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Long-term Consumption of Highland Barley Tea Promotes Healthy Aging of Skeletal Muscle

Food Science and Human Wellness 2024年

作者： Li yan Chenzhipeng nie Qingwei Zheng Mingcong Fan Waleed AL-Ansi Haifeng Qian Li Wang State Key Laboratory of Food Science and Technology， School of Food Science and Technology， Jiangnan University

Highland barley tea (HBT) is made from roasted barley seeds and is abundant in β-glucan， amino acids， minerals， phenolics， and other natural active ingredients. These natural compounds found in whole grains have been shown to slow aging and positively affect skeletal muscle function. As a result， studying the effects of HBT on the skeletal muscle health of the elderly population is critical from a scientific and societal standpoint for improving their health status and reducing the medical burden on society. The antioxidant activity and the content of natural active substances were used as indicators to screen the optimal process of HBT brewing. The effects of long-term HBT consumption on aging in mice were investigated by using HBT as a substitute for drinking water in naturally aging mice for a 5-month intervention. Afterward， various factors were measured， such as basic physiological indices， inflammation， plasma metabolites， skeletal muscle function， and exercise capacity， to evaluate the effects of HBT on aging in mice. Long-term consumption of HBT reduced body and spleen weight， increased body weight percentage of skeletal muscle， and reduced plasma inflammation levels in aging mice. Metabolomic results showed increased plasma levels of the mitochondrial marker short-chain acylcarnitine and some amino acids. Additionally， there was a decrease in bile and long-chain acylcarnitine. The level of fibrosis in the gastrocnemius muscle of aging mice was suppressed， and the percentage of type I muscle fibers was increased， improving the endurance of the mice. Thus， long-term consumption of HBT may reduce body weight and increase skeletal muscle mitochondrial activity and exercise capacity in aging mice by reducing inflammation levels and alleviating mitochondrial damage.

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DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

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Cancer Biology & Medicine 2024年第3期21卷 252-266页

作者： Junya yan Shibo Wang Jing Zhang Qiangqiang Yuan Xianchun Gao Nannan Zhang yan Pan Haohao Zhang Kun Liu Jun Yu Linbin Lu Hui Liu Xiaoliang Gao Sheng Zhao Wenyao Zhang Abudurousuli Reyila Yu Qi Qiujin Zhang Shundong Cang Yuanyuan Lu yanglin Pan yan Kong Yongzhan nie State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Air Force Military Medical UniversityXi'an 710032China Department of Oncology Henan Provincial People's HospitalZhengzhou University People's HospitalZhengzhou 450o03China Faculty of Life Science Northwest UniversityXi'an 710069China Unit 73211 of the People's Liberation Army Nanjing 211800China Key Laboratory of Resource Biology and Biotechnology in Western China(Ministry of Education) School of MedicineNorthwest UniversityXi'an 710069China Shaanxi University of Chinese Medicine Second Clinical Medicine FacultyXi'an 712046China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Renal Cancer and MelanomaPeking University Cancer Hospital and InstituteBeijing 100142China

Objective: DNA damage response(DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation(DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor(ICI) therapy in gastrointestinal(GI) ***: A DRIA signature was established based on two previously reported DNA damage immune response assays. Clinical and gene expression data from two published GI cancer cohorts were used to assess and validate the association between the DRIA score and response to ICI therapy. The predictive accuracy of the DRIA score was validated based on one ICI-treated melanoma and three pan-cancer published ***: The DRIA signature includes three genes(CXCL10, IDO1, and IFI44L). In the discovery cancer cohort, DRIA-high patients with gastric cancer achieved a higher response rate to ICI therapy than DRIA-low patients(81.8% vs. 8.8%;P < 0.001), and the predictive accuracy of the DRIA score [area under the receiver operating characteristic curve(AUC) = 0.845] was superior to the predictive accuracy of PD-L1 expression, tumor mutational burden, microsatellite instability, and Epstein–Barr virus status. The validation cohort demonstrated that the DRIA score identified responders with microsatellite-stable colorectal and pancreatic adenocarcinoma who received dual PD-1 and CTLA-4 blockade with radiation therapy. Furthermore, the predictive performance of the DRIA score was shown to be robust through an extended validation in melanoma, urothelial cancer, and ***: The DRIA signature has superior and robust predictive accuracy for the efficacy of ICI therapy in GI cancer and pancancer, indicating that the DRIA signature may serve as a powerful biomarker for guiding ICI therapy decisions.

