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ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population

World Journal of Psychiatry 2022年第7期12卷 904-914页

作者： Xin-Wei Li Ming-Yuan Zhang Zhi-Jun Li Li-Zhe Ai meng-di jin Ning-Ning Jia meng-Tong Xie Yu-QingYang Wei-Zhen Li Lin Dong Qiong Yu Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun 130021Jilin ProvinceChina Department of Endemic diseases and Parasitic diseases Prevention Yantai Center for Disease Control and PreventionYantai 264003Shandong ProvinceChina

BACKGROUND Schizophrenia(SCZ)is a complex disease which can be affected by both genetic and environmental *** famine exposure may cause changes in DNA methylation levels of ***,maternal nutrition during pregnancy is a pivotal environmental factor in the development of *** methylation may be an intermediate factor mediating exposure to famine during pregnancy and SCZ,and DNA methylation quantitative trait loci might serve as a promising tool for linking SCZ and prenatal *** To analyze the association between prenatal famine exposure and SCZ risk in Northeast Han Chinese through analysis of DNA methylation related *** A total of 954 Han Chinese from Northeast China were recruited,including 443 patients with SCZ and 511 healthy *** participants were further divided into famine(born in 1960-1962)and non-famine(born in 1963-1965)groups to investigate the effect of prenatal famine *** single-nucleotide polymorphisms(SNPs)selected according to the relevant literature were genotyped,namely,rs11917047 in PTPRG,rs2239681 in IGF2,rs3842756 in INSIGF,and rs61955196 in *** were extracted from peripheral blood samples,and the genotypes of these SNP loci were detected using the improved Multiple Ligase Detection Reaction multiple SNP typing *** associations of the DNA methylation related SNPs with SCZ risk and prenatal famine,and their interactions were analyzed using logistic regression analysis and generalized multifactor dimensionality reduction(GMDR)*** Based on the sequencing data,genotype distributions and allele frequencies of the four selected SNPs were *** genotype frequencies of the four SNPs in the healthy control group were tested for deviation from Hardy-Weinberg equilibrium(P>0.05).Logistic regression analysis showed that rs61955196 was significantly associated with SCZ risk in the log-additive model[odds ratio(OR):1.22;95%confidence interval(CI):1.01-1.48;P=0.040]

关键词： Schizophrenia Prenatal famine rs61955196 DNA methylation ABCB9 polymorphism

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Actively tunable electromagnetically induced transparency in hybrid dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： di Ke XIE meng XIA Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

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Nano Research 2025年第1期18卷 341-350页

作者： Zili Zhang Ruolin Wang Hongfei Lu di Zhang Yu Zhao jing Xu Bin Sun Zhi-Min Dang Yang jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

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Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang ding-Yue Shang Ying Chen meng Tian Cheng-Yu jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

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Optimization Scheme of Large Passenger Flow in Huoying Station,Line 13 of Beijing Subway System

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Computers, Materials & Continua 2020年第6期63卷 1387-1398页

作者： jin Zhou Haochen Wang di Sun Siqiang Xu meng Lv Feifei Yu Beijing Union University College of Urban Rail Transit and LogisticsBeijing100101China Uber Technology Incorporated San FranciscoCA94103USA

This paper focuses on the distribution of passenger flow in Huoying Station,Line 13 of Beijing subway *** transformation measures taken by Line 13 since operation are firstly *** the authors elaborate the facilities and equipment of this station,especially the node layout and passenger flow *** optimization scheme is proposed to rapidly distribute the passenger flow in Huoying Station by adjusting the operation time of the escalator in the direction of *** authors adopt Queuing theory and Anylogic simulation software to simulate the original and the optimized schemes of Huoying Station to distribute the passenger *** results of the simulation indicate that the optimized scheme could effectively alleviate the traffic congestion in the hall of Huoying Station,and the pedestrian density in other places of the hall is lowered;passengers could move freely in the hall and no new congestion points would *** rationality of the scheme is thus proved.

