shu-liang Wang Jianyi Wang Shu-Jiang Tu Bo Jiang School of Chemistry and Materials Science and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal UniversityXuzhou 221116China Medical College Guangxi UniversityNanning530004China

A new organocatalytic double annulation cascade involving scission/recombination of N-O bonds of nitrones is reported for the first time, and used to produce a range of hitherto unprecedented tricyclic bridged-fused benzo[d]azepines bearing three stereogenic centers with moderate to good yields and complete diastereoselectivity. A quinine-catalyzed reaction of yne–allenone esters with nitrones worked well and provided a convergent and regioselective pathway to access these three-dimensional scaffolds from the planar conjugated system. Density functional theory(DFT) calculations have been applied to understand the key process for forming diradical intermediates.

关键词： Bicyclization Diastereoselectivity Organocatalysis Bridged heterocycles YNE-allenone esters Nitrones

Increased expression of 70 kD heat shock protein in cultured primary human keratinocytes induced by human papillomavirus 16 E6/E7 gene

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Chinese Medical Journal 2005年第24期118卷 2058-2062页

作者： liAO Wen-jun fan Ping-shen FU meng fan Xue-li liU Yu-feng Department of Dermatology Xijing Hospital Fourth MilitaryMedical University Xi＇ an 710032 China

Background Heat shock protein 70 （HSP70） is expressed highly in epithelial tumours associated closely with human papillomavirus 16 （HPV16） infections. However, evidence about the direct relationship between HSP70 expression and HPVs infections are still lacking. In the present study, we examined the expression of HSP70 in keratinocytes introduced with HPV16 E6/E7 oncogenes. Methods Stable transfected cells were established by transfection of the plasmids pLXSN16E6/E7 into cultured primary keratinocytes and subsequently selected by plasmid specific selection antibiotic （G418） at the required concentration. The expression of HSP70 in pLXSN16E6/E7 transfected keratinocytes was determined by Western blot. The correlation of HSP70 expression and E6/E7 transfeetion was further confirmed by doubly labelled immunofluorescent staining. Results Compared to non-transfected keratinocytes, there was a significant trend for higher levels of HSP70 in pLXSN16E6/E7 transfected keratinocytes. Doubly labelled immunofluorescent staining experiment showed that the co-localization of HPV16 E6/E7 and HSP70 in transfeeted keratinoeytes was observed and increased expression of HSP70 was strongly associated with the transfection of HPV16 E6/E7. Conclusions Our studies demonstrated increased levels of HSP70 proteins in keratinocytes stably transfected by HPV16 E6/E7 oncogenes. It suggests that the expression of HSP70 is modulated by HPV16 E6/E7 proteins, which may be involved in HPV16 E6/E7 induced immortalization.

关键词： heat shock protein 70 keratinocytes human papillomavirus 16 E6/E7

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao meng Qingbin meng Hongwen Jing Bo meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

Cystic changes associated with pulmonary tuberculosis:a case report

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Chinese Medical Journal 2006年第13期119卷 1125-1128页

作者： CAI Hou-rong CAO Min meng fan-qing li Wei-chun Department of Pulmonary Medicine Drum Tower HospitalNanjing University Medical School Nanjing 210008 China

There are a wide range of computed tomography （CT） findings in patients with pulmonary tuberculosis, including diffuse or localized nodules, reticular opacities, ground glass attenuation, air trapping, consolidation, cavitation, fibrosis, lymph nodes enlargement, and septal thickening. However, CT findings of pulmonary tuberculosis that appeared as multiple cystic lesions were very rare. Herein, the CT findings appeared as multiple cystic lesions in a patient with pulmonary tuberculosis are reported.

关键词： pulmonary tuberculosis cystic lesion tomography, computed

Study on the Molecular Weight Composition and Antioxidant Activity of Peanut Bioactive Peptides

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Chinese Food Science 2012年第2期1卷 20-23页

作者： ZHANG Rui fan Yuan-jing CHEN Wei HUANG Wen-dong WANG lin meng fan-li School of Biotechnology and Food Engineering Hefei University of Technology Anhui Kaili Cereals Oils&Foodstuffs Co. Ltd.

[ Objective] To prepare peanut bioactive peptides and analyze their molecular weight composition and antioxidant activity. [ Method ] The dialysis bag of 8.0, 3.5 and 1.0 kD were used to classify the hydrolyzate derived from alcalase and flavourzyme, peanut bioactive poptides of differ-ent molecular weight were obtained and then their scavenging capacity of free radicals was measured. The molecular weight composition was stud-ied by Tricine-SDS-PAGE.[Result] The content of peptides 〈 1.0 kD were 76.21% and 83.42% in the total hydrolyzate from alcalase and fla-vourzyme respectively. All hydrolyzate with different molecular grades showed free radical scavenging capacity, which was increased with the reduc- tion of molecular mass. The peptides 〈 1.0 kD exhibited higher radical scavenging capacity of （87.41 ±0.66） % （alcalase） and （67.88 ±0.48）% （ flavourzyme）, respectively. [ Conclusion] Peanut bioactive peptides had strong effect of antioxidant capacity, especially that 〈 1.0 kD, which had great prospect.

关键词： Peanut bioactive peptides Antioxidant activity Dialysis Tricine-SDS-PAGE China

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论少数民族地区跨文化教师的培养

教师教育研究 2007年第3期19卷 12-16页

作者：孟凡丽新疆师范大学教育科学学院新疆乌鲁木齐830054

作为少数民族地区的教师,无论是哪一个民族都应该成为跨文化教师,具有相应的跨文化知识、教育教学能力。少数民族地区教师教育应体现多元文化教育理念,将培养跨文化教师作为培养目标的重要组成部分,并在课程设置和实践教学上加以落实。

关键词：少数民族地区跨文化教师文化教育

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao lingyan meng Kang Du Xuezhi li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein