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Dual innervation of spinal ganglion neurons on perineum and bladder

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Chinese Science Bulletin 1998年第2期43卷 137-140页

作者： Guowei Lü zhuo meng Baohong Li Zhigao Jin Capital Univ Med Sci Dept Neurobiol Beijing 100054 Peoples R China Chinese Acad Tradit Chinese Med Inst Acupuncture Beijing 100700 Peoples R China

Experiments were performed on 13 Wister rats. Fastblus (FB) was injected into subcutaneous tissue in perineum area and nuclear yellow (NY) was injected into subserous lamina of the bladder wall, respectively. FB, NY and FB+NY were mostly found in the spinal ganglions of L6, S1 ans S2 segments. The numbers of FB,NY and FB+NY labeled cells were 146, 186 and 81, in a total of 463 labeled cells and their proportion was 40%, 51% and 9%, respectively. The result indicates that the spinal ganglion neurons dually innervate both the somatic and visceral tissues, and the convergence of somato_visceral sensory pathways might occur in the spinal ganglion cells.

关键词： spinal ganglion double fluorescent labeling somatovisceral interaction.

The Modern Approach to "Xungu Leads to(Confucian) Yili"

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Social Sciences in China 2023年第4期44卷 71-87页

作者： meng zhuo Huang Deyuan School of Chinese Language and Literature Beijing Normal University 不详

The proposition that "xungu tong yili"(an exegetical tradition leading to Confucian teachings) expresses the core idea of traditional Chinese philology, which threads throughout the Han and Song dynasties and reached its historical acme in the form of the Qian-Jia school. The overemphasis of scholars from this school on exegesis led to the division between Hanxue(Qing scholarship in the Han dynasty tradition) and Songxue(Qing scholarship in the Song dynasty tradition) and a disconnection between "xungu(Chinese exegetical tradition exegesis) and yili(Confucian teachings)." The modern "linguistized"shift has seen the slow death of the xunguxue tradition(the theory and practice of xungu as a discipline), under which "xungu tong yili." At the same time, modern xunguxue has clarified its own disciplinary orientation and has made great progress in both theory and practice,laying a reliable foundation for the renewed process of working out meanings through *** heights of modern xunguxue allow the scholarly development of the meanings behind the classic texts in five respects: semantic verification, context representation, validation of themes, history of xungu interpretation, and pursuit of imagery. In the cross-disciplinary collision centered on Chinese hermeneutics, the modern approach to the proposition that "xungu tong yili" has shown abundant vitality.

关键词： xungu tong yili modern xunguxue Chinese hermeneutics

Can we be aware of both visceral and somatic sensations via a single neuronal pathway?

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Chinese Science Bulletin 2002年第23期47卷 1940-1945页

作者： Guowei Lü Qingjin Li zhuo meng Xiaohong Liu Capital Univ Med Sci Dept Neurobiol Beijing 100054 Peoples R China

Sensory information arising from somatic and visceral area is thought to be respectively transmitted to the brain by two distinct sensory neuronal systems, the somatic and visceral sensory pathway. A novel and unique spinal sensory system, the spinosolitary tract-dorsal column postsynaptic neuronal system (SST-DCPS), was physiologically and anatomically identified. The spinal neurons project to both visceral (the solitary tract nucleus) and somatic sensory (the dorsal column nuclei) nuclei via their branched axons and receive both visceral and somatic sensory information ascending from periphery through dichotomized primary afferents and descending from their targets via their branched axons. The brain might thus be aware of both visceral and somatic sensation via a single SST-DCPS neuronal channel. The finding of SST-DCPS system, as an example, might be considered as an intersection or fuzzy set of the SST and DCPS system and the concept of dichotomy in classification of neurons and neuronal pathways

关键词： spinosolitary tract-dorsal column postsynaptic system branching/collateral projection dichotomized primary afferent somatovisceral sensory convergence spinal cord somatovisceral interaction referred pain.