关键词： Huoying station of Beijing subway system passenger flow escalator queuing theory system simulation Anylogic

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Dual-radiation-chamber coordinated overall energy efficiency scheduling solution for ethylene cracking process regarding multi-parameter setting and multi-flow allocation

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Chinese Journal of Chemical Engineering 2021年第6期34卷 180-197页

作者： di meng Cheng Shao Li Zhu Institute of Advanced Control Technology Dalian University of TechnologyDalian 116024China

Ethylene cracking process is the core production process in ethylene industry,and is paid more attention to reduce high energy *** of the interdependent relationships between multi-flow allocation and multi-parameter setting in cracking process,it is difficult to find the overall energy efficiency scheduling for the purpose of saving *** traditional scheduling solutions with optimal economic benefit are not applicable for energy efficiency scheduling issue due to the neglecting of recycle and lost energy,as well as critical operation parameters as coil outlet pressure(COP)and dilution *** addition,the scheduling solutions mostly regard each cracking furnace as an elementary unit,regardless of the coordinated operation of internal dual radiation chambers(DRC).Therefore,to improve energy utilization and production operation,a novel energy efficiency scheduling solution for ethylene cracking process is proposed in this ***,steam heat recycle and exhaust heat loss are considered in cracking process based on 6 types of extreme learning machine(ELM)based cracking models incorporating DRC operation and three operation parameters as coil outlet temperature(COT),COP,and dilution ratio according to semi-mechanism *** to provide long-term decision-making basis for energy efficiency scheduling,overall energy efficiency indexes,including overall output per unit net energy input(OONE),output-input ratio per unit net energy input(ORNE),exhaust gas heat loss ratio(EGHL),are designed based on input-output analysis in terms of material and energy ***,a multiobjective evolutionary algorithm based on decomposition(MOEA/D)is employed to solve the formulated multi-objective mixed-integer nonlinear programming(MOMINLP)*** validities of the proposed scheduling solution are illustrated through a case *** scheduling results demonstrate that an optimal balance between multi-flow allocation,multi-parameter setting,and D

关键词： Ethylene cracking process Energy efficiency scheduling Overall energy efficiency indexes Dual radiation chamber Multiple operation parameters Multiple energy flows

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Monotreme middle ear is not primitive for Mammalia

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National Science Review 2021年第10期8卷 10-12页

作者： jin meng Fangyuan Mao division of Paleontology American Museum of Natural History Earth and Environmental Sciences Graduate Center City University of New York Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment

The study of the evolution of the mammalian middle ear has been fueled by continuous discoveries of Mesozoic fossils in the last two decades. Wang et al. [1] recently reported a specimen of Vilevolodon diplomylos [2] that adds to the increasing knowledge about the auditory apparatus of ‘haramiyidans’, an extinct Mesozoic group of mammaliaforms. The authors hypothesized that a middle ear with a monotreme-like incus and malleus and incudomallear articulation was primitive for mammals,

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POWER FLOW ANALYSIS AND APPLICATION SIMULATION OF ELECTROMAGNETIC CONTINUOUSLY VARIABLE TRANSMISSION

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Chinese Journal of Mechanical Engineering 2008年第6期21卷 48-56页

作者： LUO Yutao TAN di meng Fanzhen Guangdong Provincial Key Laborotory of School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Scool of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China

