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Chinese medical Journal 2018年第20期131卷 2503-2505页

作者： Jing Du Xin-Wei Yang Zhi-Jian Wen Chen Xue Yao-Min wu meng-chao wu Lu-Lu Zhang Department of military Health Service Management College of Health Service Second Military Medical University Shanghai 200433 China Department of Biliary surgery Eastern Hepatobiliary Surgery Hospital Shanghai 200438 China Department of hepatobiliary Pancreatic Vascular surgery No. 174 Hospital of People's Liberation Army Xiamen University Xiamen Fujian 361000 China

To the Editor： Gallbladder cancer （GBC）, a rare entity with poor prognosis, is often discovered incidentally during or after *** tends to disseminate early through lymphatic, peritoneal, endobiliary, and hematogenous pathways. Patients usually present with metastatic diseases. If GBC is suspected during cholecystectomy, conversion to open surgery to perform radical resection after confirmation of cancer by intraoperative frozen biopsy is considered. When GBC is diagnosed after cholecystectomy, reoperation for radical resection according to depth of invasion of cancer （T stage） is inevitable. However, reoperation with radical surgery is not performed in all patients for several reasons including refusal to undergo radical surgery, poor medical condition, or cancer progression suggesting unresectability.

关键词： RADICAL RESECTION CANCER

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Clinical application of hepatic venous occlusion for hepatectomy

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Chinese medical Journal 2008年第9期121卷 806-810页

作者： PAN Ze-ya YANG Yuan ZHOU Wei-ping LI Ai-jun FU Si-yuan wu meng-chao The Third Department of Hepatic surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

Background Most liver resections require clamping of the hepatic pedicle （Pringle maneuver） to avoid excessive blood loss. But Pringle maneuver can not control backflow bleeding of hepatic vein. Resection of liver tumors involving hepatic veins may cause massive hemorrhage or air embolism from the injuries of the hepatic veins. Although total hepatic vascular exclusion can prevent bleeding of the hepatic veins effectively, it also may result in systemic hemodynamic disturbance because of the inferior vena cava being clamped. Hepatic venous occlusion, a new technique, can control the inflow and outflow of the liver without clamping the vena cava. Methods A total of 71 cases of liver tumors underwent resection with occlusion of more than one of the main hepatic veins. All tumors involved the second porta hepatis and at least one main hepatic vein. Ligation or occlusion with serreflnes, tourniquets and auricular clamps were used in hepatic venous occlusion. Results Of the 71 patients, ligation of the hepatic veins was used in 28 cases, occlusion with a tourniquet in 26, and occlusion with a serrefine in 17. Right hepatic veins were occluded in 38 cases, both right and middle hepatic veins in 2, the common trunk of the left and middle hepatic veins in 24, branches of the left and middle hepatic veins in 2, and all three hepatic veins in 5. Thirty-five cases underwent hemihepatic vascular occlusion, 4 alternate hemihepatic vascular occlusion, 23 portal triad clamping plus selective hepatic vein occlusion, and 9 portal triad clamping plus total hepatic vein occlusion. The third porta hepatis was isolated in 26 cases. The amount of intraoperative blood loss averaged （540±2.83）（range 100 to 1000） ml in the group of total hemihepatic vascular occlusion and in the group of alternate hemihepatic vascular occlusion, （620±317）（range 200-6000） ml in the group of portal triad clamping plus selective or total hepatic vein occlusion. All tumors were completely removed. Conclusions

关键词： liver neoplasms hepatic veins hepatectomy hemorrhage

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Erratum to: Xeno-repopulation of Fah-/-Nod/Scid mice livers by human hepatocytes

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Science china Life Sciences 2011年第6期54卷 588-588页

作者： SU BaoLiang1,2,LIU ChangCheng1,XIANG Dao1,ZHANG HaiBin3,YUAN SiMing4,WANG MinJun1,CHEN Fei1,ZHU HaiYing1,HE ZhiYing1,WANG Xin5 & HU YiPing1 1Department of Cell Biology,second military medical university,shanghai 200433,china 2Center for Instrumental Analysis,china Pharmaceutical university,Nanjing 210009,china 3eastern hepatobiliary surgery hospital,second military medical university,shanghai 200433,china 4Department of Plastic surgery,Nanjing General hospital of Nanjing military Command,Nanjing 210002,china 5Institute of Biochemistry and Cell Biology,shanghai Institute for Biological Sciences,Chinese Academy of Sciences,shanghai 200031,china Department of Cell Biology Second Military Medical University Shanghai China Center for Instrumental Analysis China Pharmaceutical University Nanjing China eastern hepatobiliary surgery hospital Second Military Medical University Shanghai China Department of Plastic surgery Nanjing General Hospital of Nanjing Military Command Nanjing China Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai China

