检索结果-南通市图书馆

Chemical constituents and pharmacological effects of Croton crassifolius

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Traditional Medicines 2024年第2期19卷 99-114页

作者： Luyan Yang Yibo Wang Xinyao Wang Xiaoxia Xu Yunpeng Yang meng zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Business Liaoning UniversityShenyang 110136China

Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

关键词： Croton crassifolius chemical compositions pharmacological activities

Single transmembrane GPCR modulating proteins:neither single nor simple

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2024年第6期15卷 395-402页

作者： meng Wang Jianjun Lyu Chao zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co. LtdEast Lake High-Tech Development ZoneWuhan 430205China Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)Tongji UniversityShanghai 200092China

The discovery of G-protein coupled receptor(GPCR)accessory proteins has fundamentally redefined the pharmacological concept of GPCR signaling,demonstrating a more complex molecular basis for receptor specificity on the plasma membrane and impressionable downstream intracellular cascades.GPCR accessory proteins not only contribute to the proper folding and trafficking of receptors but also exhibit selectable receptor preferences.

关键词： specificity GPCR neither

Influence of the Acoustic Liner in Large Eddy Simulation of Longitudinal Thermoacoustic Instability in a Model Annular Combustor

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 710-724页

作者： meng Sheng zhang Man GAO Yi AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Although extensive efforts have been made to dampen the thermoacoustic instability,successfully controlling the pressure oscillations in modern gas turbines or aeroengines remains challenging.The influence of the acoustic liner on the longitudinal thermoacoustic mode in a model annular combustor is investigated by Large Eddy Simulation(LES) in this work.The result of the self-excited longitudinal thermoacoustic instability without the liner agrees well with the frequency and acoustic analysis of the pressure mode based on experimental data.Three different bias flow velocities of the liner located downstream of the combustor are then simulated.The results reveal that the existence of the liner influences not only the acoustic field but also the flow field.When the bias velocity is large,it leads to intense turbulence-induced fluctuations,and the pressure oscillation is modulated intermittently.It shows that the weak coupling between flow and pressure oscillations plays a significant role in the onset of the intermittency of a thermoacoustic system.Based on the dynamic analysis of the thermoacoustic system with the acoustic liner,this intermittency is caused by the influence of the flow field on the flame-acoustic coupling.Finally,a low-order modeling method based on Van der Pol(VdP) oscillator with additive stochastic forcing is conducted to reproduce the evolving dynamics of the thermoacoustic system.Although the numerical cases demonstrated in this work are relatively simpler than those in a practical combustion system,the results are helpful for us to understand the effect of the acoustic liner and show the attractive potential to apply this device to suppress thermoacoustic instability.

关键词： thermoacoustic instability acoustic liner Large Eddy Simulation low-order modeling

Cooperative User-Scheduling and Resource Allocation Optimization for Intelligent Reflecting Surface Enhanced LEO Satellite Communication

在线全文

学校读者我要写书评

暂无评论

China Communications 2024年第2期21卷 227-244页

作者： meng meng Bo Hu Shanzhi Chen Jianyin zhang State Key Lab of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Lab of Wireless Mobile Communication China Academy of Telecommunication TechnologyBeijing 100191China Research Institute of China Mobile Beijing 100053China

Lower Earth Orbit(LEO) satellite becomes an important part of complementing terrestrial communication due to its lower orbital altitude and smaller propagation delay than Geostationary satellite. However, the LEO satellite communication system cannot meet the requirements of users when the satellite-terrestrial link is blocked by obstacles. To solve this problem, we introduce Intelligent reflect surface(IRS) for improving the achievable rate of terrestrial users in LEO satellite communication. We investigated joint IRS scheduling, user scheduling, power and bandwidth allocation(JIRPB) optimization algorithm for improving LEO satellite system throughput.The optimization problem of joint user scheduling and resource allocation is formulated as a non-convex optimization problem. To cope with this problem, the nonconvex optimization problem is divided into resource allocation optimization sub-problem and scheduling optimization sub-problem firstly. Second, we optimize the resource allocation sub-problem via alternating direction multiplier method(ADMM) and scheduling sub-problem via Lagrangian dual method repeatedly.Third, we prove that the proposed resource allocation algorithm based ADMM approaches sublinear convergence theoretically. Finally, we demonstrate that the proposed JIRPB optimization algorithm improves the LEO satellite communication system throughput.

