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Efficacy and safety of remimazolam in bronchoscopic sedation:A meta-analysis

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World Journal of Clinical Cases 2024年第6期12卷 1120-1129页

作者： Ying Zhou Cheng Zhao Yi-xun Tang Ji-Tong Liu Department of Anesthesiology The First Affiliated Hospital of Hunan Normal University(Hunan Provincial People’s Hospital)Changsha 410005Hunan ProvinceChina Department of Anesthesiology Zhangjiajie People's HospitalZhangjiajie 427000Hunan ProvinceChina

BACKGROUND Remimazolam is a new benzodiazepine used for procedural sedation and general *** studies have used remimazolam for bendable *** To assess the safety and efficacy of remimazolam for sedation in patients undergoing bendable bronchoscopy by performing a meta-analysis of randomized controlled trials(RCTs).METHODS We searched the EMBASE,PubMed,Cochrane Library,and Web of Science databases for RCTs on bendable bronchoscopic procedural sedation with remimazolam vs conventional sedatives(CS).RESULTS Five studies with 1080 cases were *** had the same sedation success rate compared with CS[relative risk(RR):1.35,95%CI:0.60-3.05,P=0.474,I2=99.6%].However,remimazolam was associated with a lower incidence of hypotension(RR:0.61;95%CI:0.40-0.95,P=0.027;I2=65.1%)and a lower incidence of respiratory depression(RR:0.50,95%CI:0.33-0.77,P=0.002,I2=42.3%).A subgroup analysis showed a higher success rate of sedation with remimazolam than midazolam(RR:2.45,95%CI:1.76-3.42,P<0.001).Compared with propofol,the incidence of hypotension(RR:0.45,95%CI:0.32-0.64,P<0.001,I2=0.0%),respiratory depression(RR:0.48,95%CI:0.30-0.76,P=0.002,I2=78.4%),hypoxemia(RR:0.36,95%CI:0.15-0.87,P=0.023),and injection pain(RR:0.04,95%CI:0.01-0.28,P=0.001)were *** Remimazolam is safe and effective during *** sedation success rate was similar to that in the CS ***,remimazolam has a higher safety profile,with fewer inhibitory effects on respiration and circulation.

关键词： Remimazolam Bronchoscopy Procedural sedation Meta-analysis

Highly Stable sp^(2) Carbon-Conjugated Porous Organic Cages

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CCS Chemistry 2024年第1期6卷 149-156页

作者： Fenglei Qiu xun Chen Wenjing Wang Kongzhao Su Daqiang Yuan State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002 College of Chemistry Fuzhou UniversityFuzhouFujian 350116 University of the Chinese Academy of Sciences Beijing 100049

The high-yield synthesis of ultrastable porous organic cages(POCs)by facile methods is highly desirable but *** by highly stable sp^(2) carbon-conjugated(C=C)covalent organic frameworks,we used rational design and synthesized the first family of sp^(2) carbon-linked POCs(sp^(2)c-POCs)with triangular prism shapes by a one-step Knoevenagel reaction that is a high yield[2+3]condensation *** stability of sp^(2)c-POC was demonstrated under strenuous conditions involving for example concentrated HCl or saturated NaOH ***^(2)c-POC was used as a robust adsorbent for efficient separation of CO_(2)/CH_(4) or CO_(2)/N_(2) *** view of their facile synthesis and unique properties,we expect widespread use of these sp^(2) C=C linkages in the development of POC materials.

关键词： porous organic cages Knoevenagel condensation sp^(2)C=C linkage exceptional chemical stability gas adsorption and separation properties

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孟浩然诗歌自然清淡的审美取向

甘肃广播电视大学学报 2014年第3期24卷 12-15页

作者：孟子勋公安边防部队士官学校基础部云南昆明650214

山水田园诗在盛唐形成一个流派,以其清淡的风味、优美的旋律,给盛唐诗歌增添了丰富的内容,开多元化之面貌。孟浩然的诗歌以清淡之美奏鸣了山水田园的序曲,呈现出了与那个表现强盛时代的诗歌迥然不同的风貌,给诗坛吹进了新鲜的空气,让人... 详细信息

山水田园诗在盛唐形成一个流派,以其清淡的风味、优美的旋律,给盛唐诗歌增添了丰富的内容,开多元化之面貌。孟浩然的诗歌以清淡之美奏鸣了山水田园的序曲,呈现出了与那个表现强盛时代的诗歌迥然不同的风貌,给诗坛吹进了新鲜的空气,让人体会大自然的真谛。研究旨在从孟浩然对待入仕的态度及表现、浩然诗风、浩然诗风的影响及后人对浩然诗歌接受等方面探讨孟浩然诗歌的审美取向。