Erratum to: SCIENCE china Life Sciences, March 2011 Vol.54 No.3: 227–234 doi: 10.1007/s11427-011-4140-7 The authors report the correction for their wrong information about Fah-/-Rag2-/-Il2rg-/- mice in three parts of this paper:Abstract, Introduction and Discussion. We announce that the wrong information should be deleted in the following sections:

关键词： Xeno-repopulation of Fah Erratum to Nod/Scid mice livers by human hepatocytes

Concomitant lung metastasis in patients with advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第20期18卷 2533-2539页

作者： Tian Yang Jun-Hua Lu Chuan Lin Song Shi Ting-Hao Chen Rong-Hua Zhao Yi Wang meng-chao wu Department of Hepatic surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of hepatobiliary surgery the First People＇s Hospital of Ziyang Ziyang 641205 Sichuan Province China Department of surgery Royal University Hospital College of Medicine University of Saskatchewan Saskatoon SK S7NOWS Canada

AIM:To investigate the clinical features and prognostic factors of advanced hepatocellular carcinoma (HCC)patients presenting with lung metastasis at initial diagnosis. METHODS:Between 2001 and 2010,we recruited 76 consecutive HCC patients initially presenting with lung metastasis,without co-existing metastasis from other *** patients were divided into three groups:untreated group(n=22),single treatment group(n= 19),and combined treatment group(n=35). RESULTS:Metastasis of bilateral lung lobes was common and noted in 35 patients(46.1%),and most of patients(59/76,77.6%)presented with multiple lung metastatic *** patients(25.0%) received single-method treatment,including hepatectomy in 4,transcatheter arterial chemoembolization in 6,radiotherapy in 5,and oral sorafenib in ***-five patients(46.1%)received combined treatment *** overall median survival of the all patients was 8.7±0.6 mo;4.1±0.3,6.3±2.5 and 18.6±3.9 mo, respectively in the untreated group,single treatment group and combined treatment group,respectively, with a significant difference(log-rank test,P<0.001). Multivariate analysis revealed that Child-Pugh score, the absence or presence of portal vein tumor thrombus,and treatment modality were three independent prognostic factors affecting survival of patients with advanced HCC and concomitant lung metastasis. CONCLUSION:Combined treatment modalities tend to result in a better survival as compared with the conservative treatment or single treatment modality for HCC patients initially presenting with lung metastasis.

关键词： Hepatocellular carcinoma Lung metastasis Prognosis Survival Prognostic factor

Undifferentiated liver embryonal sarcoma in adults: A report of four cases and literature review

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World Journal of Gastroenterology 2010年第37期16卷 4725-4732页

作者： Xiao-Wei Li Shao-Juan Gong Wei-Hua Song Jun-Jun Zhu Chun-Hua Pan meng-chao wu Ai-Min Xu Department of Inte rvention Radiotherapy Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

AIM: To evaluate the undifferentiated embryonal sarcoma of liver (UESL) in adults in order to improve its diagnosis and treatment. METHODS: Four primary and one recurrent cases of UESL were clinicopathologically evaluated and immunohistochemically investigated with a panel of antibodies using the EnVision+ system. Relevant literature about UESL in adults was reviewed. RESULTS: Three males and one female were enrolled in this study. Their chief complaints were abdominal pain, weight loss, or fever. Laboratory tests, imaging and pathological features of UESL in adults were similar to those in children. Immunohistochemistry showed evidence of widely divergent differentiation into mesenchymal and epithelial phenotypes. The survival time of patients who underwent complete tumor resection followed by adjuvant transcatheter arterial chemoembolization (TACE) was significantly longer than that of those who underwent surgical treatment ***: UESL in adults may undergo pluripotential differentiation and its diagnosis should be made based on its morphological and immunohistochemical features. Complete tumor resection after adjuvant TACE may improve the survival time of such patients.