关键词： convex optimization intelligent reflecting surface LEO satellite communication OFDM

Incidence Coloring of Outer-1-planar Graphs

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 840-848页

作者： meng-ke QI Xin zhang School of Mathematics and Statistics Xidian UniversityXi'an 710071China

A graph is outer-1-planar if it can be drawn in the plane so that all vertices lie on the outer-face and each edge crosses at most one another edge.It is known that every outer-1-planar graph is a planar partial3-tree.In this paper,we conjecture that every planar graph G has a proper incidence(Δ(G)+2)-coloring and confirm it for outer-1-planar graphs with maximum degree at least 8 or with girth at least 4.Specifically,we prove that every outer-1-planar graph G has an incidence(Δ(G)+3,2)-coloring,and every outer-1-planar graph G with maximum degree at least 8 or with girth at least 4 has an incidence(Δ(G)+2,2)-coloring.

关键词： incidence coloring outer--planar graph planar graph

Kinesin 26B modulates M2 polarization of macrophage by activating cancer-associated fibroblasts to aggravate gastric cancer occurrence and metastasis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第20期30卷 2689-2708页

作者： Lian-meng Huang Ming-Jin zhang Department of General Surgery The 901st Hospital of PLAHefei 230031Anhui ProvinceChina

BACKGROUND The regulatory effects of KIF26B on gastric cancer(GC)have been confirmed,but the specific mechanism still needs further exploration.Pan-cancer analysis shows that the KIF26B expression is highly related to immune infiltration of cancerassociated fibroblasts(CAFs),and CAFs promote macrophage M2 polarization and affect cancers’progression.AIM To investigate the regulatory functions of KIF26B on immune and metastasis of GC.METHODS We analyzed genes’mRNA levels by quantitative real-time polymerase chain reaction.Expression levels of target proteins were detected by immunohistochemistry,ELISA,and Western blotting.We injected AGS cells into nude mice for the establishment of a xenograft tumor model and observed the occurrence and metastasis of GC.The degree of inflammatory infiltration in pulmonary nodes was observed through hematoxylin-eosin staining.Transwell and wound healing assays were performed for the evaluation of cell invasion and migration ability.Tube formation assay was used for detecting angiogenesis.M2-polarized macrophages were estimated by immunofluorescence and flow cytometry.RESULTS KIF26B was significantly overexpressed in cells and tissues of GC,and the higher expression of KIF26B was related to GC metastasis and prognosis.According to in vivo experiments,KIF26B promoted tumor formation and metastasis of GC.KIF26B expression was positively associated with CAFs’degree of infiltration.Moreover,CAFs could regulate M2-type polarization of macrophages,affecting GC cells’migration,angiogenesis,invasion,and epithelial-mesenchymal transition process.CONCLUSION KIF26B regulated M2 polarization of macrophage through activating CAFs,regulating the occurrence and metastasis of GC.

关键词： metastasis invasion macrophage

Segment-wise learning control for trajectory tracking of robot manipulators under iteration-dependent periods

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第3期67卷 155-166页

作者： Fan zhang Deyuan meng Kaiquan CAI The Seventh Research Division Beihang University School of Automation Science and Electrical Engineering Beihang University School of Electronics and Information Engineering Beihang University

This paper is concerned with the amplitude boundedness problem of adaptive iterative learning control(AILC) for robot manipulators operating with iteration-dependent periods. By introducing virtual memory slots for storing historical data, a practical AILC method is proposed to achieve the segmentwise learning. This method requires less memory storage for historical information of previous iterations,especially in comparison with that of the conventional AILC methods using point-wise learning strategies.It is shown that not only the energy boundedness but also the amplitude boundedness of estimates and inputs of practical AILC can be guaranteed. Moreover, the practical AILC method can achieve the perfect tracking objective regardless of iteration-dependent periods when the robot manipulators have a persistent full learning property. In addition, a solution to the visual manipulator platform is provided and deployed based on Coppeliasim and Matlab, which helps to show the amplitude boundedness of learning results and the perfect tracking performances of the proposed practical AILC method for robot manipulators.