Anaerobic treatment of wastewater containing methanol in up-flow anaerobic sludge bed (UASB) reactor

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Frontiers of Environmental Science & Engineering 2008年第2期2卷 241-246页

作者： Yishan LIN Yanling HE zhuo meng Shucheng YANG Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

The direct conversion of methanol into methane is the main process in anaerobic treatment of methanol containing ***,acetic acid can also be produced from methanol theoretically,which may probably result in an abrupt pH drop and deteriorate the anaerobic ***,it is interesting to know what would really happen in an anaerobic reactor treating methanol *** this study,an up-flow anaerobic sludge bed(UASB)reactor treating methanol wastewater was *** chemical oxygen demand(COD),acetic acid and pH of the effluent were monitored at different loadings and influent *** results showed that the anaerobic reactor could be operated steadily at as low as 119 mg/L of influent alkalinity and high organic loading rate with no obvious pH *** fatty acids accumulation was not observed even at strong shock *** microorganisms in the sludge at the end of the test became homogeneous in morphology,which were mainly spherical or spheroidal in shape.

关键词： up-flow anaerobic sludge bed(UASB) methanol anaerobic treatment wastewater

Crystal structures of Bbp from Staphylococcus aureus reveal the ligand binding mechanism with Fibrinogen a

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Protein & Cell 2015年第10期6卷 757-766页

作者： Xinyue Zhang meng Wu Wei zhuo JinkeGu Sensen Zhang Jingpeng Ge Maojun Yang Key Laboratory for Protein Sciences of Ministry of Education Tsinghua-Peking Center for Life Sciences School of Life Sciences Tsinghua University Beijing 100084 China

Bone sialoprotein-binding protein （Bbp）, a MSCRAMMs （Microbial Surface Components Recognizing Adhesive Matrix Molecules） family protein expressed on the surface of Staphylococcus aureus （S. aureus）, mediates adherence to fibrinogen a （Fg a）, a component in the extracellular matrix of the host cell and is important for infection and pathogenesis. In this study, we solved the crystal structures of apo-Bbp273-598 and Bbp273-598-Fg a561-575 complex at a resolution of 2.03 A and 1.45 A, respectively. Apo-Bbp273-598 contained the ligand binding region N2 and N3 domains, both of which followed a DE variant IgG fold characterized by an additional DI strand in N2 domain and D1＇ and D2＇ strands in N3 domain. The peptide mapped to the Fg o561-575 bond to Bbp273-sgs on the open groove between the N2 and N3 domains. Strikingly, the disordered C-terminus in the apo-form reorganized into a highly-ordered loop and a β-strand G＂ covering the ligand upon ligand binding. BbpAla298-Gly301 in the N2 domain of the Bbp273-598-Fg a561-575 complex, which is a loop in the apo-form, formed a short a-helix to interact tightly with the peptide. In addition, Bbpser547-Glns61 in the N3 domain moved toward the binding groove to make contact directly with the peptide, while BbpAsp338-Gly355 and BbpThr365-Tyr387 in N2 domain shifted their configurations to stabilize the reorganized C-terminus mainly through strong hydrogen bonds. Altogether, our results revealed the molecular basis for Bbp-ligand interaction and advanced our understanding of S. aureus infection process.

关键词： bone sialoprotein-binding protein (Bbp),fibrinogen serine-aspartate repeat (Sdr) Microbial SurfaceComponents Recognizing Adhesive Matrix Molecules(MSCRAMM) Staphylococcus aureus

Research progress of slippage characteristic and gas film stability enhancement methods on biomimetic hydrophobic surfaces

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Journal of Hydrodynamics 2024年第1期36卷 87-101页

作者： meng-zhuo Zhang Hai-bao Hu Liu-zhen Ren Lu-yao Bao Jun Wen Luo Xie School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research and Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518063China