关键词： Undifferentiated embryonal sarcoma Liver Pluripotential differentiation Transcatheter arterial chemoembolization Adult

Combined hepatocellular and cholangiocarcinoma originating from the same clone:a pathomolecular evidence-based study

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Chinese Journal of Cancer 2016年第11期35卷 585-595页

作者： Qian Zhao Wen-Long Yu Xin-Yuan Lu Hui Dong Yi-Jin Gu Xia Sheng Wen-Ming Cong meng-chao wu Department of Pathology Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Biliary surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University Department of Hepatic surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

Background:Combined hepatocellular and cholangiocarcinoma(CHC) is a unique subtype of liver cancer comprising both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC);however,its cellular origin remains *** purpose of this study was to investigate the clinicopathologic features and the clonal relationship between HCC and ICC in 34 patients with ***:The clinicopathologic features and prognosis of the 34 CHC patients were compared with those of 29 patients with separated HCC and ICC(5HC).Loss of heterozygosity(LOH) at 10 highly polymorphic microsatellite markers was detected in 16 CHC and 10 SHC tissues for determination of the clonal origin of *** of hepatocyte markers[hepatocyte paraffin 1(Hep Par 1) and glypican 3(GPC3)]and cholangiocyte markers[cytokeratin(CK)7 and 19]in tumor tissues was examined by immuno histochemical ***:In the 16 CHC specimens,the difference in LOH patterns between HCC and ICC was less than 30%,suggesting the same clonal origin of HCC and *** with this finding,immunohistochemical analysis revealed that hepatocyte markers(Hep Par 1 and GPC3) and cholangiocyte markers(CK7 and CK19) were simultaneously expressed in both the HCC and ICC components in 52.9%of CHC specimens,suggesting that the two components shared a similar phenotype with hepatic progenitor cells(HPCs).On the contrary,in all 10 SHC cases,the difference in LOH patterns between the HCC and ICC components was greater than 30%,suggesting different clonal origins of HCC and *** survival and disease-free survival were shorter for patients with CHC than for patients with SHC(P < 0.05).Conclusions:Our results suggest that the HCC and ICC components of CHC may originate from the same clone,having the potential for dual-directional differentiation similar to *** tended to exhibit the biological behaviors of both HCC and ICC,which may enhance the infiltrative capacity of tumor cells,leading to poor clinical ou

关键词： Combined hepatocellular and cholangiocarcinoma Hepatocellular carcinoma Intrahepatic cholangiocellular carcinoma Loss of heterozygosity Clonal origin Prognosis

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A special growth manner of intrahepatic biliary cystadenoma

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World Journal of Gastroenterology 2009年第48期15卷 6134-6136页

作者： Bin Yi Qing-Bao Cheng Xiao-Qing Jiang Chen Liu Xiang-Ji Luo Hui Dong Bai-He Zhang meng-chao wu Department of Biliary surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Department of Pathology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

We report a case of a 56-year-old woman with intrahepatic biliary cystadenoma(IBC)accompanying a tumor embolus in the extrahepatic bile duct,who was admitted to our department on October 13,*** showed an asymmetry dilation of the biliary tree,different bile signals in the biliary tree,a multiloculated lesion and an extrahepatic bile duct lesion with internal septation.A regular left hemihepatectomy en bloc was performed with resection of the entire tumor,during which a tumor embolus protruding into the extrahepatic bile duct and originating from biliary duct of segment 4 was ***,the multiloculated tumor was confirmed to be a biliary cystadenoma with an epithelial lining composed of biliary-type cuboidal cells and surrounded by an ovarian-like *** aggressive en bloc resection was recommended for the multiloculated *** workup,clinicians and surgeons need to be aware of this different presentation.

关键词： Intrahepatic biliary cystadenoma Growth manner Tumor embolus

Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma

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Cell Research 2001年第3期11卷 209-216页

作者： QIN WEN XIN, DA FANG WAN, FEN YONG SUN, PING PING ZHANG, LI WEI HAN, YI HUANG, HUI QIU JIANG, XIN TAI ZHAO, MEI HE. YUN YE, WEN MING CONG, meng chao wu, LI SHENG ZHANG, NAN wu YANG, JIAN REN GU National LaBoratory for Oncogenes and Related Gencs, shanghai 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. 2shanghai GeneCore Biotechnologies 200 Tian Lin Road Shanghai 200233 China. 2shanghai GeneCore Biotechnologies 200 Tian Lin Road Shanghai 200233 China. 3eastern hepatobiliary surgery hospital Second Military Medical University 225 Changhai Road Shanghai 200433 China. 3eastern hepatobiliary surgery hospital Second Military Medical University 225 Changhai Road Shanghai 200433 China. 4Cancer hospital Guangxi Medical University Nanning 500021 China. 4Cancer hospital Guangxi Medical University Nanning 500021 China. 1National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China.

Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open rea(ling frame 25, previously named it HC71A), from the deletion region on chromosome 17p13.3. The cDNA encodes a protein of 313 amino acids with a calculated molecular mass of 34.8 kDa. C17orf25 is divided into 10 exons and 9 introns, spanning 23 kb of genomic DNA. Northern blot analysis showed that the mRNA expression of C17orf25 was decreased in hepatocellular carcinoma samples as compared to adjacent noncancerous liver tissues from the same patients. The transfection of C17or25 into the hepatocellular carcinoma cell SMMC7721 and overexpression could inhibit the cell growth. The above results indicate that C17orf25 is a novel human gene, and the cloning and preliminary characterization of C17orf25 is a prerequisite for further functional analysis of this novel gene in human hepatocellular carcinoma.

关键词： Chromosome 17p13.3 1lss of heterozygosity hepatocellular carcinoma transfection novel human gene (C17orf25)

Risk factors and surgical outcomes for spontaneous rupture of BCLC stages A and B hepatocellular carcinoma: A case-control study

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World Journal of Gastroenterology 2014年第27期20卷 9121-9127页

作者： Jing Li Liang Huang Cai-Feng Liu Jie Cao Jian-Jun Yan Feng Xu meng-chao wu Yi-Qun Yan Department of Hepatic surgery Ⅰ Eastern Hepatobiliary Surgery Hospital Second Military Medical University

AIM: To investigate the risk factors and surgical outcomes for spontaneous rupture of Barcelona Clinic Liver Cancer (BCLC) stages A and B hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Rupture Risk factor Tumor location Surgical outcome

Antitumor activity of an hTERT promoter-regulated tumor-selective oncolytic adenovirus in human hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第47期12卷 7613-7620页

作者： Chang-Qing Su Xing-Hua Wang Jie Chen Yong-Jing Liu Wei-Guo Wang Lin-Fang Li meng-chao wu Qi-Jun Qian Laboratory of Viral and Gene Therapy Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Xinyuan Institute of Medicine and Biotechnology College of Life Science Zhcjiang Sci-T~ch University Hangzhou 310018 Zhejiang Province China Changhai hospital Second Military Medical University Shanghai 200438 China Jiangsu Key Laboratory for Molecular and medical Bioteclmology Life Science College Nanjing Normal University Nanjing 210097 Jiangsu Province China

AIM: To construct a tumor-selective replication-competent adenovirus (RCAd), SG300, using a modified promoter of human telomerase reverse transcriptase (hTERT). METHODS: The antitumor efficacy of SG300 in hepatocellular carcinoma was assessed in vitro and in vivo. In vitro cell viability by MTT assay was used to assess the tumor-selective oncolysis and safety features of SG300, and in vivo antitumor activity of SG300 was assessed in established hepatocellular carcinoma models in nude mice. RESULTS: SG300 could lyse hepatocellular carcinoma cells at a low multiplicity of infection (MOI), but could not affect growth of normal cells even at a high MOI. Both in Hep3B and SMMC-7721 xenograft models of hepatocellular carcinoma, SG300 had an obvious antitumor effect, resulting in a decrease in tumor volume. Its selective oncolysis to tumor cells and safety to normal cells was also superior to that of ONYX-015. Pathological examination of tumor specimens showed that SG300 replicated selectively in cancer cells and resulted in apoptosis and necrosis of cancer cells. CONCLUSION: hTERT promoter-regulated replicativeadenovirus SG300 has a better cancer-selective replication-competent ability, and can specifically kill a wide range of cancer cells with positive telomerase activity, and thus has better potential for targeting therapy of hepatocellular carcinoma.

关键词： Virotherapy Oncolytic adenovirus Human telomerase reverse transcriptase Hepatocellular carcinoma Animal tumor model