关键词：孟浩然仕宦之路自然清淡影响与接受

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论国家监察体制改革背景下的宪法因应

太原理工大学学报（社会科学版） 2017年第4期35卷 53-57页

作者：孟子寻武汉大学法学院湖北武汉430072

国家监察体制改革是政治体制改革的重要组成部分,它整合了原有机关的监督职权,成立了新的监察机关监察委员会,改变了现行宪法构建的国家权力分配模式。改革不可避免会突破现有法律规定,但是改革措施和成果必须依赖法律的巩固与保障。这... 详细信息

国家监察体制改革是政治体制改革的重要组成部分,它整合了原有机关的监督职权,成立了新的监察机关监察委员会,改变了现行宪法构建的国家权力分配模式。改革不可避免会突破现有法律规定,但是改革措施和成果必须依赖法律的巩固与保障。这也就要求对宪法制度中的人民代表大会制度、国家机构架构、公民权利等相关内容做出相应的调整,从而实现依法治国与监察体制改革的有机统一。

关键词：监察宪法制度改革修改宪法

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双船联合举升多体协同作业系统横摇稳性评估

河海大学学报（自然科学版） 2023年第4期51卷 115-122页

作者：李德江邓兴旗赵树杰孟珣中国海洋大学工程学院山东青岛266100 烟台中集来福士海洋工程有限公司山东烟台264035

基于ADAMS平台,构建特定场景双船联合举升多体协同作业系统虚拟样机,对新型一体化拆解作业双船联合举升过程中待拆除组块横摇稳性进行预测与评估。构建了该系统拓扑模型,使用几何参数描述系统中上部组块横摇运动特征;通过虚拟样机仿真... 详细信息

基于ADAMS平台,构建特定场景双船联合举升多体协同作业系统虚拟样机,对新型一体化拆解作业双船联合举升过程中待拆除组块横摇稳性进行预测与评估。构建了该系统拓扑模型,使用几何参数描述系统中上部组块横摇运动特征;通过虚拟样机仿真探究了双船不同耦合运动情况时上部组块最危险失稳状态,并分析了上部组块重心至连接点连线垂直距离与水平距离比值对横摇角度的影响规律。结果表明:物理模型试验数据驱动的虚拟样机技术可以有效评估该系统运动特征,与几何拓扑模型得到的上部组块横摇失稳角度理论公式计算结果吻合;双船同相位横摇与反相位垂荡耦合运动时对上部组块横摇稳性影响最大;待拆除上部组块横摇失稳时的极限纵横比可以作为复杂多体系统横摇稳性评估参数,为实际工程方案选择提供参考。

关键词：双船举升作业多体耦合横摇稳性几何拓扑虚拟样机

Potential mosquito-associated melioidosis and analysis of sample processing results in Hainan, China, 2023

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Asian Pacific Journal of Tropical Medicine 2024年第5期17卷 235-236页

作者： xun Kang Shaowen Cheng Rui Zheng Hengjie Zhu Qianfeng Xia NHC Key Laboratory of Tropical Disease Control School of Tropical MedicineHainan Medical UniversityHainanHaikou 571199China Department of Wound Repair the First Affiliated Hospital of Hainan Medical UniversityHainanHaikou 571199China

Burkholderia(B.)pseudomallei is a Gram-negative bacterium causing melioidosis,a tropical infection that is being recognized as a growing public health problem[1].Melioidosis,with mortality rates ranging from under 10%to 40%,is a significant concern in Southeast Asia,Australia,and beyond[2].The underdiagnosis,particularly in rural areas,emphasizes the need for improved awareness,surveillance,and management,potentially classifying melioidosis as a neglected tropical disease[3].