The biomimetic hydrophobic surface is a potentially efficient underwater drag reduction method and the drag reduction mechanism of this kind of surface comes from the interfacial *** now,it is a hotspot to grasp the slippage characteristic and explore slippage enhancement *** paper not only summarizes our numerical simulation and experimental results of slippage characteristic at the solid-liquid interface(SLI)of hydrophobic surfaces(HS)and the gas-liquid interface(GLI)of superhydrophobic surfaces(SHS)in recent years,but also introduces some innovative methods that can effectively improve the gas film stability and drag reduction effect of ***,we used the molecular dynamics(MD)simulation method to figure out the effect of the solid-liquid interaction strength,the system temperature and the shear rate on the slippage of SLI,and expound their action mechanism from molecular ***,by MD and multibody dissipative particle dynamics(MDPD)method,the slippage behavior at the GLI was studied under the influence of the microstructure size and the flow driving *** proposed a new kind of hybrid slip boundary condition model to describe the slippage characteristic on *** addition,we found through experiment that a three-dimensional backflow will appear on the GLI under the interfacial adsorption of surfactants,and the backflow direction will reverse with the change of GLI ***,we put forward the wettability step structure and gas injection method to enhance the stability and drag reduction effect of the gas film on SHS.

关键词： Hydrophobic surface superhydrophobic surface interfacial slip underwater drag reduction

Coordinated silencing of the Sp1-mediated long noncoding RNA MEG3 by EZH2 and HDAC3 as a prognostic factor in pancreatic ductal adenocarcinoma

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Cancer Biology & Medicine 2020年第4期17卷 953-969页

作者： Ting Han meng zhuo Cuncun Yuan Xiuying Xiao Jiujie Cui Guangrong Qin Liwei Wang Feng Jiao Department of Oncology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Pathology Fudan University Eye Ear Nose and Throat HospitalShanghai 201114China Shanghai Center for Bioinformation Technology Shanghai 201203China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China

Objective:Pancreatic ductal adenocarcinoma(PDAC)is a disease with high *** so-called"junk"noncoding RNAs need to be discovered in *** purpose of this study was therefore to investigate the function and regulatory mechanism of the long noncoding RNA MEG3 in ***:The Gene Expression Omnibus database(GEO database)was used to determine the differential expression of long noncoding RNAs in PDAC,and MEG3 was selected for subsequent *** and cell samples were used to verify MEG3 expression,followed by functional detection in vitro and in *** were used to characterize long noncoding RNA and mRNA expression *** endogenous RNA analyses were used to detect differential MEG3 and relational miRNA expression in ***,promoter analyses were conducted to explain the downregulation of MEG3 ***:We generated a catalogue of PDAC-associated long noncoding RNAs in the GEO *** ectopic expression of MEG3 inhibited PDAC growth and metastasis in vitro and in vivo,which was statistically significant(P<0.05).Microarray analysis showed that multiple microRNAs interacted with *** also showed that MEG3,as a competing endogenous RNA,directly sponged miR-374a-5p to regulate PTEN *** transcription factor,Sp1,recruited EZH2 and HDAC3 to the promoter and transcriptionally repressed MEG3 ***,clinical data showed that MEG3 and miR-374a-5p expressions were correlated with clinicopathological ***,Sp1,EZH2,HDAC3,and miR-374 a-5p were negatively correlated with MEG3(P<0.05).Conclusions:Reduced MEG3 levels played a crucial role in the PDAC malignant phenotype,which provided insight into novel and effective molecular targets of MEG3 for pancreatic cancer treatment.

