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芽胞杆菌及其代谢物抑制包膜病毒感染的研究进展

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微生物学杂志 2024年第2期44卷 97-108页

作者：姚俞洁孟广勋韩颖颖李娟上海理工大学健康科学与工程学院上海200093 中国科学院上海巴斯德研究所微生物、发育与健康研究中心中国科学院分子病毒与免疫重点实验室中国科学院大学上海200031 中科南京生命健康高等研究院江苏南京211135

包膜病毒指具有一层脂质双层膜的病毒,如流感病毒、冠状病毒等,这些包膜病毒每年在世界范围内导致许多严重的疾病,严重威胁人类健康。使用抗病毒药物是预防与治疗病毒感染的主要策略,芽胞杆菌(Bacillus)及其代谢物能够抑制多种包膜病毒... 详细信息

包膜病毒指具有一层脂质双层膜的病毒,如流感病毒、冠状病毒等,这些包膜病毒每年在世界范围内导致许多严重的疾病,严重威胁人类健康。使用抗病毒药物是预防与治疗病毒感染的主要策略,芽胞杆菌(Bacillus)及其代谢物能够抑制多种包膜病毒的感染。本文综述了芽胞杆菌代谢的粗提物、肽、酶、胞外聚合物、小双链RNA和热灭活的枯草芽胞杆菌孢子在抗包膜病毒感染中发挥的重要作用,其机制是通过直接破坏病毒包膜、阻止膜融合、与病毒基因组RNA直接配对、催化裂解病毒RNA、激活天然免疫反应等对抗病毒,期望为包膜病毒的持续预防和治疗提供参考。

关键词：包膜病毒芽胞杆菌代谢产物病毒感染抗病毒机制

Nonlinear semi-analytical modeling of liquid sloshing in rectangular container with horizontal baffles

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1973-2004页

作者： xun meng Ying SUN Jiadong WANG Ruili HUO Ding ZHOU College of Civil Engineering Nanjing Tech UniversityNanjing 211816China School of Transportation and Civil Engineering Nantong UniversityNantong 226019Jiangsu ProvinceChina Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina

A nonlinear semi-analytical scheme is proposed for investigating the finiteamplitude nonlinear sloshing in a horizontally baffled rectangular liquid container under the seismic *** sub-domain method is developed to analytically derive the modal behaviors of the baffled linear *** viscosity dissipation effects from the interior liquid and boundary layers are *** the introduction of the generalized time-dependent coordinates,the surface wave elevation and velocity potential are represented by a series of linear modal *** infinite-dimensional modal system of the nonlinear sloshing is formulated based on the Bateman-Luke variational principle,which is further reduced to the finite-dimensional modal system by using the NarimanovMoiseev asymptotic *** base force and overturning moment induced by the nonlinear sloshing are derived as the functions of the generalized time-dependent *** present results match well with the available analytical,numerical,and experimental *** paper examines the surface wave elevation,base force,and overturning moment versus the baffle parameters and excitation amplitude in detail.

关键词： rectangular container nonlinear sloshing baffe sub-domain multi-modal method

Analytical Modeling of Fluid Sloshing in A 2D Rectangular Container with A Bottom-Mounted T-Shaped Baffle

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China Ocean Engineering 2022年第2期36卷 299-310页

作者： meng xun MA Xiao-zhong ZHANG You-ming FANG Hai ZHOU Ding College of Civil Engineering Nanjing Tech UniversityNanjing 211816China Flood Control and Drought Relief Rescue Center of Jiangsu Province Nanjing 211500China

An analytical procedure is presented to evaluate the fluid sloshing characteristics in a two-dimensional(2D)rectangular container with a bottom-mounted T-shaped *** fluid region is divided into several sub-domains with hypothetical interfaces and the velocities and pressures of the fluid on adjacent interfaces should be *** separation of variables in conjunction with the superposition principle is employed to formulate the velocity potential of each *** Fourier series expansion is used to derive the eigenvalue equation by substituting the velocity potential solutions into the free surface conditions and the continuity conditions on adjacent *** the horizontal base excitation,the total velocity potential of fluid is decomposed of the impulsive and perturbed velocity *** orthogonality of the sloshing modes is demonstrated by implementing Gauss *** dynamic response equation is established by incorporating the total velocity potential solution into the surface wave *** agreements are achieved between the present results and those from the reported literature and finite element *** results are exhibited to reveal the effect of the baffle parameters and excitation frequency on sloshing characteristics and responses of liquid.