关键词： tropical Hainan neglected

Eco-evolutionary evidence for the global diversity pattern of Cycas(Cycadaceae)

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Journal of Integrative Plant Biology 2024年第6期66卷 1170-1191页

作者： Jian Liu Anders JLindstrom Yiqing Gong Shanshan Dong Yusheng(Chris)Liu Shouzhou Zhang xun Gong CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Global Biodiversity Conservancy 144/124 Moo3Soi Bua ThongBangsalaeSattahipChonburi 20250Thailand Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen&Chinese Academy of SciencesShenzhen 518004China Department of Earth and Environmental Sciences Indiana University-IndianapolisIndianapolisIN 46202USA

The evolution of the latitudinal diversity gradient(LDG),characterized by a peak in diversity toward the tropics,has captured significant attention in evolutionary biology and ***,the inverse LDG(i-LDG)mechanism,wherein species richness increases toward the poles,remains inadequately *** are among one of the oldest lineages of extant seed plants and have undergone extensive diversification in the ***,the extant cycad abundance exhibits an i-LDG pattern,and the underlying causes for this phenomenon remain largely ***,using 1,843 nuclear genes from a nearly complete sampling,we conducted comprehensive phylogenomic analyses to establish a robust species-level phylogeny for Cycas,the largest genus within *** then reconstructed the spatial-temporal dynamics and integrated global environmental data to evaluate the roles of species ages,diversification rates,contemporary environment,and conservatism to ancestral niches in shaping the i-LDG *** found Cycas experienced decreased diversification rates,coupled with the cooling temperature since its origin in the Eocene from continental *** regions have distinctively contributed to the formation of i-LDG for Cycas,with the northern hemisphere acting as evolutionary museums and the southern hemisphere serving as ***,water-related climate variables,specifically precipitation seasonality and potential evapotranspiration,were identified as paramount factors constraining Cycas species richness in the rainforest biome near the ***,the adherence to ancestral monsoonal climates emerges as a critical factor in sustaining the diversity *** study underscores the imperative of integrating both evolutionary and ecological approaches to comprehensively unravel the mechanisms underpinning global biodiversity patterns.

关键词： cycads latitudinal diversity gradient niche conservatism spatiotemporal diversification species richness

LC-MS法检测大鼠血浆中酒石酸美托洛尔的方法学研究

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军事医学科学院院刊 2009年第6期33卷 543-545页

作者：张帆崔孟珣张振清军事医学科学院毒物药物研究所军事医学科学院药物代谢与药代动力学重点实验室北京100850

目的:建立准确、灵敏、可靠的LC-MS法检测大鼠血浆中酒石酸美托洛尔的浓度。方法:血浆样品用乙酸乙酯液-液萃取,内标选用盐酸普萘洛尔,液相色谱柱为ThermoODS-C18(5.0μm,100mm×2.1mm),流动相为含0.1%甲酸的乙腈:甲醇:水(20:20:60,体积... 详细信息

目的:建立准确、灵敏、可靠的LC-MS法检测大鼠血浆中酒石酸美托洛尔的浓度。方法:血浆样品用乙酸乙酯液-液萃取,内标选用盐酸普萘洛尔,液相色谱柱为ThermoODS-C18(5.0μm,100mm×2.1mm),流动相为含0.1%甲酸的乙腈:甲醇:水(20:20:60,体积比),流速为0.2ml/min;仪器选用Agilent公司1100LC/MSDSL型液相色谱-质谱联用仪,采用电喷雾离子化电离源(ESI),选择性离子监测(SIM)方式进行正离子检测,用于定量分析的离子反应分别为m/z267→268(美托洛尔)和m/z259→260(普萘洛尔)。结果:在本实验条件下,美托洛尔与内标盐酸普萘洛尔分离良好,保留时间分别为1.79和4.01min,0.1～50ng/ml范围内线性关系良好(r2=0.99411),提取回收率均大于80%,日内日间精密度均小于15%(n=5)。结论:该方法快速、准确、灵敏度高,专属性好,可用于酒石酸美托洛尔在大鼠体内药物代谢动力学的研究。

关键词：美托洛尔药代动力学液相质谱法

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肾素血管紧张素系统与支架内再狭窄

中华老年医学杂志 2013年第3期32卷 350-352页

作者：黄猛珣侯勇王联发中国人民解放军第105医院心内二科合肥230031

血管内支架置入术是一种微创、安全、有效的方法，然而，支架内再狭窄成为影响支架介入术广泛开展和临床应用效果的主要原因之一。支架内再狭窄多发生在术后1～3个月，目前尚无有效的方法抑制或治疗支架内再狭窄。金属裸支架术后冠状动... 详细信息

血管内支架置入术是一种微创、安全、有效的方法，然而，支架内再狭窄成为影响支架介入术广泛开展和临床应用效果的主要原因之一。支架内再狭窄多发生在术后1～3个月，目前尚无有效的方法抑制或治疗支架内再狭窄。金属裸支架术后冠状动脉再狭窄发生率较高，

关键词：肾素-血管紧张素系统冠状动脉造影支架内再狭窄