With the structure of two air gaps and two rotors, the electromagnetic continuously variable transmission（EMCVT） is a novel power-split continuously variable transmission（CVT）. There are two kinds of power flowing through the EMCVT, one is mechanical power and the other is electric power. In the mean time, there are three power ports in the EMCVT, one is the outer rotor named mechanical power port and the other two are the inner rotor and the stator named electric power ports. The mechanical power port is connected to the driving wheels through the final gear and the electric ports are connected to the batteries through the transducers. The two kinds of power are coupled on the outer rotor of the EMCVT. The EMCVT can be equipped on the conventional vehicle being regarded as the CVT and it also can be equipped on the hybrid electric vehicle（HEV） as the multi-energy sources assembly. The power flows of these two kinds of applications are analysed. The back electromotive force（EMF） equations are illatively studied and so the dynamic mathematic model is theorized. In order to certify the feasibility of the above theories, three simulations are carried out in allusion to the above two kinds of mentioned applications of the EMCVT and a five speed automatic transmission（AT） vehicle. The simulation results illustrate that the efficiency of the EMCVT vehicles is higher than that of the AT vehicle owed to the optimized operation area of the engine. Hence the fuel consumption of the EMCVT vehicles is knock-down.

关键词： Electromagnetic continuously variable transmission Power flow analysis back electromotive force application simulation

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Range-wide genetic diversity in natural populations of Larix principis-rupprechtii Mayr.

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Journal of Forestry Research 2021年第1期32卷 319-327页

作者： Xiaoyan di Xiangxiang meng mengben Wang Institute of Loess Plateau Shanxi UniversityTaiyuan 030006People’s Republic of China

Prince Rupprecht’s larch(Larix principis-rupprechtii Mayr.),a deciduous conifer,widely grows in middle and high elevations of Northern *** natural distribution has sharply decreased and has become fragmented,which may have resulted in the loss of genetic *** this study,ten natural populations across the entire range of this species were analyzed using amplifi ed fragment length polymorphism markers.A total of 309 loci were detected from 225 individuals of these populations,of which 261(84.5%)were *** the species level,the genetic diversity was high(average of the Nei’s genetic diversity H e=0.2602,and Shannon’s information index I=0.3967).The results of molecular variance analysis showed that 90.71%of the genetic diversity occurred within *** genetic diff erentiation among populations was moderate as a whole(F ST=0.0929,G ST=0.1510),which is consistent with the moderate level of gene fl ow among populations(N m=2.8116).Based on the unweighted pair group method with arithmetic mean and STRU CTU RE analysis,these populations were grouped into three genetically distinct *** degree of inter-population diff erentiation(G ST=0.1338)for the south group was larger than that for the north group(G ST=0.0915).There was a signifi cant correlation between genetic distance and geographic distance across the species range(r=0.316,Pdiversity was signifi-cantly associated with longitude but not elevation or climatic *** populations with high genetic diversity from each cluster are therefore recommended for future conservation and management of this species.

关键词： Larix principis-rupprechtii Amplifi ed fragment length polymorphism markers(AFLP) Genetic diversity Environmental factors

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Mesozoic mammals of China: implications for phylogeny and early evolution of mammals

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National Science Review 2014年第4期1卷 521-542页

作者： jin meng Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences division of Paleontology American Museum of Natural History

All Mesozoic mammaliaforms reported from China are briely documented *** forms can be divided into at least ive major assemblages:Lufeng,Yanliao(Daohugou),Jehol,Fuxin and Bayan Mandahu,ranging from the Early Jurassic to the Late Cretaceous *** the temporal and geographic distributions of these mammaliaforms are not dense,the records do reveal a patern that is generally consistent with paterns that have been recognized *** initial stage of mammalian evolution was represented by stem mammaliaforms or primitive‘triconodonts’from the *** was followed by the Middle-Late Jurassic Yanliao episode that showed a high diversity and disparity of mammaliaforms in which terrestrial,swimming,arboreal and gliding species were *** disparity,at least in molar morphology and types of locomotion,decreased but the diversity persisted into the Cretaceous,a period that was dominated by eutriconodontans,multituberculates and *** superb specimens from nearly all major groups of Mesozoic mammals in China provided a great amount of information that contributed to our understanding on some major issues in phylogeny and the early evolution of mammals,such as divergences of mammals and the evolution of the mammalian middle ear.A hypothesis on the transformation of the allotherian tooth patern is proposed as an example to illustrate the potential for future studies of mammalian evolution.

关键词： mammals Mesozoic phylogeny evolution China

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