关键词： rectangular container T-shaped baffle sub-domain sloshing characteristics dynamic response

疫苗国家监管体系临床试验监管相关板块的评估与思考

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中国食品药品监管 2024年第3期 42-47页

作者：杜娟高天睿崔孟珣蓝恭涛湖南省药品审评与不良反应监测中心国家药品监督管理局食品药品审核查验中心国家药品监督管理局

2022年8月23日,世界卫生组织(WHO)宣布我国通过疫苗国家监管体系(NRA)评估,此次疫苗NRA评估指标大幅增加、内容更加全面、标准更加严格。本文介绍了WHO全球基准评估工具临床试验监管相关板块的要求,探讨了近年来临床试验监管的发展变化... 详细信息

2022年8月23日,世界卫生组织(WHO)宣布我国通过疫苗国家监管体系(NRA)评估,此次疫苗NRA评估指标大幅增加、内容更加全面、标准更加严格。本文介绍了WHO全球基准评估工具临床试验监管相关板块的要求,探讨了近年来临床试验监管的发展变化,以期为相关单位提升临床试验质量和完善临床试验监管提供参考。

关键词：疫苗国家监管体系临床试验监管质量管理体系

Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cells

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Virologica Sinica 2022年第3期37卷 380-389页

作者： Hang Yang Huijun Yuan Xiaohui Zhao meng xun Shangrui Guo Nan Wang Bing Liu Hongliang Wang Department of Pathogen Biology and Immunology School of Basic Medical SciencesXi'an Jiaotong University Health Science CenterXi'an710061China School of Pharmacy Xi’an Jiaotong University Health Science CenterXi'an710061China BioBank The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondonSW72AZUnited Kingdom Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong UniversityXi'an710061China

The recent COVID-19 pandemic poses a global health *** entry of the causative agent SARS-CoV-2 is mediated by its spike protein interacting with cellular receptor-human angiotensin converting enzyme 2(ACE2).Here,by using lentivirus based pseudotypes bearing spike protein,we demonstrated that entry of SARS-CoV-2 into host cells was dependent on clathrin-mediated endocytosis,and phosphoinositides played essential roles during this *** addition,we showed that the intracellular domain and the catalytic activity of ACE2 were not required for efficient virus ***,we showed that the current predominant Delta variant,although with high infectivity and high syncytium formation,also entered cells through clathrin-mediated *** results provide new insights into SARS-CoV-2 cellular entry and present proof of principle that targeting viral entry could be an effective way to treat different variant infections.

关键词： SARS-CoV-2 Endocytosis Phosphoinositides Angiotensin converting enzyme 2(ACE2) Syncytium

Phase-field lattice-Boltzmann study on fully coupled thermal-solute-convection dendrite growth of Al-Cu alloy

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China Foundry 2024年第2期21卷 125-136页

作者： Yin-qi Qiu meng-wu Wu xun-peng Qin Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Dendrite growth is a complex liquid-solid phase transition process involving multiple physical factors.A phase-field lattice-Boltzmann method was developed to simulate the two-and three-dimension dendrite growth of Al-Cu *** effect of fully coupled thermal-solute-convection interaction on the dendrite growth was investigated by incorporating a parallel-adaptive mesh refinement algorithm into the numerical *** accurately reproducing the latent heat release,solute diffusion and convective transport behaviors at the liquidsolid interface,the interaction mechanism among thermal-solute-convection transport as well as their coupling effects on the dendrite growth dynamics were *** simulation results show that the release of latent heat slows down the dendrite growth rate,and both natural and forced convection disrupt the symmetrical growth of *** combination makes the growth of dendrites more complex,capturing important physical aspects such as recalescence,dendrite tip splitting,dendrite tilting,dendrite remelting,and solute plume in the simulation *** on the robustness and powerful ability of the numerical model,the formation mechanisms of these physical aspects were revealed.