关键词： DNA damage response-related immune activation immune checkpoint inhibitors biomarker gastrointestinal cancer pan-cancer

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Study on Antitumor Activity of Piperidine Derivatives

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Agricultural Biotechnology 2024年第3期13卷 81-85,89页

作者： Zhenwei nie Hongxia LI Weizhen LI Hangyu meng Wei XU School of Biological and Food Engineering Suzhou UniversitySuzhou 234000China

[Objectives]This study was conducted to investigate the effects of piperidine derivatives on the proliferation and apoptosis of tumor cells(Hele).[Methods]The target end product(piperidine derivative)was synthesized through a series of organic *** MTT assay was adopted to detect the effect of piperidine derivative on the proliferation activity of Hele *** ROS fluorescence probe method was used to detect the changes of reactive oxygen *** JC-1 method was applied to detect the changes of MMP in Hele *** cytometry was adopted to detect the apoptosis of Hele cells.[Results]The cell survival rates were 70.84%,65.46%and 54.48%when the drug concentration was 100,110 and 120μmol/L,*** the drug concentration increased to 120μmol/L,the cell survival rate decreased by nearly *** fluorescence intensity of active oxygen in the control group was 1,and when the drug concentrations were 100,110 and 120μmol/L,the fluorescence intensity of active oxygen was,respectively,1.315,1.478 and 1.677,which were higher than that in the control *** red/green fluorescence intensity of the MMP control group was 1.819,and that of drug groups was,respectively,1.643,1.164 and 0.665,which were lower than that of the control *** apoptosis rates were 10.79%,22.91%and 38.54%at the drug concentrations of 100,110 and 120μmol/L,respectively,showing a concentration dependent *** results showed that the piperidine derivative could inhibit the proliferation of Hele cells and induce apoptosis,which was positively correlated with the concentration.[Conclusions]This study provides theoretical basis and reference for the anti-tumor research of piperidine.

关键词： Piperidine derivative Hele cell Anti-cancer activity

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Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

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World Journal of Gastroenterology 2024年第13期30卷 1911-1925页

作者： Fei-Lin Ge yan yang Lan-Lan Si Yuan-Hua Li meng-Zhen Cao Jun Wang Zhao-Fang Bai Zhi-Gang Ren Xiao-He Xiao yan Liu Department of Chinese Medicine State Key Laboratory of Antiviral DrugsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina The Fifth Medical Center of Chinese PLA General Hospital Beijing 100039China College of Traditional Chinese Medicine Chongqing Medical UniversityChongqing 400010China Beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China Department of Infectious Diseases State Key Laboratory of Antiviral Drugsthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Liuweiwuling Tablet(LWWL)is a Chinese patent medicine approved for the treatment of chronic inflammation caused by hepatitis B virus(HBV)*** studies have indicated an anti-HBV effect of LWWL,specifically in terms of antigen inhibition,but the underlying mechanism remains *** To investigate the potential mechanism of action of LWWL against *** In vitro experiments utilized three HBV-replicating and three non-HBV-replicating cell *** in vivo experiment involved a hydrodynamic injectionmediated mouse model with HBV *** and metabolomics were used to investigate the underlying mechanisms of action of *** In HepG2.1403F cells,LWWL(0.8 mg/mL)exhibited inhibitory effects on HBV DNA,hepatitis B surface antigen and pregenomic RNA(pgRNA)at rates of 51.36%,24.74%and 50.74%,*** inhibition rates of LWWL(0.8mg/mL)on pgRNA/covalently closed circular DNA in HepG2.1403F,HepG2.2.15 and HepG2.A64 cells were 47.78%,39.51%and 46.74%,*** of transcriptomics and metabolomics showed that the anti-HBV effect of LWWL was primarily linked to pathways related to apoptosis(PI3K-AKT,CASP8-CASP3 and P53 pathways).Apoptosis flow analysis revealed that the apoptosis rate in the LWWL-treated group was significantly higher than in the control group(CG)among HBV-replicating cell lines,including HepG2.2.15(2.92%±1.01%vs 6.68%±2.04%,P0.05),L02 cells(5.49%±0.80%vs 5.48%±1.01%,P>0.05)and LX2 cells(6.29%±1.54%vs 6.29%±0.88%,P>0.05).TUNEL staining revealed a significantly higher apoptosis rate in the LWWL-treated group than in the CG in the HBVreplicating mouse model,while no noticeable difference in apoptosis rates between the two groups

关键词： Hepatitis B virus Chinese patent medicine Antiviral activity Antiviral mechanism Selective apoptosis

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Thermally cross-linkable hole-transport materials enable solution-processed blue OLED with LT95 over 150 h

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Science China Materials 2024年第9期67卷 2767-2777页

作者： Xinkang Zhang Hao yan Xiaopeng Zhang Hong meng School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen518055China