关键词： Pancreatic ductal adenocarcinoma MEG3 Sp1 EZH2 HDAC3 miR-374a-5p

Predictive value of positive lymph node ratio in patients with locally advanced gastric remnant cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 833-843页

作者： meng zhuo Lei Tian Ting Han Teng-Fei Liu Xiao-Lin Lin Xiu-Ying Xiao Department of Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Traditional lymph node stage(N stage)has limitations in advanced gastric remnant cancer(GRC)patients;therefore,establishing a new predictive stage is *** To explore the predictive value of positive lymph node ratio(LNR)according to clinicopathological characteristics and prognosis of locally advanced *** Seventy-four patients who underwent radical gastrectomy and lymphadenectomy for locally advanced GRC were retrospectively *** relationship between LNR and clinicopathological characteristics was *** survival analysis was performed using Kaplan-Meier survival curves and Cox regression *** Number of metastatic LNs,tumor diameter,depth of tumor invasion,Borrmann type,serum tumor biomarkers,and tumor-node-metastasis(TNM)stage were correlated with LNR stage and N *** analysis revealed that the factors affecting survival included tumor diameter,anemia,serum tumor biomarkers,vascular or neural invasion,combined resection,LNR stage,N stage,and TNM stage(all P<0.05).The median survival time for those with LNR0,LNR1,LNR2 and LNR3 stage were 61,31,23 and 17 mo,respectively,and the differences were significant(P=0.000).Anemia,tumor biomarkers and LNR stage were independent prognostic factors for survival in multivariable analysis(all P<0.05).CONCLUSION The new LNR stage is uniquely based on number of metastatic LNs,with significant prognostic value for locally advanced GRC,and could better differentiate overall survival,compared with N stage.

关键词： Gastric remnant cancer Positive lymph node ratio Clinicopathological characteristics Prognosis

Assessing the Performance of a Dynamical Downscaling Simulation Driven by a Bias-Corrected CMIP6 Dataset for Asian Climate

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Advances in Atmospheric Sciences 2024年第5期41卷 974-988页

作者： Zhongfeng XU Ying HAN meng-zhuo ZHANG Chi-Yung TAM Zong-Liang YANG Ahmed M.EL KENAWY Congbin FU Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China School of Atmospheric Sciences Nanjing UniversityNanjing 210093China Earth System Science Programme The Chinese University of Hong KongHong KongChina Department of Geological Sciences Jackson School of GeosciencesThe University of Texas at AustinAustinTexasUSA Instituto Pirenaico de Ecología Consejo Superior de Investigaciones Científicas(CSIC)Campus de Aula Dei1005Zaragoza 50059Spain Department of Geography Mansoura UniversityMansoura 35516Egypt

In this study,we aim to assess dynamical downscaling simulations by utilizing a novel bias-corrected global climate model(GCM)data to drive a regional climate model(RCM)over the Asia-western North Pacific *** simulations were conducted with a 25-km grid spacing for the period 1980–*** first simulation(WRF_ERA5)was driven by the European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5)dataset and served as the validation *** original GCM dataset(MPI-ESM1-2-HR model)was used to drive the second simulation(WRF_GCM),while the third simulation(WRF_GCMbc)was driven by the bias-corrected GCM *** bias-corrected GCM data has an ERA5-based mean and interannual variance and long-term trends derived from the ensemble mean of 18 CMIP6 *** demonstrate that the WRF_GCMbc significantly reduced the root-mean-square errors(RMSEs)of the climatological mean of downscaled variables,including temperature,precipitation,snow,wind,relative humidity,and planetary boundary layer height by 50%–90%compared to the WRF_***,the RMSEs of interannual-tointerdecadal variances of downscaled variables were reduced by 30%–60%.Furthermore,the WRF_GCMbc better captured the annual cycle of the monsoon circulation and intraseasonal and day-to-day *** leading empirical orthogonal function(EOF)shows a monopole precipitation mode in the WRF_*** contrast,the WRF_GCMbc successfully reproduced the observed tri-pole mode of summer precipitation over eastern *** improvement could be attributed to a better-simulated location of the western North Pacific subtropical high in the WRF_GCMbc after GCM bias correction.

关键词： bias correction multi-model ensemble mean dynamical downscaling interannual variability day-to-day variability validation