关键词： simulation phase field dendrite growth thermal-solute-convection interaction

Construction of coxsackievirus B5 viruses with luciferase reporters and their applications in vitro and in vivo

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Virologica Sinica 2023年第4期38卷 549-558页

作者： Shangrui Guo meng xun Tingting Fan Xinyu Li Haoyan Yao Xiaozhen Li Bo Wu Hang Yang Chaofeng Ma Hongliang Wang Department of Pathogen Biology and Immunology Xi’an Jiaotong University Health Science CenterXi’an710061China Department of Gynecology and Obstetrics The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an710061China Department of Viral Diseases Laboratory Xi’an Center for Disease Control and PreventionXi’an710061China

Coxsackievirus belongs to the Picornaviridae family and is one of the major pathogens that cause hand,foot and mouth disease(HFMD)in infants and children with potential serious complications and even *** pathogenesis of this virus is not fully elucidated and no vaccine or antiviral drug has been *** this study,a full-length infectious cDNA clone of coxsackievirus B5 virus was assembled and the recombinant virus displayed similar growth kinetics and ability to cause cytopathic effects as the parental *** reporter was then incorporated to generate both full-length and subgenomic replicon(SGR)reporter *** full-length reporter virus is suitable for high-throughput antiviral screening,while the SGR is a useful tool to study viral-host *** importantly,the full-length reporter virus has also been shown to infect the suckling mouse model and the reporter gene could be detected using an in vivo imaging system,thus providing a powerful tool to track viruses in *** summary,we have generated coxsackievirus B5 reporter viruses and provided unique tools for studying virus-host interactions in vitro and in vivo as well as for high-throughput screenings(HTS)to identify novel antivirals.

关键词： Coxsackievirus Luciferase High-throughput screening Mouse model

Distributed Economic MPC for Synergetic Regulation of the Voltage of an Island DC Micro-Grid

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Nb_(2)CT_(x)MXene boosting PEO polymer electrolyte for all-solid-state Li-S batteries:two birds with one stone strategy to enhance Li+conductivity and polysulfide adsorptivity

自动化学报（英文版） 2024年第3期

作者： Yi Zheng Yanye Wang xun meng Shaoyuan Li Hao Chen

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稀有金属:英文版 2023年第8期42卷 2562-2576页

作者： Si-Ming Liu meng-xun Chen Ying Xie Deng-Hua Liu Jin-Fei Zheng Xiang Xiong Heng Jiang Li-Chang Wang Heng Luo Kai Han State Key Laboratory for Powder Metallurgy College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Shinghwa Advanced Material Group Co. LtdDongying 257500China School of Physics and Electronics Central South UniversityChangsha 410083China Department of Chemistry Oregon State UniversityCorvallis OR 97331-4003USA School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

All-solid-state lithium-sulfur(Li-S)battery is regarded as next-generation high energy density and safety battery *** key challenge is to develop a compatible high-performance solid-state ***,a two birds with one stone strategy is proposed to simultaneously enhance Li+conductivity and polysulfide adsorptivity of poly(ethylene oxide)(PEO)-based polymer electrolyte via the integration of Nb_(2)CT_(x)***,the sheet size of Nb_(2)CT_(x)MXene is crucial for the enhancement of Li^(+)conductivity and polysulfide adsorptivity,attributing to the difference in a specific surface area related to the percolation *** tuning the sheet size of Nb_(2)CT_(x)MXene from 500-300 nm to below 100 nm,the ionic conductivity of the PEO electrolyte is increased to2.62×10^(-4)S·cm^(-1)with improved Li+transference number of 0.37 at ***,theoretical calculation and X-ray photoelectron spectroscopy(XPS)conjointly prove that poly sulfides could be effectively adsorbed by Nb2CTxnanosheets via forming Nb-S bonding to inhibit their shuttle in the PEO *** a result,the all-solid-state Li-S cell exhibits an initial capacity of 1149 mAh·g^(-1)at 0.5C and good cycling stability with 491 mAh·g^(-1)after 200 *** results demonstrate the necessity of polysulfide inhibition and the application of Nb_(2)CT_(x)MXene in PEO-based electrolytes for all-solid-state Li-S batteries.

关键词： All-solid-state Li-S batteries Polyethylene oxide(PEO)-based electrolyte Nb_(2)CT,MXene Shuttle effect inhibition