The solution-processed method for organic light-emitting diodes(OLEDs)offers the benefits of cost-effectiveness and enhanced material *** the multilayer architecture of solution-processed OLEDs(SOLEDs),the role of hole-transport materials(HTMs)is pivotal for cascade hole ***,commercial HTMs such as poly-(9,9-dioctylfluorene-alt-N-(4-sec-butylphenyl)-diphenylamine)(TFB)are hampered by incompatible energy levels and redissolution with overlayer solvent,prompting the exploration of cross-linkable HTMs(X-HTMs)for better *** this study,we have developed two novel small-molecule X-HTMs,N^(1),N^(1)′-((perfluoropropane-2,2-diyl)bis(4,1-phenylene))bis(N^(4),N^(4)-diphenyl-N^(1)-(4-vinylphenyl)benzene-1,4-diamine)(FTPA-V)and N,N′-((perfluoropropane-2,2-diyl)bis-(4,1-phenylene))bis(9-phenyl-N-(4-vinylphenyl)-9H-carbazol-3-amine)(FPCz-V),which incorporate thermally cross-linkable vinyl groups and electron-rich trifluoromethyl *** X-HTMs enhance interfacial contact through superior film formation and solvent resistance,along with optimal energy *** application of X-HTMs significantly enhances the efficiencies and longevities of blue,green,and red ***,blue SOLED incorporating FPCz-V exhibits unprecedented lifetime(LT95)extending to over 150 h,setting a new record for blue *** electrochemistry stability,high bond dissociation energy,and triplet energy levels of X-HTMs can effectively minimize exciton annihilation and prolong the *** findings underscore the potential of X-HTM optimization to propel the development of stable solution-processed luminescent technologies.

关键词： solution-processed OLED cross-linkable HTMs solvent resistance bond dissociation energy exciton-polaron annihilation

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A review:the mechanism of plant-derived polysaccharides on osteoblasts and osteoclasts

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未来食品学报(英文) 2024年第3期4卷 183-192页

作者： mengjie Ren Adel F.Ahmed meng Li menghan Li Zhiruo yan Jinmei Wang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China Medicinal and Aromatic Plants Researches Department Horticulture Research InstituteAgricultural Research CenterGiza 12511Egypt

Bone loss and deterioration of bone microarchitecture would increase the bone fragility and fracture risk,leading to the *** and more evidences proved that plant-derived polysaccharides could have a remarkable influence on osteoblasts and osteoclasts,exerting anti-osteoporosis *** to the previous research,the extract of Cibotium barumoz,Achyranthes bidentata,Curculigo orchioides,Epimedium brevicornum,Angelica sinensis,Polygonatum sibiricum,Dendrobium officinale,Morinda officinalis,Nelumbo mucifera,Diospyros kaki,Hordeum vulgare,Cistanche deserticola,Commiphora Myrrha and other plant-derived polysaccharides could benefit to the osteoblasts and *** essential mechanisms are mainly related to the activation or inhibition of many factors,including runt-related transcription factor 2(Runx2),B-catenin,osterix(Osx),activator protein-1(AP-1),osteocalcin(OCN/BGP),alkaline phosphatase(ALP),osteopontin(OPN),bone morphogenetic protein(BMP),phosphatidylinositol 3-kinase(PI3K)/C-Jun N-terminal kinase(JNK)/extracellular regulated protein kinase(ERK),osteoprotegerin(OPG),receptor activator of nuclear factor-kB(RANK),monocyte/macrophage colony-stimulating factor(M-CSF),tumor necrosis factor receptor-associated factor 6(TRAF-6),receptor activator of nuclear factor(NF)-KB ligand(RANKL),nuclear factor of activated T cells 1(NFATc1),c-Fos,matrix metallopeptidase-9(MMP-9),glycogen synthase kinase 3β(GSK3B)/B-catenin,nuclear factor E2-related factor 2(Nf2),as well as these related pathways,such as Wnt/p-catenin,BMP-2/SMAD1/5/8,PI3K/AKT,OPG/RANKL/RANK,NF-κB,MAPKs,*** plant-derived polysaccharides could improve the dynamic balance of bone formation and resorption through promoting the differentiation and maturation of osteoblast or inhibiting its *** reviewed plant-derived polysaccharides and their regulating mechanisms on the osteoclasts and osteoblasts provide the evidences for the development of osteoporosis therapeutics.