关键词： amplitude boundedness iteration-dependent period iterative learning control robot manipulator segment-wise virtual memory slot

The roles of macrophage migration inhibitory factor in retinal diseases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 309-315页

作者： Hongbing zhang Xianjiao zhang Hongsong Li Bing Wang Pei Chen Jiamin meng Shaanxi Institute of Ophthalmology Xi’anShaanxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Department of Pathology First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina

Macrophage migration inhibitory factor(MIF),a multifunctional cytokine,is secreted by various cells and participates in inflammatory reactions,including innate and adaptive immunity.There are some evidences that MIF is involved in many vitreoretinal diseases.For example,MIF can exacerbate many types of uveitis;measurements of MIF levels can be used to monitor the effectiveness of uveitis treatment.MIF also alleviates trauma-induced and glaucoma-induced optic nerve damage.Furthermore,MIF is critical for retinal/choroidal neovascularization,especially complex neovascularization.MIF exacerbates retinal degeneration;thus,anti-MIF therapy may help to mitigate retinal degeneration.MIF protects uveal melanoma from attacks by natural killer cells.The mechanism underlying the effects of MIF in these diseases has been demonstrated:it binds to cluster of differentiation 74,inhibits the c-Jun N-terminal kinase pathway,and triggers mitogen-activated protein kinases,extracellular signal-regulated kinase-1/2,and the phosphoinositide-3-kinase/Akt pathway.MIF also upregulates Toll-like receptor 4 and activates the nuclear factor kappa-B signaling pathway.This review focuses on the structure and function of MIF and its receptors,including the effects of MIF on uveal inflammation,retinal degeneration,optic neuropathy,retinal/choroidal neovascularization,and uveal melanoma.

关键词： diabetic retinopathy glaucoma macrophage migration inhibitory factor migration inhibitory factor receptor optic neuropathy retinal degeneration retinal neovascular uveal melanoma uveitis

Churning loss characteristics of a wet three-phase high-speed reluctance motor

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 251-267页

作者： Zhenzhou zhang Mingzhu DAI Chenchen zhang Yi CHEN Bin meng College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China

With the increasing requirements of electro-hydrostatic actuators(EHAs)for power,volume,and pressure,there is a growing tendency in the industry to combine the motor and pump to form a so-called'motor pump'to improve the integration.In this paper,a novel structure for a wet three-phase high-speed reluctance motor pump is proposed,which can further improve integration by removing the dynamic seal on the pump shaft,thereby avoiding the problems of dynamic seal wear and oil leakage and improving heat dissipation under high-speed working conditions.However,after the motor is wetted,the churning loss caused by immersion of the rotor in the oil causes additional fluid resistance torque.Based on fundamental fluid mechanics,an analytical model of the churning torque of a wet motor was established.To verify the accuracy of the analytical model,a simulation model of churning loss was established based on computational fluid dynamics(CFD),and the churning torque and flow field state were analyzed.Finally,an experimental prototype was designed and manufactured,and a test bench for churning loss was built.The oil churning torque was measured at different speeds and temperatures.The results from the analytical,simulation,and experimental models agreed well.The experimental results validated the analytical model and CFD simulation.This research provides a practical method for calculating the churning loss and serves as guidance for future optimization of churning loss reduction.

关键词： Motor pump Wet motor Churning loss Analytical model Computational fluid dynamics(CFD)