关键词： Osteoporosis Plant-derived polysaccharides Osteogenesis promotion Osteoclasts inhibition

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Human Expansion-Induced Biodiversity Crisis over Asia from 2000 to 2020

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Research 2024年第2期2023卷 647-658页

作者： Chao yang Qingquan Li Xuqing Wang Aihong Cui Junyi Chen Huizeng Liu Wei Ma Xuanyan Dong Tiezhu Shi Fanyi meng Xiaohu yan Kai Ding Guofeng Wu MNR Key Laboratory for Geo-Environmental Monitoring of Great Bay Area&Guangdong Key Laboratory of Urban Informatics&Shenzhen Key Laboratory of Spatial Smart Sensing and Services Shenzhen UniversityShenzhen 518060China School of Architecture and Urban Planning Shenzhen UniversityShenzhen 518060China College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen 518107China Center for Hydrogeology and Environmental Geology China Geological SurveyBaoding 071051China Department of Geography Hong Kong Baptist UniversityHong Kong Special Administrative Region 999077China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China institute for Advanced Study and Tiandu-Shenzhen University Deep Space Joint Laboratory Shenzhen UniversityShenzhen 518060China School of Civil Engineering Chongqing Jjiaotong UniversityChongging 400074China Department of Cil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan School of Artificial Intelligence Shenzhen PolytechnicShenzhen 518055China School of Computer Science and Technology Dongguan University of TechnologyDongguan 523419China

Asia stands out as a priority for urgent biodiversity conservation due to its large protected areas(PAs)and threatened *** the 21st century,both the highlands and lowlands of Asia have been experiencing the dramatic human ***,the threat degree of human expansion to biodiversity is poorly ***,the threat degree of human expansion to biodiversity over 2000 to 2020 in Asia at the continental(Asia),national(48 Asian countries),and hotspot(6,502 Asian terrestrial PAs established before 2000)scales is investigated by integrating multiple large-scale *** results show that human expansion poses widespread threat to biodiversity in Asia,especially in Southeast Asia,with Malaysia,Cambodia,and Vietnam having the largest threat degrees(~1.5 to 1.7 times of the Asian average level).Human expansion in highlands induces higher threats to biodiversity than that in lowlands in one-third Asian countries(most Southeast Asian countries).The regions with threats to biodiversity are present in~75%terrestrial PAs(including 4,866 PAs in 26 countries),and human expansion in PAs triggers higher threat degrees to biodiversity than that in *** findings provide novel insight for the Sustainable Development Goal 15(SDG-15 Life on Land)and suggest that human expansion in Southeast Asian countries and PAs might hinder the realization of *** reduce the threat degree,Asian developing countries should accelerate economic transformation,and the developed countries in the world should reduce the demands for commodity trade in Southeast Asian countries(i.e.,trade leading to the loss of wildlife habitats)to alleviate human expansion,especially in PAs and highlands.

关键词： Human terrestrial integrating

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Phase modulation of nickel-tin alloys in regulating electrocatalytic nitrogen reduction properties

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Rare Metals 2024年第6期43卷 2851-2858页

作者： Lin Wang Hang-Ning Liu Xin meng Chang-Hui Sun Hai-Dong Liu Liang-Yu Gong Zhen-Hua yan Jie Wang College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China Department of Chemistry-Angstrom Laboratory Uppsala University75121UppsalaSweden Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Electrocatalytic nitrogen reduction reaction(NRR)is one of the attractive methods for ammonia(NH_(3))production at ambient conditions,but the catalytic performance largely depends on the physical properties of the ***,Ni-Sn alloy nanoparticles with well-controlled physical properties have been synthesized via a simple two-step method,which are applied as efficient electrocatalysts for the NRR.

关键词： alloys alloy nickel

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Molar ratio induced crystal transformation from coordination complex to coordination polymers

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Chinese Chemical Letters 2024年第4期35卷 539-543页

作者： Peng meng Qian-Cheng Luo Aidan Brock Xiaodong Wang Mahboobeh Shahbazi Aaron Micallef John McMurtrie Dongchen Qi yan-Zhen Zheng Jingsan Xu School of Chemistry and Physics&Centre for Materials Science Queensland University of TechnologyBrisbaneQLD 4000Australia Frontier Institute of Science and Technology Xi'an Jiaotong UniversityXi'an 710054China Central Analytical Research Facility Institute for Future EnvironmentsQueensland University of TechnologyBrisbaneQLD 4000Australia

Coordination complex of a copper cyanurate(Cu(Ⅱ)-CA) was transformed into coordination polymers upon the stimulus of extra Cu(Ⅱ) through “directed Ostwald ripening”. By increasing the molar ratio of Cu(Ⅱ) to CA, we obtained two coordination polymers with selective coordination sites: Cu(Ⅱ)-κ N(HCA)κ NCu(Ⅱ) and Cu(Ⅱ)-κ N(HCA)κ O-Cu(Ⅱ), which display disparate magnetic interactions.

关键词： Molar ratio dependent crystal transformation Copper cyanurate Ostwald ripening Molecular magnetism One-dimensional chain

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Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

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Zoological Research 2024年第4期45卷 805-820页

作者： Wei yan Zi-Jie Li Zi-Yi Lin Shu-Qin Ji William Ka Fai Tse Zhi-Qiang meng Chang Liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

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